Articles tagged with Colorectal Cancer
A study of 99,654 individuals found that lifetime light alcohol drinkers had the lowest combined risk of mortality or developing cancer. The risk increased linearly with lifetime alcohol consumption, with heavy and very heavy drinkers facing significantly higher risks.
A large international study found that higher circulating vitamin D concentrations are significantly associated with lower colorectal cancer risk. Optimal vitamin D concentrations for colorectal cancer prevention may be higher than current recommendations.
A new study published in JAMA found that increased follow-up testing of colorectal cancer patients does not improve survival rates. The study showed that patients who underwent surgery for colorectal cancer experienced the same five-year survival rate regardless of whether they received two or five follow-up tests.
The American Cancer Society recommends earlier colorectal cancer screening for average-risk adults beginning at age 45, based on research showing an increased incidence of CRC in younger adults. Colorectal cancer incidence has declined steadily over the past two decades in people 55 and older due to screening.
Colorectal cancer screening may need to be started earlier than previously recommended, with a new study suggesting starting at age 45. Researchers estimate that cutting mortality from colorectal cancer could save up to 70% of lives if everyone followed the revised guidelines.
A preclinical study found that combining soy lecithin with an NSAID increased anticancer properties and reduced gastrointestinal bleeding. The combination provided superior protection against colorectal cancer without the usual side effects, according to researchers at UTHealth.
Two studies found that more frequent follow-up testing did not significantly impact mortality rates from any cause or colorectal cancer over five years. However, a related editorial suggests that current guidelines should be reevaluated in the context of these findings and potential harms associated with more frequent testing.
Researchers are testing a two-pronged approach combining a DNA vaccine and antibody to boost the immune response against tumors in patients with advanced stage CRC. Preliminary mouse studies showed promising results, including an immune memory that prevented re-challenge with the same tumor.
Researchers identified a correlation between gut microbial composition and microRNA expression in human colorectal cancer. The study found that dozens of microRNAs are differentially regulated in colorectal cancer tumors and are correlated with the abundance of microbes in the tumor microenvironment.
A new 'scoring' system developed by Johns Hopkins Medicine enhances the prediction of survival in people with colorectal cancers that have spread to the liver. The system includes traditional Fong indicators plus genetic and morphological evaluation (GAME) factors, which outperform the existing Fong system in predicting patient outcomes.
A study confirms a curable state between single and widespread cancers by identifying molecular patterns that predict patient outcomes. Researchers found that patients with limited spread of disease could achieve prolonged survival with surgery or targeted radiation therapy.
A study published by The BMJ found no evidence of 'gaming' after death rates for bowel surgeons were publicly reported. However, improvements were seen in mortality rates for patients undergoing non-emergency surgery, suggesting that the introduction of public reporting may have triggered better outcomes through teamwork.
Researchers at Thomas Jefferson University successfully killed tumors and prevented metastatic growth in mouse models of colorectal cancer using CAR-T cell therapy, targeting the GUCY2C antigen. The therapy achieved high survival rates without side effects, paving the way for potential human clinical trials.
Researchers at UMass Amherst have identified a new molecular mechanism explaining the link between obesity and increased risk of colon inflammation, a major risk factor for colorectal cancer. Inhibiting an enzyme called soluble epoxide hydrolase may abolish this risk, suggesting a potential treatment for obesity-induced colonic inflamm...
Researchers at Sanford Burnham Prebys Medical Discovery Institute discovered that PKC zeta deficiency promotes liver metastasis through the inactivation of enzyme ADAR2, leading to increased secretion of miR-200s. Treatment with a compound inhibiting miR-200s reduced liver metastasis in mice with colorectal cancer.
Colorectal cancer rates have increased by 22% among young adults under 50, prompting researchers to create an effective screening method. A new imaging technology called nanocytology will be used to identify high-risk patients and ensure timely treatment.
Researchers developed a new technology to detect and quantify RAS protein mutations, which are found in over 20% of human cancers. The 'top-down' approach provides precise characterization of KRAS4b proteins, revealing new avenues for cancer treatment.
A preclinical study by MD Anderson Cancer Center researchers found that precancerous colon polyps in patients with Lynch syndrome display immune system activation, challenging traditional models of cancer immune activation. The study suggests immunotherapy may be useful for colorectal cancer prevention in certain high-risk groups.
A study published in the International Journal of Cancer found that regularly eating red meat increases the risk of distal colon cancer in women, with those on a red meat-free diet experiencing lower rates. The research suggests that a diet free from red meat significantly reduces the risk of this type of colon cancer.
