Articles tagged with Cardiomyopathy
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Washington State University researchers are studying mutations in three proteins that cause cardiomyopathy, a genetic heart condition affecting 1 in 500 people worldwide. The four-year project aims to improve diagnostics and develop new treatments for hereditary heart conditions.
Researchers from Georgia State University are investigating the role of mitochondrial dysfunction in developing diabetic cardiomyopathy, a leading cause of heart failure and death in diabetic patients. They aim to understand how increased FUNDC1 expression impairs mitochondrial function, leading to cardiac damage and dysfunction.
Researchers discovered that gene mutations in titin protein can impact heart function even in healthy individuals, potentially affecting up to 35 million people globally. The study sheds light on the paradox of how some people with genetic mutations appear unaffected.
Researchers identified a genetic variant in MYBPC3 that predisposes South Asians to hypertrophic cardiomyopathy, an enlarged heart condition. Early screening of this variant can help reduce the incidence of sudden cardiac death in this population.
Active marijuana use was linked to an increased risk of developing stress cardiomyopathy, a sudden weakening of the heart muscle reducing its ability to pump. Marijuana users were more likely to experience cardiac arrest and require implanted defibrillators compared to non-users.
A study published in PLOS Neglected Diseases reveals that Chagas disease has a significant presence in the Rio Grande Valley of Texas, affecting up to 30% of those infected with Trypanosoma cruzi developing fatal cardiomyopathy. The research estimates 4,600 people are currently infected and 1,300 at risk for cardiac disease.
Researchers at Marshall University have discovered a peptide, pNaKtide, that can reduce oxidant stress and ameliorate experimental uremic cardiomyopathy. This finding has significant implications for treating patients with kidney disease, which affects millions of people worldwide.
Researchers used electron microscopy to capture the first three-dimensional image of a myosin filament in a Thai water bug. This discovery sheds light on how mutations in myosin can cause cardiomyopathy, a disease of the heart muscle. The study provides new insights into muscle contraction and relaxation.
Research presented at ESC Congress 2016 found that sudden cardiac death in patients with hypertrophic cardiomyopathy occurs relatively rarely during sport activity, but more often at rest and sometimes during sleep. Better strategies aimed at detecting the disease are needed to prevent deaths.
A phase II-a randomized trial showed that intravenously administered mesenchymal stem cells resulted in improved health status and functional capacity in patients with chronic non-ischemic cardiomyopathy, but no significant cardiac structural or functional improvements were observed.
A new consensus paper defines and classifies atrial cardiomyopathies, which can lead to atrial fibrillation, strokes, and other complications. The guidelines also discuss the triggers of atrial fibrillation and provide advice on prevention and treatment options.
A new study reveals that the splicing regulator RBFOX2 plays a key role in diabetic cardiomyopathy, impairing normal gene expression patterns and leading to abnormal calcium signaling in the heart. This understanding may lead to the development of new tools for diagnosing, preventing or treating this form of heart damage.
Researchers have identified a new disease gene associated with severe pediatric cardiomyopathies, allowing for improved genetic counselling, predictive testing, and early treatment. The discovery also provides a potential drug development target for treating affected children and family members.
Researchers developed a predictive model that uses patient-specific stem cells and genetic data to forecast heart defect types in pediatric patients. The model was tested on human cardiomyocyte cells from patients with specific mutations, achieving accurate predictions of hypertrophic or dilated cardiomyopathy.
A Florida State University researcher is studying the regulation of calcium in heart cells to correct a calcium imbalance and develop new treatment strategies for cardiomyopathies. The goal is to identify components involved in disease development and open the door for more effective treatments inside the cell.
Researchers have discovered a gene signature that characterizes the transition from dilated cardiomyopathy (DCM) to heart failure. The study found increased expression of fibrotic and inflammatory genes, as well as changes in heart muscle cell proliferation and metabolic profiles.
Researchers found that GSK3β inhibition improves cardiac function and reduces fibrosis and inflammation in murine models of arrhythmogenic cardiomyopathy. The study suggests GSK3β inhibition has potential as a therapeutic strategy for treating ACM.
Researchers develop small molecule inhibitor to address hypertrophic cardiomyopathy, a common cause of sudden death in young athletes. The treatment has shown promising results in mice bred with the mutation, preventing the disease from surfacing.
Researchers demonstrate MYK-461's ability to prevent and reverse hypertrophic cardiomyopathy (HCM) in genetically modified mouse models. The study supports a therapeutic hypothesis that reducing sarcomere power output can improve structural pathology, potentially treating HCM.
A new study reveals that the β-1 adrenergic receptor and RAGE work together to cause myocardial injury and progression to cardiomyopathy. Blocking RAGE signaling after β-adrenergic agonist-induced heart failure mitigates cell death and restores cardiac function.
