Articles tagged with Celiac Disease
Researchers have identified a new immune function of human M cells, which can process and present gluten antigens, suggesting a potential link to celiac disease. This discovery sheds light on gut immunity and may support future research into celiac disease diagnosis or treatment.
Scientists have created a detailed map of cell behavior in the small intestine of people with coeliac disease using single-cell RNA sequencing. The study found that immune signals from immune system proteins encourage fibroblasts to support changes in the gut lining, suggesting communication between cells plays a key role in the disease.
Researchers at the Weizmann Institute of Science have discovered a coordinated network of four cell types crucial for preventing immune reactions to food. This network is initiated by ROR-gamma-t cells, which temporarily suspend tolerance mechanisms to combat infection, and then resume when the threat has passed.
Researchers discovered that certain immune cells in the gut of refractory coeliac disease patients carry genetic mutations, driving ongoing intestinal inflammation and symptoms. The study's findings suggest a new way to diagnose and potentially treat the most severe form of coeliac disease.
A new study has found that people with celiac disease can safely kiss their partners without worrying about gluten transfer. In a two-part study, researchers found minimal gluten in the saliva of partners with celiac disease, even when they kissed after consuming gluten.
Researchers have developed new seed varieties of wheat that remove harmful gluten proteins without affecting breadmaking quality. The modified wheat can reduce the risk of triggering celiac disease in people without the condition and improve flour quality.
The AGA-Beyond Celiac Pilot Research Award in Celiac Disease will support independent scientists researching new directions in celiac disease. The award aims to uncover new insights and treatments that will make a lasting impact on patients' lives.
A scoping review found associations between myositis disease activity and gluten exposure in patients with inflammatory myopathies and celiac disease. The study suggests that gluten may act as an exogenous antigen driving myositis in genetically predisposed patients.
The TEDDY study aims to understand the causes of type 1 diabetes in children, finding a connection between enterovirus infection, autoantibodies, and disease development. Probiotics may also reduce risk in infants at high danger of developing diabetes-related antibodies.
Researchers from UT Arlington sequenced RNA genes of pythons, discovering conserved pathways in humans that are activated uniquely by these snakes. This knowledge helps explain intestinal regeneration and metabolism changes, offering potential therapeutic targets.
A team of researchers at McMaster University discovered that the epithelium plays a crucial role in directing the inflammatory response to gluten in celiac disease. They found that this inner lining of the upper intestine is not just involved in absorbing nutrients, but also activates immune cells in response to gluten.
Subnormal serum liver enzyme levels can result from deficiencies in pyridoxal 5'-phosphate (vitamin B6), as well as conditions such as chronic kidney disease. Recognizing these patterns is crucial for early diagnosis and management of diseases, allowing for targeted treatments and improved patient outcomes.
Researchers at Tampere University analyzed the molecular activity of over 10,000 genes to investigate the efficacy of ZED1227, a transglutaminase 2 inhibitor. The study found that ZED1227 effectively prevented gluten-induced intestinal mucosal damage and inflammation in celiac patients.
Researchers at Bielefeld University discovered that certain gluten-derived molecules, including the 33-mer deamidated gliadin peptide (DGP), form nanosized structures that accumulate in gut epithelial cells and lead to leaky gut syndrome. This triggers chronic inflammation and autoimmune responses in celiac disease patients.
The study, conducted by Children's Hospital Colorado, found improvements in symptoms and quality of life for children diagnosed with celiac disease after participating in a mass screening program. Mass screening for pediatric celiac disease may become more common in the US, following similar conclusions drawn from European studies.
Women with autoimmune disease are 30% more likely to experience perinatal depression, while those with perinatal depression have a 30% higher risk of developing an autoimmune disease. The strongest association is seen with multiple sclerosis.
Researchers have developed a new method, SECRE, to identify genetic regulators of cytokine secretion in autoimmune diseases. The technique has been validated on cells known to play a crucial role in inflammatory bowel disease (IBD) and shows promising results for treating conditions with few therapeutic options.
Researchers at Pritzker Molecular Engineering have developed an 'inverse vaccine' that can eliminate autoimmune reactions associated with multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. The vaccine works by removing the immune system's memory of a molecule, allowing it to tolerate healthy tissues.
A new study reveals that pathogenic bacteria fuel their growth by consuming sialic acid, a key component of the protective intestinal mucus layer. The findings suggest a potential treatment target for intestinal bacterial infections and chronic diseases linked to gut bacteria, including IBD and celiac disease.
