Articles tagged with Colorectal Cancer
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Researchers found a significant spike in new colorectal cancer diagnoses between ages 49 and 50, indicating many latent cases were likely going undiagnosed until screening began. The majority of these cases (93%) were invasive, requiring aggressive treatment, including surgery.
A study published in Nature Metabolism reveals that serine racemase enhances the growth of colorectal cancer cells by producing pyruvate from serine. The research provides a novel target for anti-cancer therapies and shows promise in improving treatment efficacy.
Kaiser Permanente research reveals that post-menopausal women with colorectal cancer who have low social support are more likely to die from the disease or any cause. The study found a significant association between high levels of emotional, informational, tangible, and positive interactional support and lower mortality rates.
A study by University of Pittsburgh researchers found that the expansion of health insurance coverage in Massachusetts led to a 7% decline in advanced stage colorectal cancer diagnoses. This early diagnosis increase is attributed to increased access to screening and diagnostic services.
Researchers found that certain bacteria, including F. nuc and Moraxella osloensis, are more prevalent in younger patients' tumors than older patients', suggesting a potential link between gut bacteria and the rising incidence of colorectal cancer in people under 45.
Patients with ulcerative colitis have a significantly elevated risk of developing and dying of colorectal cancer, even with modern therapy. A large study found that these patients have a 66% higher chance of being diagnosed with colorectal cancer compared to the control group.
The American Cancer Society's annual report on cancer rates and trends shows a steady 26-year decline in overall cancer mortality, with long-term drops in lung, colorectal, breast, and prostate cancers. Lung cancer death rates have dropped by 51% since 1990, with the most rapid progress in recent years.
City of Hope scientists have found that aspirin appears to reduce tumor growth and inhibit recurrence of colorectal cancer. The right dosage of aspirin is being identified to act as a prophylactic without triggering dangerous side effects.
A new noninvasive diagnostic method using circulating tumor DNA can detect colorectal cancer in at-risk patients with high accuracy. The technology, developed by Huiyan Luo et al., uses methylation markers to identify patients with a sensitivity and specificity of 87.5% and 89.9%, respectively.
Researchers have identified a key protein, Importin-11, that transports the cancer-causing protein βcatenin into the nucleus of colon cancer cells. Inhibiting this transport step could block the growth of most colorectal cancers caused by elevated βcatenin levels.
The Affordable Care Act provision allowing young adults to be covered under their parents' insurance led to improved care for colorectal cancer patients. Young adults diagnosed with stage IIB-IIIC colorectal cancer were 34% more likely to receive adjuvant chemotherapy post-ACA compared to pre-ACA.
The NCI-MATCH trial found a 36% response rate across various cancers with DNA mismatch repair deficiencies, including rare and uncommon tumor types. The results provide an important signal for further study and potential treatment options.
A Mayo Clinic study of 5,540 patients with metastatic colorectal cancer found that maintenance chemotherapy after initial treatment is more beneficial for patients whose disease is under control. The preferred regimen is fluoropyrimidine with or without bevacizumab, according to the analysis.
Recent colorectal cancer screening rates more than doubled among people ages 45 to 49, a trend unique to this age group. The increase in screening was attributed to the release of updated American Cancer Society guidelines recommending screening in that age range.
A new imaging technique combining machine learning and optical coherence tomography detects precancerous and cancerous tissue with 100% accuracy, according to a pilot study. The technology may assist traditional colonoscopy by providing real-time, non-invasive imaging for deeper precancerous polyps and early-stage cancers.
A study published in the International Journal of Cancer suggests that weight loss surgery may increase the risk of colon cancer. Patients who underwent such surgery had a higher risk of colon cancer compared to the general population, especially over time.
A new study published in Gastroenterology reports that prostaglandin E2 (PGE2) promotes metastasis of colorectal cancer through the microRNA MIR675-5p, which silences the expression of p53. Researchers found that mice treated with PGE2 had increased metastases compared to controls, and tumor cells expressed more MIR675-5p and less p53.
A study published in PNAS found that gut microbiota imbalance promotes the onset of colorectal cancer. A non-invasive blood test has been developed to identify the epigenetic phenomenon associated with dysbiosis, which was validated in 1,000 individuals.
A study on cancer trends in Canada from 1971 to 2015 found an increase in breast and colorectal cancers among younger adults, particularly women aged 30-39. In contrast, cancer incidence has decreased in older age groups, with declines seen in cervical, lung, bladder, and prostate cancers across most age categories.
A study published in The BMJ found substantial variation in bowel cancer rates after colonoscopies in England, with lower rates seen at NHS providers. Reducing this variation could prevent or diagnose more cancers earlier, the researchers suggest.
