Articles tagged with Colorectal Cancer
A long-term health study found a 24% increase in cancer risk among participants with severe periodontitis compared to those with mild to no periodontitis. The highest risk was observed in cases of lung cancer, followed by colorectal cancer.
A diet high in inflammatory foods like meats, refined grains, and sugary drinks is associated with a higher risk of developing colorectal cancer. Higher scores on the inflammatory potential index were linked to an increased risk in both men and women.
A large study has found a significant link between severe gum disease and an increased risk of cancer, particularly lung and colorectal cancer. The study, which used data from over 7,400 participants, found that those with advanced gum disease were 24% more likely to develop cancer than those without.
Researchers at the University of Luxembourg have discovered a new promising biomarker for colorectal cancer. The biomarker, MYO5B, has been found to decrease in concentration as the disease progresses, indicating lower chances of disease- and metastasis-free survival.
Researchers have engineered probiotics that can target and kill colorectal cancer cells using a substance found in broccoli. The mixture killed over 95% of colorectal cancer cells in a dish and reduced tumour numbers by 75% in mice with colorectal cancer.
The US cancer death rate has dropped 26% since its peak in 1991, resulting in nearly 2.4 million fewer cancer deaths. This decline is mainly due to reductions in smoking and advances in early detection and treatment.
A high-protein diet can protect against colorectal cancer in those with inflammatory bowel disease, while a low-protein diet may be beneficial for those with a genetic predisposition. Researchers suggest tailoring treatments based on the amount of protein in the diet.
A study from Michigan Medicine found that 20% of young colon cancer patients have an inherited genetic abnormality, highlighting the need for broader genetic testing. The research suggests that even without family history, these alterations can impact care and family members.
A new study by Voskarides suggests that genetic variants beneficial for survival at extreme temperatures can predispose individuals to cancer. The study analyzes the relationship between cancer risk and local average annual temperatures, concluding that extremely cold environments contribute to cancer risk.
A new study suggests that an American Cancer Society program has been effective in promoting improvements in colorectal cancer screening rates in federally qualified health centers. Funded FQHCs increased their CRC screening rates significantly more than nonfunded FQHCs, with increases of 8.7% and 12.7% over three years.
A new American Cancer Society study calculates the contribution of several modifiable risk factors to cancer occurrence. The study found that more than 42% of all cancer cases and deaths in the US are associated with these major modifiable risk factors, many of which can be mitigated with prevention strategies.
Researchers discovered that women with stronger social networks had better survival rates after a colorectal cancer diagnosis. The study found that patients with more intimate ties, such as family and friends, were associated with lower death rates. Social network strengthening could be a tool for managing colorectal cancer.
A modified XELIRI regimen with reduced doses of irinotecan and capecitabine has been shown to be non-inferior to FOLFIRI in terms of overall survival. The treatment, combined with bevacizumab, demonstrated favourable tolerability and efficacy comparable to XELOX plus bevacizumab.
A new study published in Gastroenterology found that health insurance coverage differences account for nearly half of the black-white survival disparity in colorectal cancer patients. The study analyzed data from 199,098 CRC patients aged 18-64 and found a significant impact of insurance status on treatment outcomes.
A study published in the Journal of Hepatology found that nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of liver, colorectal, and breast cancers. Patients with NAFLD were 16.73 times more likely to develop hepatocellular carcinoma and twice as likely to develop colorectal cancer.
Researchers at the University of Arizona Cancer Center are investigating the effects of selenium supplementation on colorectal cancer risk, particularly in individuals with advanced polyps. The study aims to unravel the mystery of why some participants experienced a reduction in recurrence while others saw an increase in diabetes risk.
Researchers discover that CDK8 plays a critical role in allowing cancer cells to use glucose for energy. Blocking CDK8 activity combined with glycolysis inhibitors slows cancer cell growth more effectively than either approach alone.
Researchers developed a new three-step system targeting and eliminating colorectal cancer using nuclear medicine. The treatment achieved a 100-percent cure rate in mouse models without toxic effects.
The Cleveland Clinic has been awarded a 5-year, $2.6 million grant from the National Cancer Institute to create innovative models of colorectal cancer. The project aims to better understand how the disease develops and spreads.
A large-scale epidemiological study has associated certain air pollutants with increased mortality from kidney, bladder, and colorectal cancers. The study followed over 600,000 adults in the US and found that exposure to PM2.5, nitrogen dioxide, and ozone was linked to higher cancer death rates.
