Cardiomyopathy
Articles tagged with Cardiomyopathy
Researchers develop innovative model for risk assessment for hypertrophic cardiomyopathy
A new model for predicting outcomes in hypertrophic cardiomyopathy has been developed by incorporating prospective data, including clinical history, imaging, and blood biomarker tests. This study found that integrating these methods into risk assessment can improve the prediction of fatal and nonfatal cardiac events.
Patients with Duchenne are driving the development of a ‘heart-on-a-chip’ to halt the cardiac damage caused by muscular dystrophy
Researchers are developing a 'heart-on-a-chip' platform with sensors to track cardiac damage and fibrosis in real-time. The project aims to improve the understanding of cardiac involvement in Duchenne muscular dystrophy and speed up treatment evaluation.
High-intensity interval training shows strongest vascular benefits in cardiovascular patients
High-intensity interval training shows strongest vascular benefits in cardiovascular patients. HIIE consistently improves flow-mediated dilation and vasodilation, with combined high-intensity programs showing the largest estimated effects on endothelial function.
Study points to new treatment target for fatal infant heart disease
Researchers at Keck School of Medicine have identified a new potential treatment target for AARS2-related cardiomyopathy, a rare and fatal heart muscle disease in infants. By targeting the PCBP1 gene, they aim to restore healthier AARS2 function in heart cells and prevent damage.
Long-term durability of acoramidis efficacy in transthyretin amyloid cardiomyopathy
Early and continuous acoramidis treatment resulted in sustained incremental reductions in all-cause mortality, cardiovascular-related mortality, and first cardiovascular hospitalization. The findings support the importance of early and continuous long-term treatment with acoramidis in transthyretin amyloid cardiomyopathy.
Global trial supported by SickKids stem cell research shows targeted heart drug reduces obstructive HCM in youth
A global clinical trial led by SickKids has found that mavacamten improves blood flow and reduces obstruction in youth with hypertrophic cardiomyopathy (HCM), a genetic heart disease. The study's results offer hope to families avoiding open-heart surgery, setting the stage for precision therapeutics.
AI-driven chart review accurately identifies potential rare disease trial participants in new study
A new study by Cleveland Clinic and Dyania Health demonstrates the potential of large language models in accurately identifying patients who could benefit from clinical research. The AI system reviewed 1,476 patients and identified 46 as potential matches, resulting in a more diverse patient population.
Diagnosis of cardiomyopathy is on the rise
A new study from Uppsala University reveals a substantial increase in cardiomyopathy diagnoses in Sweden between 2004 and 2023, associated with high excess mortality rates. The study highlights the need for improved detection and targeted treatments to address this growing public health concern.
Could gene therapy treat a deadly heart condition that targets young athletes?
Researchers at University of California San Diego discover gene therapy restoring connexin-43 improves heart function and extends survival in several forms of arrhythmogenic cardiomyopathy. The approach may have broader therapeutic potential across multiple genetic forms of the disease, addressing a critical unmet need.
Human heart regrows muscle cells after heart attack, world-first study shows
Researchers have shown that human hearts can regrow muscle cells after a heart attack, paving the way for new treatments to reverse heart failure. The discovery was made possible by pioneering techniques that use living tissue samples taken from patients during bypass surgery.
Nature Communications study from the Lundquist Institute identifies molecular mechanism underlying peripartum cardiomyopathy
Researchers at The Lundquist Institute have identified PTRH2 as a critical gene that protects the maternal heart during pregnancy, shedding light on the causes of peripartum cardiomyopathy. Loss of this gene leads to severe postpartum heart failure, highlighting the urgent need for better treatments.
Battle of the Legends football game highlights lifesaving CPR, heart health for HBCU fans
The American Heart Association brought hypertrophic cardiomyopathy and Hands-Only CPR awareness to a historic college football game, aiming to empower young athletes and their families with critical knowledge. The organization aims to double cardiac arrest survival rates by 2030 through its Nation of Lifesavers movement.
Accessible imaging technique can predict cardiac risks in patients with Chagas disease
A simple echocardiography method analyzes myocardial deformation to predict cardiac complications in chronic Chagas disease. The study found that patients with a greater GLS value had a higher risk of death and complications.
Assessing heart-pumping glitch may reduce stroke risk in adults with heart muscle disease
Researchers have found that atrial electromechanical dissociation (AEMD) can predict stroke risk in people with transthyretin amyloid cardiomyopathy, even when the heart rhythm appears normal. A non-invasive assessment tool may help identify those at increased risk and guide earlier conversations about preventive strategies.
