Research on colorectal and bowel cancer. Covers AI-audited colonoscopy, gut-bacteria links, family risk, and early-onset differences.
Researchers at University of Copenhagen have discovered a potential treatment for colorectal cancer by targeting the TOP2A gene aberration. The new treatment has shown promise in reducing treatment time and cost, with an estimated efficiency rate of 10% in patients with this gene defect.
New research published in The Journal of Nuclear Medicine found that radioembolization therapy can extend survival for patients with colorectal cancer liver metastases by approximately 50 percent. This treatment option has shown promise as a life-extending treatment for salvage patients who have failed current treatments.
A new study published in mBio found that transferring gut microbes from mice with colon tumors increased the risk of tumors in germ-free mice. The research indicates that inflammation and interactions between gut microbiota play a critical role in tumor formation.
A study by Penn State researchers found that US citizenship increases a woman's likelihood of receiving mammograms and cancer tests. Foreign-born non-citizens have significantly lower odds of being screened for colorectal, breast, and cervical cancers compared to U.S.-born citizens.
Researchers at the McGill University Health Centre have identified genetic changes in the colon lining that could be used as biomarkers for early diagnosis of colorectal cancer. The study, published online in Cancer Prevention Research, has implications for the nearly one million people diagnosed annually worldwide.
Men who spend more than 11.38 hours a day engaged in sedentary behaviors are 45% more likely to experience colorectal adenoma recurrence compared to those who spend fewer than 6.90 hours. The study found that sedentary behavior independently contributes to increased cancer risk beyond the accompanying reduction in physical activity.
Researchers found that tumors may switch dependence from VEGF-A to related growth factors like VEGF-C, VEGF-D, and placental growth factor when targeted by bevacizumab. This change allows colorectal cancer to continue growing despite the blockage of VEGF-A.
A common genetic variant affecting 1 in 3 people increases colorectal cancer risk from red and processed meat consumption. Eating more fruits and veggies may lower risk for some individuals with a specific genetic variation.
A new study found a significant gene-diet interaction between processed meat consumption and genetic variants associated with reduced risk of colorectal cancer. The study suggests that understanding these interactions may lead to targeted prevention strategies for individuals at higher risk.
Researchers at UAlberta have discovered a potential new treatment for colitis by using a leukemia drug to reverse symptoms in lab tests. The discovery suggests that inhibiting inflammation can reduce the likelihood of patients with ulcerative colitis developing colorectal cancer later in life.
A recent study found that current national screening guidelines for colon cancer may miss up to 10 percent of cases in first-degree relatives. The research examined nearly 127,000 individuals who underwent colonoscopy in Utah between 1995 and 2009.
A CU Cancer Center study found that young patients with metastatic colorectal cancer have a higher risk of treatment failure and worse survival rates compared to middle-aged patients. The study analyzed data from over 20,000 patients and showed a significant increase in disease progression and death among those under 40.
Research found that patients with more primary care visits have lower colorectal cancer incidence and mortality rates. Increasing access to primary care may reduce the national burden of CRC.
A recent study found that colorectal cancer screening programs in European countries have a significant impact on reducing mortality rates. The researchers analyzed data from 11 European countries and found that the scope and take-up of CRC screening activities were strongly related to the reductions in death rates.
A large-scale analysis of 20,034 patients found that young age is associated with worse overall survival and progression-free survival in those with metastatic colorectal cancer. The study suggests that these patients have a poorer prognosis if their disease has metastasized.
A new study published in the New England Journal of Medicine reinforces the value of colonoscopy screening for colorectal cancer prevention. Researchers analyzed data from nearly 90,000 people and found that colonoscopy lowered cancer-occurrence rates in both the distal and proximal sections of the colorectum.
A 22-year study of 88,902 participants found that colonoscopy reduced death from colorectal cancer by up to 40% compared to sigmoidoscopy. The study suggests that colonoscopy is the most effective screening method for preventing colorectal cancer.
A study published in the New England Journal of Medicine found that colonoscopy significantly reduces the risk of developing or dying from colorectal cancer compared to sigmoidoscopy. The comprehensive exam visualizes the entire colon, reducing risk throughout its entirety.
A large study found that colonoscopy screening can prevent up to 40% of colorectal cancers, with more frequent intervals recommended for those with a personal history of adenoma or family history of colorectal cancer. The study also suggests that sigmoidoscopy alone is insufficient for reducing the incidence of proximal colon cancer.
Researchers aim to understand and address disparities in CRC screenings for African Americans, with a focus on developing effective intervention strategies. The study seeks to compare the effectiveness of narrative and didactic approaches to educating African Americans about screening.
