Articles tagged with Colorectal Cancer
Providing computed tomography colonography as an alternative to conventional colonoscopy could improve colorectal cancer screening rates. The study found that patients preferred virtual colonoscopy due to its convenience and perceived safety.
A new study shows that fatalistic thinking in Latinas may prevent them from using cancer screening services. Seven out of eleven studies found a statistically significant inverse association between fatalism and utilization of cancer screening services.
Studies reveal notable disparities in colorectal cancer diagnosis, treatment, and outcomes among different racial groups. African Americans are advised to start screening at age 45, while Hispanics have lower screening rates and worse survival rates after diagnosis. The findings suggest that earlier screening may be recommended for His...
A new study published in Gastroenterology has found that type 2 diabetes mellitus and insulin use are associated with an increased risk of colorectal cancer among men. The association was not observed in women, suggesting a gender disparity in the link between these conditions.
A systematic review of 22 studies with over 2.5 million participants found a statistically significant reduction in colorectal cancer risk among statin users. Long-term use of statins, particularly lipophilic types like atorvastatin, was associated with the strongest effect.
The American College of Gastroenterology's 75th Annual Scientific Meeting featured groundbreaking research on C. difficile, colorectal cancer, obesity, and inflammatory bowel disease, providing new insights into prevention, treatment, and management strategies.
A new study found that only one-fifth of primary care physicians follow practice guidelines for all recommended colorectal cancer screening tests. Many clinicians overuse or underuse screening, leading to unnecessary testing and potential complications.
Researchers reported that adding cetuximab to a three-drug chemotherapy regimen for first-line treatment of metastatic colorectal cancer did not improve response rates, progression-free survival, or overall survival. The NORDIC VII study included 566 patients and found no statistically significant differences between the treatment groups.
Researchers found a significant correlation between low socioeconomic status and late-stage, non-localized colorectal cancer diagnoses. Participants from less deprived neighborhoods had a lower incidence rate of 16.2%, while those from more disadvantaged areas had a higher incidence rate of 19.8%.
A new microRNA screening assay detected the majority of early-stage colorectal cancers with good specificity and sensitivity from a single plasma sample. The test has the potential to be safe, cheap, robust, accurate, and convenient for national screening programs.
Researchers found that individuals who don't speak English at home are less likely to receive colorectal cancer screenings compared to those who do. The study suggests that patient-provider language barriers and unmeasured differences in patient characteristics contribute to disparities in health care access.
Scientists at the University of Leicester are pioneering the use of turmeric extract to target chemo-resistant cancer cells. The research aims to improve chemotherapy effectiveness and prevent disease recurrence.
Researchers found that virtual colonoscopies (CTC) doubles the yield of identifying significant early extracolonic lesions, resulting in lives saved. CTC also increases the odds of identifying high-risk lesions by 78 percent.
Researchers at Tel Aviv University discovered that low hemoglobin levels can indicate a potential for colon cancer years before it's diagnosed. A continuous long-term decline of more than 0.28 grams per decilitre over a four-year period may serve as a warning of illness on the horizon.
A new study published in Psychological Science found that men are less likely to seek cancer screening when presented with misleading information about the prevalence of screening among other men. The researchers suggest that framing health messages to emphasize the benefits of screening rather than relying on relative numbers can be a...
A recent study found that a significant number of patients are willing to undergo computed tomography colonography (CTC) for colorectal cancer screening, but are hesitant to pay out-of-pocket fees. The study suggests that CTC availability could improve screening rates if insurance coverage were more widely available.
A study by researchers from the University of British Columbia and Dalhousie University found that colorectal cancer screening can reduce mortality by 39-83% and incidence by 26-81%. Regular screening, such as fecal tests or colonoscopies every ten years, is recommended for average-risk individuals.
Multimedia talking touchscreens are helping researchers and clinicians improve communication, knowledge, and adherence to treatment for patients with diverse language skills. The technology provides a more private and accessible way for patients to complete questionnaires and access health information.
McMaster University researchers have made a breakthrough in understanding the molecular mechanisms of hereditary colorectal cancers. They discovered how a specific protein, MutL, works within cells to repair DNA errors, paving the way for alternative cancer treatments and assessment tools.
A study found that smoking is associated with molecularly defined DNA changes and a subtype of colorectal cancer that emerges more frequently among older women. The researchers suggest that epigenetic modifications may play a role in the development of smoking-related colorectal carcinogenesis.
Researchers have identified hydrophobic proteins as potential biomarkers for colorectal cancer detection. The study used two-dimensional gel electrophoresis and mass spectrometry to analyze protein profiles from colorectal cancer tissues, revealing differentially expressed proteins related to tumor stages, grades, and patient gender.
