A study found that up to 87% of childhood cancer survivors are not following recommended screening guidelines, leaving them vulnerable to late effects such as heart disease and certain cancers. The lack of awareness and barriers to adherence may contribute to this low rate, highlighting the need for improved support and education.
SourceCanadian Medical Association Journal·JournalCanadian Medical Association Journal·TypeObservational study·DateMar 11, 2024
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
A new vest can map electric impulses of the heart in fine detail, detecting abnormalities from a potentially fatal heart disease much earlier. The study found that the vest identified electrical changes among 1 in 4 individuals with a gene mutation for whom no signs of disease were detected via standard tests.
SourceUniversity College London·JournalJournal of the American College of Cardiology·TypeObservational study·DateFeb 28, 2024
A new genetic marker for cardiomyopathy has been identified through whole genome sequencing, suggesting that tandem repeat expansions may cause four percent of cases. This discovery provides a promising lead for early detection and the development of precision therapies.
SourceThe Hospital for Sick Children·JournalEBioMedicine·DateFeb 27, 2024
A new study found that chronic exposure to PM2.5 is associated with increased risk of hospital admission for various cardiovascular conditions, particularly ischemic heart disease and cerebrovascular disease. The study suggests that lowering annual average PM2.5 levels could decrease overall cardiovascular hospitalizations by 15%.
SourceHarvard T.H. Chan School of Public Health·JournalBMJ·TypeObservational study·DateFeb 21, 2024
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
A study published in Nature Cardiovascular Research reveals that a dynamic synergy between cell types facilitates cardiac renewal, challenging existing paradigms. Targeting the microenvironment rather than specific cell types is key to healing injured hearts.
SourceTexas Heart Institute·JournalNature Cardiovascular Research·TypeExperimental study·DateFeb 14, 2024
Researchers have found that a gene-based therapy targeting plakophilin-2 can interrupt the progression of arrhythmogenic right ventricular cardiomyopathy, a rare inherited disorder. The treatment reduced episodes of arrhythmia and slowed the deterioration of the heart's walls in mice.
SourceNYU Langone Health / NYU Grossman School of Medicine·JournalCirculation Genomic and Precision Medicine·TypeExperimental study·DateJan 30, 2024
Researchers found that two common biomarkers, global longitudinal strain and N-terminal-pro-B-type natriuretic peptide, can identify asymptomatic childhood cancer survivors at elevated risk of declining heart muscle function. These biomarkers may lead to earlier treatment to prevent further heart damage.
SourceSt. Jude Children's Research Hospital·JournalJournal of Clinical Oncology·DateJan 11, 2024
A recent study published by the Mayo Clinic found that an AI-enabled digital stethoscope can detect peripartum cardiomyopathy, a potentially life-threatening condition, more accurately than regular care. The researchers identified twice as many cases using the AI-powered tool.
A new study by UCL researchers suggests that a vest mapping the heart's electrical activity could help identify people at high risk of sudden cardiac death. The electrocardiographic imaging (ECGI) vest combines signals with MRI images to generate 3D models, potentially predicting risk factors for life-threatening heart rhythms.
SourceUniversity College London·JournalJournal of Cardiovascular Magnetic Resonance·TypeRandomized controlled/clinical trial·DateDec 18, 2023
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers uncover the role of IGF2BP2 in responding to cardiac stress, highlighting its potential reversibility and clinical relevance. Elevated IGF2BP2 expression leads to dilated cardiomyopathy, but controlled reduction prompts recovery.
SourceThe Hebrew University of Jerusalem·JournalNature·TypeExperimental study·DateDec 9, 2023
Researchers developed a gene therapy approach to target the root cause of ACM, restoring plakophilin-2 levels and improving heart function. Clinical trials starting in 2024 aim to explore this approach in patients with PKP2 mutations.
