Researchers from the Smidt Heart Institute found that individuals with spherical hearts are 31% more likely to develop atrial fibrillation and 24% more likely to develop cardiomyopathy. The study identified four genes associated with cardiomyopathy and a greater risk of developing atrial fibrillation.
Researchers found that dexamethasone prevents cytokine storms in severe COVID-19 patients by inhibiting ion channels and reducing immune cell inflammation. This led to improved lung function and reduced mortality rates. The study's findings provide new insights into the mechanisms of steroid treatment in severe COVID-19.
A new study found that 20% of households have too little allocated parking and 13.4% of surveyed households do not own a car but are still allocated a parking space. Experts are calling for planning policy to 'unbundle' parking spaces from apartments to reduce housing costs and alleviate street parking woes.
A phase 3 randomised controlled trial found monthly injections of fitusiran effective in reducing bleeds in patients with severe haemophilia A or B. The study included 56 male patients with inhibitors, who experienced no bleeds after nine months on prophylactic treatment.
A new subspecies of rainbow trout, O. mykiss calisulat, has been identified after genetic analysis revealed its distinctiveness. This discovery is significant as it marks the first newly identified Pacific trout subspecies since 2008 and the youngest rainbow trout subspecies by more than 100 years.
Research analysis reveals gaps and uncertainties in evidence base for cancer drugs, including lack of relevance and inconsistent reporting. Findings emphasize the importance of improving communication of benefits and harms to support informed decision-making by patients and clinicians.
The Energy Circulation Theory (ECT) simulates the formation of galaxies with different shapes, such as disc, spiral, and elliptical ones. The study demonstrates that various galactic distributions result from stellar seed releases and galactic seed interactions.
A new study reveals a surprising exception to the rule of uniformity across the Indo-West Pacific coral reef ecosystem. Chlorodielline crabs with overlapping ranges have uniquely shaped gonopods, but otherwise appear identical, suggesting genetic divergence in different geographic areas.
A new study from the University of Exeter finds that a vegan diet rich in mycoprotein can support muscle growth during resistance training to the same extent as an omnivorous diet. The study shows comparable increases in muscle mass and strength in response to both diets.
Research by Whitehead et al. reveals that cellular senescence triggers amyloidosis through changes in small extracellular vesicles and extracellular matrix composition. The study provides novel insights into the formation of aortic medial amyloid and offers potential therapeutic targets for mitigating its effects.
Researchers found that syntactic surprise, a measure of unexpected word arrangement, significantly improves marketing message efficacy. The optimal level of syntactic surprise falls within the middle range, with messages being most effective at a medium level.
A new study by University of Copenhagen researchers found that stereotypes about senior employees influence their retirement decisions, leading to premature retirements. Senior employees often feel uncertain about their status and worry about being perceived as inflexible or unproductive.
Researchers developed a robust multiagent trajectory-planner that enables drones to generate collision-free trajectories even with delayed communications. The system achieved a 100% success rate in simulations and flight experiments, guaranteeing safe group operations.
Researchers at KTH Royal Institute of Technology developed a thermal wood composite using coconuts and lemons that can store both heat and cold. The material, which is transparent and energy-saving, can regulate temperatures around 24C, reducing energy consumption for heating and cooling.
Seer researchers identified four structurally distinct protein isoforms that were differentially expressed in non-small cell lung cancer patients. These findings suggest that these protein isoforms may play a role in NSCLC disease pathogenesis, potentially leading to the development of new diagnostic markers or therapeutic targets.
A new initiative has shown that holistic, team-based care that bridges clinic treatment to community resources can improve diabetes care and management. Healthcare organizations partnering with community groups to address social factors such as food insecurity also shows promise in empowering patients to better manage their own symptoms.
Researchers modeled how elements move across star-forming regions, finding that galactic winds influence temperature and metal distribution. The study's findings suggest a non-spherical wind pattern, contrary to previous spherical models.
A new study predicts that Antarctic deep ocean currents will slow by over 40% in the next 30 years and may collapse, with significant impacts on climate and marine ecosystems. The decline of this circulation could stagnate the bottom of the oceans and trap nutrients, affecting marine life for centuries to come.
Researchers Paul Byrne and Rebecca Hahn have compiled a global catalog of 85,000 volcanoes on Venus, providing the most comprehensive understanding of the planet's volcanic properties. The dataset includes detailed analyses of volcano distribution, size, and clustering, which will aid in locating future active lava flows.
A recent study from Brigham Young University proves that artificial intelligence can respond to complex survey questions just like a real human. The researchers found high correspondence between how AI and humans voted in 2012, 2016, and 2020 U.S. presidential elections.
