Articles tagged with Colorectal Cancer
Depressive symptoms observed in cancer survivors between one and ten years after diagnosis increase the risk of premature death. Cancer survivors with depression are twice as likely to have died early compared to those without depression.
The UIC Center for Clinical and Translational Science has selected six research projects to receive $30,000 per year pilot grants. These grants aim to support the development of new ideas and generate preliminary data for applying for highly competitive grants from outside sources.
A mathematical model of tumor growth inhibition predicts treatment effect with bevacizumab for patients with metastatic colorectal cancer. The best metric for predicting overall survival was time to tumor growth, which worked equally well in Western and Chinese patients.
A study found that long sleep duration is associated with an increased risk of developing colorectal cancer, particularly among individuals who are overweight or snore regularly. The researchers suggest that obstructive sleep apnea may contribute to this association by reducing sleep quality and increasing tumor growth.
Researchers discovered that abnormal histone protein modification impairs DNA repair machinery, leading to a potential new way of detecting colorectal cancers. The study, published in Cell, reveals a novel mechanism explaining the root cause of some forms of colorectal cancers.
Researchers at Mount Sinai have identified a soy-based compound, genistein, that can inhibit tumor cell growth and block Wnt signaling hyperactivity in colorectal cancer. Genistein has shown promise as an adjunctive treatment for metastatic colorectal cancer when used in combination with chemotherapy.
Researchers found that cosmic radiation impairs the ability of cells in the intestines of mice to eliminate oncogenic proteins, substantially increasing development of colorectal tumors. The study suggests that space travelers may be at increased risk of developing colorectal cancer due to prolonged exposure to cosmic radiation.
A Phase III clinical trial found that adding cetuximab to chemotherapy enables previously inoperable patients to undergo surgery, tripling the rates of successful surgery for liver metastasis. The combination also extends median overall survival by 10 months compared to chemotherapy alone.
A Penn Medicine study found that computed tomography colonography (CTC) was used appropriately in asymptomatic Medicare patients. The study suggests that CTC may have expanded colorectal cancer screening beyond the population screened with standard optical colonoscopy.
The GIE special issue discusses the management of serrated colon polyps, including risk factors and management recommendations. Prophylactic clip closure is shown to reduce delayed postpolypectomy hemorrhage in large sessile or flat lesions.
Researchers at Rhode Island Hospital have found that decreasing tube voltage in CT colonography does not negatively impact image quality, allowing for reduced radiation doses. The study, published in Radiology, aims to improve the safety of colon cancer screenings while maintaining diagnostic quality.
A new study confirms the effectiveness of colonoscopy in preventing advanced colorectal cancer diagnoses, particularly for tumors on the right side of the colon. The study found a 70 percent reduction in risk for average-risk adults, supporting current medical recommendations.
Researchers used electronic health records to identify patients overdue for colon cancer screening and encouraged them to be screened. The centralized approach doubled on-time screening rates and saved health costs over two years.
The American College of Physicians publishes a special supplement on patient safety strategies, featuring articles on reducing cancer risk through colonoscopy screening and increasing colorectal cancer screening adherence via electronic health records. Researchers found that colonoscopy screening reduces late-stage cancer diagnosis by ...
A new study confirms colonoscopy is safe, with only a few cases of severe complications per 10,000 procedures. Regular screening can prevent colon cancer and significantly reduce mortality rates.
Women with Lynch Syndrome have a 50-60% lifetime risk of developing colorectal cancer, but an 11% risk of breast cancer, 11% risk of kidney cancer, and 9% risk of bladder cancer. This study expands the spectrum of cancers associated with Lynch Syndrome.
Research found that obesity increases the risk of colorectal cancer with a specific molecular characteristic, known as CTNNB1-positive cancer. Physical activity, on the other hand, was linked to a lower risk for this type of cancer.
A study has identified variations in four genes associated with an increased risk of colorectal cancer. Carrying one or two copies of these genetic variants increases the risk by 10-40% compared to those without the variants.
A University of Colorado Cancer Center review found that resistant starch kills pre-cancerous cells and reduces inflammation, promoting the growth of good bugs in the bowel. Consuming resistant starch, found in legumes, green bananas, and starchy products, may also have implications for breast cancer prevention.
A recent Mayo Clinic study found that using high-definition imaging tools during screening colonoscopies can increase adenoma detection rates by up to 25% in women and 41% in men. The study suggests that national benchmarks for detecting polyps may be too low, especially when using advanced technology.