SourceHubrecht Institute·JournalNature Cardiovascular Research·TypeExperimental study·DateDec 7, 2023
Researchers at the University of Pittsburgh have discovered a potential new target for treating Barth syndrome, a rare genetic disease with devastating consequences. They identified a molecular culprit that could be targeted to potentially reverse the disease course and developed a small-molecule drug candidate to correct genetic tafaz...
SourceUniversity of Pittsburgh·JournalNature Metabolism·TypeExperimental study·DateNov 23, 2023
A new study found that genetic screening can identify patients with an inherited risk of cardiomyopathy, allowing for closer monitoring and improved treatment. The study suggests that widespread genetic testing can lead to better outcomes for these patients, including reduced deaths.
SourceIntermountain Healthcare·TypeObservational study·DateNov 12, 2023
A recent study published in Circulation found that non-ischemic or dual cardiomyopathy occurs in 1 out of every 6 patients with coronary artery disease. These conditions are characterized by heart muscle damage and can lead to worse long-term outcomes. The researchers used cardiac MRI to determine the cause of cardiomyopathy, which has...
SourceUniversity of Minnesota Medical School·JournalCirculation·TypeRandomized controlled/clinical trial·DateNov 10, 2023
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
A study by the University of Helsinki has identified two genetic risk factors, RNF207 and PRKAA2, that contribute to dilated cardiomyopathy in both humans and Dobermanns. The research offers a new perspective on the disease and may lead to the development of early diagnostic tests for breeders.
SourceUniversity of Helsinki·JournalGenome Medicine·DateSep 22, 2023
A new computational approach removes movement in heart cell and tissue images, allowing direct monitoring of electro-mechanical coupling. The algorithm mimics a drug's action, giving insight into heart diseases.
SourceWashington University in St. Louis·JournalProceedings of the National Academy of Sciences·DateSep 11, 2023
Autophagy helps protect cardiomyocytes from damage caused by anthracycline drugs like Doxorubicin. The study found that a protein regulator called ER-phagy alleviates Dox-induced cardiomyopathy, promoting cell survival.
SourceTokyo Medical and Dental University·JournalJACC CardioOncology·DateAug 31, 2023
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
The European Society of Cardiology has published its first international guidelines on cardiomyopathies, covering all subtypes and specific recommendations for other than hypertrophic cardiomyopathy. The guidelines aim to improve diagnosis, treatment and management of heart muscle diseases, emphasizing patient-centered care.
SourceEuropean Society of Cardiology·JournalEuropean Heart Journal·DateAug 25, 2023
A new study found that younger atrial fibrillation (AFib) patients who underwent MRI-guided ablation treatments had better outcomes. The treatment significantly improved arrhythmia recurrence rates by 50% for patients under 58 years old.
Researchers found that African ancestry patients with dilated cardiomyopathy have fewer clinically actionable variants in DCM genes compared to European ancestry patients. The study enrolled 1,198 patients with dilated cardiomyopathy, revealing a racial imbalance in genetic trials for heart failure.
SourceLouisiana State University Health Sciences Center·JournalJAMA·TypeObservational study·DateAug 3, 2023
A new multi-center study found that having a genetic variant in the prealbumin gene alone is not sufficient for diagnosing transthyretin amyloid cardiomyopathy in older Black patients. Researchers suggest that a blood test measuring prealbumin levels may be useful in identifying patients at risk of developing cardiac amyloidosis.
SourceBoston Medical Center·JournalJournal of the American Heart Association·DateJul 28, 2023
Researchers developed a new method to detect hypertrophic cardiomyopathy (HCM) using combined cardiac diffusion tensor imaging and cardiac MRI perfusion scans. The study identified abnormal microstructure and microvascular disease in people with genetic mutations but no symptoms, allowing for early detection of the condition.
SourceUniversity College London·JournalCirculation·TypeImaging analysis·DateJul 19, 2023
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers created a digital replica of patients' hearts to inform arrhythmogenic right ventricular cardiomyopathy (ARVC) diagnosis and treatment. The 'genotype-specific digital-twin' strategy could tailor therapies based on individual genetics, improving precision healthcare in other diseases.
