Articles tagged with Colorectal Cancer
A large-scale case-control study found no association between GSTM1 and GSTT1 null genotypes and increased risk of gastric and colorectal cancer in Koreans. Smoking, alcohol consumption, and age did not modify this association.
Key advances in DNA sequencing technology and gene mutations have identified candidate cancer genes that contribute to colorectal cancer. The study also highlights the importance of understanding biological pathways deregulated in colon cancer, which can form the basis of new therapeutic agents.
Researchers at Dana-Farber Cancer Institute found that men with colorectal cancer who engage in regular exercise have a 53% higher chance of surviving without the disease. The benefit of exercise was seen across various factors such as age, cancer progression and previous physical activity.
Men with a history of nonmetastatic colon cancer who engage in moderate to vigorous physical activity have a significantly lower risk of death from colon cancer and any cause. The study found that men who exercised for more than 27 MET hours per week had over 50% lower mortality rates compared to inactive men.
The German ICGC network will analyze 300 tumor samples of two childhood brain tumors, medulloblastoma and pylocytic astrocytoma. Researchers aim to identify cancer-specific changes and develop new treatment approaches with targeted drugs.
Adding cetuximab to neoadjuvant chemotherapy significantly increases tumor response rates, making more patients eligible for potentially curative surgery. The treatment also improves the proportion of tumors deemed resectable, with a notable increase after treatment.
Scientists at the University of Wisconsin-Madison School of Medicine and Public Health have identified a critical link between two signaling pathways that contribute to the development of colorectal tumors. The study reveals how CRD-BP binds to and increases GLI1 messenger RNA, leading to cancer-promoting gene activation.
New research reveals that African-American patients with colorectal cancer are more likely to be diagnosed with advanced disease and have a lower likelihood of undergoing surgical procedures compared to Caucasians. This disparity can be attributed to unequal access to care, leading to poorer survival rates.
A study comparing optical diagnosis with conventional histopathology found that optical methods accurately identified up to 93% of small colorectal polyps. The method also enabled quicker follow-up colonoscopies and saved patients an estimated £6560 in clinical appointments.
Studies highlight racial disparities in gastrointestinal disease, particularly colon cancer and Barrett's Esophagus, among African Americans, Latinos, and women. These disparities underscore the importance of education, early screenings, and potentially more aggressive screening tactics for these populations.
A study found that unsedated colonoscopy for primary colorectal cancer screening is as effective as sigmoidoscopy in terms of patient acceptance and need for sedation. The procedure eliminates risks associated with sedation, reduces recovery time, and decreases costs.
A new study found that Jewish survivors of World War II have a higher risk of developing cancer, with increased risks observed for breast and colorectal cancer. The study, which analyzed data from over 300,000 Israeli Jews, suggests that early exposure to extreme stressors during childhood may increase cancer susceptibility later in life.
Researchers found that aspirin and folic acid do not affect inflammation markers in patients with colorectal adenomas. However, low-dose aspirin was found to stabilize C-reactive protein levels, which may be affected by high folate intake.
Women with metastatic colorectal cancer tend to live longer than men, with those under 45 years old experiencing the greatest survival advantage. However, this benefit disappears with age, suggesting that hormones may be contributing to better outcomes in younger patients.
A new study found that investing in colorectal cancer screening programs could reduce treatment costs by more than half. The study suggests that the increasing use of expensive cancer drugs will make screening programs more cost-effective, making them a desirable investment for governments and insurance companies.
Researchers have developed two new blood tests that can aid in the early identification of patients with gastrointestinal (GI) cancers, making diagnosis simpler, cost-effective, and more acceptable to patients. The tests use DNA methylation to detect cancerous cells and show high sensitivity and specificity rates.
Researchers have discovered genetic biomarkers relevant to CRC, allowing for personalized medication and improved survival rates. The integration of conventional agents with novel targeted therapies has led to median overall survival exceeding two years in metastatic CRC.
A new study published in the Journal of the National Cancer Institute found that fecal DNA methylation can detect gastric and colorectal cancers. Methylation patterns were more likely to be found in advanced tumors, with detection rates of 57% for gastric cancer patients and 75% for colorectal cancer patients.
Regular aspirin use after diagnosis was associated with reduced risks of colorectal cancer-specific death and overall mortality. Participants who regularly used aspirin had a 29% lower risk of colorectal-specific mortality compared to nonusers.
Regular postdiagnosis aspirin use may reduce the risk of dying from colorectal cancer, with a nearly 30% lower risk seen in patients taking aspirin at least twice a week. The benefit is strongest among patients with COX-2-positive tumors.