New method enables researchers to investigate the cause of heart diseases
A new study from the University of Copenhagen enables researchers to investigate the cause of heart diseases by analyzing thousands of proteins in heart tissue. This groundbreaking method reveals molecular patterns characteristic of heart diseases.
ROS and hypertrophic cardiomyopathy: new insights
A recent study revealed ROS-induced oxidative stress accelerates hypertrophic cardiomyopathy (HCM) in MYBPC3-deleted hiPSC-CMs. The researchers found that melatonin alleviates HCM by inhibiting the PI3K/AKT/FOXO3a signaling pathways.
CRF announces TCT 2025 late-breaking clinical trials and science
Late-breaking clinical trials and science at TCT 2025 will present pivotal data on novel therapies, devices, and techniques aimed at preventing and treating cardiovascular conditions. The symposium delivers high-impact findings that shape clinical practice and enhance outcomes for patients with heart and vascular disease.
Including more females in cardiac device trials benefits all patients
A cardiac device trial published in eClinicalMedicine found that improving enrollment of females in such trials can better guide care for all patients. One-year interim study results revealed that participants assigned male at birth were twice as likely to die or experience life-threatening heart rhythm abnormalities, while females sho...
American College of Cardiology launches HCM Digital Registry
The American College of Cardiology has established a digital registry for hypertrophic cardiomyopathy (HCM) to broaden understanding and provide equitable access to treatment. The registry will capture data on HCM symptoms, diagnostic images, treatment plans, and outcomes to improve diagnosis and management.
New study uncovers how genetics and lifestyle drive the heart disease dilated cardiomyopathy
Researchers found that individuals with a mutation in the TTN gene are 21 times more likely to develop dilated cardiomyopathy than those without. Lifestyle factors such as being overweight or having high alcohol consumption contribute to an earlier diagnosis, and men with the mutation are more likely to develop DCM at a younger age.
Masonic Medical Research Institute publishes breakthrough study on combating heart disease linked to obesity and high-fat diet
A groundbreaking study published in Science Signaling has identified protein tyrosine phosphatase PTP1B as a key driver of maladaptive cardiac metabolism and dysfunction under dietary stress. Mice lacking PTP1B in cardiomyocytes were resistant to harmful changes, highlighting the enzyme's role in heart disease progression.
$2.6 million NIH grant backs search for genetic cure in deadly heart disease
Scientists are working on a genetic cure for the world's most common inherited heart disease, hypertrophic cardiomyopathy (HCM), with a new gene editing tool. The team aims to correct mutations that cause the disease, which affects 14 million people worldwide.
Genetics of cardiomyopathy risk in cancer survivors differ by age of onset
Researchers found common variants in TTN and BAG3 associated with reduced late-onset cardiomyopathy in childhood cancer survivors, similar to the general population. However, rare variants linked to early-onset cardiomyopathy in adults showed no association with late-onset risk in children.
MRI scans could help detect life-threatening heart disease
Researchers found that MRI scans can detect heart inflammation, scarring, and impaired function in carriers of a mutated LMNA gene. This information can help clinicians predict which patients are at higher risk and inform decisions about treatments such as defibrillators or transplants.
AI algorithm can help identify high-risk heart patients to quickly diagnose, expedite, and improve care
A new AI algorithm, Viz HCM, can quickly and specifically identify high-risk heart patients with hypertrophic cardiomyopathy (HCM) and provide individualized risk assessments. The algorithm's findings can help doctors prioritize the highest-risk patients for earlier appointments and treatment.
AI algorithm can help identify high-risk heart patients to quickly diagnose, expedite, and improve care
A new AI algorithm has been calibrated to quickly identify patients with hypertrophic cardiomyopathy (HCM) and provide individualized risk assessments. The tool can help prioritize high-risk patients for earlier appointments and treatment, leading to better patient outcomes.
Breakthrough gene therapy offers hope for rare, deadly heart disease in young men
A team of researchers has developed a gene-therapy strategy to treat arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5), a rare and deadly hereditary disease. The treatment, using adeno-associated viruses, improved cardiac function and prolonged survival in mice with ARVC5-like disease.
Impact of preoperative anemia in ischemic cardiomyopathy with or without coronary artery bypass grafting
Preoperative anemia is a recognized risk factor for adverse outcomes in CABG, but it does not affect the long-term survival advantage associated with CABG. This study provides evidence that surgical intervention can still be beneficial for ICM patients despite preoperative anemia.
A simple supplement improves survival in patients with a new type of heart disease
A study published in Nature Cardiovascular Research found that tricaprin improved long-term survival and recovery from heart failure in patients with triglyceride deposit cardiomyovasculopathy. The supplement reversed structural changes and improved heart muscle function, leading to higher survival rates compared to controls.
