Articles tagged with Colorectal Cancer
A new study suggests that consuming resistant starch alongside red meat can lower the risk of colorectal cancer. The study found that butyrated resistant starch reduced levels of certain genetic molecules associated with cell proliferation and increased risk of cancer.
A team of geneticists decodes the role of non-coding DNA in colorectal cancer, identifying two types of mutations that contribute to disease progression. The study reveals the importance of non-coding regions in regulating gene expression and suggests a new approach for understanding the genetics behind various cancers.
A Vanderbilt University-led team has identified protein 'signatures' of genetic mutations that drive colorectal cancer. The study's findings may lead to new advances in diagnosing and treating the disease by identifying patients who would benefit most from chemotherapy after surgery.
A new study reveals that gut microbes metabolize carbohydrates, causing intestinal cell proliferation and tumor formation in mice genetically predisposed to colorectal cancer. Treatment with antibiotics or a low-carbohydrate diet significantly reduced tumors, suggesting these interventions could prevent this type of cancer in humans.
The phase III RECOURSE trial found that TAS-102 improves overall and progression-free survival in patients with metastatic colorectal cancer refractory to standard therapies. The study showed a median overall survival of 7.1 months for TAS-102, compared to 5.3 months for placebo.
A study of adoptees found that genetics play a significant role in the development of these three types of cancer. The risk was 80% higher when an adoptee had at least one biological parent with the same cancer.
A study published in JNCI: Journal of the National Cancer Institute found that a shorter time to first cigarette (TTFC) is associated with an increased risk of lung cancer in both heavy and light smokers. The researchers analyzed data from over 3,200 current and former smokers, revealing that TTFC was statistically significantly higher...
A growing number of colorectal cancer deaths in Europe necessitates an increase in nurse endoscopy training, with regular screening reducing the risk by 20-30%. UEG and ESGENA are working together to standardize training requirements and improve workforce availability.
A multipart intervention increased adherence to annual fecal occult blood testing for colorectal cancer screening, particularly among vulnerable populations. The study found that 82.2% of patients who received the intervention completed screening compared to 37.3% of those in usual care.
Researchers propose mailing fecal immunochemical tests to improve colon cancer screening rates among low-income communities, where disparities are most prevalent. Follow-up diagnostic colonoscopies often face cost barriers, which exacerbate existing health inequities.
A new study by Northwestern University found that community-based outreach programs can significantly increase colorectal cancer screening rates among low-income and minority populations. By using a combination of automated reminders, mailed letters, phone calls, and personal outreach, the program was able to nearly double screening ra...
A new class of tumor-targeting agents can seek out and find dozens of solid tumors, even illuminating brain cancer stem cells that resist current treatments. The agents deliver two types of payloads directly to cancer cells, resulting in direct imaging or treatment.
A study found that colorectal cancer rates declined significantly after increasing cancer screening tests. The incidence of late-stage and early-stage cancers decreased, resulting in a reduction of 550,000 cancers during the period.
The number of cancer survivors in the US is expected to grow from 14.5 million to almost 19 million by 2024 due to an aging population and improved treatment outcomes. The majority of cancer survivors were diagnosed five or more years prior, with nearly half aged 70 or older.
A combination therapy of vermurafenib, cetuximab and irinotecan has shown significant improvements in patients with advanced colorectal cancer, achieving a 50% response rate in an early Phase I trial. The treatment targets BRAF-mutated patients who have previously shown poor response rates to single-agent therapies.
Individuals with poor kidney function have a higher risk of developing kidney and urothelial cancers, according to a recent study. The study found that those with lower estimated glomerular filtration rates (eGFR) had a significant increase in cancer risk, particularly for renal cell carcinoma.
A recent study highlights the challenges faced by refugees from Iraq and Syria in accessing affordable cancer treatment, with host countries struggling to find the money and medicine. Innovative financing schemes are needed to improve access to quality care for these patients.
A study found that using positron emission tomography combined with computed tomography before surgery did not improve outcomes for patients with colorectal cancer and limited liver spread. The study suggests that PET-CT scans may not be necessary to change surgical management in these cases.
A study published in JAMA found that further imaging using positron emission tomography (PET) scans before surgery did not significantly change the surgical treatment of colorectal cancer with liver metastases. The study enrolled 404 patients and involved 21 surgeons at nine hospitals in Ontario.
Researchers have identified PPAR delta as a crucial molecule linking dietary fats to colon cancer progression. The study found that deleting PPAR delta in a mouse model of colon cancer stopped key steps required for tumor growth, providing new clues for developing therapeutics.
