Articles tagged with Chronic Fatigue Syndrome
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A team of researchers at Lancaster University has created a digital platform called 'Pace Me' to help people with Long COVID manage their energy levels. The study, published in Nature Communications, found that the intervention was safe and well-received, but did not outperform standard care in reducing symptoms.
A new Griffith University study found altered brain connection in people with ME/CFS and Long COVID, leading to cognitive difficulties such as memory problems and slowed thinking. The research used ultra-high field MRI technology to investigate the disruption in brain connectivity during a mentally demanding task.
Researchers at Griffith University found a consistent biological feature of ME/CFS: faulty TRPM3 ion channel function in immune cells. This discovery provides clear evidence for developing a diagnostic test and guiding new therapeutic targets.
A study at Macquarie University identified simultaneous abnormalities in energy metabolism, immune cells, and blood vessel function in people with ME/CFS. The researchers found 'energy stress' in white blood cells, altered T-lymphocyte subsets, and disruptions to vascular homeostasis.
A new study has discovered a strong link between chronic fatigue syndrome and abnormal breathing patterns, which may be worsening symptoms. Dysfunctional breathing was found in nearly half of the patients, with 71% experiencing breathing problems during exercise.
Researchers analyzed blood samples from 56 ME/CFS patients and 52 healthy controls, revealing disruptions in metabolic processes and immune dysregulation. The study suggests specific intracellular pathways correlate with symptoms, leading to potential biomarkers for targeted interventions.
Researchers are using total-body PET imaging to investigate the relationship between long COVID symptoms and activated immune T cells, as well as blood vessel damage. The goal is to gain a better understanding of how these processes are related and how they contribute to long COVID symptoms.
The Mount Sinai Hospital has launched the country's first clinical manual for treating infection-associated chronic illnesses (IACIs), a comprehensive guide for diagnosis and care. The manual covers extensive learnings from the Cohen Center and provides practical strategies for clinicians to support patients with conditions such as lon...
Cornell University researchers developed a diagnostic tool that can detect ME/CFS by analyzing cell-free RNA in blood plasma. The approach identified six cell types, including plasmacytoid dendritic cells, with 77% accuracy in detecting ME/CFS.
A study analyzing 249 individuals reveals disrupted interactions between the gut microbiome, immune system, and metabolism in ME/CFS patients. Biomarkers linked to symptoms such as sleep disturbances, headaches, and fatigue provide hope for future diagnostic tools.
Long-haul COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome share similar pathophysiologies, including oxidative stress, autoantibodies, and impaired mitochondrial energy conversion. These conditions also exhibit neurodegenerative outcomes, such as fatigue, sleep disturbances, and increased risk of dementia.
A new study has identified consistent blood differences associated with chronic inflammation, insulin resistance, and liver disease in ME/CFS patients. The results support the long-term goal of developing a blood test to diagnose ME/CFS.
Research from the Medical University of Vienna found a connection between altered inflammatory markers, intestinal barrier disturbances, and post-viral fatigue in PCS patients. The study suggests that monitoring gastrointestinal symptoms and biomarkers could help identify at-risk patients and develop targeted treatment strategies.
A study published in BMC Public Health found that ME/CFS cases in England are significantly higher than initially projected, affecting approximately 404,000 people. The condition disproportionately affects white British individuals, who are almost five times more likely to be diagnosed than those from other ethnic groups.
A new study published in the Journal of General Internal Medicine found that COVID-19 infection significantly increases the rate of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) among COVID-19 survivors. Nearly eight times more people with ME/CFS were infected with SARS-CoV-2 than those without, according to the research.
EBViously aims to prevent infectious mononucleosis and secondary diseases such as ME/CFS, while also protecting against certain types of cancer. The company's innovative vaccine candidate uses virus-like particles derived from EBV to trigger a targeted immune response.
Chronic fatigue syndrome patients' immune T cells become exhausted, a condition well-studied in cancer. Researchers now explore potential treatments to reverse this state, which may benefit ME/CFS patients.
The review paper examines the scope of people affected by long COVID, ranging from fatigue to cognitive impairment, and current treatment options. Researchers emphasize the need for biomarkers and targeted therapies to address root causes of the disease.
A new study led by UCLA found a 3% to 4% prevalence of ME/CFS-like illness among participants who tested positive for SARS-CoV-2 infection, similar to those who tested negative. The research suggests COVID-19 may not be the primary cause of ME/CFS.
Researchers at Tulane University identified a promising new approach to treating persistent neurological symptoms associated with Lyme disease. Fibroblast growth factor receptor inhibitors showed promise in reducing inflammation and cell death in brain and nerve tissue samples infected with Borrelia burgdorferi.
