Research on colorectal and bowel cancer. Covers AI-audited colonoscopy, gut-bacteria links, family risk, and early-onset differences.
Experts from United European Gastroenterology call on European governments to develop early detection techniques for digestive cancers, including faecal microbiota screening and gastric cancer screening. The aim is to improve outcomes and save thousands of European lives.
Researchers at NUS combine artemisinin, an anti-malarial drug, with Aminolaevulinic acid (ALA), a photosensitiser, to enhance its anti-cancer properties. This novel combination therapy kills colorectal cancer cells and suppresses tumour growth with fewer side effects.
A study published in Nature Research's Scientific Reports reveals that the novel protein SATB2 can cause normal cells to become malignant, grow and spread like cancer stem cells. Silencing SATB2 suppresses cell growth and cancer stem cell characteristics, suggesting a potential new target for therapy.
A study by London School of Hygiene & Tropical Medicine found that alcohol industry organisations distort information on cancer risk, particularly for breast and colorectal cancers. The researchers call for policymakers to reconsider relationships with these bodies, which develop alcohol policy and disseminate health info.
Two studies published in JAMA Network found that outreach interventions improved colorectal cancer screening completion rates among patients who were not up-to-date or nonadherent with CRC screening. The studies showed that fecal immunochemical test and colonoscopy outreach programs led to higher screening process completion rates comp...
Researchers present a comprehensive overview of novel approaches to combating metastatic colorectal cancer, highlighting the potential of immunotherapies and targeted biological agents. The article discusses recent progress and future prospects for these treatments, including combination therapies and overcoming drug resistance.
The LSU Health New Orleans School of Public Health will receive a $15 million grant over five years to support its cancer education, early detection, and control programs. The funding will help improve cancer screening rates and reduce disparities in cancer care across the state.
A study published in JAMA found that colorectal cancer mortality rates declined in black individuals but rose in white individuals between 1970 and 2014. The disparity was particularly pronounced among younger adults, with increased mortality rates observed in white men and women since the mid-1990s.
A new report reveals a significant increase in colorectal cancer mortality rates among adults under 55, with the rise confined to white individuals. Despite declining CRC incidence rates in other age groups, the authors suggest that rising mortality may be due to true disease occurrence rather than earlier detection.
A study found that wealthier, long-term residents in Ontario are more likely to get screened for colorectal cancer through colonoscopies rather than non-invasive tests. This gap is driven by the higher number of advantaged residents who prefer colonoscopies over fecal occult blood tests.
A new community-based program using patient navigators in barbershops has been shown to increase early detection of colorectal cancer among black men. The study found that participants who received help were twice as likely to get screened, compared to those who did not receive extra support.
A new study has found a link between adolescent obesity and an increased risk of developing colon and rectal cancer in adulthood. The study analyzed data from over 1.7 million Israeli males and females, finding that being overweight or obese at age 17 was associated with a significantly higher risk of colorectal cancer.
A new study suggests that a simple financial incentive of $100 can boost the rate of colon cancer screenings, increasing it from 1.6% to 3.7%. The study found that offering this inducement more than doubled the rate of screening when compared to a simple emailed request.
A subspecies of the bacterium Streptococcus gallolyticus actively promotes the development of colorectal cancer by driving CRC cell proliferation through β-catenin cell signaling. The study found that infected mice developed more tumors and greater β-catenin production than control mice.
A new study published in Radiology found that insurance coverage for CT colonography significantly increases the likelihood of screening for colorectal cancer. The study, which analyzed data from over 33,000 patients under age 65, showed a 48% greater chance of screening among those with insurance coverage.
A new study indicates that Holocaust survivors have a small but consistent increase in cancer risk, linked to extreme population-level tragedies. Survivors exposed to starvation, overcrowding, and psychological stress had higher risks of developing certain types of cancer, including colorectal and lung cancers.
Researchers identify JAK2-STAT3 cellular signaling pathway as key link between high-fat diet and tumor growth in the colon. The study provides insight into how diet influences cancer stem cell populations, potentially leading to new therapeutics.
A new study suggests that adhering to a Mediterranean diet with high levels of fish and fruit consumption can significantly reduce the risk of advanced colorectal polyps. The researchers found that even minimal consumption of two to three components of the diet was associated with half the odds of advanced polyps.
The task force ranked tests into three tiers according to the strength of the recommendation for average-risk people. Colonoscopy is highly sensitive for cancer and precancerous lesions, while fecal immunochemical testing (FIT) is non-invasive and lower-cost but must be repeated annually. The new guidelines also recommend starting scre...
