Articles tagged with Colorectal Cancer
Colorectal cancer mortality rates are projected to decrease in most countries, but increase in Europe, North America, and Oceania. The number of deaths is expected to rise globally by 60.0% and 71.5% until 2035.
Researchers at Johns Hopkins have discovered a protein that can serve as an early biomarker for colorectal cancer. The protein, beta-1,4-GalT-V, is involved in cell proliferation and new blood vessel formation, which are critical processes in cancer growth.
A large Kaiser Permanente study shows that 10 years after a negative colonoscopy, members had a 46% lower risk of developing colorectal cancer and an 88% lower risk of dying from it. This evidence supports the recommended 10-year rescreening interval after a normal colonoscopy finding.
A study of over 280,000 people found a significant association between work stress and increased risk of colorectal and esophagus cancers. However, no link was observed for prostate, breast, or ovarian cancers, with the relationship varying by region.
Scientists identified that loss of two genes drives serrated colorectal cancer and found a combination treatment that has treated the cancer in mice. This discovery holds implications for patient care and may provide insights into the link between inflammatory bowel disease and colorectal cancer.
A study found 29% of veterans who underwent recommended colonoscopies were uncomfortable with stopping screenings when benefits were expected to be low. Participants preferred a more personalized approach to screening decisions, citing mistrust in life expectancy calculators and age-based guidelines.
A program providing individually tailored lifestyle recommendations for patients undergoing colorectal cancer screening helped encourage healthy behavior, according to a study published in Cancer Epidemiology, Biomarkers & Prevention. Participants who received tailored feedback increased their cancer preventive behaviors by 0.11 compar...
Researchers discovered 40 new genetic variants associated with an increased risk of colon cancer, validating 55 previously identified variants. The study also identified a rare protective variant for sporadic colorectal cancer, offering hope for targeted treatments.
A Finnish study found that men who participated in the national colorectal cancer screening programme were less likely to require emergency surgery, chemotherapy, and incomplete tumour removals. The benefits of screening were particularly pronounced among male patients with left-sided colorectal cancer.
A recent study published in Cancer Epidemiology, Biomarkers & Prevention found that many patients diagnosed with adenomas often do not receive subsequent colonoscopies within the recommended time frame. The study analyzed patterns and factors associated with the receipt of colonoscopy within approximately three years of a diagnosis of ...
A systematic review and meta-analysis found that racial differences in colorectal cancer incidence are not due to biological factors. The study suggests that screening should begin at age 50 regardless of race, with consideration for individual risk factors and preferences. Improved access to screening is crucial to reducing disparitie...
Research reveals a 6% annual increase in European colorectal cancer incidence rates among adults aged 20-39 years between 2008 and 2016. This trend is driven by increased risk factors such as sedentary lifestyles, obesity, and poor diets.
A new immunotherapy combination shows durable clinical benefits in patients with microsatellite instability-high (MSI-H) metastatic colorectal cancer, with 60% objective response rate and 84% of patients experiencing tumour shrinkage. The treatment is also well-tolerated, with manageable side effects.
Researchers report a 100% major pathological response rate in early-stage colon cancers with mismatch repair deficiencies treated with nivolumab and ipilimumab. The regimen was well-tolerated, and patients underwent radical resection without delays.
A new study found that healthy diets are associated with a lower risk of death from colorectal cancer, both before and after diagnosis. Those who followed the American Cancer Society's guidelines on nutrition and physical activity had a 22% lower risk of all-cause mortality.
A recent survey found that social vulnerability and medical skepticism are major barriers to cancer screening participation, particularly for colorectal and lung cancer screenings. Researchers call for a combined approach incorporating new technologies and personalized messaging to address inequalities in screening uptake.
A new study has found that women with higher BMIs are more than twice as likely to develop colorectal cancer before age 50. The researchers estimate that around 22% of these cases could have been prevented if participants had a normal BMI between 18.5-24.9.
The report emphasizes tobacco control as the top priority in a national cancer control plan due to its significant health benefits. Tobacco use remains the leading cause of preventable cancer deaths, accounting for nearly 30% of all cancer-related deaths in the US.
Researchers at RCSI have discovered that chromosomal instability can predict which patients will benefit from the colorectal cancer drug Avastin. Patients with intermediate-to-high levels of chromosomal instability responded better to Avastin treatment, while those with low levels of chromosomal instability benefited less.
Researchers found a significant correlation between H. pylori infections and colorectal cancer incidence, especially in African Americans. The study analyzed data from over 4,000 cases and found that antibodies to four H. pylori proteins were most often present among those with colorectal cancer.