Researchers found differences in brain and immune systems of people with post-infectious ME/CFS. Abnormalities in the temporal-parietal junction and low levels of catecholamines were associated with fatigue, cognitive symptoms, and motor performance.
A recent study published in the Journal of Clinical Medicine identifies potential biomarkers for ME/CFS diagnosis and treatment. Researchers found that patients can be divided into subgroups based on immune system function, revealing differences in intestinal barrier function and immune competence.
A comprehensive report on pediatric long COVID symptoms has been published, revealing clues to risk factors and common symptoms such as fatigue, headaches, and musculoskeletal pain. The study found that older age, more severe initial infection, and underlying medical conditions are associated with an increased risk of long COVID.
A University of Otago study found strong links between Long COVID and ME/CFS, suggesting a coordinated treatment approach could improve patient outcomes. The research confirmed changes in immune system activity between Long COVID patients and healthy controls, reflecting chronic dysfunction.
Researchers found that the complement system remains activated in Long Covid patients, causing cell damage and tissue destruction. This abnormal activity can lead to thromboinflammation and other symptoms of the condition.
Researchers at Universitat Oberta de Catalunya used machine learning to simulate patient conditions based on questionnaire answers, predicting stress test performance and identifying symptoms. This approach provides a warning for early diagnosis and referral to specialized units.
The Mount Sinai Hospital's Cohen Center will expand its research and clinical care to include 'long Lyme Disease/Lyme+', exploring key similarities and differences with long COVID. The center will offer novel therapies, including virtual reality and non-invasive brain stimulation technologies, as well as personalized cognitive rehabili...
A recent study published in the International Journal of Infectious Diseases found that individuals infected with the Omicron variant have a significantly lower risk of developing long COVID compared to those infected with earlier variants. The study analyzed data from over 11,000 people and found that around half of all wild-type infe...
The DecodeME study reveals that women are more severely affected by ME/CFS, experiencing more symptoms and co-occurring conditions than men. The study confirms a sex bias among ME/CFS patients, with women making up 83.5% of respondents.
A new research case study published in The Lancet highlights the need for greater awareness of the 'blue legs' symptom associated with Long Covid. Acrocyanosis, a venous pooling of blood in the legs, can be a symptom of dysautonomia and postural orthostatic tachycardia syndrome (POTS) in patients with Long Covid.
A review article by senior investigators at Brigham and Women's Hospital found that long COVID and chronic fatigue syndrome share similar symptoms, including brain, immune system, heart, lung, gut, and energy metabolism abnormalities. The study aims to identify areas requiring further research for improved diagnostic tests and treatments.
Researchers at McMaster University have found that solriamfetol is the most effective treatment for excessive daytime sleepiness (EDS) in individuals with obstructive sleep apnea (OSA). A systematic review of 14 clinical trials and analysis of data from various databases revealed solriamfetol to be the best option.
Researchers are collecting data from patients' homes to improve diagnosis and treatment of ME/CFS. The study aims to tackle the unknown causes, characteristics, and effective treatments of the disease.
Tulane University researchers discovered a possible genetic cause of hypermobility and hypermobile Ehlers-Danlos syndrome, linking it to folate deficiency due to the MTHFR gene variation. Elevated folate levels in blood tests can aid in diagnosis, while methylated folate has shown promising treatment results for patients.
Researchers found epigenetic changes in post-COVID patients, including genes associated with taste and smell, as well as cell metabolism. These findings may lead to the development of new diagnostic tools for this and similar diseases.
Researchers at Columbia University's Mailman School of Public Health have identified differences in gut microbiomes between people with ME/CFS and healthy controls. Gut bacteria Faecalibacterium prausnitzii and Eubacterium rectale, which are normally health-promoting, were reduced in ME/CFS participants. The study found a deficient mic...
A recent study published in Nature Cardiovascular Research found a link between COVID-19 and postural orthostatic tachycardia syndrome (POTS), with patients infected five times more likely to develop the condition. Vaccination was also linked, but at a lower risk, emphasizing the importance of vaccination in reducing POTS.
A recent study from Linköping University found that COVID-19 reactivated several latent viruses, including the Epstein-Barr virus, in people with chronic fatigue syndrome (ME/CFS). The study suggests that these reactivated viruses may contribute to the disease's symptoms and could potentially be used as a diagnostic tool.
A Charité study found that SARS-CoV-2 can trigger chronic fatigue syndrome (ME/CFS) in patients. Approximately half of post-COVID patients met the diagnostic criteria for ME/CFS, with distinct differences in laboratory results and disease progression between groups.
A new home-based test, aAP, allows patients to monitor their autonomic responses and make lifestyle changes to alleviate symptoms. This test reduces NHS resource demand and provides clinicians with valuable insights into patient triggers.
