Articles tagged with Colorectal Cancer
A new study found that even low-intensity exercise was associated with a nearly 20% reduction in cancer progression or death in patients with advanced colorectal cancer. Patients who engaged in moderate exercise while undergoing chemotherapy tended to have delayed disease progression and fewer severe side effects from treatment.
A study of UK patients diagnosed with colorectal cancer between 2006 and 2013 found that those under 50 experienced more non-specific symptoms before referral to specialists. Younger patients also had longer intervals between diagnosis and referral, highlighting a need for primary care awareness.
Four biomedical research projects funded by iTHRIV will address disparities in healthcare access for underserved communities. The projects focus on improving colorectal cancer screening, addressing postpartum depression, and the benefits of urban walking. Community organizations and academic researchers will collaborate to develop sust...
Researchers at UT Southwestern Medical Center have discovered that precision editing the gut microbiome can reduce inflammation-associated colorectal cancer in mice. The study suggests targeting metabolic pathways specific to intestinal inflammation could prevent or reduce cancer risk.
The incidence of colorectal cancer among younger adults in Canada has increased over the past few decades. The study found that men under 50 had an average annual percentage change of 3.47% and women under 50 had a 4.45% increase from 2006 to 2015.
A recent study published in CANCER found that the incidence of colorectal cancer in adults under 50 years old has increased in the United States since 1970. Younger adults are diagnosed with more advanced disease, and African American and Hispanic populations have a higher proportion of young onset disease.
A recent study published in Nutrients found that an inflammatory diet increases the risk of colorectal cancer by almost twice. The researchers suggest adopting a Mediterranean diet rich in fruits, vegetables, nuts, whole grains, and healthy oils to reduce the risk of colon cancer.
A new study finds that trends in colonoscopy rates did not fully align with the rise in colorectal cancer incidence among younger adults, suggesting other factors may be driving the increase. Colorectal cancer incidence rates increased by 28% between 2000 and 2015, despite stable or increasing past-year colonoscopy rates.
A large French study suggests that high sugary drink consumption may contribute to an increased risk of cancer. The researchers found a strong association between daily consumption of sugary drinks and breast cancer, as well as overall cancer risk.
A phase III trial found that a three-drug combination of encorafenib, binimetinib, and cetuximab significantly improved overall survival in patients with BRAF-mutated metastatic colorectal cancer. The treatment resulted in a median overall survival of 9 months compared to 5.4 months for standard therapy.
A study at ESMO World Congress on Gastrointestinal Cancer 2019 found that a more flexible dosing regimen for regorafenib improves patients' quality of life while maintaining its efficacy. The reduced and intermittent dose groups showed numerical improvements in tolerance to side effects such as fatigue and hand-foot syndrome.
A new combination of targeted therapies improved overall survival and objective response in patients with BRAF-mutant colorectal tumours. The BEACON CRC Phase III trial showed that triplet therapy significantly outperformed standard care, suggesting a potential replacement for chemotherapy for eligible patients.
A new iPad app, mPATH-CRC, will be tested in North Carolina and Kentucky clinics to increase colorectal cancer screenings. The project aims to determine the optimal way to implement technology-based programs to improve medical care delivery.
Stanford researchers found that up to 80% of metastatic colorectal cancers have already spread to distant locations by the time the original tumor is clinically detectable. This discovery has implications for patient stratification and earlier detection of cancer.
A recent study published in Nature Medicine Letters reveals that specific microbiome organisms are linked to the early stages of colorectal cancer development. The researchers found increases in these microorganisms in fecal samples from patients, which could potentially provide vital diagnostic clues.
Researchers found that identifying a patient's Consensus Molecular Subtype (CMS) could help oncologists determine the most effective course of treatment. CMS categorizes colorectal cancer into four distinct subgroups based on tumor mutations, and each subgroup is associated with different treatment outcomes.
A University of Colorado study found that young-onset patients with colorectal cancer often experience prolonged rectal bleeding before diagnosis, leading to advanced stage cancer at the time of diagnosis. The average delay between symptom onset and diagnosis was 294 days.
Early-onset colorectal cancer incidence has been increasing rapidly in Western US states, despite low rates of smoking and physical inactivity. The study found that rates rose faster for rectal tumors than colon tumors, with average increases exceeding 2.5% per year in ten states.
A new study found that one-third of patients with metastatic pancreatic cancer do not see a medical oncologist, and even more do not receive cancer-directed treatment. The data suggest that there are many missed opportunities for important discussions between patients and cancer specialists.
Researchers used genetically modified fruit flies to test candidate treatments for a patient with KRAS-mutant metastatic colorectal cancer. The approach identified trametinib plus zoledronate as a promising combination that prolonged survival and reduced targeted tumors.