A study found that cetuximab was not cost-effective for all patients with advanced colorectal cancer. However, it showed promise when used in patients whose tumors had wild-type KRAS genes. The authors suggest restricting cetuximab treatment to these patients to save costs.
The new UIC Center of Excellence in Eliminating Health Disparities aims to reduce health disparities in Chicago by conducting research, education, policy changes, and community partnerships. Researchers will focus on prostate and colorectal cancer, as well as breast cancer initiatives.
Researchers have discovered a key link between protein CCKR2 and progastrin-related colonic hyperproliferation. Deletion of the Cck2r gene in mice with human progastrin overexpression abolished colonic hyperproliferation and reduced colorectal cancer, suggesting CCKR2 as a viable target for treatment.
Researchers at Children's Hospital of Philadelphia have identified an immune mechanism responsible for graft failure in a mouse model of IUHCT. Maternal alloantibodies, produced in response to IUHCT, trigger a postnatal immune response that limits engraftment following in utero hematopoietic cell transplantation. This finding opens the...
A new study found that most older long-term cancer survivors with an interest in diet and exercise actually have poor health habits. However, those who exercised regularly and followed a healthy diet experienced improved physical health and quality of life.
A study found that increasing lymph node removal did not increase the number of patients with stage III colorectal cancer. Despite higher lymph node yields, the proportion of patients diagnosed with stage III cancer remained unchanged.
A decision-analytic model suggests that more frequent and strict colonoscopy recommendations can be cost-effective strategies for screening second primary colorectal cancers in male cancer survivors. The most vulnerable population aged 40 years old may benefit from COL5, while the general population aged 50 years old may follow COL10.
Researchers found that ultrasound outperforms symptom analysis in detecting ovarian cancer, with TVS performing better for malignancies. Racial disparities in colorectal cancer survival dissipate after adjusting for demographic and clinical factors. Thyroid cancer incidence increases across all tumor sizes, suggesting screening is not ...
Researchers at Max Delbrück Center for Molecular Medicine have identified 115 genes associated with metastatic potential in colorectal cancer. The study found that BAMBI gene is more active in metastatic tumors, promoting metastasis formation through key signaling pathways.
A University at Buffalo study found that improved communication between patients and primary care physicians increases the chances of those due for screening following their doctor's advice. The more convenient the screening process is, the greater the chance patients will follow through.
Researchers identified a novel mechanism linking a common single-base variant in chromosome 8 to an increased risk of colorectal cancer. This variant is carried by nearly all African populations and contributes significantly to the disease at a population level, yet its impact on individual susceptibility is minimal.
A recent study found that colorectal cancer incidence rates decreased significantly among whites aged 65 and over, but not among those in poorer communities. The researchers suggest that lack of access to healthcare may be the reason for this disparity. Colorectal endoscopic screening rates also increased among whites, but were lower a...
Researchers found increased mRNA levels of PN-1, a prostasin inhibitor, in colorectal tissue samples from patients with mild/moderate dysplasia and severe dysplasia before colorectal cancer. Elevated PN-1 levels coincide with the acquisition of malignant properties in colorectal tissue.
Researchers have identified N-Myc downstream-regulated gene 4 (NDRG4) as a potential biomarker for colorectal cancer and a candidate tumor suppressor gene. The study found that NDRG4 promoter methylation was more prevalent in colorectal cancers than in noncancerous colon mucosa.
A new CT scan method has been shown to be accurate in detecting colorectal cancer in individuals at increased risk. The study found a sensitivity of 85.3% and specificity of 87.8%, making it a potentially effective alternative to colonoscopy for screening.
A recent study found that US counties with a higher percentage of African-American patients tend to have fewer gastroenterologists and radiation oncologists, while those with more Asian Americans have more specialists. This disparity is linked to disparities in access to quality healthcare services.
A study published in World Journal of Gastroenterology found that patients with extrahepatic disease, high carcinoembriogenic antigen levels, or multiple nodules have poorer survival rates. Despite this, advances in surgical technique and complementary treatments are increasing the number of patients benefiting from curative treatment.
A study published in the World Journal of Gastroenterology found that current alcohol drinking and a high body mass index (BMI) ≥ 24.0 kg/m2 are independent risk factors for colon and rectal cancer. Former alcohol consumption and a positive family history of cancer are also linked to an increased risk of colon cancer.
Researchers develop synthetic protein that induces blood clotting, cutting off tumor's nutrient and oxygen supply. The treatment resulted in a 53% decrease in tumor volume and slowed cancer cell growth by 49%.
Australian researchers have developed gene expression biomarkers that can accurately detect pre-cancerous and cancerous colorectal growths from non-cancerous controls. This breakthrough is a result of a collaborative study involving CSIRO, Flinders University, and Clinical Genomics Pty Ltd.