Long-term colorectal cancer survivors who use NSAIDs experience a 25% reduction in all-cause mortality and a 40% survival benefit when taking the drugs after diagnosis for KRAS wild-type tumors
A clinical trial found that adding vemurafenib to treatment with cetuximab and irinotecan significantly improved progression-free survival for patients with BRAF V600E mutation, from 2.0 months to 4.3 months. The study suggests combining BRAF inhibitors with EGFR inhibitors may be a more potent approach.
At ASCO 2017, SWOG investigators reported trials involving more than 10 cancer types and presented results on treatment-resistant metastatic colorectal cancer, breast cancer chemotherapies, high-risk prostate cancer, and the benefits of public funding for cancer research. The group's research has led to the approval of 14 cancer drugs,...
Researchers at Queen's University Belfast have made a significant advance in treating bowel cancer by defining precise gene signatures within cells. This allows for the development of novel prognostic and predictive markers, enabling personalized medicine approaches.
Researchers found that raising the age limit for Lynch syndrome genetic testing can detect new affected families who would not have been identified previously. This can lead to a reduction in deaths from the disease by over 60% over 15 years.
The study found a 31% higher risk for African-Americans compared to whites, even after adjusting for polyp detection rate and other factors. Blacks were more likely to receive colonoscopies from physicians with lower polyp detection rates, indicating lower quality care.
An analysis of nearly 273,000 patients found a 1% increase in breast, lung, and colorectal cancers diagnosed at stage I between 2013 and 2014. This trend suggests that increased health insurance coverage may lead to better cancer outcomes.
Researchers found that a strategy combining personalized support and decision-making tools increased screening rates among patients at community health centers. 68% of participants were screened for colorectal cancer within 6 months, compared to 27% without the intervention.
A decision aid and support strategy increased screening completion among patients with historically lower screening rates, with 68% screened for colorectal cancer within six months. The intervention provided clear information about screening options and personalized support, facilitating shared decision-making with physicians.
The Illinois Colon CARES portal, launched by UChicago Medicine and the Center for Asian Health Equity, aims to increase access to colorectal cancer screenings for uninsured and vulnerable populations. The initiative seeks to enhance communication across health systems and provide timely results to patients.
A Cleveland Clinic survey found that individuals with healthier lifestyles, including regular exercise and a balanced diet, were less likely to have a personal history of colorectal cancer or colon polyps. However, less than 10% of respondents met daily fruit and vegetable intake recommendations.
Researchers have developed a highly sensitive method to detect even earlier stages of colorectal cancer by analyzing metabolites in blood plasma. The new screening method exceeds 96% sensitivity and specificity, confirming its effectiveness even for early-stage patients.
A Kaiser Permanente study found that patients with positive fecal screening tests should undergo colonoscopy within several months to reduce colorectal cancer risk. The study reviewed 70,124 members and found no significant differences in risk for colonoscopy follow-up times of two to nine months.
A study found that delaying colonoscopy after a positive fecal immunochemical test result by more than 10 months increases the risk of colorectal cancer and advanced-stage disease. The researchers discovered this association specifically for patients with stage II-IV colorectal cancer.
Researchers have identified specific types of bacteria that are abundant in individuals with colorectal cancer. Using a combination of markers, scientists anticipate the development of a noninvasive, sensitive clinical diagnostic test. The study confirms previously reported bacteria and identifies new ones associated with the disease.
Colorectal cancer rates in New Zealand are increasing, particularly among younger adults. The study found a significant rise in rectal cancer incidence in men and women under 50, while older adults saw an increase in proximal cancer incidence.
A phase II trial found that adding rice bran to the diet of colorectal cancer survivors increased microbiome richness and diversity. The study also showed reduced cell growth in treated cells when participants consumed high amounts of rice bran.
The Case Comprehensive Cancer Center has been named to a new national colorectal cancer dream team, comprising scientists and clinicians from top institutions. The team will test a promising new therapy for the first time in human patients, combining glutaminase inhibitor CB-839 with chemotherapy medication capecitabine.
Researchers have developed a new humanized mouse model of colorectal cancer, allowing them to test immunotherapies and potential combination treatments. The model has shown promise in preclinical studies, including the successful activation of the immune system against cancer cells.
A study from Penn State College of Medicine found that a patient's confidence in scheduling and conducting their part in colorectal screening methods is crucial in determining their intention to get screened. Self-efficacy emerged as the most important factor, reflecting knowledge, experience, or understanding of the testing options.