Scientists have found that low TIP60 expression leads to uncontrolled jumping gene expression, triggering tissue inflammation that supports tumor growth. The discovery opens new avenues for cancer treatment using anti-HIV drugs.
The report reveals a high burden of prostate and colorectal cancers among Hispanic men in Puerto Rico, contrasting with lower rates among non-Hispanic whites. The study emphasizes the need for culturally tailored strategies to address these disparities and promote healthy lifestyle behaviors.
Current guidelines on anticoagulation therapy for atrial fibrillation may be insufficient due to varying stroke rates among studies, suggesting a need for individualized risk assessments. A case report also highlights the successful treatment of multiple cancers with pembrolizumab in a patient with Lynch syndrome
Dr. Lan Zhou's research focuses on the impact of gut microbiome imbalance, immune response, and genetics on colorectal cancer development through the serrated pathway. Her team will use mouse models and human tissue to study carcinogenic transformation and inflammation-related pathways.
The ACCION program has increased screening rates in West Texas to around 50 percent, compared to a national average of about 70 percent. The program's success is attributed to its use of promotoras and partnerships with community organizations to make screenings more accessible.
A new study confirms that Kaiser Permanente's organized screening program has led to a 52% decrease in colorectal cancer mortality and a 25.5% decline in incidence, saving thousands of lives.
A study published in Nature Communications reveals that inhibiting Jagged 1 protein can prevent colon and rectal tumour growth, even removing existing tumours. This approach may offer a promising therapeutic strategy for selectively targeting malignant stem cells in colon cancer.
A study found that a diet discouraging alcohol consumption and promoting healthy eating was associated with reduced overall and breast, prostate, and colorectal cancer risks. Adherence to the WCRF/AICR score had the strongest association with reduced risk.
Using complementary medicine alongside conventional cancer therapy is associated with a higher risk of death from cancer. The study analyzed data from over 1.9 million patients and found that those who used complementary medicine were more likely to refuse conventional treatments.
A study at UNC Lineberger Comprehensive Cancer Center found that mailing colorectal cancer screening tests to patients insured by Medicaid increased screening rates for this population. The project resulted in a nearly 9 percentage point increase in screening rates compared to patients who just received a reminder.
A study of 99,654 individuals found that lifetime light alcohol drinkers had the lowest combined risk of mortality or developing cancer. The risk increased linearly with lifetime alcohol consumption, with heavy and very heavy drinkers facing significantly higher risks.
A large international study found that higher circulating vitamin D concentrations are significantly associated with lower colorectal cancer risk. Optimal vitamin D concentrations for colorectal cancer prevention may be higher than current recommendations.
A new study published in JAMA found that increased follow-up testing of colorectal cancer patients does not improve survival rates. The study showed that patients who underwent surgery for colorectal cancer experienced the same five-year survival rate regardless of whether they received two or five follow-up tests.
The American Cancer Society recommends earlier colorectal cancer screening for average-risk adults beginning at age 45, based on research showing an increased incidence of CRC in younger adults. Colorectal cancer incidence has declined steadily over the past two decades in people 55 and older due to screening.
Colorectal cancer screening may need to be started earlier than previously recommended, with a new study suggesting starting at age 45. Researchers estimate that cutting mortality from colorectal cancer could save up to 70% of lives if everyone followed the revised guidelines.
A preclinical study found that combining soy lecithin with an NSAID increased anticancer properties and reduced gastrointestinal bleeding. The combination provided superior protection against colorectal cancer without the usual side effects, according to researchers at UTHealth.
Two studies found that more frequent follow-up testing did not significantly impact mortality rates from any cause or colorectal cancer over five years. However, a related editorial suggests that current guidelines should be reevaluated in the context of these findings and potential harms associated with more frequent testing.
Researchers are testing a two-pronged approach combining a DNA vaccine and antibody to boost the immune response against tumors in patients with advanced stage CRC. Preliminary mouse studies showed promising results, including an immune memory that prevented re-challenge with the same tumor.
Researchers identified a correlation between gut microbial composition and microRNA expression in human colorectal cancer. The study found that dozens of microRNAs are differentially regulated in colorectal cancer tumors and are correlated with the abundance of microbes in the tumor microenvironment.
A new 'scoring' system developed by Johns Hopkins Medicine enhances the prediction of survival in people with colorectal cancers that have spread to the liver. The system includes traditional Fong indicators plus genetic and morphological evaluation (GAME) factors, which outperform the existing Fong system in predicting patient outcomes.
A study confirms a curable state between single and widespread cancers by identifying molecular patterns that predict patient outcomes. Researchers found that patients with limited spread of disease could achieve prolonged survival with surgery or targeted radiation therapy.
