Articles tagged with Colorectal Cancer
A UK-led team of scientists has developed a more accurate way of identifying aggressive forms of bowel cancer, which should lead to better treatment and survival rates. The study found that patients with a stem cell marker protein called Lamin A present in their tissue are more likely to have an aggressive form of the disease.
Researchers have developed a more accurate way to identify aggressive bowel cancer forms, suggesting patients with the Lamin A marker should receive chemotherapy in addition to surgery for improved recovery and survival. The study aims to develop a robust prognostic tool for widespread use in bowel cancer treatment.
A genetic trait linked to a 10-20 percent incidence in colorectal cancer patients significantly increases the risk of developing cancer to 50 percent if inherited, surpassing other known gene mutations.
A study published in Cancer Research found that the CB1 receptor plays a tumor-suppressing role in human colorectal cancer. Researchers discovered that CB1 expression is lost in most colorectal cancers, leading to increased tumor growth. Restoring CB1 expression with an existing drug showed promise in reducing tumors.
A study published in the Journal of the National Cancer Institute found that higher education levels were associated with significant mortality reductions in four common cancers: lung, colorectal, prostate, and breast. Individuals with a college degree experienced greater declines in cancer mortality rates compared to those with less e...
A study by UT Southwestern Medical Center reveals that the protein TCF7L2 actually suppresses the growth of human cancer cells in culture, contrary to its previous role in promoting colorectal cancer. This groundbreaking finding opens new avenues for understanding and treating colorectal cancer.
A study analyzing national surveys found racial disparities in colon cancer screening rates, with blacks and Hispanics having lower rates than whites. The findings suggest that culturally targeted interventions and improved access to healthcare may help address these disparities.
Researchers at MIT discovered a new compound, cDPCP, that targets colorectal cells more effectively than oxaliplatin, potentially sparing other body tissues from damage. The study found that cDPCP requires the assistance of organic cation transporters to enter cells.
A new study found that African Americans with a family history of colorectal cancer are less likely to be screened, contrary to expectations. Regular screening is crucial for early detection and prevention of colorectal cancer, which affects African Americans disproportionately due to their high incidence and mortality rates.
Researchers at A*STAR have discovered a novel approach to kill colon cancer cells using a genetic regulator called DACT3. The team developed a pharmacological strategy to restore DACT3 expression, leading to effective inhibition of Wnt/β-catenin signaling and massive death of colon cancer cells.
A family history of colorectal cancer is associated with a significant reduction in cancer recurrence and death, especially among patients receiving chemotherapy treatment. The study found that having more affected first-degree relatives further increased the protective effect, suggesting a distinct underlying molecular mechanism.
A USC study found that pre-menopausal women with metastatic colorectal cancer lived longer than younger men, while older women had significantly worse overall survival. The study also showed ethnic differences in survival rates, with Hispanics and Asians having better outcomes than Caucasians and African-Americans.
Researchers found that serum RASSF1A promoter hypermethylation is a promising biomarker for diagnosing gastric and colorectal cancer. The study detected higher rates of this abnormality in tumor tissues and patient sera compared to benign disease or healthy individuals.
New developments in sedation techniques, including computer-assisted systems and propofol administration, are expected to increase the effectiveness of colonoscopy and ease patient concerns. These advancements aim to encourage patients to get screened for colorectal cancer, which is curable when detected early.
A new study suggests that the depth of cancer penetration in the bowel wall affects survival rates, and proposes changes to current guidelines. Patients with thin lesions confined to the bowel wall have better survival outcomes than those with thicker cancers.
Ning Wong, a physician at Fox Chase Cancer Center, has received the ASCO Career Development Award for her exceptional work in genitourinary malignancies and health services research. The $200,000 grant will support her independent clinical cancer research program.
A Mayo-led study found that smoking is associated with an increased risk of developing colorectal tumors lacking DNA repair proteins. Women who smoked were more likely to develop these tumors, which may be due to the loss of function in genes responsible for repairing genetic damage.
A study found that moderate drinking in women increases the risk of developing ER+/PR+ breast cancer, with higher risks observed for those who consumed more alcohol. Researchers also identified a link between specific genetic variations and increased breast cancer risk among postmenopausal drinkers.
Studies show that introducing patient navigators in safety net health systems increases colonoscopy completion rates among urban minorities, reducing no-show rates by up to 9.8%. This individual intervention approach may be particularly effective in addressing the complex barriers to colorectal cancer screening in low-income and minori...