A study explores the genetic mechanisms by which alterations in colon-associated microbes might promote colorectal cancer. Alterations in gut microbes have been linked to increased DNA methylation changes and CRC risk.
The American College of Physicians recommends screening for colorectal cancer in adults at average risk who do not have symptoms. The recommended screening frequency varies depending on the chosen strategy, with options including fecal immunochemical tests, colonoscopy, and flexible sigmoidoscopy.
The American College of Physicians (ACP) has released a new guidance statement for colorectal cancer screening in average-risk adults between 50 and 75 years old. The guidance suggests that physicians select the most suitable screening test for each patient based on factors such as benefits, harms, costs, availability, frequency, and p...
Researchers aim to increase colorectal cancer screening and follow-up care among underserved individuals in Appalachia through a multi-institutional $5.7 million grant. The goal is to improve guideline-recommended screenings and healthcare services, particularly in rural communities where trust is a barrier.
A novel methodology was developed to extract data on symptoms from EHRs and investigate associations between symptom clusters and disease. The study identified distinct symptom clusters for breast cancer and colorectal cancer patients, providing critical information for patient care teams and researchers.
A major study across 195 countries found that global death rates for pancreatic cancer and incidence rates for colorectal cancer increased by 10% between 1990 and 2017. The study also reported significant increases in cases of inflammatory bowel disease (IBD) and a rise in obesity-related risk factors for pancreatic cancer.
Researchers found that direct-to-consumer genetic tests can result in clinical false-negative results, particularly for certain populations. For example, 40% of individuals with MUTYH mutations would have been missed, while 19% of Ashkenazi Jewish individuals with BRCA1/2 mutations would also be missed.
Researchers at TAU and Ichilov Hospital developed a new antibiotic treatment that significantly reduces intestinal polyp numbers and improves quality of life for FAP patients. The innovative therapy, which targets 'nonsense mutations' in the APC gene, showed promising results in a clinical trial.
A phase III study showed that the combination of encorafenib, binimetinib, and cetuximab significantly improved overall survival (9.0 months) and objective response rates compared to standard care. The treatment was well-tolerated, suggesting a potential paradigm shift in treating BRAF-mutant metastatic colorectal cancer.
The BEACON CRC Phase III clinical trial found that the three-drug combination of encorafenib, binimetinib, and cetuximab significantly improved overall survival in patients with BRAF-mutated metastatic colorectal cancer. Median OS for the triplet-targeted therapy was 9 months compared to 5.4 months for standard therapy.
A liquid biopsy test can predict which patients with colorectal cancer are likely to relapse after surgery, and guide treatment. The test identified patients who were more or less likely to remain disease-free two years after chemotherapy.
Researchers discovered the mechanism behind cetuximab's effectiveness in patients with a specific KRAS gene mutation, which enables doctors to prescribe the drug to this patient group. This finding has direct clinical implications and could benefit up to 10,000 colorectal cancer patients per year.
Researchers have identified colibactin-645 as the culprit of DNA double-strand breaks, revealing a new link between E. coli toxins and colorectal cancer risk. The discovery provides a model for designing potent DNA cleaving agents.
Researchers from City of Hope have identified a subgroup of colorectal cancer patients who, despite having many immune cells in their tumors, experience poorer health outcomes due to an overactive immune system. These patients may benefit from immunotherapy to reduce disease recurrence and improve survival rates.
Researchers identified a potential new indication for anti-EGFR treatment in patients with metastatic colorectal cancer and specific BRAF mutations. Class 3 BRAF mutations showed enhanced response rates compared to class 2 mutations, offering hope for personalized oncology.
A study found that patients presenting with non-alarming gastrointestinal symptoms experienced longer wait times for referral, while those with red flag symptoms had shorter wait times. The study highlights the need for earlier reconsideration of initial diagnoses and strict follow-up consultations to reduce wait times.
A study in rural Vermont found that more children are receiving care from pediatricians instead of family medicine doctors. A new smartphone-operated electrocardiogram has been shown to accurately detect cardiac arrhythmias in non-acute patients in primary care settings. Additionally, a stepwise approach may be most effective for asses...
A new study by the American Cancer Society finds that colorectal cancer incidence is increasing exclusively in young adults in nine high-income countries. The rates are rising in contrast to stable or declining trends in older adults, suggesting changes in early-life exposures are increasing CRC risk.
A new study from the University of Pennsylvania School of Medicine found that providing patients with more testing choices, such as home fecal immunochemical testing (FIT), does not increase participation in colorectal cancer screening. However, framing choice did impact patient decision-making, leading to a decrease in colonoscopy rates.
A recent study by Penn Medicine researchers found that automated text message conversations increased the rate of colonoscopies from 62 to 90 percent. The study used text reminders, instructions, and two-way messaging to engage patients before their appointments.