A new study found that states that expanded Medicaid saw larger increases in colorectal cancer screening, with an additional 236,573 people screened. The study suggests that Medicaid expansion can improve cancer screening rates among low-income adults.
A new study estimates that 5.2% of invasive cancer cases in the US are related to poor diet, with colorectal cancer and mouth, pharynx, and larynx being the most affected. The study found that low whole grain intake was associated with the largest number and proportion of new cancer cases.
The study found significant increases in colon and rectal cancer incidence among young adults in several high-income countries, including Australia, Canada, Denmark, Ireland, New Zealand, Norway, and the UK. The incidence of colon cancer increased significantly each year in people aged 0-49 years, while rectal cancer incidence was most...
Researchers discovered that MEK inhibitors activate Wnt signalling pathway in colorectal cancer cells, leading to accumulation of tumor cells with stem cell characteristics. This explains why these drugs are not effective in treating colorectal cancer.
A study of 33 practices found that physicians ordered fewer cancer screenings as the clinic day progressed, and patients completed them less often. Screening test order rates were highest at 8 a.m. and lowest at 5 p.m., suggesting timing may influence physician and patient behavior.
A meta-analysis of 14 studies involving 130,994 patients found that pre-diagnosis statin use reduced the risk of early death from any cause and cancer by 15% and 18%, respectively. Post-diagnosis statin use also showed lower mortality rates
Researchers investigated whether taking aspirin before a fecal immunochemical test could improve the ability to detect cancer precursors. The study found no statistically significant difference in detection rates between those who took aspirin and those who took a placebo.
A large study found that adults with high fitness levels had a lower risk of developing lung and colorectal cancer, as well as improved survival rates after diagnosis. Fitness testing is common among adults and may provide valuable information about cancer risk and prognosis.
Researchers found that tumor mutation score is associated with responses to immunotherapy in metastatic colorectal cancer patients. Patients with high mutation scores are more likely to respond to immunotherapy, while those with low scores may benefit from chemotherapy.
A combination of prebiotics and probiotics reduces the expression of pro-carcinogenic genes and may help treat colorectal cancer. The study used a unique gut-on-a-chip model to investigate diet-microbiome-host interactions, revealing a mechanistic basis for the observed beneficial effects.
A novel colorectal cancer vaccine has demonstrated positive phase I results, with patients showing no signs of serious adverse events and activation of immune cells. The vaccine was found to be safe and effective in a small sample of human subjects, paving the way for further testing to determine its potential as a treatment.
Researchers have identified two proteins that, when inactivated, make tumoral cells more sensitive to chemotherapy and reduce metastatic capacity. This finding provides a rationale for creating new therapies against colorectal cancer, particularly in fibroblast-rich tumor subgroups.
A new study reveals blocking specific regions of UHRF1 switches on hundreds of cancer-fighting genes, impairing colorectal cancer cells' ability to grow and spread. This protein is akin to a molecular Swiss army knife, with many different parts that each have a different job.
Researchers at Medical College of Georgia found that higher levels of CCR4 gene are associated with better survival rates and longer lifespan in patients with colorectal cancer. The gene helps the immune system differentiate between good cells and bad cells.
Researchers from University of Copenhagen and EMBL found consistent changes in gut bacteria across seven countries, providing a universal signature for colorectal cancer. These microbiome changes may play a role in developing the cancer and could be used as biomarkers for diagnosis and therapeutic targets.
Researchers have established disease-specific microbiome changes that are globally robust, despite differences in environment, diet, and lifestyle. These findings provide a basis for future non-invasive cancer screening and may enable new research into the causal role of gut microbes in colorectal cancer development.
Researchers mapped gut microbes of colorectal cancer patients to identify disease-specific changes globally robust despite environmental differences. The study establishes a panel of gut microbes associated with colorectal cancer and shows potential for non-invasive cancer screening.
A preclinical study has shown that a cancer preventive vaccine may be effective in preventing cancers associated with Lynch syndrome. The vaccine was found to reduce intestinal tumor burden and improve survival in mice with the genetic mutation, suggesting potential as a treatment option.
Researchers found signature of 16 disease-related microbial species associated with colorectal cancer and identified Fusobacterium nucleatum and choline trimethylamine-lyase gene in fecal samples. The study paves the way for non-invasive predictive tests for different populations.
Starting colorectal cancer screening at age 45 rather than 50 would decrease U.S. cancer deaths by as much as 11,100 over five years and cases by up to 29,400. Screening a greater number of older adults would avert nearly three times as many diagnoses and deaths at a lower cost.