Disrupted recycling of proteins found to damage heart health
A new study identified USP5 as an enzyme crucial for breaking down unneeded or damaged proteins in the heart. Low levels of USP5 lead to protein buildup, triggering dilated cardiomyopathy in animal models. Increasing USP5 levels helps clear protein 'junk', improving heart function and reducing disease progression.
University of Birmingham researchers awarded grant to tackle early-stage heart disease in chronic kidney disease
University of Birmingham researchers have been awarded a grant to study the mechanisms driving early cardiac dysfunction in CKD. The study aims to identify interventions that can reverse or prevent heart disease in its earliest stages.
Research reveals why more men than women are diagnosed with deadly heart disease
A new study suggests that current guidelines for diagnosing a potentially deadly heart condition may be missing women due to natural differences in sex and body size. The researchers developed a personalized approach using AI, which improved diagnosis accuracy by 20 percentage points for female patients.
New treatment option for severe hypertrophic cardiomyopathy in children shows promise
Trametinib reduces mortality and morbidity in children with severe HCM caused by pathogenic variants in the RAS/MAPK pathway. The study provides strong evidence for personalized treatment targeting the underlying genetic causes of RASopathies.
President Biden signs bipartisan HEARTS Act into law
The American Heart Association strongly supports the legislation, which aims to double survival rates from cardiac arrest nationwide by 2030. The HEARTS Act includes key provisions such as CPR training, AEDs, and cardiac emergency response plans, which can more than double survival rates in schools with these resources.
Researchers describe a potential target to address a severe heart disease in diabetic patients
Researchers have discovered a potential target to address diabetic cardiomyopathy, a serious condition affecting diabetic patients. The PPARβ/δ receptor's activation can help slow down inflammation and fibrosis, providing a new therapeutic strategy.
New effort to improve care for hidden heart disease
The American Heart Association has launched a new three-year initiative to standardize HCM systems of care and support better management of the disease. The initiative aims to overcome gaps in care for hypertrophic cardiomyopathy, leading to delayed treatment, increased risk of complications, and preventable death.
Predicting cardiac issues in cancer survivors using a serum protein panel test
A study by St. Jude Children's Research Hospital has identified a serum protein panel test that accurately predicts cardiomyopathy risk in childhood cancer survivors. The test, using a panel of 27 proteins, was tested on 46 survivors and correctly predicted risk in 38 cases.
New genetic explanation for heart condition revealed
A new study has found that hundreds of genes, rather than a single 'aberrant' genetic variant, contribute to the development of dilated cardiomyopathy. Researchers developed a polygenic risk score to assess individual risk and found those with the highest genetic risk had a fourfold chance of developing the disease.
Children’s Hospital Colorado Heart Institute earns national recognition for excellence in cardiomyopathy care
The Heart Institute is celebrated for delivering unparalleled treatment and support to children with heart conditions. It has consistently provided high-quality cardiac care and specialized disease management for all forms of cardiomyopathy.
Kidney outcomes in transthyretin amyloid cardiomyopathy
Patients with transthyretin amyloid cardiomyopathy experience frequent decline in kidney function, associated with higher mortality risk. eGFR decline is an independent marker of disease progression guiding treatment optimization.
Interpreting population mean treatment effects in the Kansas City Cardiomyopathy Questionnaire
New study suggests that small group differences may reflect important benefits for individual patients with cardiomyopathy. The authors recommend explicitly describing patient-level data to support clinical interpretation of results.
Validation of the Kansas City Cardiomyopathy Questionnaire in patients with tricuspid regurgitation
The Kansas City Cardiomyopathy Questionnaire (KCCQ) demonstrated strong psychometric properties in patients with severe tricuspid regurgitation. The KCCQ can effectively measure symptoms, function, and quality of life, making it a valuable tool for assessing patient outcomes.
NIH grant supports research to discover better treatments for heart failure
Researchers at the University of Arizona Health Sciences are studying the molecular mechanisms of coagulation factor XII as a contributor to heart failure with reduced ejection. The goal is to develop better preventive and treatment options for this irreversible condition, which affects millions of Americans.
Pregnancy-related heart failure is under-detected; AI-enabled stethoscope helped doctors diagnose twice as many cases
A study at the European Society of Cardiology Congress found that an AI-enabled digital stethoscope helped doctors identify twice as many cases of pregnancy-related heart failure compared to a control group. The tool was 12 times more likely to flag heart pump weakness, leading to better diagnosis and potentially life-saving treatment.
Vutrisiran offers a new lifeline to patients with progressive heart condition
A phase 3 study has shown that vutrisiran, an RNA interference therapeutic, reduces all-cause mortality and recurrent cardiovascular events by 28% and 33% respectively in patients with transthyretin amyloidosis with cardiomyopathy. The treatment also improves functional capacity, quality of life, and NYHA class.