Ludwig scientists present new data on cancers including colorectal, brain, breast, and ovarian cancer, as well as innovative clinical trials and novel approaches to cancer immunotherapy. The research focuses on mobilizing immunity against ovarian cancer and personalizing cancer treatment strategies.
Researchers found a single upfront genomic test to be more effective for detecting Lynch syndrome in colorectal cancer (CRC) patients than traditional multiple testing. This approach helps guide treatment decisions while identifying those at risk of developing CRC and other cancers.
Researchers have discovered that PAWS1 plays a significant impact in controlling the Wnt signalling pathway, which is associated with developmental defects and diseases like alopecia and colorectal cancer. The study found that PAWS1 mutations can inhibit Wnt signalling, leading to potential interventions for these conditions.
Scientists found that a small daily dose of Viagra significantly reduces colorectal cancer risk in genetically predisposed animal models. The drug works by increasing levels of cyclic GMP, which suppresses excessive cell proliferation and promotes normal cell differentiation.
A large study found that Métis adults have higher rates of lung, liver, and breast cancers, as well as poorer prostate cancer survival rates. The study also identified lower incidence rates for melanoma and leukemia in Métis adults compared to non-Aboriginal people.
European researchers predict that colorectal cancer death rates will continue to fall by around seven percent compared to 2012, resulting in nearly 392,300 avoided deaths. The decline is attributed to improved diagnosis and management of the disease, as well as reduced risk factors such as tobacco, alcohol, and obesity.
A new iPad app that educates patients about different options for colon cancer screening and allows them to order their preferred test has been shown to significantly increase screening rates. In a randomized controlled trial, patients who used the app were twice as likely to undergo screening compared to those in the usual care group.
A study published in CANCER found that living in low-income areas increases the risk of early death among patients with anal cancer. The researchers analyzed data from 9,550 patients and found that those in lower income areas had worse overall survival and cancer-specific survival compared to those in higher income areas.
A combined analysis of family history and genetic markers improves risk prediction for colorectal cancer, revealing that individuals with a positive family history and numerous genetic variants are at increased risk. This approach can help adjust preventive measures and screening schedules.
A large-scale study found a possible association between highly processed food intake and an increased risk of overall cancer, breast cancer, and lower risks of other types. The study suggests that rapid consumption of ultra-processed foods may drive a growing burden of cancer in the next decades.
A recent study by Texas Tech University Health Sciences Center El Paso aims to identify the most accurate stool test for detecting colorectal cancer. The research consortium will compare four different fecal immunochemical tests (FITs) to determine their effectiveness in detecting blood in the stool, a common early sign of cancer.
A diet high in inflammatory foods like meats, refined grains, and sugary drinks is associated with a higher risk of developing colorectal cancer. Higher scores on the inflammatory potential index were linked to an increased risk in both men and women.
A long-term health study found a 24% increase in cancer risk among participants with severe periodontitis compared to those with mild to no periodontitis. The highest risk was observed in cases of lung cancer, followed by colorectal cancer.
A large study has found a significant link between severe gum disease and an increased risk of cancer, particularly lung and colorectal cancer. The study, which used data from over 7,400 participants, found that those with advanced gum disease were 24% more likely to develop cancer than those without.
Researchers at the University of Luxembourg have discovered a new promising biomarker for colorectal cancer. The biomarker, MYO5B, has been found to decrease in concentration as the disease progresses, indicating lower chances of disease- and metastasis-free survival.
Researchers have engineered probiotics that can target and kill colorectal cancer cells using a substance found in broccoli. The mixture killed over 95% of colorectal cancer cells in a dish and reduced tumour numbers by 75% in mice with colorectal cancer.
The US cancer death rate has dropped 26% since its peak in 1991, resulting in nearly 2.4 million fewer cancer deaths. This decline is mainly due to reductions in smoking and advances in early detection and treatment.
A high-protein diet can protect against colorectal cancer in those with inflammatory bowel disease, while a low-protein diet may be beneficial for those with a genetic predisposition. Researchers suggest tailoring treatments based on the amount of protein in the diet.
A study from Michigan Medicine found that 20% of young colon cancer patients have an inherited genetic abnormality, highlighting the need for broader genetic testing. The research suggests that even without family history, these alterations can impact care and family members.
A new study by Voskarides suggests that genetic variants beneficial for survival at extreme temperatures can predispose individuals to cancer. The study analyzes the relationship between cancer risk and local average annual temperatures, concluding that extremely cold environments contribute to cancer risk.
A new study suggests that an American Cancer Society program has been effective in promoting improvements in colorectal cancer screening rates in federally qualified health centers. Funded FQHCs increased their CRC screening rates significantly more than nonfunded FQHCs, with increases of 8.7% and 12.7% over three years.