A study led by Dr. Sohn DK demonstrated the safety of endoscopic piecemeal resection (EPMR) for large sessile colorectal polyps. The research showed low relapse rates in patients with benign polyps after EPMR, but higher recurrence rates in malignant lesions. The authors suggest that complete removal of cancer cells is crucial to preve...
A new study reveals that disparities in cancer stage and treatment account for the majority of excess deaths among uninsured and Medicaid-insured rectal cancer patients. Improving insurance coverage and reducing cost-related barriers to primary care and high-quality treatment can help mitigate these disparities.
A new study found a strong association between smoking and the presence of flat adenomas (precancerous polyps) in the colon. The study suggests that smoking may explain why smokers often present with colorectal cancer at a younger age and at a more advanced stage than nonsmokers.
The American Society for Gastrointestinal Endoscopy (ASGE) has issued guidelines addressing ethnicity and gastrointestinal diseases. The guideline recommends that colorectal cancer screening begin at age 45 for average-risk African-American men and women, emphasizing the importance of early detection in reducing mortality rates.
Researchers developed a non-invasive imaging technique combining PET and CT scans without bowel preparation, detecting all significant polyps found by colonoscopy. Patients preferred this method over colonoscopy due to its comfort and lack of sedation.
Researchers found that African American women are more aware of the importance of screening and are more willing to undergo the procedure, while men report barriers such as lack of trust in the healthcare system and fear of the procedure. Despite these differences, both groups recognize the benefits of early detection and prevention.
A meta-analysis found that the G allele of PPAR-γ gene polymorphism 34 C>G decreases colon cancer risk, indicating its potential as an early diagnosis and treatment target. The study confirms previous data linking the polymorphism to CRC risk.
A study presented at the ARRS 2010 Annual Meeting found that FDG-PET/CT accurately confirmed a suspected colorectal cancer recurrence in 40 out of 71 patients. This early detection enables improved treatment planning and targeted patient care for those with recurrent colorectal cancer.
Researchers examine data on minority and older populations to understand adherence to recommended screening guidelines. Studies find that virtual colonoscopies did not decrease the use of traditional optical colonoscopies for colorectal cancer screenings.
Research at Mayo Clinic reveals stool DNA testing can identify two types of colorectal pre-cancers in IBD patients and serrated polyps. The tests show a high detection rate for these precancerous lesions, offering promise for improving colon cancer prevention.
A recent study published by Mayo Clinic has found that older women with diabetes are at a more than doubled risk for certain types of colorectal cancer. The research team analyzed data from over 37,000 participants and identified associations between diabetes and specific molecular markers.
Researchers at Ohio State University discovered that microRNA-155 can silence genes protecting against DNA mutations, contributing to cancer progression. The study suggests miR-155 expression may be a key stratification factor in cancer prognosis and treatment.
A single sigmoidoscopy examination between ages 55 and 64 significantly reduced colorectal cancer mortality by 43% and incidence by one-third in those screened. The study found a lasting protective effect of screening, with 59% of cases detected during screening and only a few post-screening detections.
Researchers discovered a genetic variant that affects cancer protection from statin drugs, enabling personalized use of the drug. The study suggests offering patients a test to determine if they have the right gene profile to benefit from current statins.
Researchers at Fox Chase Cancer Center have found that a new form of naproxen, called nitric oxide-donating naproxen (NO-naproxen), can block early molecular changes leading to colorectal cancer development while reducing gastrointestinal toxicity. This novel agent may be more effective than standard naproxen in inhibiting tumor growth.
Researchers found a significant association between high fiber intake and reduced colorectal cancer risk when using food diaries, but no association was found with food frequency questionnaires. The study suggests that accurate measurement of dietary components remains a challenge in studies of diet and cancer risk.
A genetic test identifies a specific gene variant that affects how statins control both colorectal cancer and cardiovascular disease risk. The study found that statins have more benefit for reducing both colorectal cancer risk and cholesterol in the gene's long version.
Researchers at UAB Comprehensive Cancer Center discovered four microRNA biomarkers that predict patient survival in colorectal cancer, with differences in outcomes between Caucasian and African-American patients.
A new study reveals that Hispanics living in areas with low endoscopy capacity are less likely to undergo colorectal cancer screening. The study found a modest increase in screening rates as endoscopy capacity improved, suggesting that addressing local capacity constraints could help reduce disparities in screening.
Research found a significant association between high LRP16 expression and early disease progression or death in patients with colorectal cancer. The study suggests that LRP16 expression may serve as a molecular marker for predicting prognosis.
