A study at ESMO 2020 found that adding abemaciclib to hormonal therapy reduces the risk of cancer recurrence by 25% in patients with high-risk early hormone receptor positive breast cancer. This new treatment approach improves invasive disease free survival and may spare chemotherapy in this group of patients.
A major trial shows olaparib, a PARP inhibitor, is more effective than modern hormone treatments in slowing down prostate cancer growth and spread. Patients with genetic alterations in DNA repair genes who received olaparib had a median overall survival of 19.1 months.
The PROfound trial demonstrates the efficacy of PARP inhibitor olaparib in treating metastatic castration-resistant prostate cancer (mCRPC) with at least one alteration in BRCA1 or BRCA2 genes. Olaparib significantly improves overall survival, particularly in patients with alterations in these genes.
A phase 1 clinical trial of sotorasib (AMG 510) demonstrated anti-cancer activity in patients with heavily pretreated advanced solid tumors. Patients with non-small cell lung cancer had a 32% response rate and median progression-free survival of 6.3 months.
Research found that increased exercise capacity lowers all-cause mortality risk in T2D patients, with moderate exercise reducing risk by 25% and high-intensity exercise by 32%. The study used data from Taiwan's National Health Interview Survey and National Health Insurance research database.
A study of 200,000 UK Biobank blood samples found over 2,000 undiagnosed cases of type 2 diabetes, with patients waiting on average 2.3 years for a clinical diagnosis. Population-level screening using HbA1c testing could identify cases earlier and reduce complications.
Researchers investigate marine heatwaves and their effects on regional ocean circulation, marine life, and fisheries. They found that extreme warming events can extend to 300 meters below the surface in certain areas, impacting ecosystems and economies.
A new study found that rheumatoid arthritis is associated with a 23% increased risk of developing type 2 diabetes. The research suggests that systemic inflammation may contribute to the development of diabetes in individuals with RA, highlighting the need for more intensive screening and management of diabetes risk factors.
Research shows spousal concordance is strongest for behavioral risk factors like diet and physical activity, while pathophysiological factors show weaker concordance. Couples with similar dietary habits and high-intensity exercise tend to have lower type 2 diabetes risk.
In a Phase I clinical trial, sotorasib achieved a confirmed response rate of 32.2% and disease control rate of 88.1% in patients with KRAS G12C-mutant non-small cell lung cancer, with durable clinical benefits and manageable toxicities
Researchers from the University of Queensland have discovered two pain-blocking peptides in the Venezuelan Pinkfoot Goliath tarantula's venom, showing great potential as treatments for chronic intestinal pain. The peptides inhibit the most important ion channels underlying pain and nearly stopped chronic visceral pain in a model of IBS.
A study found that people with type 2 diabetes who go to bed early and wake up early have a significantly more active lifestyle than those who prefer late bedtimes. This research highlights the importance of sleep chronotypes in managing diabetes and suggests that adjusting bedtime can lead to improved physical activity levels.
A recent study published in Diabetologia reveals that people with type 1 diabetes have a 33% higher risk of falls compared to the general population, while those with type 2 diabetes face a 19% increased risk. The research also identifies various risk factors for falls and fractures in individuals with diabetes.
A new study on over 540 baboons in Amboseli National Park in Kenya reveals that male baboons who have close female friends are more likely to survive than those without them. Males with strong social connections, particularly with females, live longer lives.
A large randomized trial found that post-operative radiotherapy (PORT) does not significantly improve disease-free survival in completely resected non-small-cell lung cancer (NSCLC) patients. The study included 501 patients and showed no significant difference in overall survival between the PORT group and the control group.
A study published in BMJ Open found large discrepancies in payments made by drug companies and UK patient organisations. Patient organisations claimed £33 million, while drug companies disclosed £54 million - a shortfall of over £21 million.
A new study found that humans exhibit slower epigenetic aging than chimpanzees, with certain DNA sites gaining or losing chemical tags in a clock-like pattern. The researchers analyzed over 850,000 DNA sites in blood samples from 83 chimpanzees aged 1 to 59 and found that aging leaves its mark on the chimpanzee genome, similar to humans.