The Cleveland Clinic has developed a clinical screening program for Lynch syndrome, the most common genetic cause of colon cancer in adults. The program uses universal screening for colorectal cancers surgically removed at the clinic and successfully referred individuals whose tumors screen positive to genetics professionals.
Researchers at UT MD Anderson Cancer Center found that tumor endothelial cells can trigger changes in cancer cells, making them more resistant to chemotherapy and more likely to spread. This signaling process involves the activation of the Notch molecular pathway and may be targeted by existing drugs under development.
Researchers found that tailored phone interventions and mailings significantly increased colorectal cancer screening rates. Patients who received these interventions were almost three times more likely to undergo screening six months later compared to those with no intervention.
Researchers discovered that grape seed extract selectively targets advanced colorectal cancer cells with fewer genetic mutations, leading to increased effectiveness in treatment. The compound induces oxidative stress and programmed cell death, reversing its effects when antioxidants are present.
A study found that including CTC as a HEDIS-compliant colorectal cancer screening test can increase overall screening rates. The analysis used demographic and healthcare utilization data to demonstrate the potential impact of adding CTC as a qualifying test for HEDIS CRC screening metrics.
A new study found that fingolimod, a multiple sclerosis drug, could potentially eliminate or reduce the progression of colitis-associated cancer by decreasing inflammation and blocking key signaling molecules. The researchers used animal models to demonstrate the efficacy of the drug in reducing CAC development and progression.
A Mayo Clinic-developed two-hour training course increased adenoma detection rates among experienced endoscopists, lowering colorectal cancer risk. The study found that even non-academic physicians can benefit from the training.
A recent study published in The BMJ suggests that cancer screening for patients with a life expectancy of less than 10 years may not be beneficial. The researchers analyzed data from five breast and four colorectal cancer trials, finding that the benefits of screening often outweigh the risks. However, they also emphasize that individu...
Researchers at Vanderbilt University Medical Center have identified three new genetic variants linked to an increased risk of colorectal cancer. The study, published in Nature Genetics, provides new insight into the biology of the disease and could lead to new therapeutic targets.
A new analysis suggests that individuals with Lynch syndrome, who have a high risk of developing colorectal and other cancers, may lower their risk by adopting an eating pattern low in snack foods. The study found that those with higher intakes of snack foods were twice as likely to develop precancerous lesions.
Researchers found that patients with a family history of colorectal cancer are more likely to develop tumors with low-level methylation of LINE-1, a molecular sign associated with an aggressive form of the disease. Testing for this sign may help identify patients in need of aggressive treatment and inform familial cancer-risk assessments.
Researchers have developed a simple breath analysis technique that can screen for colorectal cancer with an accuracy of over 75%. The method analyzes volatile organic compounds in exhaled breath, which are different in patients with cancer.
A cost-effectiveness analysis found that KRAS testing is cost-saving, while BRAF testing offers additional savings. The study suggests that molecular testing primarily generates cost savings by identifying nonresponders, rather than improving survival.
Scientists have discovered that a gene switch regulates the expression of genes and promotes cancer development, according to a study published in Science. The study found that removing a specific region containing a genetic variant increased resistance to tumor formation in mice.
A study led by Vanderbilt University Medical Center researchers found that regular green tea consumption is associated with a reduced risk of digestive system cancers, particularly for stomach/esophagus and colorectal cancers. Women who drank green tea at least three times a week had a 17-21% lower risk compared to non-tea drinkers.
A recent study found that over one-third of cancer survivors in the US experience physical and mental health problems after treatment. The study identified groups at higher risk for long-term quality-of-life issues, with those with certain types of cancer facing significant challenges.
A nationwide study led by Dana-Farber Cancer Institute found that 69% of advanced lung cancer and 81% of advanced colorectal cancer patients believe chemotherapy can cure their disease. However, skilled clinicians can set realistic expectations without losing hope or trust.
A recent study from Stanford University School of Medicine found that increased use of colonoscopy screening may be responsible for the significant decrease in colorectal cancer incidence over the past decade. The study analyzed data from over 2 million patients and found a correlation between Medicare's extension of colonoscopy covera...
Thomas Jefferson University researcher Scott Waldman receives a $1.2 million NCI grant to investigate the relationship between obesity and cancer, with a focus on guanylyl cyclase C hormone receptor. The research aims to understand how obesity increases colorectal cancer risk and potentially identify a therapeutic target.
Patients with chronic constipation may be at higher risk of developing colorectal cancer and benign neoplasms. The study found a consistent association between chronic constipation and the development of these conditions.