Research shows long-term aspirin use significantly reduces digestive cancer incidence, with substantial reductions in liver and oesophageal cancers. Aspirin use also shows promise in reducing risk of certain other cancers, while raising cardiovascular risk when stopped.
Korean researchers have discovered a potential cancer treatment method using nanoporous acupuncture needles, which were found to reduce the incidence of abnormal vascular clusters in rats with colorectal cancer. The treatment also affected the maturation rate of colorectal cancer in rats.
Researchers found a 400% increase in neoplasia detection in patients aged 45-49 compared to 40-44, with similar increases seen for polyps and adenoma detection. The findings support screening starting at 45 years old to detect colorectal cancer in young adults.
Research reveals that APC protein mutations harm the immune system, preventing it from controlling gut inflammation, which supports cancer development. This dysfunction affects regulatory T cells, leading to a deregulation of the immune system.
A new study by American Cancer Society investigators finds workers at organizations with fewer than 25 employees are less likely to have been screened for three cancers. After adjusting for socioeconomic factors and insurance status, most of the difference in screening rates disappears.
Research finds that people with both serrated polyps and conventional adenomas are at a higher risk for colorectal cancer than those with conventional adenomas alone. The study suggests that these individuals may need more intense surveillance to detect potential high-risk adenomas.
Researchers at Osaka University developed a non-invasive imaging technique using multiphoton microscopy (MPM) to quantify cancer severity. The method, called non-labeling multiphoton microscopy (NL-MPM), uses second harmonic generation and autofluorescence to detect malignancy with high accuracy.
A study published in Cancer Research found that inhibiting two metabolic enzymes, NADK and KHK, reduced the growth of KRAS-mutant colorectal cancer cells in mice by approximately 50%. The research also identified new genes that, when inactivated, increased tumor growth in KRAS-mutant cancers.
Experts from United European Gastroenterology call on European governments to develop early detection techniques for digestive cancers, including faecal microbiota screening and gastric cancer screening. The aim is to improve outcomes and save thousands of European lives.
Researchers at NUS combine artemisinin, an anti-malarial drug, with Aminolaevulinic acid (ALA), a photosensitiser, to enhance its anti-cancer properties. This novel combination therapy kills colorectal cancer cells and suppresses tumour growth with fewer side effects.
A study published in Nature Research's Scientific Reports reveals that the novel protein SATB2 can cause normal cells to become malignant, grow and spread like cancer stem cells. Silencing SATB2 suppresses cell growth and cancer stem cell characteristics, suggesting a potential new target for therapy.
A study by London School of Hygiene & Tropical Medicine found that alcohol industry organisations distort information on cancer risk, particularly for breast and colorectal cancers. The researchers call for policymakers to reconsider relationships with these bodies, which develop alcohol policy and disseminate health info.
Two studies published in JAMA Network found that outreach interventions improved colorectal cancer screening completion rates among patients who were not up-to-date or nonadherent with CRC screening. The studies showed that fecal immunochemical test and colonoscopy outreach programs led to higher screening process completion rates comp...
Researchers present a comprehensive overview of novel approaches to combating metastatic colorectal cancer, highlighting the potential of immunotherapies and targeted biological agents. The article discusses recent progress and future prospects for these treatments, including combination therapies and overcoming drug resistance.
A new report reveals a significant increase in colorectal cancer mortality rates among adults under 55, with the rise confined to white individuals. Despite declining CRC incidence rates in other age groups, the authors suggest that rising mortality may be due to true disease occurrence rather than earlier detection.
The LSU Health New Orleans School of Public Health will receive a $15 million grant over five years to support its cancer education, early detection, and control programs. The funding will help improve cancer screening rates and reduce disparities in cancer care across the state.
A study published in JAMA found that colorectal cancer mortality rates declined in black individuals but rose in white individuals between 1970 and 2014. The disparity was particularly pronounced among younger adults, with increased mortality rates observed in white men and women since the mid-1990s.
A study found that wealthier, long-term residents in Ontario are more likely to get screened for colorectal cancer through colonoscopies rather than non-invasive tests. This gap is driven by the higher number of advantaged residents who prefer colonoscopies over fecal occult blood tests.
A new community-based program using patient navigators in barbershops has been shown to increase early detection of colorectal cancer among black men. The study found that participants who received help were twice as likely to get screened, compared to those who did not receive extra support.
A new study has found a link between adolescent obesity and an increased risk of developing colon and rectal cancer in adulthood. The study analyzed data from over 1.7 million Israeli males and females, finding that being overweight or obese at age 17 was associated with a significantly higher risk of colorectal cancer.
