Articles tagged with Colorectal Cancer
The American Gastroenterological Association (AGA) has launched a new PatientINFO Center to provide high-quality, readable information on colorectal cancer. The center addresses gaps in existing resources, offering detailed information on screening options, risk factors, and prevention strategies.
Researchers found that colorectal tumors have different regions with varying levels of epigenetic changes, which relate to the tumor's growth rate and aggressiveness. This heterogeneity can be used to predict prognosis and treatment resistance.
A recent study by the University of California - Davis Health found that Hispanic men in California have lower rates of screening for colorectal cancer compared to white men. The study suggests that increased screening can help reduce the incidence and mortality rates of the disease among this population.
A new study reveals that fusobacteria use a special sugar-binding protein to stick to developing colorectal polyps and cancers. This mechanism may inform ways of blocking fusobacteria from homing in on tumors, and could potentially prevent colorectal cancer progression.
A study at Columbia University's Mailman School of Public Health found that obesity prevalence increased from 22% to 32% among cancer survivors between 1997 and 2014. Colorectal and breast cancer survivors, as well as non-Hispanic blacks, were particularly affected.
Case Western Reserve University researchers identified why colorectal cancer cells depend on glutamine and developed a way to starve them. In a mouse model, exposing tumors with PIK3CA mutation to glutamine metabolism inhibitors suppressed tumor growth, providing a promising new therapeutic avenue for colorectal tumors.
The ESMO consensus guidelines reflect a personalized treatment approach to managing metastatic colorectal cancer, incorporating molecular markers and patient selection. The guidelines aim to improve outcomes by providing evidence-based recommendations for treatment options.
Researchers have developed a blood-based screening test to gauge colon cancer recurrence and monitor chemotherapy effects. The test detects tumor DNA fragments in the blood, which can identify patients at high risk of relapse and track treatment efficacy.
Researchers identified genetic mutations in immune system genes that may lead to synchronous colorectal cancer, a rare type of bowel tumor. The study found that these patients have inherited damaging mutations that can cause an inflammatory environment in the gut, increasing the frequency of independent cancer-initiating events.
MABp1 improves symptoms, reduces inflammation and increases clinical response rate by 76%, with a 3x longer survival time for responders. Excellent safety and tolerability were also observed.
A new study reveals that only 8% of patients with large, apparently benign polyps have cancer, suggesting advanced endoscopic treatments like EMR and ESD as viable options. This finding could improve patient outcomes, reduce complications, and lower healthcare costs.
A phase I trial found that combining anti-PD-L1 immunotherapy with a MEK inhibitor achieves partial responses and is well-tolerated in patients with microsatellite-stable metastatic colorectal cancer. The combination was shown to increase the number of active immune cells in tumors, leading to improved responses.
A team of scientists has developed a computational method to map cancer progression, which offers new insights into the factors that spur this affliction. The researchers used gene sequencing data to create a model that predicts how a tumor's genomes will change over time.
Consistent reductions in cancer incidence and mortality were observed with adherence to cancer prevention guidelines. These guideline adherence showed a significant reduction of 10-45% in all cancer incidence and 14-61% in all cancer mortality. The review also found consistent reductions in breast, endometrial, and colorectal cancers.
Researchers identified TIP60 as an enzyme required for HIF1A activity in human colorectal cancer cells, showing its potential as a target for cancer treatment. The study also revealed the molecular mechanisms by which TIP60 promotes HIF1A activity and highlights the importance of basic research in cancer discovery.
Researchers developed pretargeted radioimmunotherapy, combining an anti-GPA33 antibody with radionuclide agents to deliver radiation directly to tumors. In mouse models, the technique achieved complete remission of colorectal cancer without collateral toxicity.
A study found that about 40% of Hispanic adults with colorectal cancer used complementary and integrative health practices. Women were more likely to have used these practices than men, according to the study published in The Journal of Alternative and Complementary Medicine.
A study found that genes involved in the Wnt signaling pathway are more frequently altered in younger patients with colorectal cancer. This pathway drives the growth and proliferation of cancer stem cells. The research suggests targeting this pathway may be a promising strategy for treating aggressive CRC in young patients
A study found that while overall colorectal cancer rates are decreasing, the incidence of late-stage cancer in young patients is increasing. The study, which analyzed data from Colorado patients, reveals a significant rise in late-stage CRC diagnoses among those under 50.
Researchers developed a new method of diagnosing colorectal cancer using 3D hydrogel biochips, which detect tumor-associated glycans and improve sensitivity. The study analyzed sera from 33 patients with colorectal cancer, 69 healthy donors, and 27 patients with inflammatory bowel disease.