A team from the National Eye Institute identified Reserpine as a compound that keeps light-sensitive photoreceptors alive in three models of Leber congenital amaurosis type 10, an inherited retinal ciliopathy disease. The study suggests a potential treatment strategy for addressing retinal ciliopathies caused by multiple genes.
A machine learning model developed by Colorado State University researchers has been tested with forecasters at the Storm Prediction Center to improve medium-range severe weather forecasts. The tool provides a probabilistic measure of hazardous weather events, such as tornadoes and hail, four to eight days in advance.
Researchers at UC San Diego and UC Merced developed a high-throughput method to study the circadian clock in real time, shedding light on its internal functions. The study found that kinases play a crucial role in relaying the circadian rhythm from the core oscillator to gene expression.
A recent study published in the European Journal of Preventive Cardiology found that regular physical activity can help offset the detrimental effects of inadequate or excessive sleep on mortality risk. The research included over 90,000 adults and used accelerometry to track physical activity and sleep duration.
A large case-control study identified nine genes associated with stomach cancer risk and found that pathogenic genetic variations exacerbate the damage caused by H. pylori infection, significantly increasing the risk of gastric cancer. The study suggests that screening for pathogenic variants can help prioritize interventions.
A study published in Science Advances reveals that viral SARS-CoV-2 variants are developing resistance to protease inhibitors, including Paxlovid. Researchers warn that this could undermine the effectiveness of antiviral treatments and highlight the need for next-generation compounds with different resistance profiles.
A study found that as alcohol consumption increased, the probability of a firearm-involved suicide also rose until a certain blood alcohol concentration was reached. Interventions focusing on heavy alcohol use may help reduce suicide mortality rates, particularly those involving firearms.
Fruit fly gut remodels itself to accommodate beneficial microbiome species, maintaining long-term stability of the gut environment. The research team identified physical conditions and substances that facilitate colonization by desirable species.
Researchers at USC have developed a new type of chip with the best memory of any chip thus far for edge AI. The chip uses metal oxide memristors to store information in a compact and stable way, eliminating the von Neumann bottleneck in current computing systems.
Researchers at Heidelberg University developed new methods to detect biogenic carbon in zircon minerals, which can preserve traces of life hundreds of millions of years old. The study's findings open up new possibilities for research into the Earth's early period, where fossils and sediments are scarce.
Scientists at US national laboratories are developing new chemical recycling methods to make sustainable, high-quality plastic materials. They aim to transform plastic waste into valuable chemicals and reduce plastic pollution, paving the way for a circular economy.
Research found increased trust in scientists during COVID-19 pandemic, with polarized attitudes emerging, influencing behavior and vaccine adoption. Those with initial positive views became even more positive, while those with negative views became more entrenched.
A new method using brain signal processing has been developed to categorize different types of depression. The study achieved a 91% accuracy rate in detecting anxious and non-anxious depression, showing promise for improved diagnosis and treatment.
Researchers found that moths can pollinate flowers more quickly than day-flying insects like bees. The study shows that allowing patches of bramble to flower can provide important food sources for moths.
A survey of Earth's organisms reveals that biomass is concentrated in the largest and smallest sizes, with a pattern favoring large and small organisms across all species. The study found that land-based organisms exhibit this pattern more pronouncedly than marine environments.
Researchers used in-situ cryogenic TEM imaging to directly observe formation of pure-phase ice I c on low-temperature substrates. The study resolves the long-standing debate about cubic ice's existence, with implications for materials science, geology, and climate science.
Researchers have generated artificial mice that mimic the genetic and immunological diversity of multiple myeloma in patients, allowing for more effective and personalized treatments. The mouse avatars can also predict treatment outcomes and identify correlations between genetic traits and response to preclinical therapies.
Researchers found that immune checkpoint inhibitors increase the mobilization of overlapping tumor-reactive CD8+ T cells, leading to antitumor effects. The diverse subset of T-cell clones plays a key role in this response, with polyclonal clones exhibiting more proliferative potential and contributing to effective treatment outcomes.
A team of researchers from Ohio University discovered that CIDEC protein improves vascular and metabolic dysfunction, reducing insulin resistance and lipid levels in high-fat diet-induced mice. The study contributes to understanding the role of the vascular endothelium in regulating systemic metabolism.
Researchers at Colorado State University have created a synthetic molecule with an asymmetric oxygen atom that remains stable and nonreactive. This feat is significant because chiral molecules can have drastically different properties and are crucial in fields like drug discovery and materials engineering.