A study published in Cell Death & Disease reveals that a protein cross-linking enzyme called TG2 exacerbates kidney fibrosis by polarizing M2 macrophages. The researchers hope to develop treatments for diseases caused by inflammation imbalance, such as fibrosis, cancer, and atherosclerosis.
Researchers have developed a new gluten-free flour made from orange sweet potatoes that is rich in antioxidants and has potential uses in fermented products and baked goods. The team found that grinding the flour at different temperatures and methods produced distinct properties, with single-grind flours ideal for breads and double-gri...
A new serological test, PepSeq, allows scientists to quickly test antibody binding against hundreds of thousands of protein targets, helping prepare for and respond to pandemics. The technology identifies specific antibodies that provide protection against infection, holding promise for developing effective vaccines and treatments.
The study reveals that the small intestinal microbiome is unstable and changes in response to diet, but certain species persist and adapt through subspecies changes. The findings have important implications for understanding intestinal diseases such as celiac disease and Crohn's disease.
A new system allows for fast and accurate detection of gluten in food using a cell phone, reducing analysis time from hours to minutes. The test can also help prevent fraud in meat products by detecting added grains.
A new study reveals that a specific bacterium breaks down xanthan gum in the human gut, leading to the production of short-chain fatty acids. The widespread consumption of xanthan gum may alter the gut microbiome, potentially affecting intestinal health and total caloric intake.
A new method for diagnosing celiac disease using saliva has been developed by researchers from the University of the Basque Country. This non-invasive approach can considerably reduce the number of endoscopies needed, making it a useful tool for screening patients suspected of having celiac disease.
A longitudinal study of infants found substantial microbial changes in the intestines months before celiac disease onset. The study's findings suggest that these preclinical alterations could inform novel strategies for diagnosis and treatment of celiac disease through microbiome manipulation.
A longitudinal study of infants at risk of developing celiac disease found increased microbial strains and metabolites associated with autoimmune conditions, while decreased protective effects were observed. These preclinical gut microbiome changes may serve as early markers of disease progression.
A team of researchers has deciphered the mechanisms leading to the concave shape of intestinal crypts and the migration movement of cells towards peaks. The study used a combination of computer modeling and in vitro experiments, revealing that mechanical forces exerted by cells control both processes.
An observational study of over 1,000 middle-aged women without celiac disease found no link between gluten consumption and cognitive decline. The study suggests that the relationship between gluten and cognitive function is more complex than previously thought.
Researchers aim to explore the link between gut microbes and metabolites in childhood celiac disease pathogenesis. The study will analyze pediatric celiac disease samples and compare them to healthy matched controls, shedding light on environmental triggers of the chronic disease.
Research suggests that impaired tryptophan metabolism may contribute to celiac disease inflammation. A high-tryptophan diet and specific bacteria or drugs can alleviate symptoms in mice with the disease.
A study published in Science Translational Medicine found that tryptophan, an amino acid present in turkey, combined with certain probiotics, can help individuals with celiac disease heal and manage symptoms. The research suggests targeting tryptophan metabolism in the gut may offer a potential therapy for better symptom control.
Researchers at Columbia University Irving Medical Center discovered a distinct antibody profile in patients with non-celiac gluten sensitivity, which differs from those with celiac disease. This finding could lead to better detection methods and potential new therapies for celiac disease treatment.
A comprehensive review of vaccine data over 20 years found vaccines to be remarkably safe, with most safety issues identified through existing postmarketing surveillance programs. The study confirms the effectiveness of the vaccine approval system and postmarketing surveillance in ensuring public health benefits while minimizing risks.
Researchers at McMaster University have established a strong association between inflammatory bowel disease (IBD) and celiac disease. The study found a nine-fold increased risk of IBD in patients with a previous diagnosis of celiac disease, highlighting the importance of proper screening and treatment for both conditions.
Research at NYU Langone Health found a link between elevated blood levels of toxic chemicals and an increased risk for celiac disease in young people. Young females were eight times more likely to become gluten intolerant, while males were twice as likely with fire-retardant exposure.
Researchers have identified specific Bifidobacteria strains that can break down gluten proteins into smaller fragments, reducing immune response damage. These findings pave the way for new treatments and improved patient outcomes for celiac disease patients.
A new study from Karolinska Institutet and Columbia University finds that celiac disease is associated with increased risk of death from cardiovascular disease, cancer, and respiratory disease. The study examined almost 50,000 patients with celiac disease and found a 21% increase in overall mortality compared to controls.
Researchers developed nanoparticles containing gliadin to treat celiac disease by restoring immune tolerance. In mouse models, these nanoparticles reduced inflammation and tissue damage, inducing gene expression profiles associated with immune tolerance.