A free colonoscopy program for uninsured patients has been shown to detect cancer at an earlier stage and appears to be cost-neutral. The program, which was expanded to all hospitals in Louisville, is being hailed as a model for statewide implementation in Kentucky.
A recent study published in The Lancet found that the global economic crisis was associated with an increase in cancer mortality, particularly among treatable cancers. Universal health care coverage may protect patients from the health consequences of rising unemployment and reduced public-sector healthcare spending.
Researchers found a significant increase in colorectal cancer cases under 50 years old, with advanced stages at diagnosis. The study suggests healthcare providers need to be more vigilant in detecting symptoms in younger patients.
Researchers identified 2,314 genetic changes in polyps and adjacent mucosa, revealing potential drug targets for colorectal cancer prevention. The study also found similarities between premalignant and cancerous tissue, suggesting that polyps with more genetic changes may be more likely to develop into CRC.
A study using whole-exome sequencing has identified genomic alterations in both colorectal adenomas and at-risk mucosa, shedding light on the evolution of normal mucosa to precancer. The research provides a catalog of genomic changes preceding colorectal cancer development in patients with familial adenomatous polyposis.
A Mayo Clinic study found that endoscopists with knowledge of a positive Cologuard test detected polyps or hemorrhagic lesions 83% of the time, compared to 68% without this information. This increased detection led to more true-positive results and fewer false-negative results.
Researchers used genetically-engineered mice to study the role of a Western-style diet in colon cancer development. They found that a low-fiber, high-fat diet increased the risk of colon cancer and identified key changes in gene expression profiles before tumor formation.
A new Kaiser Permanente study found that overweight colorectal cancer patients had a significantly lower risk of death from their cancer compared to normal-weight patients. The study analyzed data from over 3,400 patients and found that those who were in the high-overweight category at diagnosis had a 55% lower risk of mortality.
Researchers discovered an alternative pathway emerges when ERK1/2 is blocked, allowing tumor cell proliferation to continue. Targeting both ERK pathways concurrently with drug inhibitors halted colorectal cancer growth more effectively in mouse models and human cell lines.
A new blood marker, FCGR2A, identifies patients with metastatic colorectal cancer who will benefit from the drug cetuximab. The discovery helps personalize cancer medicine for those with colorectal disease, improving treatment outcomes.
Researchers have found that a specific blood marker is common among patients with a subset of metastatic colorectal cancer, increasing their chances of responding to the drug. This breakthrough builds on an international clinical trial and could lead to more effective treatment options for patients running out of time.
Research shows that 1 in 5 colorectal cancer patients are depressed at diagnosis, and this can significantly impact their quality of life. The study highlights the importance of considering psychological factors in patient care and support.
A new study links MS drug mitoxantrone to an increased risk of colorectal cancer, with patients treated with the medication being three times more likely to develop the disease. However, the overall rate of cancer was low enough that the researchers suggest continuing its use for severely affected patients.
A new study suggests that removing the ovaries may increase the risk of colorectal cancer in women. Among 195,973 Swedish women who underwent ovary removal between 1965 and 2011, a 30% higher rate of colorectal cancer was found compared to the general population. The risk was even higher for women who had both ovaries removed.
A large case-control study found that statin use is associated with a reduced risk of colorectal cancer, but the difference in risk between statin users and non-users was not significant. Increased serum cholesterol levels were also independently linked to decreased risk of colorectal cancer.
A large case-control study suggests that high cholesterol levels, rather than statin use, may influence the risk of colorectal cancer. The study found an inverse relationship between blood cholesterol levels and colorectal cancer risk, with higher cholesterol levels associated with lower risk.
The phase 1b clinical trial of atezolizumab has reported promising results in 23 patients with metastatic colorectal cancer. Fifty-two percent responded to treatment, and median progression-free survival was 14.1 months. Another patient, Rodney Bearfoot, has remained on the study for over three years despite a stage 4 diagnosis.
Researchers developed a risk prediction model integrating 19 environmental and lifestyle risk factors with 64 common genetic risk factors to identify individuals at high risk of developing colorectal cancer. The model aims to improve colonoscopies for those at higher risk, while avoiding unnecessary procedures for low-risk individuals.
A study found patients with flat adenomas are more likely to have large and advanced adenomas as well as multiple adenomas. This may require more frequent screenings for these patients. Colonoscopy is an effective screening test for colon cancer, allowing doctors to remove precancerous polyps.
Scientists have identified 182 genome instability suppressing (GIS) genes in yeast and over 400 previously unknown cooperating GIS genes. These findings suggest a complex genetic network maintaining genome integrity and highlight potential therapeutic targets for cancer treatment.