The new scientific statement highlights the importance of identifying the root cause of pediatric cardiomyopathy to develop effective treatment strategies. Genetic testing is recommended for all children with cardiomyopathy, which may lead to financial and emotional cost savings.
SourceAmerican Heart Association·JournalCirculation·DateJun 8, 2023
A groundbreaking study has shown that a devastating heart condition can spontaneously reverse in three men, who are now free of symptoms. The condition, transthyretin cardiac amyloidosis, is progressive and previously considered irreversible.
SourceUniversity College London·JournalNew England Journal of Medicine·TypeCase study·DateJun 7, 2023
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Researchers found that a mutation in RPL3L, expressed only in heart and skeletal muscle, leads to impaired cardiac contractility by causing ribosomal collisions and protein folding abnormalities. The study aims to develop new treatments for cardiomyopathy and atrial fibrillation.
SourceKyushu University·JournalNature Communications·TypeExperimental study·DateMay 18, 2023
A study funded by the National Institutes of Health found that vigorous exercise is safe for people with hypertrophic cardiomyopathy, a rare inherited disorder affecting the heart muscle. The research, published in JAMA Cardiology, suggests that restrictions on exercise may be unnecessary for individuals with HCM.
SourceNIH/National Heart, Lung and Blood Institute·JournalJAMA Cardiology·DateMay 17, 2023
Researchers have discovered a novel feature of long intergenic noncoding RNAs (lincRNAs) that can serve as markers indicating specific types of tissue. This finding has the potential to lead to highly specific disease treatments by targeting diseased tissues.
SourceUniversity of Tokyo·JournaliScience·TypeExperimental study·DateApr 26, 2023
A study found that extended ECG monitoring detected a higher incidence of clinically relevant arrhythmias in patients with hypertrophic cardiomyopathy, including non-sustained ventricular tachycardia. The increased detection led to reclassification of more than one-fifth of patients to a higher risk category.
Researchers from the Smidt Heart Institute found that individuals with spherical hearts are 31% more likely to develop atrial fibrillation and 24% more likely to develop cardiomyopathy. The study identified four genes associated with cardiomyopathy and a greater risk of developing atrial fibrillation.
SourceCedars-Sinai Medical Center·JournalMed·DateMar 29, 2023
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
A recent study suggests that cardiac sphericity, or the roundness of the heart, may be a useful indicator for diagnosing cardiovascular conditions. The research used machine learning to analyze medical images and found a link between increased sphericity and future heart troubles.
SourceCell Press·JournalMed·TypeObservational study·DateMar 29, 2023
Researchers found that a plakophilin-2 mutation leads to increased desmosomal protein degradation in ACM hearts, causing structural and functional changes. Studying human heart samples and mice models confirmed the role of protein degradation in ACM development.
SourceHubrecht Institute·JournalScience Translational Medicine·TypeExperimental study·DateMar 22, 2023
Researchers have discovered a new strategy for treating arrhythmogenic cardiomyopathy by restoring the trafficking protein GJA1-20k, which enables healthy connections between heart cells. This finding may also be applicable to treating dangerous arrhythmias associated with other conditions.
SourceUniversity of Utah Health·JournalCirculation Research·TypeExperimental study·DateMar 17, 2023
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
A new study shows that transcatheter mitral valve repair significantly reduces hospitalizations by almost 50 percent and death by nearly 30 percent in heart failure patients with severe mitral regurgitation. The procedure, using Abbott's MitraClip system, improves symptoms, reduces hospitalizations, and leads to longer survival.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateMar 5, 2023
Researchers identified a new mutation in the desmoplakin gene that leads to cardiac disease arrhythmogenic cardiomyopathy (ACM). The mutation affects heart muscle cell connections and ion channel function, highlighting the importance of desmosomes in maintaining healthy heart function.