A new study suggests a hybrid screening strategy that combines annual or biennial fecal immunological tests with a single colonoscopy at age 66 may reduce colorectal cancer incidence and mortality while lowering costs. This approach can deliver health benefits comparable to current strategies, making it an attractive alternative.
Two studies link fusobacteria from mouth to colorectal cancer formation by stimulating bad immune responses and activating cancer growth genes. Fusobacteria rely on FadA molecule to attach to and invade human cells, promoting tumor growth.
A new study found a positive link between diet high in sugar and fat and an increased risk of colorectal cancer. Researchers identified new dietary risk factors, including fizzy drinks, cakes, and high-energy snack foods, that were associated with an increased risk of bowel cancer.
Long-term aspirin use has been linked to reduced colorectal cancer risk, but alternate-day dosing shows increased gastrointestinal bleeding. Electronic health records adoption led to ambulatory cost savings of 3% per member per month and reductions in radiology costs in experimental pilot communities.
A large study found that regular aspirin use is associated with a lower risk of BRAF-wild-type colorectal cancer, but not BRAF-mutated cancer. The researchers also observed a significant risk reduction for BRAF-wild-type cancer with increasing aspirin tablets per week and longer duration of use.
A new study found that virtual colonoscopy screenings can be safely delayed for women by 5-10 years compared to men, with minimal impact on cancer detection rates. The findings suggest that women under 55 may only need to undergo screening every 10 years, while those over 60 can wait up to 5 years longer.
Researchers have identified a new biomarker for colorectal cancer detection using serum DNA analysis, detecting 87% of all stages of CRC cases. The SDC2 methylation test has high sensitivity and specificity, making it a promising non-invasive alternative to colonoscopy.
Researchers found a strong correlation between MET protein levels and epithelial-mesenchymal transition (EMT) phenotype in colorectal cancer. This association suggests that MET protein may serve as a surrogate biomarker for aggressive colon cancer, potentially enabling personalized treatment approaches.
A new LSUHSC paper has been selected as the Best Paper of the Year by the National Cancer Registrars Association for its innovative evaluation of cancer stages. The study found that lung and prostate cancers had the highest percentages of unknown stages, with non-hospital reporting sources being a key predictor.
A novel transcriptome-based classification of colon cancer has been developed, improving disease stratification based on clinicopathological variables and common DNA markers. The analysis identified six molecular subtypes associated with distinct clinical and pathological characteristics.
Researchers examined new methods for managing digestive health through diet and lifestyle changes. Vitamin D supplementation was found to significantly relieve symptoms of Crohn's disease, including muscle strength and fatigue.
A new smartphone application has been shown to significantly improve colonoscopy preparation by providing personalized guidance and reminders for patients. The study found that 84% of individuals who used the app received a good score on the Boston Bowel Preparation Scale, compared to 56% of those who did not use the app.
Depressive symptoms observed in cancer survivors between one and ten years after diagnosis increase the risk of premature death. Cancer survivors with depression are twice as likely to have died early compared to those without depression.
The UIC Center for Clinical and Translational Science has selected six research projects to receive $30,000 per year pilot grants. These grants aim to support the development of new ideas and generate preliminary data for applying for highly competitive grants from outside sources.
A mathematical model of tumor growth inhibition predicts treatment effect with bevacizumab for patients with metastatic colorectal cancer. The best metric for predicting overall survival was time to tumor growth, which worked equally well in Western and Chinese patients.
A study found that long sleep duration is associated with an increased risk of developing colorectal cancer, particularly among individuals who are overweight or snore regularly. The researchers suggest that obstructive sleep apnea may contribute to this association by reducing sleep quality and increasing tumor growth.
Researchers discovered that abnormal histone protein modification impairs DNA repair machinery, leading to a potential new way of detecting colorectal cancers. The study, published in Cell, reveals a novel mechanism explaining the root cause of some forms of colorectal cancers.
Researchers at Mount Sinai have identified a soy-based compound, genistein, that can inhibit tumor cell growth and block Wnt signaling hyperactivity in colorectal cancer. Genistein has shown promise as an adjunctive treatment for metastatic colorectal cancer when used in combination with chemotherapy.
Researchers found that cosmic radiation impairs the ability of cells in the intestines of mice to eliminate oncogenic proteins, substantially increasing development of colorectal tumors. The study suggests that space travelers may be at increased risk of developing colorectal cancer due to prolonged exposure to cosmic radiation.
