Articles tagged with Colorectal Cancer
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Researchers found no significant reduction in cardiovascular events, but a lower incidence of nonfatal heart attack and transient ischemic attack. Aspirin increased the risk of extracranial hemorrhage requiring hospitalization.
A new study by American Cancer Society researchers found that more preventable deaths from colorectal cancer occur in southern states due to socioeconomic inequalities. The report highlights the importance of addressing disparities in education, income, and access to screening and treatment services.
Researchers found that the current classification system for colorectal cancer cannot be used to predict drug responses to FOLFIRI. The study suggests that a new approach is needed to make informed treatment decisions.
According to a randomized trial, nurse navigators can aid in colon cancer screening follow-up by increasing follow-up rates exceeding 92 percent. The study, led by Beverly B. Green, MD, MPH, found that combining a systems approach with nurse navigation resulted in improved follow-up rates.
The incidence of colorectal cancer in people under 50 has increased, while those over 50 have seen a decline. The study found that the CRC incidence rate declined overall between 1975 and 2010, but rose among young adults, with the biggest increase seen in patients 20-34 years old.
NSAIDs protect against colorectal cancer by inducing cell suicide pathways in intestinal stem cells carrying a mutated gene. The research team found that NSAIDs activate the so-called death receptor pathway, selectively triggering a suicide program in dysfunctional cells. This mechanism could help design new drugs to prevent colon cancer.
Two studies found pediatric breast cancer patients experienced longer time between diagnosis and treatments, often diagnosed at later stages. Pediatric colon cancer patients had lower five-year survival rates than adults due to more aggressive tumors and treatments.
A new study suggests fecal immunochemical tests (FIT) can detect all colorectal cancers and 61% of advanced adenomas, similar to colonoscopy screening. FIT may offer a less invasive option for high-risk individuals with familial colorectal cancer.
Researchers identified RNF43 mutations in 20% of colorectal and endometrial cancers, suggesting a potential biomarker for targeted treatments. The mutation affects the Wnt signaling pathway, making tumors sensitive to new inhibitors currently in clinical trials.
A study examined hospital readmission rates after colorectal cancer surgery and found that when adjusting for patient characteristics, coexisting illnesses, and operation types, there was no significant variation in readmission rates. The overall 30-day readmission rate was 12.3 percent.
A new study using LSU Health New Orleans data found Acadian parishes in Louisiana have the highest colorectal cancer rates among nation's founder populations. The Cajun population, with limited genetic variation, may be linked to the high risk of disease.
Researchers found that combining five key healthy lifestyle behaviors - a healthy weight, low abdominal fat, regular physical activity, not smoking, and a balanced diet high in fruits and fiber - reduces the risk of bowel cancer. The study analyzed data from 347,237 men and women over 12 years and found a significant decrease in risk f...
Fruit fly research reveals that a transcription factor called Mirror regulates tumour-like growth in the intestines. A similar system may be at work in humans, suggesting a potential role for Irx transcription factors in cancer progression. This study could lead to new treatments using the fruit fly model.
A recent study published in the Journal of General Internal Medicine found that healthy Americans who undergo colonoscopies do so too frequently, with many receiving repeat screenings long before they should. The study suggests that endoscopists should adhere to national guidelines more closely.
A study found that endoscopists recommended shorter follow-up intervals than guidelines support, resulting in frequent colonoscopy overuse. This leads to potential excess healthcare spending of $1 million or more per year.
Biennial colorectal cancer screening in France's Cote-D'Or region increased the rate of diagnosis of high-risk pre-cancerous adenomas by 89%. The study also found that fecal occult blood testing may be more efficient than colonoscopy for high-risk patients.
The US Multi-Society Task Force on Colorectal Cancer released new consensus guidelines highlighting the importance of good bowel cleansing for high-quality colonoscopy. The guidelines aim to reduce missed precancerous lesions and increase patient safety, with an 85% target for adequate cleansing rate.
Researchers have identified 5 genes differentially expressed in normal accompanying cells of colorectal tumors. These genes can be used to classify tumors and predict patient outcomes, enabling clinicians to make informed decisions about chemotherapy treatment.
The pilot program aims to increase colorectal cancer screening rates and follow-up care for patients served by community health centers. Nine national medical professional societies will join forces with the National Association of Community Health Centers and other organizations to support the effort.
A study by researchers at the University of Kansas reveals a new function for APC in protecting against chronic colitis-induced inflammation and tumor development. The team found that functional nuclear APC is necessary to suppress Wnt signaling pathway, controlling goblet cell differentiation.
