A new study by Oxford researchers has found vedolizumab to be effective in inducing remission in patients with chronic pouchitis after surgery for ulcerative colitis. The treatment improved remission rates and quality of life, making it a game-changer for these patients.
Researchers found that metformin + leucine (MET+LEU) treatment prevents myotube atrophy by reversing cellular senescence and improving proteostasis. The study used C2C12 myoblasts, aged mouse single myofibers, and human primary myotubes to demonstrate MET+LEU's skeletal muscle cell-autonomous properties.
Researchers found that exceptional weather conditions over several years are turning European forests brown. Characteristic weather patterns, such as prolonged dry periods and high temperatures, precede these events, with a legacy effect contributing to future low-forest greenness.
A low-cost, high-effective program provides community-based groups to teach women and partners about nutrition, caregiving, and health from pregnancy to age one. The study found significant improvements in brain development, cognitive skills, and language abilities at age two compared to usual healthcare.
Researchers at IISc have developed a novel ultramicro supercapacitor with enhanced electrochemical capacitance, exceeding 3000% increase in capacitance under certain conditions. The device uses Field Effect Transistors as charge collectors and solid gel electrolyte for improved electron mobility.
Researchers at Baylor College of Medicine discovered crucial steps that promote ciprofloxacin resistance in bacteria, pointing to potential strategies to extend antibiotics' effectiveness. The study found that RNA polymerase plays a major role in regulating DNA repair and identified a key molecule involved in modulating this response.
A systematic review and meta-analysis of 4.8 million participants found no significant association between daily low or moderate alcohol intake and all-cause mortality risk. However, increased risk was evident at higher consumption levels, starting at lower levels for women than men.
Researchers aim to assess the effectiveness of spinal cord transcutaneous stimulation and a cognitive training program in improving processing speed abilities and upper extremity function after spinal cord injury. The studies will test innovative approaches to enhance rehabilitation outcomes for individuals with spinal cord injuries.
Researchers at the University of São Paulo developed a kraft paper-based electrochemical sensor that can detect traces of pesticides in fruit and vegetables in real time. The device resembles a glucometer and has been shown to be highly sensitive, fast, and inexpensive.
Researchers discovered a plant biological clock-regulated mechanism that helps plants tolerate cold temperatures and damage from bright light. The mechanism, controlled by the SIG5 gene, signals proteins in chloroplasts to protect against environmental stress, potentially improving crop resilience for colder climates.
A new study by Boston University researchers reveals that visual stimulation can induce large-scale changes in cerebrospinal fluid flow during wakefulness. The findings have implications for treating conditions like Alzheimer's disease, which are associated with declines in fluid flow.
A research team from Pohang University of Science & Technology has engineered an artificial kidney to detect adverse drug reactions and provide personalized treatment. The team successfully fabricated a glomerular microvessel-on-a-chip that recapitulates the kidney's filtering function and evaluates its response to various toxins.
MIT researchers discovered unconventional activation functions that enable optimal neural network performance, leading to better classification on various datasets. The findings suggest that selecting the correct activation function can significantly improve data accuracy in machine learning applications.
Researchers used virtual reality to study how memories are selected for long-term storage, revealing the anterior thalamus as a crucial stopover site. Stimulating this region enhanced memory consolidation, while inhibiting it hindered long-term retention.
Researchers found that after 96 weeks, some patients achieved loss of detectable HBsAg and reduced liver inflammation levels, indicating functional cure. The study suggests that discontinuing long-term antiviral therapy may be more effective than continuing it for certain patients.
Researchers found that applying ice to minor muscle damage in rats enhances muscle repair and reduces inflammation. The study used an animal model of mild injuries and showed that icing attenuates the recruitment of pro-inflammatory macrophages, preventing injury expansion. This contradicts previous findings on the negative effects of ...
Recent studies have reported significant advances in iridium-based catalysts for green hydrogen production. However, addressing high costs and research challenges are crucial to realizing their full potential.
Researchers at the University of Washington developed GlucoScreen, a new system that leverages smartphone capacitive touch sensing to measure blood glucose levels. The system's accuracy is comparable to standard glucometer testing, making it potentially less costly and more accessible for widespread screening.
Scientists have identified specific genetic variants in wheat and barley that enable plants to adapt to nitrogen deficiency by increasing root growth and improving nitrogen content. These findings offer promising opportunities for plant breeding to develop varieties with enhanced nitrogen use efficiency.
Researchers at the University of Kansas propose a data project life cycle to equip students with essential data skills, including spreadsheet wherewithal. The approach emphasizes planning, acquiring, organizing, analyzing, and interpreting data in simple spreadsheets.