Researchers analyzed 43 genes in 172 women with peripartum cardiomyopathy, finding that a genetic mutation in the TTN gene is a common cause. This discovery could inform future research and potentially improve care for affected women.
TGen and Barrow researchers identified rare genetic changes associated with stress-triggered heart disease, a condition previously referred to as 'broken heart syndrome.' The study's findings may help guide care and treatment before and after patients experience a life-threatening stressor.
The European Cardiomyopathy Registry Pilot study found that nearly 60% of patients with arrhythmogenic right ventricular cardiomyopathy received implantable cardioverter-defibrillators, a common yet underutilized treatment strategy. Genetic testing was also widely used, with over half of tests yielding positive results.
Researchers have identified the molecular basis for a heart condition called dilated cardiomyopathy and found a potential treatment that partially restores function to diseased cells. The study used induced pluripotent stem cells to model the disease, revealing how a key signaling pathway develops in healthy vs. diseased cells.
Early RA patients exhibit cardiomyopathy, reduced vascular function, and increased cardiovascular mortality. Cardiac MRI revealed aortic stiffness, left ventricular volumes, and geometry changes indicative of cardiac abnormalities.
A new study reveals that environmental stress significantly increases the development of hypertrophic cardiomyopathy in individuals with gene mutations, putting them at greater risk of developing the disease. The findings suggest that stressors like high blood pressure, diabetes, and alcohol use may trigger the onset of symptoms in car...
A study found that decreased blood levels of Klotho increase the risk of heart disease in mice with chronic kidney disease, suggesting potential treatment strategy to protect kidney disease patients' heart health. If confirmed in humans, increasing Klotho levels may help protect the hearts of patients with chronic kidney disease.
Recent research has shown that children with dilated cardiomyopathy are living longer without heart transplants, with a survival rate of 15% without transplantation. The study found that the more recent era (2000-09) had better survival rates and was associated with factors other than transplantation availability.
Researchers developed a novel ultrasound technology to screen for heart conditions, enabling earlier diagnosis and more effective treatment. The technology helps identify blood flow patterns in the heart, which is crucial for diagnosing hypertrophic cardiomyopathy and non-ischemic dilated cardiomyopathy.
The new guidelines provide a risk calculator to estimate five-year risk of sudden cardiac death in HCM patients. The guidelines also recommend genetic testing, specialized tests, and multidisciplinary team referrals to improve diagnosis and management.
The European Society of Cardiology has launched newregistries for cardiac oncology and ACS, aiming to monitor treatment practices and outcomes. The registries will provide robust data on cardiovascular disease burden and treatment in Europe.
A US study found clusters of 'broken heart' syndrome in Vermont and Missouri after major natural disasters, suggesting stress as a trigger. Researchers call for greater awareness among emergency responders to improve diagnosis and treatment of the condition.
Researchers at the University of Missouri have successfully treated laboratory mice with a genetic heart defect using a new compound. The study found that the compound reduced the thickness of the mice's heart muscles and improved their cardiac functioning, offering potential hope for treating hypertrophic cardiomyopathy.
Researchers at Northwestern University discovered that doxorubicin accumulates in cardiomyocyte mitochondria, promoting ROS production and iron accumulation. Limiting mitochondrial iron transport with specific proteins or dexrazoxane may mitigate doxorubicin-induced cardiotoxicity.
A new classification system called MOGE(S) has been developed to classify cardiomyopathies, a group of diseases affecting the heart muscle. The system uses a descriptive nomenclature with letters to explain individual patients' cardiomyopathy types and genetic mutations.
A study found that transendocardial stem cell injection with autologous mesenchymal stem cells and bone marrow mononuclear cells is safe for patients with ischemic cardiomyopathy. The treatment also showed promise in improving quality of life and walking distance.
Researchers at UTMB have discovered that PKC activation leads to alternative splicing events in the heart, causing developmental shift and preventing correct functioning. This finding could help lead to prevention and treatment of heart failure in diabetics.
A long-term study found that infants and children with congestive heart failure and genetic disorders have the lowest transplant-free survival rates. Children diagnosed after one year old with unknown cause have the best outcome, a 97% rate of transplant-free survival.
Children with inherited metabolic diseases, hypertrophic cardiomyopathy, or multiple risk factors have worse prognosis. Younger age, lower weight, congestive heart failure, and abnormal left ventricle structure are significant risk factors for death or transplantation.
Researchers at the University of Liege discovered a molecule, miR-146a, that can serve as a biomarker for peripartum cardiomyopathy. Elevated serum miR-146a levels were found in pregnant women who developed PPCM, suggesting its potential use to predict disease risk.
New study finds MR images taken during systole phase show more accurate detection of myocardial scars in ischemic cardiomyopathy patients. Systolic images revealed scars not visible on diastolic images, particularly in the left ventricle area prone to ischemic damage.