A genetic variant found in one in three people increases the risk of colorectal cancer when consuming processed meat. The study, involving 18,000 participants, suggests that targeted prevention strategies may be possible based on genomic profiles.
Researchers found that women treated with radiation for cervical cancer were at higher risk of developing colon and rectal cancers, with some cases appearing up to 35 years after initial diagnosis. The study suggests new screening guidelines for young survivors, starting eight years after diagnosis.
A study published in JAMA Surgery found that patients over 65 have a higher risk of complications and longer hospital stays after colorectal cancer surgery compared to younger patients. The study analyzed over 1 million patients with colorectal cancer and found that mortality rates improved across all age groups during the decade studied.
Silibinin from milk thistle extract reduces self-renewal of colorectal cancer stem cells, affecting cell signaling associated with inflammation. The compound also decreases levels of CSC self-renewal-promoting mRNAs.
A large study of over 224,000 patients and 314,000 colonoscopies found that higher adenoma detection rates are associated with a decreased subsequent risk of colorectal cancer. The study confirms that adenoma detection rates are an accurate quality metric for clinicians performing colonoscopies.
A new NIH study reveals that obesity primes the colon for cancer, with frequent exercise and calorie control shown to lower the risk. The research suggests that molecular signals in the gut lead to cancer progression in obese mice, highlighting the importance of a healthy lifestyle in preventing colorectal cancer.
A study published in GIE: Gastrointestinal Endoscopy found that cold snare polypectomy significantly reduces the risk of delayed bleeding in patients taking anticoagulants. The procedure outperformed conventional polypectomy in removing small colorectal polyps without causing significant harm to submucosal vessels.
A study by researchers from Huntsman Cancer Institute found that about 6 percent of colorectal cancers are missed during colonoscopies, particularly in patients over 65 and those with a family history of the disease. The cancers may develop rapidly after the procedure or be overlooked due to factors like polyp size or location.
Cologuard detects precancer and cancer with high sensitivity rates, surpassing existing non-invasive tests, offering a user-friendly approach to expand screening effectiveness and curb colorectal cancer rates. The test's accuracy has transformed how we think about colorectal cancer screening.
A new non-invasive genetic test detected 92% of colon cancer cases, outperforming a traditional fecal immunochemical test in asymptomatic participants. The test's high sensitivity could lead to increased screening rates and reduced deaths from colorectal cancer.
A new multi-target stool DNA test detects 92.3% of colon cancers, outperforming the current standard fecal immunochemical test. The test identified advanced precancerous polyps nearly 70% of the time compared to 45% for the existing method.
A recent study found that colon cancer incidence rates have dropped by 30 percent in the US among adults 50 and older due to widespread colonoscopy adoption. Colonoscopy use has almost tripled among adults ages 50-75, leading to significant declines in mortality rates as well.
The American Gastroenterological Association highlights significant new colorectal cancer (CRC) research in Clinical Gastroenterology and Hepatology and Gastroenterology. Studies reveal the impact of patient factors on colonoscopy preparation quality, as well as the relationship between dietary fiber intake and reduced CRC risk.
A study published in The Journal of Experimental Medicine reveals that gut microbes contribute to the development of intestinal tumors, leading to colorectal cancer. Disrupting gut bacteria with antibiotics prevented polyp formation in mice, suggesting a link between inflammation and tumor growth.
A new study found that despite improved cancer treatments, survival rates for Blacks and Hispanics have not increased significantly. The disparity is largely attributed to factors such as poorer health and lower socioeconomic status, leading to barriers in healthcare access.
A new evidence review finds that fecal immunochemical tests (FITs) detect about 79% of colorectal cancers and correctly identify 94% of patients without cancer. The test is simple, can be done at home, and can save lives, making it a great tool for assessing which patients have cancer and which do not.
An international study has developed a refined method to identify people at risk for certain inherited cancers associated with Lynch syndrome. The study uses genetic data from thousands of variants identified worldwide to classify variants of unknown significance and improve genetic counseling for families.
A study found that follow-up tests improved the rate of surgical treatment for cancer recurrence in patients who had undergone curative surgery for primary colorectal cancer. The benefits were seen in both computed tomography and carcinoembryonic antigen screening methods, with no advantage in combining these tests.
A new tool called CRC-PRO predicts an individual's risk of colorectal cancer, providing a more accurate estimate than current guidelines. The calculator includes gender, race, and family history as calculable risk factors, enabling physicians to identify high-risk patients for earlier screenings.