A new study by the National Cancer Institute found that health care utilization, rather than biology, plays a more important role in colorectal cancer disparities among African Americans. The study revealed that blacks were less likely to receive follow-up colonoscopies after screening, leading to delayed diagnosis and treatment.
A recent study found that blacks in the US are less likely to follow up on abnormal colon cancer screening test results, highlighting disparities in healthcare utilization. The study analyzed data from a large national trial and found that 62.6% of black participants went for a diagnostic colonoscopy, compared to 72.4% of white partici...
A large-scale study of 10,000 adults found that virtual colonoscopy identifies more unsuspected cancers outside the colon than within it. The majority of these cancers were detected at an early stage and have positively affected survival.
Studies reveal significant health disparities among Asian Americans, Native Hawaiians, and Pacific Islanders, with culturally appropriate care shown to reduce cancer rates and heart disease. Immigrant women face high risk of death from breast cancer, while obesity and high blood pressure are major concerns for Native Hawaiians.
Two studies found that using the Third Eye Retroscope (TER) during colonoscopy detected 13.2% more polyps than standard colonoscopy alone, including 11% additional adenomas. The TER improved polyp detection rates significantly with experienced endoscopists.
A recent study found that new chemotherapy drugs for metastatic colorectal cancer can increase life expectancy by 6.8 months, but at a cost of $37,100 per patient. The cost-effectiveness of these treatments is disputed, with the study estimating a cost of $99,100 per quality-adjusted life year gained.
A new study found that obesity is associated with a higher risk of developing colorectal tumors lacking microsatellite instability. The study also revealed that the relationship between body mass index and adult weight gain differs for tumors with varying levels of MSI.
A study published in World Journal of Gastroenterology found that the mean age of colorectal cancer in China increased across four regions, with East Guangdong having the highest mean age. The anatomic distribution, histological type, and differentiation type also varied significantly between regions.
Expression of EpCAM and ABCG5 within tumor buds stratify patients with colorectal cancer into prognostic subgroups, particularly those with node-negative disease. These biomarkers may identify patients at high risk of poor outcome, warranting adjuvant therapy.
A study found that individuals who had colonoscopies performed by non-gastroenterologists, such as general surgeons or internists, were at a higher risk of developing subsequent colorectal cancer. In contrast, gastroenterologists were more proficient at colonoscopy and had a reduced incidence of CRC.
Certain patients with inflammatory bowel disease have an increased risk of developing colorectal cancer. The AGA recommends individualized surveillance plans based on each patient's unique situation, taking into account disease duration, primary sclerosing cholangitis, and family history.
Advanced breast cancer diagnosis among black women is 30-90% higher than among white women between 1992 and 2004. The disparity in advanced colorectal cancer also widens over time. Black women are more likely to be diagnosed with aggressive, hormone-receptor-negative breast cancers that are difficult to detect and treat.
A survey found that most patients are interested in obtaining a video recording of their colonoscopy procedure, with younger patients more willing to pay for the service. Awareness of missed lesions during colonoscopy is a significant predictor of interest in having a video recording.
A study published in Radiology found that computed tomographic colonography (CTC), or virtual colonoscopy, is a safe and effective screening tool for older adults. The advanced neoplastic prevalence was 7.6 percent, with no significant difference in accuracy compared to younger patients.
Researchers at George Mason University are conducting a clinical trial to treat late-stage colorectal cancer patients with tailored therapies based on their tumor's protein profile. The trial uses a novel drug target mapping technology and Gleevec, a medicine typically prescribed for leukemia and gastrointestinal tumors.
Two studies by University of Pittsburgh researchers found that surveillance colonoscopy is being overused in low-risk patients and underused in high-risk patients. The studies suggest that colonoscopy use should be aligned with patient risk to improve healthcare spending.
Researchers found that nine cases of colorectal cancer were diagnosed over 7,626 person-years of observation, with most cancers detected at early stages. The study highlights the importance of close follow-up for patients with a history of advanced adenoma.
A new study published in the Journal of the National Cancer Institute found that colonoscopies significantly reduced the prevalence of left-sided advanced colorectal neoplasms by 85% in a community setting. The study, which analyzed data from 3,287 participants, also showed no significant reduction in right-sided advanced neoplasms.
A new study found that MSH6 mutation carriers have a high risk of developing colorectal and endometrial cancers, as well as cancers associated with Lynch syndrome. The estimated cumulative risks to ages 70 and 80 years were 22% and 44% for colorectal cancer in men, and 26% and 44% for women.