The USPSTF recommends taking low-dose aspirin for primary prevention of cardiovascular disease and colorectal cancer in adults aged 50-69 years with increased risk. Aspirin use can outweigh harms for some patients, including those at high risk for CVD, improving life expectancy and quality of life.
Researchers found that radiation treatment killed 95% of breast cancer cells when delivered during a peak in p53 production, but only 20% when applied during an oscillatory phase. The study suggests that timing may be crucial in understanding the effectiveness of anticancer treatments.
The study found that regular aspirin use significantly reduces the overall risk of cancer, with a 19% lower risk of colorectal cancer. Aspirin may complement, but not replace, cancer screening methods like colonoscopy, and has potential benefits for individuals with risk factors.
Regular low-dose aspirin use for at least six years was associated with a modestly reduced overall risk for cancer, primarily due to a lower risk for gastrointestinal tract cancer. The study found that regular aspirin use may complement CRC screening and have an absolute benefit regardless of endoscopy status.
Researchers found that patients with lung and colorectal cancer who had financial distress at diagnosis reported significantly increased pain, symptom burden, and poorer quality of life. The study highlights the need for clinicians to target resources and treatments for patients struggling financially.
A new Canadian guideline recommends fecal occult blood testing (FOBT) every two years or flexible sigmoidoscopy every 10 years for routine screening of colorectal cancer in asymptomatic, low-risk adults aged 50-74. The guideline also recommends against colonoscopy as a primary screening tool, citing lack of direct evidence.
The American Cancer Society report reveals progress in reducing cancer death rates among African-Americans, but racial disparities persist in breast and colorectal cancers. The study finds that disparities in access to care and screening contribute to these disparities.
Colorectal cancer patients require follow-up colonoscopy after surgery to detect second cancers and polyps, with recommended intervals varying from one to nine years. The US Multi-Society Task Force updates guidelines to emphasize the role of colonoscopy in post-surgical surveillance.
The American College of Physicians (ACP) offers guidance on evaluating blood in the urine, emphasizing the importance of referring patients with gross hematuria and confirming heme-positive results. For adults with microscopically confirmed hematuria, urology referral for cystoscopy and imaging is recommended.
A study of US data found that one in seven colorectal cancer patients is younger than 50 years old, often presenting with advanced stage disease. However, these patients tend to receive more aggressive therapy and have a slightly longer survival rate without recurrence.
Research by Michigan Medicine found that nearly 15% of colorectal cancer patients were diagnosed before age 50, often with more advanced disease. Younger patients had better survival rates due to aggressive treatment, suggesting the need for improved long-term survivorship resources.
A University of Colorado study found distinct genetic drivers in colorectal cancer among young and old patients, with potential implications for targeted therapies.
Research at Thomas Jefferson University reveals obesity is associated with a key hormone's absence, leading to tumor suppressor pathway deactivation and increased colorectal cancer risk. A therapeutic approach using the pill linaclotide, structurally related to the lost hormone, may prevent cancer in obese patients.
Seven scientists with novel approaches to fighting cancer have been named recipients of the Damon Runyon-Rachleff Innovation Award. The grant funds cancer research by exceptionally creative thinkers with 'high-risk/high-reward' ideas, aiming to significantly impact cancer prevention, diagnosis, and treatment.
A recent US study found that minority and ethnic groups are being diagnosed with colorectal cancer at younger ages than non-Hispanic whites. The study reveals that these groups have twice the risk of developing the disease before age 50, with advanced stages at diagnosis.
Researchers at University of Missouri-Columbia discovered that the gene Sprouty2, previously believed to suppress cancer growth, may actually promote metastasis in colorectal cancer. This finding has significant implications for understanding and treating the disease.
A new study by Sylvester researchers describes the immune system's response to tumor development, highlighting the stimulator of interferon genes (STING) signaling pathway's potential suppression of colorectal cancer. Impaired STING responses may enable damaged cells to evade the immune system.
A study published in JNCI Journal of the National Cancer Institute found that virtual colonoscopy had higher detection rates than traditional methods like FIT and OC. The researchers concluded that combination of lower attendance and higher detection rate makes CTC a key factor for optimization of its role in population screening.
A new American Cancer Society study reveals that excess medical expenditures and productivity losses vary significantly among cancer survivors by age and cancer site. Nonelderly survivors of colorectal and breast cancers experience higher annual expenditures compared to those without a cancer history.
A study published in JAMA found that nearly half of working individuals with stage III colorectal cancer lost their jobs due to their diagnosis. However, those with access to paid sick leave were more likely to retain their jobs and experience reduced personal financial burdens. The study highlights the importance of providing paid sic...