A global study found colorectal cancer incidence rates for males and females increased in 27 countries between 1983 and 2002. The rise is attributed to Westernization and lifestyle changes, including obesity, physical inactivity, and diet.
Incidence rates of colorectal cancer are rising among young adults in the US due to increased obesity and unfavorable dietary patterns. Studies found a 1.5% annual increase in incidence rates from 1992-2005, with left-sided tumors being more common.
A new DNA stool test has been developed by Mayo Clinic researchers to detect digestive cancers in multiple organs, including pancreas, stomach, and esophageal cancers. The test was shown to be highly sensitive, detecting cancers at each organ site with high accuracy.
Recent studies have shown that patients under deep sedation during colonoscopy are more likely to have large polyps detected, which could lead to earlier detection of colon cancer. Additionally, research suggests that removing advanced pre-malignant polyps sooner than recommended may be beneficial in reducing the risk of colon cancer.
A new study by Memorial Sloan Kettering Cancer Center found that most patients with stage IV colorectal cancer do not require surgery to remove the primary tumor. Chemotherapy is an effective treatment option for these patients, allowing them to avoid surgical complications and start treatment sooner. The retrospective study analyzed 2...
Researchers at M.D. Anderson Cancer Center found a significant increase in median overall survival from 8 to 30 months for patients with advanced disease, and a projected five-year survival rate of over 30 percent. The study attributes the improvements to better surgical interventions and new chemotherapeutic agents.
A meta-analysis of 12,294 patients found bevacizumab significantly increases the risk of gastrointestinal perforation, especially in those with advanced colorectal and renal cell cancers. The study also showed a dose-dependent relationship between bevacizumab dose and GI perforation risk.
A novel marker of TSPAN1 has been identified as a significant prognostic indicator for patients with colorectal adenocarcinoma. The protein's expression was found to correlate with histological grade, cell proliferation, lymph nodal metastasis, and TNM staging, leading to a shorter survival period in those with overexpression.
Researchers have identified a common genetic variation associated with the risk of colorectal cancer and its functional implications. The study found that this variation causes the expression of a nearby gene, SMAD7, to decrease, leading to critical signaling events that can set cells on the path to cancer.
A large study found that hormone therapy use was associated with a 28% lower incidence rate of colorectal cancer in older women. However, the mechanisms behind this protective effect are still unclear. The study also found no associations between hormone use and specific molecular markers or DNA methylation patterns.
Researchers at Medical College of Wisconsin discovered that CXCL12 can prevent colorectal cancer cells from adhering to underlying proteins, leading to programmed cell death. The study suggests a potential mechanism for slowing cancer spread and improving patient prognosis.
Researchers analyzed primary care records of 5,477 colorectal cancer patients and 38,314 controls to quantify the exact risks posed by eight clinical features. The study found that rectal bleeding carries a high risk warranting investigation regardless of other symptoms.
Researchers found a possible genetic cause for increased risk of advanced colorectal cancer in African-Americans, with the Pro72 allele linked to higher mortality rates. The study analyzed 137 tumors and found that African-Americans had a higher frequency of this allele, which was associated with shorter survival rates.
Research suggests that folate intake can have dual positive and negative effects, with adequate intake offering protection against cancer but excessive amounts facilitating tumor growth. The optimal level of folate intake varies depending on the individual's specific circumstances, highlighting the need for tailored guidelines.
Research suggests that aspirin can reduce the risk of polyps forming in the colon or rectum, a precursor to colorectal cancer. Studies have shown mixed results regarding the optimal dose and duration of use, but experts call for more evidence on the effects of aspirin on cancer.
Researchers found that inhibiting the enzyme 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) with licorice extract or by silencing its gene prevents colorectal cancer progression in mice. This approach produces effects specific to the colon and kidney, unlike existing preventive therapies.
The German colonoscopy program has prevented approximately 15,000 cases of colorectal cancer between 2003 and 2010. The program's effectiveness is attributed to the early detection of cancer precursors through endoscopic examinations.
Researchers found that inhibiting an enzyme called 11-beta-HSD2 blocks COX-2 activity, preventing colorectal cancer growth and metastasis. Long-term inhibition did not cause side effects on the heart and blood vessels.
Researchers found that using a novel water method for unsedated colonoscopy improved cecal intubation rates and patient willingness to repeat the procedure. The study also revealed that the duration of the interval between bowel preparation completion and colonoscopy start time predicts prep quality.
Researchers found that gene expression profiles differed between tumor samples from patients who had taken vitamin E, selenium, or both supplements compared to those on placebo. The study provides insight into the effects of preoperative supplement use on prostate cancer gene expression, a potential area for future investigation.