This study of 690 patients with early-stage breast cancer found racial disparities in pathological complete response to neoadjuvant chemotherapy, affecting survival outcomes. Racial disparities varied across different breast cancer subtypes and highlight the importance of understanding tumor biology.
A new study reveals that autistic children have distinct brain activity when viewing complex visual motion patterns as early as 5 months old. This suggests that autistic individuals process visual motion differently from a young age, which may impact their development and learning.
A recent study published in Frontiers found that maternal vaginal microbiome composition does not significantly influence the development of infants' stool microbiome during the first weeks and months of life. Instead, exposure to breast milk and environmental factors are believed to play a more significant role.
A study from the University of California, Davis found that fewer than 10% of patients were screened for food insecurity during the pandemic. Screening increased to 10% after COVID-19 vaccines became available, but remained low at telehealth appointments.
Researchers have developed an AI algorithm that can remove atmospheric blur from astronomical images, resulting in more accurate scientific measurements and clearer data. The tool produces faster and more realistic images than current methods, producing 38.6% less error compared to classic methods.
The article explores knowledge gaps between laboratory and industrial manufacturing of batteries, highlighting the need for a shift in research priorities. Researchers propose new ways to design experiments that account for industry challenges, such as cost efficiency and impurity tolerance. The study aims to bridge the gap between fun...
The March special issue of SLAS Discovery introduces protocol articles highlighting detailed scientific methods and procedures in drug discovery. The issue covers topics such as 3D imaging, cancer treatments, and high-throughput screening, emphasizing transparency and rigor in research methodology.
Researchers at Nagoya University found that localized IDH wild-type histologically diffuse astrocytomas have a poor prognosis similar to the most malignant types of brain and spinal cord tumors. This highlights the importance of proper clinical diagnosis and treatment for patients with gliomas.
Researchers at Drexel University discovered that a thin MXene coating can enhance a material's ability to trap or shed heat. The coating, which is 200-300 times thinner than a human hair, can be used for both localized thermal management and large-scale radiative heating and cooling systems.
Researchers discovered a new mechanism to control turbulent heat transport by manipulating coherent structures in thermal turbulence systems. This mechanism enhances heat transfer efficiency without modifying the flow intensity.
Astronomers have observed an extremely rare and aspherical Fast Blue Optical Transient (FBOT) explosion 180 million light years away. The explosion, similar to a flat disc shape, challenges scientists' current understanding of stellar explosions.
Researchers at Cranfield University are developing a new generation of lithium-sulfur batteries that offer improved performance and reduced weight compared to traditional lithium-ion batteries. The technology has the potential to support electrification of short-haul aircraft, light goods vehicles, and passenger vehicles.
Ecologist Jonathan Chase will receive funding to develop new tools and analyses for understanding biodiversity change, closing knowledge gaps in quantifying changes and attributing causes. He aims to improve forecasting of future biodiversity change using large datasets and statistical methods.
A research team at Toyohashi University of Technology discovered that the flickering of flames can be controlled by moving two flames closer together or further apart. By periodically adjusting the distance between flames, they were able to stably express the state of “stopping the flickering of flames”, a phenomenon previously unknown...
Scientists developed a new RNA-based toolkit that can regulate gene expression, potentially improving regenerative medicine, gene therapy, and biotechnology. The technology uses small molecules to control the activity of synthetic RNA, allowing for precise control over gene expression.
A recent study found that heavy alcohol use changes signaling pathways in the brain, affecting cognitive functions like decision-making and impulse control. The mechanism involves the brain's immune system and the molecule interleukin 1β, which regulates inflammation and neurotransmitter release.
Researchers at the University of Texas M. D. Anderson Cancer Center have developed a novel approach to administer intrathecal and intravenous immunotherapy to treat leptomeningeal disease (LMD) in melanoma patients, showing promising results in improving survival rates and quality of life for some patients.
The research team developed a new biosensor based on a fluorescent protein utilizing human M3 muscarinic acetylcholine receptor (hM3R), a type of GPCR. They found that a GPCR-based single receptor sensor exhibited consecutive structural conversion via the G protein cycle, and that G-protein activation caused a two-step change in the hM...
A new study in Scotland reveals that stakeholders have diverse and nuanced views on potential lynx reintroduction, with disagreements over sheep farming and ecosystem management. The research highlights the need for a participatory approach to discuss the issue.