Researchers found that individuals with blindness, intellectual disability, or spinal cord injury are less likely to receive recommended colorectal screenings. The study's findings emphasize the importance of increased awareness and advocacy efforts to ensure all individuals are screened appropriately for this preventable cancer.
Hispanics have a higher burden of poor health-related quality of life (HR-QoL) compared to white and black patients. Meanwhile, Hispanics experience longer median survival times, averaging 85.4 months, followed by blacks at 47.8 months and whites at 43.2 months.
Researchers have identified a new molecular target, OR51B4 olfactory receptor, in colorectal cancer cells, which can be activated by the odorant troenan. This activation leads to inhibition of tumour growth, slowing down cell proliferation and increasing apoptosis.
Researchers at Case Western Reserve University discovered changes in specific regions of DNA that 'enhance' harmful gene expression to promote tumor growth. These recurrent changes in DNA activate genes involved in colorectal cancer progression.
Researchers developed a predictive risk model combining genetic and lifestyle information to classify population into groups according to colon cancer risk. Lifestyle influences cancer risk more than genetics, making it a modifiable factor in disease prevention.
A recent study found a significant increase in colorectal cancer incidence rates among young adults, including those in their early 50s. Rectal cancer rates are rising even faster, with three in ten diagnoses now in patients under 55.
A large review found strong associations between obesity and risk of certain cancers, including oesophageal, bone marrow, colon, rectal, biliary tract system, pancreatic, endometrial, and kidney cancers. The study calls for more research to confirm these findings.
A recent study found that normal-weight postmenopausal women who are metabolically unhealthy have a significantly increased risk for colorectal cancer compared to those who are metabolically healthy. This highlights the importance of assessing metabolic health status in women, which can be done using standard clinical tests.
A recent study among over 1000 colorectal cancer patients found that about 10% carry mutations associated with increased cancer susceptibility. The research recommends genetic testing for all patients to identify these risks and prevent future cases. This expanded approach could also benefit at-risk family members by providing earlier ...
A new study found that a 'prudent' diet rich in whole grains and fiber can lower the risk of colorectal cancer by altering the balance of microorganisms in the digestive tract. Participants with tumors containing Fusobacterium nucleatum had a sharply lower risk, but those without the bacteria received no extra protection.
A study published in Health Affairs found that the Affordable Care Act resulted in an 8% increase in early-stage colorectal cancer diagnoses among U.S. seniors aged 65 and older, but had no distinguishable effect on breast cancer diagnoses over the same time period.
A new study reveals significantly better outcomes for patients with metastatic colorectal cancer when combining vemurafenib with standard treatments. The three-drug combination improved progression-free survival rates and tumor response rates compared to traditional therapies.
A study by Osaka University reveals that colorectal cancer cells can survive under glucose-depletion conditions by maintaining TCA cycle activity and ATP production. Key proteins GLUD1 and SLC25A13 play pivotal roles in nutritional stress and are associated with tumor aggressiveness.
A recent study led by Georgia State University researcher found that living in segregated communities can affect colorectal cancer diagnosis timing. Residents of highly segregated Asian communities are more likely to receive late diagnoses, while those in African American communities are less likely.
Researchers identified MMP9 as a tumor suppressor role in colitis-associated cancer (CAC), which is driven by chronic inflammation. The study found that MMP9 suppresses tumors by activating the MMP9-Notch1-ARF-p53 axis pathway.
The new Special Issue addresses topics in epidemiology, basic science, and policy, providing reliable information on digestive cancers in Latin America. Key findings include the rising incidence of gastric cancer and the need for awareness, with five articles from experts in the region.
The ColoCare study, led by Huntsman Cancer Institute, aims to identify elements that impact colorectal cancer patients' survival and recovery. The study analyzes health and lifestyle factors to predict patient outcomes and determine the most effective treatments.
Researchers found that vitamin E and selenium supplements did not prevent colorectal adenomas in a large-scale study. The findings suggest that these antioxidants have no evidence of preventing cancer.
Research suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) can prevent the recurrence of advanced neoplasia after polyp removal, with ibuprofen showing superior benefits over aspirin or supplements. However, the choice of NSAID should be individualized based on patient risk factors and health considerations.
A statewide colorectal cancer screening study found that 16% of patients diagnosed under age 50 have an inherited genetic mutation increasing their cancer risk. The study identified a broad spectrum of mutations in early-onset colon cancer patients, including those linked to breast cancer risk.
A study of 450 patients found 72 with 75 unique gene mutations, affecting 16 percent of younger-onset CRC cases, suggesting genetic counseling and multigene panel testing for early-onset patients