A Phase III clinical trial found that adding cetuximab to chemotherapy enables previously inoperable patients to undergo surgery, tripling the rates of successful surgery for liver metastasis. The combination also extends median overall survival by 10 months compared to chemotherapy alone.
A Penn Medicine study found that computed tomography colonography (CTC) was used appropriately in asymptomatic Medicare patients. The study suggests that CTC may have expanded colorectal cancer screening beyond the population screened with standard optical colonoscopy.
The GIE special issue discusses the management of serrated colon polyps, including risk factors and management recommendations. Prophylactic clip closure is shown to reduce delayed postpolypectomy hemorrhage in large sessile or flat lesions.
Researchers at Rhode Island Hospital have found that decreasing tube voltage in CT colonography does not negatively impact image quality, allowing for reduced radiation doses. The study, published in Radiology, aims to improve the safety of colon cancer screenings while maintaining diagnostic quality.
A new study confirms the effectiveness of colonoscopy in preventing advanced colorectal cancer diagnoses, particularly for tumors on the right side of the colon. The study found a 70 percent reduction in risk for average-risk adults, supporting current medical recommendations.
Researchers used electronic health records to identify patients overdue for colon cancer screening and encouraged them to be screened. The centralized approach doubled on-time screening rates and saved health costs over two years.
The American College of Physicians publishes a special supplement on patient safety strategies, featuring articles on reducing cancer risk through colonoscopy screening and increasing colorectal cancer screening adherence via electronic health records. Researchers found that colonoscopy screening reduces late-stage cancer diagnosis by ...
A new study confirms colonoscopy is safe, with only a few cases of severe complications per 10,000 procedures. Regular screening can prevent colon cancer and significantly reduce mortality rates.
Women with Lynch Syndrome have a 50-60% lifetime risk of developing colorectal cancer, but an 11% risk of breast cancer, 11% risk of kidney cancer, and 9% risk of bladder cancer. This study expands the spectrum of cancers associated with Lynch Syndrome.
Research found that obesity increases the risk of colorectal cancer with a specific molecular characteristic, known as CTNNB1-positive cancer. Physical activity, on the other hand, was linked to a lower risk for this type of cancer.
A study has identified variations in four genes associated with an increased risk of colorectal cancer. Carrying one or two copies of these genetic variants increases the risk by 10-40% compared to those without the variants.
A University of Colorado Cancer Center review found that resistant starch kills pre-cancerous cells and reduces inflammation, promoting the growth of good bugs in the bowel. Consuming resistant starch, found in legumes, green bananas, and starchy products, may also have implications for breast cancer prevention.
A recent Mayo Clinic study found that using high-definition imaging tools during screening colonoscopies can increase adenoma detection rates by up to 25% in women and 41% in men. The study suggests that national benchmarks for detecting polyps may be too low, especially when using advanced technology.
The Cleveland Clinic has developed a clinical screening program for Lynch syndrome, the most common genetic cause of colon cancer in adults. The program uses universal screening for colorectal cancers surgically removed at the clinic and successfully referred individuals whose tumors screen positive to genetics professionals.
Researchers at UT MD Anderson Cancer Center found that tumor endothelial cells can trigger changes in cancer cells, making them more resistant to chemotherapy and more likely to spread. This signaling process involves the activation of the Notch molecular pathway and may be targeted by existing drugs under development.
Researchers found that tailored phone interventions and mailings significantly increased colorectal cancer screening rates. Patients who received these interventions were almost three times more likely to undergo screening six months later compared to those with no intervention.
Researchers discovered that grape seed extract selectively targets advanced colorectal cancer cells with fewer genetic mutations, leading to increased effectiveness in treatment. The compound induces oxidative stress and programmed cell death, reversing its effects when antioxidants are present.
A study found that including CTC as a HEDIS-compliant colorectal cancer screening test can increase overall screening rates. The analysis used demographic and healthcare utilization data to demonstrate the potential impact of adding CTC as a qualifying test for HEDIS CRC screening metrics.
A new study found that fingolimod, a multiple sclerosis drug, could potentially eliminate or reduce the progression of colitis-associated cancer by decreasing inflammation and blocking key signaling molecules. The researchers used animal models to demonstrate the efficacy of the drug in reducing CAC development and progression.
A recent study published in The BMJ suggests that cancer screening for patients with a life expectancy of less than 10 years may not be beneficial. The researchers analyzed data from five breast and four colorectal cancer trials, finding that the benefits of screening often outweigh the risks. However, they also emphasize that individu...
A Mayo Clinic-developed two-hour training course increased adenoma detection rates among experienced endoscopists, lowering colorectal cancer risk. The study found that even non-academic physicians can benefit from the training.