A study analyzing data from almost 30,000 nurses found that physical activity in adolescence and later life cumulatively reduce the risk of advanced adenomatous polyps, a precursor to colorectal cancer. The study showed that adequate physical activity in both adolescence and adulthood reduces the risk by 39%.
A new study found that even low-intensity exercise was associated with a nearly 20% reduction in cancer progression or death in patients with advanced colorectal cancer. Patients who engaged in moderate exercise while undergoing chemotherapy tended to have delayed disease progression and fewer severe side effects from treatment.
A study of UK patients diagnosed with colorectal cancer between 2006 and 2013 found that those under 50 experienced more non-specific symptoms before referral to specialists. Younger patients also had longer intervals between diagnosis and referral, highlighting a need for primary care awareness.
Four biomedical research projects funded by iTHRIV will address disparities in healthcare access for underserved communities. The projects focus on improving colorectal cancer screening, addressing postpartum depression, and the benefits of urban walking. Community organizations and academic researchers will collaborate to develop sust...
Researchers at UT Southwestern Medical Center have discovered that precision editing the gut microbiome can reduce inflammation-associated colorectal cancer in mice. The study suggests targeting metabolic pathways specific to intestinal inflammation could prevent or reduce cancer risk.
The incidence of colorectal cancer among younger adults in Canada has increased over the past few decades. The study found that men under 50 had an average annual percentage change of 3.47% and women under 50 had a 4.45% increase from 2006 to 2015.
A recent study published in CANCER found that the incidence of colorectal cancer in adults under 50 years old has increased in the United States since 1970. Younger adults are diagnosed with more advanced disease, and African American and Hispanic populations have a higher proportion of young onset disease.
A recent study published in Nutrients found that an inflammatory diet increases the risk of colorectal cancer by almost twice. The researchers suggest adopting a Mediterranean diet rich in fruits, vegetables, nuts, whole grains, and healthy oils to reduce the risk of colon cancer.
A new study finds that trends in colonoscopy rates did not fully align with the rise in colorectal cancer incidence among younger adults, suggesting other factors may be driving the increase. Colorectal cancer incidence rates increased by 28% between 2000 and 2015, despite stable or increasing past-year colonoscopy rates.
A large French study suggests that high sugary drink consumption may contribute to an increased risk of cancer. The researchers found a strong association between daily consumption of sugary drinks and breast cancer, as well as overall cancer risk.
A new combination of targeted therapies improved overall survival and objective response in patients with BRAF-mutant colorectal tumours. The BEACON CRC Phase III trial showed that triplet therapy significantly outperformed standard care, suggesting a potential replacement for chemotherapy for eligible patients.
A phase III trial found that a three-drug combination of encorafenib, binimetinib, and cetuximab significantly improved overall survival in patients with BRAF-mutated metastatic colorectal cancer. The treatment resulted in a median overall survival of 9 months compared to 5.4 months for standard therapy.
A study at ESMO World Congress on Gastrointestinal Cancer 2019 found that a more flexible dosing regimen for regorafenib improves patients' quality of life while maintaining its efficacy. The reduced and intermittent dose groups showed numerical improvements in tolerance to side effects such as fatigue and hand-foot syndrome.
A new iPad app, mPATH-CRC, will be tested in North Carolina and Kentucky clinics to increase colorectal cancer screenings. The project aims to determine the optimal way to implement technology-based programs to improve medical care delivery.
Stanford researchers found that up to 80% of metastatic colorectal cancers have already spread to distant locations by the time the original tumor is clinically detectable. This discovery has implications for patient stratification and earlier detection of cancer.
Researchers found that identifying a patient's Consensus Molecular Subtype (CMS) could help oncologists determine the most effective course of treatment. CMS categorizes colorectal cancer into four distinct subgroups based on tumor mutations, and each subgroup is associated with different treatment outcomes.
A recent study published in Nature Medicine Letters reveals that specific microbiome organisms are linked to the early stages of colorectal cancer development. The researchers found increases in these microorganisms in fecal samples from patients, which could potentially provide vital diagnostic clues.
A University of Colorado study found that young-onset patients with colorectal cancer often experience prolonged rectal bleeding before diagnosis, leading to advanced stage cancer at the time of diagnosis. The average delay between symptom onset and diagnosis was 294 days.
Early-onset colorectal cancer incidence has been increasing rapidly in Western US states, despite low rates of smoking and physical inactivity. The study found that rates rose faster for rectal tumors than colon tumors, with average increases exceeding 2.5% per year in ten states.
A new study found that one-third of patients with metastatic pancreatic cancer do not see a medical oncologist, and even more do not receive cancer-directed treatment. The data suggest that there are many missed opportunities for important discussions between patients and cancer specialists.