SourceHubrecht Institute·JournalStem Cell Reports·TypeExperimental study·DateMar 2, 2023
A recent study led by Murdoch Children's Research Institute has revealed a new pathway for how genetic mutations impact heart muscle function. The research identifies the gene ALPK3 as a key player in cardiomyopathy, a group of diseases affecting the heart's ability to pump blood, and provides hope for new targeted therapies.
SourceMurdoch Childrens Research Institute·JournalNature Cardiovascular Research·TypeExperimental study·DateMar 1, 2023
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
Researchers identified a genetic variant linked to digestive disturbances in patients with Chagas megaesophagus, a disorder characterized by esophageal dilation and loss of motility. The study suggests that increased interferon-gamma production leads to mitochondrial dysfunction, contributing to the development of the disease.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalBiomedicines·DateDec 5, 2022
A multicenter study found that left ventricular global longitudinal strain is a significant independent predictor of all-cause mortality and/or heart-failure hospitalization in patients with ischemic or nonischemic dilated cardiomyopathy. The study used cardiac MRI feature tracking to calculate six myocardial strain parameters.
SourceAmerican Roentgen Ray Society·JournalAmerican Journal of Roentgenology·TypeImaging analysis·DateNov 9, 2022
Researchers found that the presence of one Mindbomb1 mutation does not always lead to non-compaction cardiomyopathy, but depends on genetic context provided by other gene mutations. The study identified modifier genes contributing to disease severity and diversity in affected individuals.
SourceCentro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)·JournalCirculation·TypeExperimental study·DateNov 7, 2022
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Researchers evaluated the safety and efficacy of NTLA-2001 in patients with transthyretin amyloid cardiomyopathy. The results showed significant reductions in circulating TTR protein levels, which were sustained for up to six months after treatment.
Researchers genetically modified mice to develop a similar disease to humans, identifying previously unknown mechanisms and potential therapeutic targets. The study found that reduced adhesion between cardiac muscle cells leads to scarring and arrhythmia, providing new insights into the disease.
SourceUniversity of Basel·JournalCirculation·DateNov 1, 2022
Dr. Christine E. Seidman, a renowned physician-scientist, has made groundbreaking discoveries in genetics and cardiomyopathy, leading to new pharmacological treatments. Her work has improved our understanding of disease risks and has led to unique targeted therapies.
A novel screening tool has been developed to diagnose a serious heart condition in young athletes. The tool uses non-invasive ultrasound techniques to accurately identify cardiomyopathy, reducing false positives and providing better protection for the athletes of tomorrow.
SourceUniversity of Exeter·JournalInternational Journal of Cardiology·DateOct 25, 2022
Researchers have developed genetic testing to diagnose cardiomyopathy in children, identifying those at risk of heart failure and requiring a transplant. The test provides precise clinical diagnosis, enabling targeted treatment options and reducing the need for life-threatening interventions.
SourceCentenary Institute·JournalCirculation Genomic and Precision Medicine·TypeExperimental study·DateOct 12, 2022
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
A recent study published in Life Metabolism found that impaired phosphorylation of SERCA2a plays a bidirectional role in myocardial insulin resistance, dysregulation of calcium homeostasis, and the early stages of DCM. This mechanism involves the regulation of protein stability and insulin receptor maturation.
SourceHigher Education Press·JournalLife Metabolism·TypeExperimental study·DateSep 28, 2022
Researchers found that nearly nine in ten cases of sudden cardiac death due to hypertrophic cardiomyopathy (HCM) are preceded by symptoms, ECG abnormalities, or a positive family history. Expanded screening programs could aid in the prevention of SCD in young individuals with HCM.
SourcePLOS·JournalPLOS ONE·TypeObservational study·DateSep 14, 2022
A new software application predicts the likelihood that a case of dilated cardiomyopathy has a genetic mutation. The Madrid Genotype Score identifies patients most likely to have inherited the disease, facilitating genetic screening and tailored treatment adjustments.