Whole-exome sequencing identifies three novel TTN variants in Chinese families with dilated cardiomyopathy
This study identified three novel TTN variants associated with dilated cardiomyopathy in Chinese patients. The variants were found through whole-exome sequencing and are expected to contribute to the disease's molecular mechanisms. The discovery broadens the spectrum of TTN variants and may aid in genetic screening for related diseases.
Identification of a novel DSP variant in a patient with sudden cardiac death through post-mortem genetic investigation
Researchers used WES to identify a novel deletion variant in the DSP gene associated with sudden cardiac death. This finding highlights the importance of post-mortem genetic testing for accurate risk assessment and personalized medicine.
Deep machine-learning speeds assessment of fruit fly heart aging and disease, a model for human disease
Researchers at UAB have developed a method to assess cardiac dynamics in fruit flies using deep learning and high-speed video microscopy. The study uses this approach to analyze the effects of aging and dilated cardiomyopathy on heart function, with potential applications for human cardiovascular research.
Heart disease model puts cells to work
Researchers develop a model of heart disease by tricking stem cells to behave like mature heart cells with a mutation that causes hypertrophic cardiomyopathy. The study reveals the connection between mechanical stress and electrical function in hearts, shedding light on why genetic mutations can cause arrhythmias.
New drug makes exercise, everyday tasks easier for people with common heart condition
A clinical trial found that aficamten significantly increased maximum oxygen use in patients with obstructive hypertrophic cardiomyopathy. This improvement enables patients to perform everyday tasks more easily, such as walking and household chores. Researchers believe aficamten has promise as a treatment for this condition.
Exercise, new drug class recommended for management of hypertrophic cardiomyopathy
The American College of Cardiology and American Heart Association have released a new clinical guideline for effectively managing individuals diagnosed with hypertrophic cardiomyopathy. The guideline recommends exercise as part of a healthy lifestyle, including low-to-moderate intensity recreational activities, while also introducing a...
A new Spanish study provides the first stratification of the risk of developing dilated cardiomyopathy among symptom-free genetic carriers
A new Spanish study provides the first stratification of the risk of developing dilated cardiomyopathy among symptom-free genetic carriers. Researchers found that nearly 11% of genetic carriers developed the disease within a median follow-up period of 37 months.
Elucidating the link between Guillain–Barré syndrome and Takotsubo cardiomyopathy
A recent study investigates the correlation between Takotsubo cardiomyopathy (TCM) and Guillain–Barré syndrome (GBS), revealing key factors that distinguish TCM patients from those with classical GBS. The researchers identified age at onset, disability scores, muscle weakness, and cranial nerve involvement as significant differences.
Chinese Medical Journal review identifies disrupted mitochondrial metabolism as a trigger for diabetic cardiomyopathy
A review of mitochondrial energy metabolism in diabetic cardiomyopathy reveals disrupted dynamics and oxidative stress as key triggers. Targeted therapies, such as antioxidants and ketogenic diets, show promise in combating this debilitating condition.
ADHD stimulants may increase risk of heart damage in young adults
A study presented at the American College of Cardiology's Annual Scientific Session found that young adults prescribed ADHD stimulants were significantly more likely to develop cardiomyopathy. The overall risk remained low, but researchers suggested further studies could identify subgroups at greater risk.
Most survivors of childhood cancer don't get the tests needed to detect serious long-term adverse effects
A study found that up to 87% of childhood cancer survivors are not following recommended screening guidelines, leaving them vulnerable to late effects such as heart disease and certain cancers. The lack of awareness and barriers to adherence may contribute to this low rate, highlighting the need for improved support and education.
Vest can detect earlier signs of heart muscle disease
A new vest can map electric impulses of the heart in fine detail, detecting abnormalities from a potentially fatal heart disease much earlier. The study found that the vest identified electrical changes among 1 in 4 individuals with a gene mutation for whom no signs of disease were detected via standard tests.
Whole genome sequencing reveals new genetic marker for cardiomyopathy
A new genetic marker for cardiomyopathy has been identified through whole genome sequencing, suggesting that tandem repeat expansions may cause four percent of cases. This discovery provides a promising lead for early detection and the development of precision therapies.
Chronic exposure to air pollution may increase risk of cardiovascular hospitalization among seniors
A new study found that chronic exposure to PM2.5 is associated with increased risk of hospital admission for various cardiovascular conditions, particularly ischemic heart disease and cerebrovascular disease. The study suggests that lowering annual average PM2.5 levels could decrease overall cardiovascular hospitalizations by 15%.