A study reveals that Tako-tsubo cardiomyopathy, or broken heart syndrome, can be deadly when compounded by other co-morbidities. Researchers found that severe hypotensive heart failure and low blood pressure are linked to high mortality rates in women, highlighting the need for improved diagnosis and treatment guidelines.
Midwall fibrosis detected via MRI is associated with higher mortality rates in patients with nonischemic dilated cardiomyopathy. Patients with midwall fibrosis are at an increased risk of sudden cardiac death and cardiovascular mortality.
A study published in the European Heart Journal found that relatives of young people who died suddenly from a heart-related problem are at greatly increased risk of developing cardiovascular disease. The study suggests that close relatives of these victims should be screened to detect those who would benefit from preventive treatment.
Researchers highlight two cases of selenium deficiency causing cardiomyopathy in patients who underwent gastric bypass surgery. The studies emphasize the crucial role of long-term follow-up and compliance with vitamin supplements to prevent nutritional deficiencies and related health complications.
Researchers at the Buck Institute for Research on Aging found that rapamycin improved function and extended survival in mice with a genetic mutation leading to dilated cardiomyopathy and rare muscular dystrophies. The study suggests a therapeutic possibility for human patients suffering from this form of disease.
Researchers have found that 'broken heart syndrome,' a condition causing temporary heart failure after severe emotional stress, may actually protect the heart from extremely high levels of adrenaline. The study suggests a switch in the heart's response to adrenaline might have evolved to prevent overstimulation.
Researchers have identified a genetic variant in a cardiac protein that increases the risk of heart rhythm dysfunction and sudden death in patients with dilated cardiomyopathy. The variant, known as Ser96Ala, affects calcium regulation in heart cells, leading to arrhythmias and increased mortality.
A new study has identified left-ventricular hyper-trabeculation as a common feature among black male athletes, with a prevalence of 6.8% compared to 0.4% in non-athletes. This finding raises concerns about the challenges of differentiating between athlete's heart and serious medical conditions in this demographic.
Cardiomyopathy is a deterioration of the heart muscle affecting its pumping ability. MDC-researchers identified RNA binding motif protein 20 (RBM20) as a gene regulating titin splicing, a process connected to the disease. Understanding this mechanism may lead to more efficient molecular diagnosis and therapies for cardiomyopathy.
Researchers found genetic mutations associated with dilated cardiomyopathy in nearly 17.4% of patients, with children more likely to have these mutations than older adults. This study's findings will help develop new treatments and identify potential genetic tests for inherited forms of the disease.
A genetic mutation in the TTN gene has been found to cause 18% of sporadic and 25% of familial dilated cardiomyopathy. This discovery can help diagnose and treat the condition, reducing the risk of heart failure and sudden death.
Researchers identify FoxO1 as critical for diabetic cardiomyopathy development, suggesting a promising therapeutic target. Activation of FoxO1 in mice with type 2 diabetes models triggers cardiomyopathy, highlighting the need for new treatments to address this leading cause of death in diabetics.
A new study found that therapeutic hypothermia confers similar neurologic and survival benefits in cardiac arrest patients with preexisting cardiomyopathy as those without the condition. However, cardiogenic shock was more prevalent in patients with cardiomyopathy, leading to lower survival rates with favorable neurologic outcomes.
A study found that hypertrophic cardiomyopathy patients can survive to the age of 90, with most deaths unrelated to the disease. The study analyzed data from 1,297 HCM patients and showed a greater proportion of patients reaching 90 years or older than expected in the general population.
A study found that children with dilated cardiomyopathy who have congestive heart failure, severe disease, increased age, and dilation of the left ventricle are at higher risk of death or transplantation. The study's findings may lead to broadened indications for heart transplantation in more children.
A study in JAMA found that stress cardiomyopathy (SC) affects postmenopausal women primarily, but also younger patients, men, and those without an identifiable stressful trigger. CMR imaging identified specific criteria for diagnosis, which showed complete normalization of LV function after follow-up imaging.
A new guide recommends when and how genetic testing is useful for inherited cardiac conditions, aiming to lower the risk of sudden cardiac death. The guidance focuses on 13 inherited conditions, including cardiomyopathy and long QT syndrome, and provides recommendations for their diagnosis and treatment.
The new guidelines emphasize the importance of genetic counseling and comprehensive clinical evaluation in treatment decisions. The guidelines also recommend specialized centers for genetic testing and interpretation, covering 13 inherited cardiac conditions.
A new study found that implantable cardioverter-defibrillators (ICDs) can effectively prevent sudden cardiac death in patients with ischemic cardiomyopathy and dilated cardiomyopathy. The average survival time for ICD patients was seven years, outpacing the typical lifespan of an ICD battery.