Scientists designed a synthetic molecule that mimics the hydrogen gas-producing chemical reaction performed by nickel-iron hydrogenase enzyme. The new compound efficiently produces hydrogen using earth-abundant metals, potentially replacing platinum metal in industrial electrolysis.
A new study by UC Health shows that electronic referrals to the California quitline can help patients give up tobacco. The study found that patients referred by healthcare providers had similar quit rates as those who called the quitline seeking help.
The study confirms that a significant number of people from Southwest Asia moved to the Swahili coast in medieval and early modern times, having children with local populations. Hallmarks of the Swahili civilization predated these arrivals, contradicting previous scholarly views.
Researchers compared seven dietary programmes, finding Mediterranean programmes lower risk of mortality, non-fatal heart attacks, and stroke. Low fat programmes also showed benefits for mortality and non-fatal heart attacks, but with less pronounced effects.
Overdose mortality among people aged 65 and older has quadrupled, driven by illicit drugs like fentanyl, heroin, and synthetic opioids. Researchers call for updated Medicare coverage and harm reduction supplies to curb the trend.
Researchers discovered that fomepizole, an FDA-approved drug, can significantly reduce disease in mice infected with multidrug-resistant Streptococcus pneumoniae. The combination of fomepizole and erythromycin reduced bacterial burdens by 95% in the lungs and up to 700-fold in other organs.
Researchers teamed with Ethiopian farmers to develop new wheat varieties using genomic analysis. Farmers' knowledge played a crucial role in predicting crop yields and selecting optimal traits. The project aims to preserve agrobiodiversity and promote cultural heritage.
Researchers aim to understand the allure of highly processed foods, which make up 58% of US calories. By studying their processing and added ingredients, they hope to identify underlying variables driving consumption.
A Barcelona Institute for Global Health study suggests that increasing green space in the city may help alleviate mental health issues. By 2025, the expansion of Green Axes (Eixos Verds) could lead to a 14% decrease in cases of poor mental health and prevent 13% of antidepressant use, resulting in annual savings of €45 million.
Scientists developed a novel artificial metalloenzyme using a 2-his-1-carboxylate motif, which exhibited high stereoselectivity in Michael addition reactions. The study provides insight into the reaction mechanisms of metalloenzymes and could lead to the creation of efficient biocatalysts.
Recent GSA Bulletin articles investigate the formation of N-S trending mountain ranges in Tibet and the geochemical signature of a deeply subducted slab. The studies reveal insights into surface uplift and E-W extension, challenging common views on their initiation.
Research shows that young black rockfish grown faster during a marine heat wave, while also experiencing varying levels of survival. Moderate growth rates and sufficient food led to the highest survival rates.
Researchers developed a deep learning approach to recognize and predict motion using vector-based relative change in position. The method, VecNet+LSTM, scored higher than other frameworks in recognizing motion and predicting future movements. This study has implications for machine learning in video analysis and artificial intelligence.
A recent study suggests that cardiac sphericity, or the roundness of the heart, may be a useful indicator for diagnosing cardiovascular conditions. The research used machine learning to analyze medical images and found a link between increased sphericity and future heart troubles.
A University of South Florida anthropologist has uncovered the first ancient DNA from the Swahili Civilization, revealing African and Asian ancestry patterns. The study challenges centuries-old narratives and restores pride to the millions who identify as Swahili by providing clarity to their heritage.
Researchers found exposure to transportation noise at home was associated with a higher risk of death by suicide, with robust results even after adjusting for air pollution and socio-economic indicators. Noise increases mental load, contributing to mental disorders or worsening preexisting conditions.
Researchers at Ritsumeikan University have made a breakthrough in understanding how macrophages recognize microplastics, discovering an interaction between aromatic rings that drives this process. The study suggests that while microplastics may not induce acute inflammation, chronic exposure could lead to autoimmune diseases.
Scientists at St. Jude Children's Research Hospital found a link between hemagglutinin protein stability and flu vaccine effectiveness, as well as pandemic potential in new strains. Incorporating this stability into the vaccine could prevent the emergence of unstable viruses.
Researchers found that a group of amino acids influence brain development, leading to severe effects after birth if nerve cells are starved. The study showed that mice with low levels of essential amino acids developed microcephaly and exhibited long-term behavioral abnormalities similar to those in autism spectrum disorders.
A study of over 65,000 Japanese infants found that those exposed to indoor pets during fetal development or early infancy had fewer food allergies. Children exposed to indoor dogs and cats were significantly less likely to experience specific allergies, while hamster exposure unexpectedly increased the incidence of nut allergies.