Researchers discovered that women with stronger social networks had better survival rates after a colorectal cancer diagnosis. The study found that patients with more intimate ties, such as family and friends, were associated with lower death rates. Social network strengthening could be a tool for managing colorectal cancer.
A new American Cancer Society study calculates the contribution of several modifiable risk factors to cancer occurrence. The study found that more than 42% of all cancer cases and deaths in the US are associated with these major modifiable risk factors, many of which can be mitigated with prevention strategies.
A modified XELIRI regimen with reduced doses of irinotecan and capecitabine has been shown to be non-inferior to FOLFIRI in terms of overall survival. The treatment, combined with bevacizumab, demonstrated favourable tolerability and efficacy comparable to XELOX plus bevacizumab.
A new study published in Gastroenterology found that health insurance coverage differences account for nearly half of the black-white survival disparity in colorectal cancer patients. The study analyzed data from 199,098 CRC patients aged 18-64 and found a significant impact of insurance status on treatment outcomes.
A study published in the Journal of Hepatology found that nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of liver, colorectal, and breast cancers. Patients with NAFLD were 16.73 times more likely to develop hepatocellular carcinoma and twice as likely to develop colorectal cancer.
Researchers at the University of Arizona Cancer Center are investigating the effects of selenium supplementation on colorectal cancer risk, particularly in individuals with advanced polyps. The study aims to unravel the mystery of why some participants experienced a reduction in recurrence while others saw an increase in diabetes risk.
Researchers discover that CDK8 plays a critical role in allowing cancer cells to use glucose for energy. Blocking CDK8 activity combined with glycolysis inhibitors slows cancer cell growth more effectively than either approach alone.
Researchers developed a new three-step system targeting and eliminating colorectal cancer using nuclear medicine. The treatment achieved a 100-percent cure rate in mouse models without toxic effects.
A large-scale epidemiological study has associated certain air pollutants with increased mortality from kidney, bladder, and colorectal cancers. The study followed over 600,000 adults in the US and found that exposure to PM2.5, nitrogen dioxide, and ozone was linked to higher cancer death rates.
The Cleveland Clinic has been awarded a 5-year, $2.6 million grant from the National Cancer Institute to create innovative models of colorectal cancer. The project aims to better understand how the disease develops and spreads.
Research shows long-term aspirin use significantly reduces digestive cancer incidence, with substantial reductions in liver and oesophageal cancers. Aspirin use also shows promise in reducing risk of certain other cancers, while raising cardiovascular risk when stopped.
Researchers found a 400% increase in neoplasia detection in patients aged 45-49 compared to 40-44, with similar increases seen for polyps and adenoma detection. The findings support screening starting at 45 years old to detect colorectal cancer in young adults.
Korean researchers have discovered a potential cancer treatment method using nanoporous acupuncture needles, which were found to reduce the incidence of abnormal vascular clusters in rats with colorectal cancer. The treatment also affected the maturation rate of colorectal cancer in rats.
Research reveals that APC protein mutations harm the immune system, preventing it from controlling gut inflammation, which supports cancer development. This dysfunction affects regulatory T cells, leading to a deregulation of the immune system.
A new study by American Cancer Society investigators finds workers at organizations with fewer than 25 employees are less likely to have been screened for three cancers. After adjusting for socioeconomic factors and insurance status, most of the difference in screening rates disappears.
Research finds that people with both serrated polyps and conventional adenomas are at a higher risk for colorectal cancer than those with conventional adenomas alone. The study suggests that these individuals may need more intense surveillance to detect potential high-risk adenomas.
Researchers at Osaka University developed a non-invasive imaging technique using multiphoton microscopy (MPM) to quantify cancer severity. The method, called non-labeling multiphoton microscopy (NL-MPM), uses second harmonic generation and autofluorescence to detect malignancy with high accuracy.
A study published in Cancer Research found that inhibiting two metabolic enzymes, NADK and KHK, reduced the growth of KRAS-mutant colorectal cancer cells in mice by approximately 50%. The research also identified new genes that, when inactivated, increased tumor growth in KRAS-mutant cancers.
Experts from United European Gastroenterology call on European governments to develop early detection techniques for digestive cancers, including faecal microbiota screening and gastric cancer screening. The aim is to improve outcomes and save thousands of European lives.
Researchers at NUS combine artemisinin, an anti-malarial drug, with Aminolaevulinic acid (ALA), a photosensitiser, to enhance its anti-cancer properties. This novel combination therapy kills colorectal cancer cells and suppresses tumour growth with fewer side effects.