Researchers found higher levels of autozygosity among colorectal cancer patients, particularly those of Jewish heritage, which may lead to novel cancer-causing genes. The study suggests a new type of genetic signpost that clinicians can follow for a range of cancers in various population groups.
The EORTC Intergroup trial found that chemotherapy plus surgery on liver tumors improved progression-free survival by 26% in patients with colorectal cancer. Patients who received chemotherapy before and after surgery had a higher rate of progression-free survival compared to those who underwent surgery alone.
Researchers found hepcidin expression positively associated with stage of colorectal disease and also expressed in a subset of colorectal cancer tissues. This suggests that cancer cells sequester iron to feed their high metabolic activity, perpetuating the cancer phenotype.
Researchers found that surgery combined with heated Intraperitoneal Hyperthermic Chemotherapy (IPHC) improves survival rates for patients with peritoneal carcinoma originating from colorectal or appendix cancer. The study also showed that IPHC may have some benefit in select patients with peritoneal carcinoma and hepatic metastases.
Researchers found non-polypoid (flat) colon lesions are relatively common and more likely to contain cancerous tissue than polypoid lesions. The study estimated the prevalence of NP-CRNs to be 9.35% and found that depressed-type NP-CRNs had a higher risk of containing cancer.
A novel hMSH2 gene mutation was found in a Chinese HNPCC kindred, associated with an increased risk of colorectal cancer in four successive generations. The mutation resulted in Asp 603 Gly of hMSH2 and was present in four out of ten family members.
A new study suggests that smokers may benefit from earlier colon cancer screening due to their increased risk of developing the disease. The research found that current smokers were diagnosed with colon cancer approximately seven years earlier than people who never smoked.
A study found that healthcare providers play a significant role in patients' likelihood of being screened for colorectal cancer. Patient barriers such as concerns about payment and fears of detection also impact screening rates. Interventions targeting both providers and patients are necessary to boost screening rates.
A study published in Gastroenterology found that smoking significantly increases the risk of developing colorectal polyps, with a two-fold increased risk for current smokers. The findings suggest that approximately 20-25% of colorectal polyps may be attributed to tobacco use.
A study found that regular aspirin use lowers the risk of colorectal cancer in men, particularly at higher cumulative doses. However, the benefits of long-term aspirin use appear to diminish after four to five years and are not evident after discontinuing use.
Researchers found patients taking statins had a lower incidence of cancer compared to non-statin users. Additionally, a new receptor may be targeted for colon cancer treatment, while a mouse model of rare kidney disorder shows promise for studying cancer development.
A new study finds that patients in high-spending areas do not necessarily have better health outcomes than those in low-spending areas. However, the authors also reveal that increased spending can be beneficial in certain cases, such as when chemotherapy is provided to patients with stage 3 colorectal cancer.
A randomized trial found that telephone mentoring from trained peer coaches increased the likelihood of keeping a first colonoscopy appointment by two times. Patients with peer support were more likely to be insured and have better primary care adherence, and nearly 70% kept their appointments.
A new study by Yale School of Medicine researchers suggests that colon cancer screenings may bring little benefit and pose harm to certain patients. The 'payoff time' method estimates the minimum time required for screening benefits to outweigh harms, revealing a significant gap in current guidelines.
The QUASAR trial found that chemotherapy with fluorouracil and folinic acid reduces the risk of recurrence by 22% and death by 18% in patients with stage II colorectal cancer. The absolute improvements are small, but still significant.
A group of UK doctors call on the government to implement folic acid fortification in flour to prevent neural tube defects, which could save around 400 pregnancies annually. They argue that two studies cited as a delay do not support a link between folic acid and colorectal cancer.
A study found that Medicare beneficiaries are not receiving adequate colorectal cancer screening, with only 25% meeting guidelines. The investigation highlights the need for continued efforts to promote screening and reduce mortality from this common disease.
Researchers have successfully implemented community-based projects to address cancer disparities among African-American and Hispanic communities, and Navajo Nation population. The initiatives improve data collection, provide insight into social factors, and lead to sustained health improvements.
Researchers found a protective effect of the TT version of the MTHFR gene against colorectal cancer in Asian populations, but not in others. The study suggests genetics may play a role in understanding health disparities in minority groups.
A study by University of California, Irvine researchers found that low doses of freeze-dried grape powder inhibit genes linked to sporadic colorectal cancer. The study suggests a diet rich in grapes may help prevent colon cancer, which kills over half a million people worldwide each year.