The new mouse model accurately reflects human genetic and immune system characteristics, enabling researchers to test new treatments. It can reverse damage to the small intestine once it has developed, providing a vital tool for improving quality of life for people with celiac disease.
A study by Children's National Hospital found that Play-Doh and dry pasta show negligible gluten transfer when used for play, making them safer for children with celiac disease. Good hand hygiene and surface cleaning can prevent most gluten transfer in these scenarios.
Researchers developed a rapid diagnostic method for detecting celiac disease antibodies, offering a promising solution to overcome the vast underdiagnosis of this condition. The new method, called RFS, can provide results in less than half an hour, significantly reducing the time and complexity of current testing procedures.
A new phase 2 clinical trial shows that technology can induce immune tolerance to gluten in individuals with celiac disease, reducing inflammation and protecting the small intestine. The treatment, called CNP-101, is a biodegradable nanoparticle containing gluten that convinces the immune system it's safe.
Research by George Mason University found that adults with untreated celiac disease had lower bone density in their thighbones and femur necks. Despite consuming more calcium and phosphorous, individuals with undiagnosed celiac disease were not correctly absorbing nutrients.
A preliminary study from Children's National Hospital found no significant gluten transfer when tools like the same toaster or knives are used for both gluten-free and gluten-containing foods. Basic kitchen hygiene can further reduce gluten transfer.
A Mayo Clinic study found that 44% of screened first-degree relatives had celiac disease, with 94% displaying no classic symptoms. The study advocates for proactive screening among family members to prevent malabsorption, nutritional deficiencies and autoimmune conditions.
Researchers developed a mass-spectrometry-based approach to detect gluten proteins specific to rye, expanding detection capabilities beyond wheat and barley. The method identified six peptides that were consistently detected in all rye varieties, allowing for more accurate labeling of 'gluten-free' foods.
Consuming more gluten during early childhood is associated with higher risk of celiac disease and autoimmunity among genetically predisposed children. The study found a significant increase in risk for every 1-gram per day increase in gluten consumption.
A new blood test for coeliac disease has been developed, detecting inflammatory markers in the blood within hours of gluten consumption. This potential diagnostic test could improve upon current methods requiring patients to consume gluten for weeks or months.
Researchers discovered that B cells specifically binding N-terminal epitopes of transglutaminase 2 (TG2) more efficiently take up and present TG2-gluten complexes to gluten-specific T cells. This suggests that B cells with this specificity are the main antigen-presenting cells for pathogenic T cells in celiac disease.
A study by Mayo Clinic researchers found that micronutrient deficiencies are common in adults diagnosed with celiac disease. The most frequent deficiency was zinc, observed in 59.4% of patients, while vitamin D, iron, copper, vitamin B12, and folate were also prevalent.
Scientists have identified a biomarker that can diagnose celiac disease in individuals following a gluten-free diet with high sensitivity and specificity. The discovery uses the relative expression of the UBE2L3 gene isoforms in blood samples, enabling accurate diagnosis without the need for gluten consumption.
Scientists at Massachusetts General Hospital have developed a 3D mini-gut model that reflects the autoimmune response to gluten in celiac patients. The study identified novel genes associated with epithelial functions related to celiac disease, including gut barrier maintenance and stem cell regeneration.
Researchers identified unique genetic signatures in patients with active celiac disease and those in remission, revealing differences in gene expressions. The study uncovered potential targets for therapeutic intervention and shed light on the underlying mechanisms of celiac disease.
A recent study by Columbia University found that over half of gluten-free pizza and pasta dishes in restaurants contained detectable amounts of gluten, with 51% of pasta samples positive for gluten.
Researchers found that autoimmune diseases like Addison's and vitiligo often cluster together due to genetic links. In contrast, celiac disease tends to be less associated with other autoimmune conditions.
A new review in Frontiers in Pediatrics suggests that microbial transglutaminase, a common food additive, could be both the cause and trigger of autoimmune attacks leading to celiac disease. The enzyme modifies gluten fragments, which are then recognized by the immune system as foreign, triggering an immune response.
A new study has identified a specific peptide that directly binds to the ion-channel CFTR, impairing its function and triggering cellular stress and inflammation. This interaction can be inhibited by a potentiator of CFTR, which may offer protection against gluten-induced intestinal symptoms.
A phase 2 study found that AMG 714 reduced symptoms and intestinal damage in celiac patients exposed to gluten. The drug was shown to protect against accidental gluten contamination, a frequent occurrence among patients following a gluten-free diet.