Researchers presented new insights on esophageal cancer prevention with statins, which showed a 30% reduction in incidence. Additionally, mortality rates from upper gastrointestinal bleeding decreased by 45%, while novel treatments for GERD and IBS were introduced, including electrical stimulation of the esophagus.
Two studies suggest that women under 50 with endometrial cancer have a four-fold increased risk of colorectal cancer, while extended family members of patients with colorectal cancer also show an elevated risk. Additionally, obesity and gender may impact adenoma detection rates.
African-Americans and those living in high-poverty areas were more likely to present with an emergency diagnosis, indicating missed opportunities for screening. The study highlights the need to address these disparities to reduce mortality from colorectal cancer.
A randomized trial of over 14,000 male physicians found that long-term daily multivitamin use resulted in a modest but statistically significant reduction in cancer incidence. The study suggests that multivitamins may have a greater benefit on more clinically relevant cancer diagnoses.
A new noninvasive test measures DNA changes and fecal blood to detect precancerous lesions, showing high detection rates for cancers and precursors. The test achieved 98% sensitivity for all cancers and 83% for precursors with high-grade dysplasia.
A study of 5,442 female health professionals found that combined folic acid, vitamin B6, and vitamin B12 supplements did not reduce the risk of colorectal adenomas. No association was seen between supplement intake and cancer risk despite previous observational studies suggesting potential protective effects.
Researchers have identified a new function of the IKKalpha enzyme variant in colorectal cancer progression. This breakthrough could lead to the design of targeted drugs that inhibit this specific form of the enzyme, reducing harm to healthy cells.
New studies report that robotic-assisted bladder procedures and minimally invasive colorectal operations can improve outcomes in older patients. Robotic-assisted bladder surgery, which was previously not offered to patients over 80, showed a seven-day hospital stay and only three complications within 90 days.
The American Gastroenterological Association and other GI societies have issued updated guidelines for colonoscopy surveillance after screening and polypectomy. These recommendations support previous guidelines, addressing areas such as the need to repeat colonoscopies every 10 years for average-risk patients with a clean exam result.
Evidence suggests aspirin may lower colorectal cancer risk by 24% and mortality rates by 35%, but concerns remain about side effects. The ESMO Congress debates whether aspirin should be used for chemoprevention of colorectal adenoma/cancer.
A new database compiled by researchers has linked 16 independent gene variants to an increased risk of colorectal cancer. The database, known as CRCgene, provides valuable insights for furthering research on the disease.
A new $13 million project at Fred Hutchinson Cancer Center aims to identify genetic links to colorectal cancer using next-generation sequencing. The study will reveal entire genome sequences of a subset of samples and capture rare variants that could lead to improved drug development and disease prevention.
The study found that RRM2 overexpression is positively correlated with invasive properties of CRC cells. Silencing RRM2 inhibited hyperplasia and invasiveness, indicating its role in CRC progression. Additionally, RRM2 depletion increased UV sensitivity, suggesting a facilitating factor in DNA damage repair.
A drug trial found that TAS-102 improved survival time, reduced risk of death, and controlled disease progression in patients with advanced, inoperable colorectal cancer. Patients treated with TAS-102 had a median overall survival of 9 months, compared to 6.6 months for the placebo group.
A study using narrow band imaging found high accuracy for predicting polyp type and suggests leaving distal colon hyperplastic polyps in place with acceptable accuracy. The technology improved visualization of mucosal characteristics, enabling real-time assessment of polyp type.
Researchers have discovered a link between reactivated R-spondin proteins and colon cancer development, potentially leading to more personalized therapies. The discovery involves gene mutations that trigger cell proliferation in the colon.
Recent studies suggest that colonoscopy-related factors are more predictive of colorectal cancer risk than polyp characteristics. High levels of lead exposure also pose significant health risks, even at low blood lead levels. Meanwhile, a new lung cancer screening model shows high accuracy in identifying patients who will benefit from ...
A recent mouse study found a clear link between inflammation in the gut and changes in bacterial communities. The research team discovered that inflammation leads to simplification of diverse microbial communities, allowing new bacteria to establish footholds, such as E. coli, which promotes tumor formation.
A systematic approach to improve screening rates for colorectal cancer resulted in a fourfold increase in screening among low-risk individuals. The protocol, which included introductory phone calls and mailed testing kits, saw CRC screening rates jump from 47 to 72 percent in three years.
A Swiss study found that colonoscopy with polypectomy significantly reduces colorectal cancer incidence and mortality. The screened group had 12 cases, while the non-screened group had 213 cases, resulting in lower cancer-related death rates.