A University of Colorado Cancer Center study found that ALK and ROS1 gene rearrangements, known to drive subsets of lung cancer, are also present in some colorectal cancers. This implies that drugs used to target ALK and ROS1 in lung cancer may have applications in treating a subset of colorectal cancer patients.
A €6 million European study led by Queen's University aims to develop new diagnostics and therapies for bowel cancer. The research will investigate two major genetic factors contributing to the aggressive spread of colorectal cancer, with the goal of improving patient survival rates.
A new study found that decreased bacterial diversity in the gut is associated with an increased risk of colorectal cancer. The research, published in the Journal of the National Cancer Institute, suggests that a reduced variety of gut microbiota may contribute to the development of CRC.
A large epidemiological study discovered a clear association between gut bacteria and colorectal cancer. Colorectal cancer patients had fewer beneficial bacteria and more harmful bacteria than healthy individuals.
AUC San Diego study reveals racial inequality in cancer treatment access, resulting in 15% higher mortality for African-American patients. Despite receiving similar treatments, black patients are less likely to receive primary tumor surgery and chemotherapy.
A study by Arizona State University researchers links CXCR2 to tumor formation, growth, and progression in colon cancer. The genetic culprit is implicated in recruiting immune cells that evade the immune response, providing a new clue for developing therapeutic targets.
Researchers at University of Copenhagen have discovered a potential treatment for colorectal cancer by targeting the TOP2A gene aberration. The new treatment has shown promise in reducing treatment time and cost, with an estimated efficiency rate of 10% in patients with this gene defect.
New research published in The Journal of Nuclear Medicine found that radioembolization therapy can extend survival for patients with colorectal cancer liver metastases by approximately 50 percent. This treatment option has shown promise as a life-extending treatment for salvage patients who have failed current treatments.
A new study published in mBio found that transferring gut microbes from mice with colon tumors increased the risk of tumors in germ-free mice. The research indicates that inflammation and interactions between gut microbiota play a critical role in tumor formation.
A study by Penn State researchers found that US citizenship increases a woman's likelihood of receiving mammograms and cancer tests. Foreign-born non-citizens have significantly lower odds of being screened for colorectal, breast, and cervical cancers compared to U.S.-born citizens.
Researchers at the McGill University Health Centre have identified genetic changes in the colon lining that could be used as biomarkers for early diagnosis of colorectal cancer. The study, published online in Cancer Prevention Research, has implications for the nearly one million people diagnosed annually worldwide.
Men who spend more than 11.38 hours a day engaged in sedentary behaviors are 45% more likely to experience colorectal adenoma recurrence compared to those who spend fewer than 6.90 hours. The study found that sedentary behavior independently contributes to increased cancer risk beyond the accompanying reduction in physical activity.
Researchers found that tumors may switch dependence from VEGF-A to related growth factors like VEGF-C, VEGF-D, and placental growth factor when targeted by bevacizumab. This change allows colorectal cancer to continue growing despite the blockage of VEGF-A.
A common genetic variant affecting 1 in 3 people increases colorectal cancer risk from red and processed meat consumption. Eating more fruits and veggies may lower risk for some individuals with a specific genetic variation.
A new study found a significant gene-diet interaction between processed meat consumption and genetic variants associated with reduced risk of colorectal cancer. The study suggests that understanding these interactions may lead to targeted prevention strategies for individuals at higher risk.
Researchers at UAlberta have discovered a potential new treatment for colitis by using a leukemia drug to reverse symptoms in lab tests. The discovery suggests that inhibiting inflammation can reduce the likelihood of patients with ulcerative colitis developing colorectal cancer later in life.
A recent study found that current national screening guidelines for colon cancer may miss up to 10 percent of cases in first-degree relatives. The research examined nearly 127,000 individuals who underwent colonoscopy in Utah between 1995 and 2009.
A CU Cancer Center study found that young patients with metastatic colorectal cancer have a higher risk of treatment failure and worse survival rates compared to middle-aged patients. The study analyzed data from over 20,000 patients and showed a significant increase in disease progression and death among those under 40.
Research found that patients with more primary care visits have lower colorectal cancer incidence and mortality rates. Increasing access to primary care may reduce the national burden of CRC.
A recent study found that colorectal cancer screening programs in European countries have a significant impact on reducing mortality rates. The researchers analyzed data from 11 European countries and found that the scope and take-up of CRC screening activities were strongly related to the reductions in death rates.
A large-scale analysis of 20,034 patients found that young age is associated with worse overall survival and progression-free survival in those with metastatic colorectal cancer. The study suggests that these patients have a poorer prognosis if their disease has metastasized.