Karin Pelka receives $50,000 fellowship for two years to study immune cell types in colorectal tumors and develop methods to enhance immunotherapy. The Peggy Prescott Early Career Scientist Award aims to accelerate research to get new therapies to patients quickly and save lives now.
Researchers found that mailing FIT kits directly to patients increased completion rates by 24-29% within two-six months. Financial incentives did not significantly improve results. The study suggests framing and context of incentives can be more important than their dollar value, highlighting the principles of behavioral economics.
A study found that consuming high-fructose corn syrup accelerates intestinal tumor growth in mouse models, independent of obesity. The sugar directly feeds cancer growth via increased fructose and glucose levels, leading to fatty acid production and tumor progression.
Researchers identified a common oncogene, KRAS, as a key player in immune checkpoint blockade therapy resistance in metastatic colorectal cancer. Restoring IRF2 expression or inhibiting MDSCs through CXCL3-CXCR2 signaling increased CRC sensitivity to ICB therapy.
The study analyzed tumor DNA from 843 patients with colorectal cancer, identifying associations between genetic mutations and treatment responses. Patients with microsatellite instability had longer survival when treated with bevacizumab, while those with high tumor mutational burden lived longer than those with less variation.
Researchers found that younger patients with early-onset colorectal cancer have unique genetic mutations and subtypes of the disease. Patients with predisposing conditions, such as inflammatory bowel disease, also exhibit distinct clinical and genetic characteristics compared to those without such conditions.
A new study by Indiana University School of Medicine and the Regenstrief Institute found that an annual noninvasive stool test is effective for colon cancer screening in average-risk adults. The test, known as FIT, identified hidden blood in stool and had high detection rates for colorectal cancer.
The study found that Medicaid patients experienced a tripling of CRC screening, with a notable increase in those from Appalachian regions. Following the expansion, CRC patients on Medicaid demonstrated improved survival rates, particularly after the first year.
Consuming garlic and onions has been shown to lower the risk of colorectal cancer in a Chinese study involving 833 patients. Adults who ate high amounts of allium vegetables had an 79% lower chance of developing the disease compared to those who consumed low amounts.
A new study led by Salk Institute scientists suggests that high-fat diets contribute to colorectal cancer growth by disrupting the balance of bile acids in the intestine. The findings could explain why younger people are developing colorectal cancer at an alarming rate.
Researchers discovered a link between Escherichia coli and colorectal cancer risk through colibactin, a genotoxic warhead that damages DNA. The study identified potential biomarkers for assessing colorectal cancer risk and provides significant mechanistic insights into the carcinogenic activities of colibactin.
The black-white cancer mortality gap has closed considerably over the past several decades, with faster declines among black Americans. The disparities have narrowed for lung, prostate, and colorectal cancers, and have stabilized since 2010 for breast cancer.
Researchers found that elevated levels of IL-33 and Tregs trigger cancer-promoting chronic inflammation, leading to the development of skin and colon cancer. Blocking this axis can prevent cancer development in mice with chronic dermatitis.
A new study found that spending more time watching TV is associated with a higher risk of developing colorectal cancer in people under 50. The research, published in JNCI Cancer Spectrum, suggests that sedentary behaviors like watching TV may be a distinct risk factor for young-onset colorectal cancer.
A new study finds rates are increasing for six of 12 obesity-related cancers in younger adults in the US, with steeper increases in progressively younger ages. Excess body weight is a known carcinogen associated with more than a dozen cancers and suspected in several more.
The American Gastroenterological Association has announced the 2019 recipients of the annual recognition awards, honoring outstanding contributions to the field of gastroenterology. The award winners include John I. Allen, MD, MBA, AGAF; Harry B. Greenberg, MD; and Timothy C. Wang, MD, AGAF.
A study at St. Michael's Hospital found that transgender patients have lower odds of being screened for certain types of cancer, including breast, cervical, and colorectal cancer. Transgender patients had a 70% lower odds of being screened for breast cancer, with similar disparities seen in cervical and colorectal cancer screening.
Researchers investigated the effect of AR inhibitor fidarestat on high-fat diet-induced intestinal polyps in ApcMin/+ mice. The study found that fidarestat reduced the number and size of polyps, as well as inhibited key proteins involved in carcinogenesis.
A study published in Cell Reports reveals a critical connection between chronic inflammation and the development of colon cancer. Researchers found that persistent inflammation leads to increased levels of myeloid-derived suppressor cells and interleukin-10, which ultimately silence tumor suppressors and contribute to cancer growth.
A study published in The Lancet reveals that consuming at least 25g to 29g of dietary fibre per day can reduce the risk of non-communicable diseases such as coronary heart disease, stroke, type 2 diabetes, and colorectal cancer by 16-24%. Whole grains also show promise in reducing mortality rates and incidence of these diseases.