A meta-analysis of 10 randomized clinical trials found that topiramate-treated patients lost 11.8 pounds more on average than placebo group members, with a higher success rate for weight loss over 28 weeks.
Girls with anorexia nervosa saw significant increases in bone density at the spine and hip after receiving physiological estrogen therapy, according to a new study. However, they still had lower bone density than healthy-weight controls.
A new study by Indiana University finds significant differences in physical fitness levels between patients at safety net community health centers and members of a medically affiliated fitness center. The research highlights the importance of access to exercise opportunities for vulnerable populations, particularly those without health...
A pilot study at Indiana University found that yoga significantly improved balance items and confidence in veterans with stroke. The participants showed a 17% improvement in balance and a 34% increase in confidence after eight weeks of group yoga classes.
A new study found that adding radiation therapy to breast-conserving surgery improves disease-free survival and reduces cancer recurrence in women with early breast cancer. The treatment significantly lowered the rate of recurrences in the breast and lymph nodes, as well as in other parts of the body.
A survey of 541 ED residents found that 84% think it's acceptable for female residents to have children during residency, and 82% would rearrange their schedule to help a pregnant colleague. The study suggests that most emergency medicine residents are supportive of their colleagues having children during residency.
A new study finds daily BPA exposure lowers male fertility in mice, causing reduced sperm counts and testosterone levels. Mice exposed to twice the recommended safe dose showed structural defects in their testicles and were considered subfertile.
Researchers identified genetic mutations associated with lower cancer risk (e.g., MSH6) and increased risk (e.g., MLH1, MSH2) for ovarian and endometrial cancer in individuals with Lynch syndrome. The study provides age- and gene-specific risk estimates for each tumor type.
A study found that formoterol improves fat burning and protein metabolism in men, increasing metabolism by over 10% and fat oxidation by nearly 25%. The results suggest potential benefits for preventing obesity and muscle loss in humans.
Research shows bariatric surgery significantly increases fracture risk, with patients experiencing a 2.3-fold higher chance of bone fractures compared to the general population. Patients who underwent gastric bypass surgery had an increased risk of fractures at nearly all skeletal sites, including feet and hands.
A clinical trial of 78,216 women found no reduction in ovarian cancer death risk with screening. Instead, screenings led to more invasive medical procedures and higher complication rates. The study suggests that annual screening may not be effective in detecting cancers early enough to reduce mortality.
A study presented at The Endocrine Society's annual meeting found that women with worse facial wrinkles during early menopause tend to have lower bone density. This association was independent of age and body composition, suggesting a potential link between skin health and bone quality.
Long-term risks of subsequent primary neoplasms were investigated in childhood cancer survivors, with digestive and genitourinary neoplasms showing the highest absolute excess risks. The study found a 3- to 6-fold increased risk for survivors compared to expected rates.
A new glioblastoma vaccine has demonstrated safety and effectiveness in a Phase 2 clinical trial, extending median survival to 11 months for patients with recurrent brain cancer. The vaccine was found to induce an immune response against tumor-specific targets, suggesting potential for improved treatment outcomes.
A Mayo Clinic study has found that a mutant gene thought to accelerate tumor growth actually inhibits the spread of malignant cells, showing promise for novel cancer therapies. The PAX8/PPARγ fusion protein functions as a tumor suppressor by upregulating anti-tumor agents.
A study published in JAMA found that delays in starting adjuvant chemotherapy after colorectal cancer surgery are associated with poorer survival outcomes. The research suggests that clinicians should prioritize timely access to chemotherapy to improve patient outcomes.
An experimental gene therapy has reversed type 1 diabetes in mice with a nearly 80 percent success rate, reversing autoimmune destruction of insulin-producing beta cells. The treatment uses neurogenin3 and betacellulin to stimulate new islet growth and inhibits immune system activity.
University at Buffalo researchers and hundreds of Western New York women participated in a phase III clinical trial evaluating exemestane, which reduces breast cancer risk by 65% in postmenopausal women at increased risk. The study found no serious toxicities and minimal changes in quality of life.
Men with prostate cancer treated with hormone deprivation therapy may be at increased risk of developing diabetes or metabolic syndrome. According to the study, men in the ADT group had a twofold increased probability of having diabetes compared to those who did not receive hormonal therapy.
Researchers identified phytochemicals in mushrooms that block aromatase enzyme activity, potentially reducing estrogen levels and killing hormone-dependent breast cancers. Early-stage studies show promise in preventing breast cancer recurrence and treating lung cancer.
Women with obesity before and after diagnosis have a higher risk of dying from breast cancer. Obesity is strongly linked to death due to breast cancer, particularly in estrogen receptor-positive cases.
Researchers at Columbia University Medical Center have developed a potential non-steroidal birth control pill for men that prevents conception with reversible male sterility. The compound, which interferes with retinoic acid receptors, showed no apparent side effects and restored fertility soon after drug administration was terminated.
A new animal study suggests that fetal programming of disease risk to the next generation depends on parental gender. The study found that exposure to stress hormones in the womb can program potential health effects, but the effects differ between mothers and fathers.
A study of 75 obese men found that bariatric surgery can reverse low testosterone levels and symptoms of male sexual dysfunction. After weight loss, testosterone levels increased significantly, indicating a potential causal relationship between obesity and low testosterone.