A recent study found that flexible sigmoidoscopy screening significantly reduced the incidence of colorectal cancer by 20% and mortality rate by 27%, compared to no screening. The screening method was effective in reducing the risk of colorectal cancer, regardless of age group.
Researchers found that gut microbiome analysis successfully distinguished healthy individuals from those with precancerous adenomatous polyps and invasive colorectal cancer. The composition of the gut microbiome was different for each group, leading to improved prediction of colorectal cancer presence.
African Americans in a VA health-care network have low participation in colorectal cancer screening, despite similar access to care. The study found that individuals with established primary care were nearly four times more likely to have had at least one CRC screening test.
The US Multi-Society Task Force on Colorectal Cancer recommends genetic testing of tumors for all newly diagnosed colorectal cancer patients with a familial risk of the disease. Genetic testing can confirm the diagnosis of Lynch syndrome and direct management for affected individuals, as well as family members.
A new study suggests that consuming resistant starch alongside red meat can lower the risk of colorectal cancer. The study found that butyrated resistant starch reduced levels of certain genetic molecules associated with cell proliferation and increased risk of cancer.
A team of geneticists decodes the role of non-coding DNA in colorectal cancer, identifying two types of mutations that contribute to disease progression. The study reveals the importance of non-coding regions in regulating gene expression and suggests a new approach for understanding the genetics behind various cancers.
A Vanderbilt University-led team has identified protein 'signatures' of genetic mutations that drive colorectal cancer. The study's findings may lead to new advances in diagnosing and treating the disease by identifying patients who would benefit most from chemotherapy after surgery.
A new study reveals that gut microbes metabolize carbohydrates, causing intestinal cell proliferation and tumor formation in mice genetically predisposed to colorectal cancer. Treatment with antibiotics or a low-carbohydrate diet significantly reduced tumors, suggesting these interventions could prevent this type of cancer in humans.
The phase III RECOURSE trial found that TAS-102 improves overall and progression-free survival in patients with metastatic colorectal cancer refractory to standard therapies. The study showed a median overall survival of 7.1 months for TAS-102, compared to 5.3 months for placebo.
A study of adoptees found that genetics play a significant role in the development of these three types of cancer. The risk was 80% higher when an adoptee had at least one biological parent with the same cancer.
A growing number of colorectal cancer deaths in Europe necessitates an increase in nurse endoscopy training, with regular screening reducing the risk by 20-30%. UEG and ESGENA are working together to standardize training requirements and improve workforce availability.
A study published in JNCI: Journal of the National Cancer Institute found that a shorter time to first cigarette (TTFC) is associated with an increased risk of lung cancer in both heavy and light smokers. The researchers analyzed data from over 3,200 current and former smokers, revealing that TTFC was statistically significantly higher...
A new study by Northwestern University found that community-based outreach programs can significantly increase colorectal cancer screening rates among low-income and minority populations. By using a combination of automated reminders, mailed letters, phone calls, and personal outreach, the program was able to nearly double screening ra...
A multipart intervention increased adherence to annual fecal occult blood testing for colorectal cancer screening, particularly among vulnerable populations. The study found that 82.2% of patients who received the intervention completed screening compared to 37.3% of those in usual care.
Researchers propose mailing fecal immunochemical tests to improve colon cancer screening rates among low-income communities, where disparities are most prevalent. Follow-up diagnostic colonoscopies often face cost barriers, which exacerbate existing health inequities.
A new class of tumor-targeting agents can seek out and find dozens of solid tumors, even illuminating brain cancer stem cells that resist current treatments. The agents deliver two types of payloads directly to cancer cells, resulting in direct imaging or treatment.
A study found that colorectal cancer rates declined significantly after increasing cancer screening tests. The incidence of late-stage and early-stage cancers decreased, resulting in a reduction of 550,000 cancers during the period.
The number of cancer survivors in the US is expected to grow from 14.5 million to almost 19 million by 2024 due to an aging population and improved treatment outcomes. The majority of cancer survivors were diagnosed five or more years prior, with nearly half aged 70 or older.
A combination therapy of vermurafenib, cetuximab and irinotecan has shown significant improvements in patients with advanced colorectal cancer, achieving a 50% response rate in an early Phase I trial. The treatment targets BRAF-mutated patients who have previously shown poor response rates to single-agent therapies.
Individuals with poor kidney function have a higher risk of developing kidney and urothelial cancers, according to a recent study. The study found that those with lower estimated glomerular filtration rates (eGFR) had a significant increase in cancer risk, particularly for renal cell carcinoma.