A study published by The BMJ found no evidence of 'gaming' after death rates for bowel surgeons were publicly reported. However, improvements were seen in mortality rates for patients undergoing non-emergency surgery, suggesting that the introduction of public reporting may have triggered better outcomes through teamwork.
Researchers at Thomas Jefferson University successfully killed tumors and prevented metastatic growth in mouse models of colorectal cancer using CAR-T cell therapy, targeting the GUCY2C antigen. The therapy achieved high survival rates without side effects, paving the way for potential human clinical trials.
Researchers at UMass Amherst have identified a new molecular mechanism explaining the link between obesity and increased risk of colon inflammation, a major risk factor for colorectal cancer. Inhibiting an enzyme called soluble epoxide hydrolase may abolish this risk, suggesting a potential treatment for obesity-induced colonic inflamm...
Researchers at Sanford Burnham Prebys Medical Discovery Institute discovered that PKC zeta deficiency promotes liver metastasis through the inactivation of enzyme ADAR2, leading to increased secretion of miR-200s. Treatment with a compound inhibiting miR-200s reduced liver metastasis in mice with colorectal cancer.
Colorectal cancer rates have increased by 22% among young adults under 50, prompting researchers to create an effective screening method. A new imaging technology called nanocytology will be used to identify high-risk patients and ensure timely treatment.
Researchers developed a new technology to detect and quantify RAS protein mutations, which are found in over 20% of human cancers. The 'top-down' approach provides precise characterization of KRAS4b proteins, revealing new avenues for cancer treatment.
A preclinical study by MD Anderson Cancer Center researchers found that precancerous colon polyps in patients with Lynch syndrome display immune system activation, challenging traditional models of cancer immune activation. The study suggests immunotherapy may be useful for colorectal cancer prevention in certain high-risk groups.
A study published in the International Journal of Cancer found that regularly eating red meat increases the risk of distal colon cancer in women, with those on a red meat-free diet experiencing lower rates. The research suggests that a diet free from red meat significantly reduces the risk of this type of colon cancer.
Ludwig scientists present new data on cancers including colorectal, brain, breast, and ovarian cancer, as well as innovative clinical trials and novel approaches to cancer immunotherapy. The research focuses on mobilizing immunity against ovarian cancer and personalizing cancer treatment strategies.
Researchers found a single upfront genomic test to be more effective for detecting Lynch syndrome in colorectal cancer (CRC) patients than traditional multiple testing. This approach helps guide treatment decisions while identifying those at risk of developing CRC and other cancers.
Researchers have discovered that PAWS1 plays a significant impact in controlling the Wnt signalling pathway, which is associated with developmental defects and diseases like alopecia and colorectal cancer. The study found that PAWS1 mutations can inhibit Wnt signalling, leading to potential interventions for these conditions.
A large study found that Métis adults have higher rates of lung, liver, and breast cancers, as well as poorer prostate cancer survival rates. The study also identified lower incidence rates for melanoma and leukemia in Métis adults compared to non-Aboriginal people.
Scientists found that a small daily dose of Viagra significantly reduces colorectal cancer risk in genetically predisposed animal models. The drug works by increasing levels of cyclic GMP, which suppresses excessive cell proliferation and promotes normal cell differentiation.
European researchers predict that colorectal cancer death rates will continue to fall by around seven percent compared to 2012, resulting in nearly 392,300 avoided deaths. The decline is attributed to improved diagnosis and management of the disease, as well as reduced risk factors such as tobacco, alcohol, and obesity.
A study published in CANCER found that living in low-income areas increases the risk of early death among patients with anal cancer. The researchers analyzed data from 9,550 patients and found that those in lower income areas had worse overall survival and cancer-specific survival compared to those in higher income areas.
A new iPad app that educates patients about different options for colon cancer screening and allows them to order their preferred test has been shown to significantly increase screening rates. In a randomized controlled trial, patients who used the app were twice as likely to undergo screening compared to those in the usual care group.
A combined analysis of family history and genetic markers improves risk prediction for colorectal cancer, revealing that individuals with a positive family history and numerous genetic variants are at increased risk. This approach can help adjust preventive measures and screening schedules.
A large-scale study found a possible association between highly processed food intake and an increased risk of overall cancer, breast cancer, and lower risks of other types. The study suggests that rapid consumption of ultra-processed foods may drive a growing burden of cancer in the next decades.
A recent study by Texas Tech University Health Sciences Center El Paso aims to identify the most accurate stool test for detecting colorectal cancer. The research consortium will compare four different fecal immunochemical tests (FITs) to determine their effectiveness in detecting blood in the stool, a common early sign of cancer.