A new procedure has shown promising results in avoiding leg amputation for patients with severe peripheral artery disease. The PROMISE II U.S. clinical trial found that 76% of patients were able to keep their legs and had completely healed or healing wounds six months post-procedure.
Frontal polymerization, a faster and more energy-efficient process, generates heat that drives natural convection. This interaction leads to patterns in the resulting solid polymeric material, affecting its properties.
A new study has identified key risk factors for surgical site infections (SSIs) following abdominal hysterectomies. The analysis of over 66,000 procedures found that patients with open surgery, obesity, diabetes, and younger age were more likely to experience an SSI.
Researchers have developed a new method to monitor shore ice using portable interferometric radar, which can detect small changes in the ice's distance and reveal signs of instability. This system can provide an early warning for humans working on shorefast sea ice and also aid in near-coastal navigation.
A study found that the change in guidelines led to a decline in mammography screening rates, particularly among women ages 50-74, an unintended consequence known as spillover. This effect resulted in 2.4 million fewer women being up-to-date with screening mammography between 2009 and 2018.
Researchers used a coupled model to simulate ocean circulation and temperature during the MMCO, finding that global average temperature was over 3℃ higher than present. Extensive forest coverage played a significant role in climate regulation, with land temperatures particularly high in the Sahara and high northern latitudes.
A new study reveals that Indigenous cultures integrated domestic horses of Spanish ancestry into their lifeways before Europeans arrived in the region. The analysis of archaeological horse remains suggests that these animals spread northward from Spanish settlements in the American Southwest during the first half of the 1600s.
The REST-COAST Summer Workshop brought together experts from around the world to discuss innovative research and management strategies for coastal restoration. Key findings included the financing of restoration projects, nature-based solutions, and coupled modelling systems for risk reduction.
A new study identifies the anterior thalamus as a key brain region linking short-term to long-term memory. The thalamus plays a crucial role in memory consolidation, stabilizing memories from the hippocampus into long-term storage in the cortex.
Researchers have detected a cold stream of atomic carbon gas feeding star formation in a massive radio galaxy. The findings support theoretical models and offer insights into the origins of cosmic materials enabling galaxy evolution.
A new computational model of the thalamic microcircuit in mouse brains offers detailed insights into its role in brain function and dysfunction, particularly in relation to sensory processing and spindles. The model replicates network-level experimental findings across different brain states, shedding light on inhibitory rebound and th...
A recent study by the University of Exeter has confirmed the widespread trading of critically endangered European eels in international markets. The research found that about 40% of North American unagi samples contained European eel, suggesting a significant role for illegal trade in their supply chain.
Biyu J. He's groundbreaking research on perceptual cognition and subjective experience has challenged traditional views of consciousness. Her work explores how past experiences shape individual perception and understanding, using innovative techniques like fMRI and EEG.
A new study of over 200 people with premature aging syndromes caused by abnormally short telomeres suggests that chromosomal instability may not be the reason for increased cancer risk. Instead, immune system cells that age and die prematurely may play a role in cancer predisposition.
Astronomers have found that Saturn's vast ring system is heating the giant planet's upper atmosphere, a phenomenon that could provide insights into the atmospheres of distant worlds. The discovery was made using archival ultraviolet-light observations from four space missions, including Hubble and Cassini.
The High Seas Treaty aims to establish cooperative approaches to improve ocean management, but scientists argue that more research is needed to effectively implement the agreement. The treaty proposes massive marine protected areas covering 30% of the ocean by 2030, which could significantly improve ocean conservation.
A new IVF method using time-lapse monitoring has been found not to improve pregnancy rates or shorten the time it takes to get pregnant. The study, which evaluated 1731 patients over a year, also found that this approach does not lead to extra costs or benefits.
Researchers from Osaka Metropolitan University have developed a system that converts waste acetone and low CO2 concentrations into biodegradable plastic using artificial photosynthesis. The study successfully synthesized 3-hydroxybutyrate with over 60% efficiency after 24 hours.
A new UC study reveals that participating in a civic leadership program empowered refugees and immigrants, increasing their perception of civic engagement. The program, designed by the refugee community, improved participants' consciousness about power, rights, and opportunities.
The research team has developed a method for mass-producing high-quality copper-graphene nanowires, enabling the production of transparent-flexible electrode materials. The technology is applicable to various energy devices, including semitransparent solar cells and transparent displays.
Researchers at West Virginia University are exploring iodine-based thrusters as an alternative to traditional fuel sources, aiming to reduce dependence on rare noble gases. They plan to develop diagnostic technology to measure the performance of these thrusters, paving the way for widespread use in space exploration.