Researchers have developed two molecular analogues of curcumin that demonstrate enhanced tumor suppressive properties against colorectal cancer. These new compounds have shown improved bioavailability and potency compared to natural curcumin.
Researchers found that children of parents who died from these cancers have significantly worse survival rates than those with good parental survival. The risk of death was increased by 75% for breast cancer and 107% for prostate cancer.
Research investigates the role of NCAM-180 as a tumor suppressor in colorectal cancer, finding low frequency and lack of prognostic value. The study concludes that routine use of NCAM-180 expression is not feasible due to its rarity.
A study published in Clinical Gastroenterology and Hepatology found that minority patients prefer optical colonoscopy (OC) over computed tomographic (CT) colonography for colorectal cancer screening. OC was associated with less discomfort, embarrassment, and pain compared to CT colonography.
A study published in the Journal of the National Cancer Institute found no correlation between vitamin D levels and overall cancer death rates. However, elevated vitamin D levels were linked to a significant decrease in colorectal cancer mortality rates.
Researchers aim to determine who is at risk for colorectal cancer and tailor screening tests accordingly. Dr. Thomas F. Imperiale advocates for more targeted approaches, such as using easily accessible factors like age and family medical history.
Researchers found that initial screening colonoscopy with polyp removal significantly reduces colon cancer mortality. The study suggests extending follow-up surveillance intervals from 3-5 years to 6 or more years, contingent on adequate bowel preparation and visualization of the colon.
New studies support continued colorectal cancer screening among healthy elderly Americans, with screenings leading to earlier stage of CRC diagnosis and improved survival. Researchers found that adenomas were detected more frequently in older patients, and asymptomatic patients had significantly improved survival rates.
Researchers found that mesalamine use among patients with inflammatory bowel disease was associated with a decreased incidence of colorectal cancer. Mesalamine use was linked to an 89% reduction in risk of colorectal cancer, according to the study.
African-Americans have a higher incidence of colorectal cancer, with advanced polyps on the right side of the colon more common. Latin Americans also show similar high-risk findings to African-Americans in colonoscopy screenings.
Research found obesity to be the highest attributable risk factor for developing colorectal cancer in women. Among participants, 20% were obese and 14% were smokers, with BMI accounting for one-fifth of significant polyps detected during colonoscopy.
The report found that cancer death rates declined by an average of 2.1 percent per year from 2002 to 2004, nearly twice the annual decrease of 1.1 percent per year from 1993 to 2002. Cancer incidence rates among American Indians and Alaska Natives varied two-fold across six geographic regions.
A study found that diabetes increases levels of CA 19-9, a tumor marker for pancreatic cancer. Elevated CA 19-9 levels in diabetics may indicate chronic pancreatitis rather than pancreatic cancer.
Researchers mapped the human genome for breast and colon cancers, finding that most cancer-causing gene mutations are diverse and vary from person to person. The study suggests that personalized medicine may focus on complex pathways linking less-commonly mutated genes.
A retrospective study of 68 postoperative CRC patients found that 18F-DG PET/CT detected more lesions than CT or ultrasonography alone in 30.4% of cases with recurrence and/or metastasis. The imaging technique also helped alter treatment plans in 16.2% of cases.
Researchers found significant IL-8 up-regulation in all inflammatory, non-malignant, and malignant colorectal entities compared to normal tissues. The study suggests an association between IL-8 expression and the development of colorectal cancer and liver metastases.
Researchers found that patients with large polyps or adenomas may need more frequent follow-up, while those with only a few small polyps can be screened less often. Relatives of patients with large polyps should also be targeted for screening.
The Fecal Immunochemical Test (FIT) detects human blood in the stool and has a high sensitivity of 81.8% for detecting colorectal cancers. FIT also has a higher specificity than traditional guaiac tests, reducing false positives and unnecessary procedures.
A new version of the colon cancer screening test effectively detects colorectal cancer and may replace the current unrehydrated guaiac test. The fecal immunochemical test had a sensitivity of 81.8% for detecting colorectal cancers, outperforming the guaiac test's 64.3% sensitivity rate.
A study found that patients with newly diagnosed coronary artery disease had nearly twice the prevalence of colorectal tumors compared to the general population. Colorectal cancer is associated with chronic inflammation, a common pathway with atherosclerosis and CAD.
Researchers found that personalized behavioral intervention services significantly improved colorectal cancer screening rates in primary care practices. The tailored interventions resulted in increased screenings among patients who were not up-to-date with guidelines, with rates reaching as high as 48%.