SourceCentro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)·JournalJournal of the American College of Cardiology·TypeRandomized controlled/clinical trial·DateSep 12, 2022
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
A study by CNIC scientists has identified a key role for the MKK3/6–p38γ/δ signaling pathway in cardiac hypertrophy. Inhibition of p38α promotes an unexpected activation of the other branch of the pathway, consisting of the proteins MKK3, p38γ, and p38δ. This activation induces another key pathway in cardiac hypertrophy, the mTOR pathway.
SourceCentro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)·JournaleLife·TypeExperimental study·DateAug 16, 2022
Researchers mapped specific gene variants to their effects on cardiac cells, revealing unique responses to different mutations. This study provides insights into the development of precision-targeted interventions for dilated cardiomyopathy and other genetic heart diseases.
SourceMax Delbrück Center for Molecular Medicine in the Helmholtz Association·JournalScience·DateAug 4, 2022
Researchers discovered distinct genetic mutations in heart failure patients, identifying potential targets for personalized treatment and improving patient care. The study's findings hold enormous potential for rethinking how to treat heart failure by understanding its root causes and the mutations that lead to changes in heart function.
SourceBrigham and Women's Hospital·JournalScience·TypeExperimental study·DateAug 4, 2022
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers found 560 proteins were differentially expressed, with 32 significantly altered, in reductive stress hearts. The proteome signature revealed oxidative stress-related pathways and mitochondrial dysfunction.
SourceUniversity of Alabama at Birmingham·JournalFrontiers in Cardiovascular Medicine·TypeExperimental study·DateAug 3, 2022
A global team of researchers, including Professor Stuart Cook, has won £30M to develop an injectable cure for genetic heart conditions. The team aims to pioneer gene therapy technologies to silence or edit faulty genes causing deadly conditions.
A team of researchers, backed by a £30m grant from the British Heart Foundation, aims to develop the first cures for inherited heart muscle diseases using ultra-precise gene therapy technologies. They plan to deploy CRISPR technology to correct or silence faulty genes, potentially delivering an injectable cure within years.
A Spanish study combines genetic and imaging data to predict patient prognosis, identifying those at risk of malignant arrhythmias or severe complications. The findings open the way for personalized medicine in treating dilated cardiomyopathy.
SourceCentro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)·JournalEuropean Journal of Heart Failure·TypeRandomized controlled/clinical trial·DateJul 26, 2022
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
The Brigham and Women's Hospital will implement and evaluate an integrated service delivery model (PEN-Plus) for severe chronic noncommunicable diseases, such as type 1 diabetes and rheumatic heart disease, in eight low- and lower-middle-income countries. The initiative aims to enable one million of the world's poorest children and you...
Research led by Texas A&M AgriLife scientist Shaodong Guo found that estrogen protects female mice from cardiomyopathy and death, reversing the effects of insulin resistance. The study suggests that estrogen replacement therapy may be a feasible treatment option for diabetic cardiomyopathy.
SourceTexas A&M AgriLife Communications·JournalCirculation·DateJun 14, 2022
Researchers discovered a new gene, ZBTB11, that drives heart muscle cell degeneration in arrhythmogenic cardiomyopathy. The gene's activity induces damage to neighboring heart cells, a key process in the disease.
SourceHubrecht Institute·JournalCardiovascular Research·TypeObservational study·DateMay 24, 2022
Researchers applied scRNA-seq to study hypertrophic cardiomyopathy, identifying novel regulatory interactions and genes driving disease-related swelling. This knowledge can be used to develop new drugs that target underlying causes, reducing disease progression.
SourceHubrecht Institute·JournalCell Reports·TypeExperimental study·DateMay 10, 2022
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
A new clinical trial found that the drug mavacamten alleviates shortness of breath in patients with obstructive hypertrophic cardiomyopathy. The treatment also improves symptoms and heart failure biomarkers.
The trial evaluated the use of mavacamten as an alternative to heart surgery or alcohol septal ablation for treating hypertrophic cardiomyopathy. Findings showed significant reduction in left ventricular outflow tract pressure gradient and improvements in quality-of-life measures.