A recent study highlights the challenges faced by refugees from Iraq and Syria in accessing affordable cancer treatment, with host countries struggling to find the money and medicine. Innovative financing schemes are needed to improve access to quality care for these patients.
A study found that using positron emission tomography combined with computed tomography before surgery did not improve outcomes for patients with colorectal cancer and limited liver spread. The study suggests that PET-CT scans may not be necessary to change surgical management in these cases.
A study published in JAMA found that further imaging using positron emission tomography (PET) scans before surgery did not significantly change the surgical treatment of colorectal cancer with liver metastases. The study enrolled 404 patients and involved 21 surgeons at nine hospitals in Ontario.
Researchers have identified PPAR delta as a crucial molecule linking dietary fats to colon cancer progression. The study found that deleting PPAR delta in a mouse model of colon cancer stopped key steps required for tumor growth, providing new clues for developing therapeutics.
A genetic variant found in one in three people increases the risk of colorectal cancer when consuming processed meat. The study, involving 18,000 participants, suggests that targeted prevention strategies may be possible based on genomic profiles.
Researchers found that women treated with radiation for cervical cancer were at higher risk of developing colon and rectal cancers, with some cases appearing up to 35 years after initial diagnosis. The study suggests new screening guidelines for young survivors, starting eight years after diagnosis.
A study published in JAMA Surgery found that patients over 65 have a higher risk of complications and longer hospital stays after colorectal cancer surgery compared to younger patients. The study analyzed over 1 million patients with colorectal cancer and found that mortality rates improved across all age groups during the decade studied.
Silibinin from milk thistle extract reduces self-renewal of colorectal cancer stem cells, affecting cell signaling associated with inflammation. The compound also decreases levels of CSC self-renewal-promoting mRNAs.
A large study of over 224,000 patients and 314,000 colonoscopies found that higher adenoma detection rates are associated with a decreased subsequent risk of colorectal cancer. The study confirms that adenoma detection rates are an accurate quality metric for clinicians performing colonoscopies.
A new NIH study reveals that obesity primes the colon for cancer, with frequent exercise and calorie control shown to lower the risk. The research suggests that molecular signals in the gut lead to cancer progression in obese mice, highlighting the importance of a healthy lifestyle in preventing colorectal cancer.
A study published in GIE: Gastrointestinal Endoscopy found that cold snare polypectomy significantly reduces the risk of delayed bleeding in patients taking anticoagulants. The procedure outperformed conventional polypectomy in removing small colorectal polyps without causing significant harm to submucosal vessels.
A study by researchers from Huntsman Cancer Institute found that about 6 percent of colorectal cancers are missed during colonoscopies, particularly in patients over 65 and those with a family history of the disease. The cancers may develop rapidly after the procedure or be overlooked due to factors like polyp size or location.
A new non-invasive genetic test detected 92% of colon cancer cases, outperforming a traditional fecal immunochemical test in asymptomatic participants. The test's high sensitivity could lead to increased screening rates and reduced deaths from colorectal cancer.
A new multi-target stool DNA test detects 92.3% of colon cancers, outperforming the current standard fecal immunochemical test. The test identified advanced precancerous polyps nearly 70% of the time compared to 45% for the existing method.
Cologuard detects precancer and cancer with high sensitivity rates, surpassing existing non-invasive tests, offering a user-friendly approach to expand screening effectiveness and curb colorectal cancer rates. The test's accuracy has transformed how we think about colorectal cancer screening.
A recent study found that colon cancer incidence rates have dropped by 30 percent in the US among adults 50 and older due to widespread colonoscopy adoption. Colonoscopy use has almost tripled among adults ages 50-75, leading to significant declines in mortality rates as well.
A study published in The Journal of Experimental Medicine reveals that gut microbes contribute to the development of intestinal tumors, leading to colorectal cancer. Disrupting gut bacteria with antibiotics prevented polyp formation in mice, suggesting a link between inflammation and tumor growth.
The American Gastroenterological Association highlights significant new colorectal cancer (CRC) research in Clinical Gastroenterology and Hepatology and Gastroenterology. Studies reveal the impact of patient factors on colonoscopy preparation quality, as well as the relationship between dietary fiber intake and reduced CRC risk.
A new study found that despite improved cancer treatments, survival rates for Blacks and Hispanics have not increased significantly. The disparity is largely attributed to factors such as poorer health and lower socioeconomic status, leading to barriers in healthcare access.
A new evidence review finds that fecal immunochemical tests (FITs) detect about 79% of colorectal cancers and correctly identify 94% of patients without cancer. The test is simple, can be done at home, and can save lives, making it a great tool for assessing which patients have cancer and which do not.