New research models how post-viral fatigue syndromes like ME/CFS and Long COVID become life-changing diseases due to neuroinflammation. The study proposes a brain-body connection sustained through chronic neuroinflammation, leading to relapse recovery cycles.
A UK study found that physical activity can improve mental health and wellbeing for some with long COVID, but excessive exercise can exacerbate symptoms. Researchers recommend a 'paced' approach to return to exercise, prioritizing individualized programs to mitigate negative effects.
A mobile application developed by Universitat Autonoma de Barcelona and UPC researchers has been tested for its ability to predict the severity of disabling fatigue in patients with chronic fatigue syndrome/myalgic encephalomyelitis, particularly in women. The app measures heart rate variability and shares results with medical staff.
A special report highlights the controversy surrounding the treatment of chronic fatigue syndrome and long COVID, with clinicians weighing in on the role of exercise in rehabilitation. While some advocates reject research on exercise, others argue that careful screening and individualized treatments are key to helping patients manage t...
The eleventh edition of the Art of Neuroscience competition has been won by Yas Crawford for her artwork 'Cognition IX', which explores neurological interoception in Myalgic Encephalomyelitis patients. The winner was chosen from over 293 entries and received praise for its perfectly composed image, full of movement and dynamic flow.
A recent study suggests that COVID-19 may cause myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in young people. Three case studies reviewed by Johns Hopkins Medicine found ME/CFS-like symptoms within two weeks of illness, with all patients meeting criteria for the condition six months later.
A longitudinal study of 4,501 college students found that those who developed chronic fatigue syndrome after infectious mononucleosis had more physical symptoms and immune irregularities at baseline. Researchers also discovered that emotional functioning and psychological states were not statistically different from those who recovered.
Researchers at Stanford University School of Medicine have created a blood test that can flag the disease, which currently lacks a standard diagnostic test. The test successfully identified participants in a study with chronic fatigue syndrome and is being used to screen for potential drugs that may help treat the condition.
A new assessment tool predicts the risk of developing chronic fatigue syndrome (CFS) in college students six months after contracting infectious mononucleosis. The study found that those with more severe mononucleosis were over three times more likely to meet CFS diagnostic criteria.
A novel online questionnaire found that most CFS patients do not receive proper care in EDs, with only a third receiving appropriate treatment. Researchers call for more training on the disorder to improve patient outcomes.
Researchers found a crucial link between chronic fatigue syndrome and lower levels of key thyroid hormones. CFS patients had lower serum levels of T3 and T4, but normal thyroid-stimulating hormone, and higher levels of reverse T3, which may indicate reduced tissue T3 levels.
A new trial has found that a guided self-help approach to a graded exercise program can be safe and may reduce fatigue in patients with chronic fatigue syndrome. The study, which involved 200 people, showed that participants who received the guidance had a smaller effect on reducing physical disability compared to those who did not.
Scientists identify abnormal levels of specific gut bacteria in individuals with chronic fatigue syndrome/myalgic encephalomyelitis (ME/CFS), including those with and without irritable bowel syndrome (IBS). The study suggests that analyzing fecal microbiome may help subtype patients with ME/CFS.
A randomized, placebo-controlled trial found that anakinra did not reduce fatigue severity in women with chronic fatigue syndrome. The study's findings suggest that interleukin-1 inhibition may not play a role in CFS, contradicting previous studies.
A study published in PNAS identifies a unique chemical signature for chronic fatigue syndrome, revealing an unexpected connection to hypometabolic syndromes like dauer. The findings show that CFS has a characteristic metabolic response, with 80% of diagnostic metabolites decreased, and provide a basis for personalized therapies.
A recent study by researchers at University of Alabama at Birmingham found that imposing a mild to moderate strain on muscles and nerves can provoke symptoms of chronic fatigue syndrome. Participants with CFS reported significantly increased body pain and concentration difficulties during the procedure, as well as greater symptom inten...
Chronic fatigue syndrome (CFS) affects millions of Americans, causing profound fatigue, cognitive dysfunction, and sleep abnormalities. A new study led by Professor Derya Unutmaz aims to develop better diagnostic tools and personalized treatments for the disease.
A study published by the American Psychological Association found that chronic fatigue syndrome patients are more likely to suppress their emotions due to a heightened fight-or-flight response. This suppression is associated with increased anxiety and distress, which can worsen fatigue symptoms.
Researchers at Griffith University identified significant impairments in cellular function of CFS patients. They found dysfunctional signalling may contribute to impaired cell activity, aligning with symptoms. The study provides further evidence for the pathology of this disabling illness.
A recent study found that almost 2% of 16-year-olds have chronic fatigue syndrome (CFS) lasting more than six months. The condition affects girls more than boys and children from families experiencing adversity are more likely to have it. Effective treatment is available for most children, but many miss school due to symptoms.