A new study suggests that a simple financial incentive of $100 can boost the rate of colon cancer screenings, increasing it from 1.6% to 3.7%. The study found that offering this inducement more than doubled the rate of screening when compared to a simple emailed request.
A subspecies of the bacterium Streptococcus gallolyticus actively promotes the development of colorectal cancer by driving CRC cell proliferation through β-catenin cell signaling. The study found that infected mice developed more tumors and greater β-catenin production than control mice.
A new study published in Radiology found that insurance coverage for CT colonography significantly increases the likelihood of screening for colorectal cancer. The study, which analyzed data from over 33,000 patients under age 65, showed a 48% greater chance of screening among those with insurance coverage.
A new study indicates that Holocaust survivors have a small but consistent increase in cancer risk, linked to extreme population-level tragedies. Survivors exposed to starvation, overcrowding, and psychological stress had higher risks of developing certain types of cancer, including colorectal and lung cancers.
Researchers identify JAK2-STAT3 cellular signaling pathway as key link between high-fat diet and tumor growth in the colon. The study provides insight into how diet influences cancer stem cell populations, potentially leading to new therapeutics.
A new study suggests that adhering to a Mediterranean diet with high levels of fish and fruit consumption can significantly reduce the risk of advanced colorectal polyps. The researchers found that even minimal consumption of two to three components of the diet was associated with half the odds of advanced polyps.
The task force ranked tests into three tiers according to the strength of the recommendation for average-risk people. Colonoscopy is highly sensitive for cancer and precancerous lesions, while fecal immunochemical testing (FIT) is non-invasive and lower-cost but must be repeated annually. The new guidelines also recommend starting scre...
Long-term colorectal cancer survivors who use NSAIDs experience a 25% reduction in all-cause mortality and a 40% survival benefit when taking the drugs after diagnosis for KRAS wild-type tumors
A clinical trial found that adding vemurafenib to treatment with cetuximab and irinotecan significantly improved progression-free survival for patients with BRAF V600E mutation, from 2.0 months to 4.3 months. The study suggests combining BRAF inhibitors with EGFR inhibitors may be a more potent approach.
At ASCO 2017, SWOG investigators reported trials involving more than 10 cancer types and presented results on treatment-resistant metastatic colorectal cancer, breast cancer chemotherapies, high-risk prostate cancer, and the benefits of public funding for cancer research. The group's research has led to the approval of 14 cancer drugs,...
Researchers at Queen's University Belfast have made a significant advance in treating bowel cancer by defining precise gene signatures within cells. This allows for the development of novel prognostic and predictive markers, enabling personalized medicine approaches.
Researchers found that raising the age limit for Lynch syndrome genetic testing can detect new affected families who would not have been identified previously. This can lead to a reduction in deaths from the disease by over 60% over 15 years.
The study found a 31% higher risk for African-Americans compared to whites, even after adjusting for polyp detection rate and other factors. Blacks were more likely to receive colonoscopies from physicians with lower polyp detection rates, indicating lower quality care.
An analysis of nearly 273,000 patients found a 1% increase in breast, lung, and colorectal cancers diagnosed at stage I between 2013 and 2014. This trend suggests that increased health insurance coverage may lead to better cancer outcomes.
A decision aid and support strategy increased screening completion among patients with historically lower screening rates, with 68% screened for colorectal cancer within six months. The intervention provided clear information about screening options and personalized support, facilitating shared decision-making with physicians.
Researchers found that a strategy combining personalized support and decision-making tools increased screening rates among patients at community health centers. 68% of participants were screened for colorectal cancer within 6 months, compared to 27% without the intervention.
The Illinois Colon CARES portal, launched by UChicago Medicine and the Center for Asian Health Equity, aims to increase access to colorectal cancer screenings for uninsured and vulnerable populations. The initiative seeks to enhance communication across health systems and provide timely results to patients.
A Cleveland Clinic survey found that individuals with healthier lifestyles, including regular exercise and a balanced diet, were less likely to have a personal history of colorectal cancer or colon polyps. However, less than 10% of respondents met daily fruit and vegetable intake recommendations.
A study found that delaying colonoscopy after a positive fecal immunochemical test result by more than 10 months increases the risk of colorectal cancer and advanced-stage disease. The researchers discovered this association specifically for patients with stage II-IV colorectal cancer.
Researchers have developed a highly sensitive method to detect even earlier stages of colorectal cancer by analyzing metabolites in blood plasma. The new screening method exceeds 96% sensitivity and specificity, confirming its effectiveness even for early-stage patients.