Articles tagged with Coronary Artery Disease
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Researchers at Duke University Medical Center found that women with coronary artery disease are twice as likely to die if they exhibit symptoms of depression. The study analyzed the Beck Depression Inventory scores of 265 women admitted for a diagnostic cardiac catheterization and followed them for up to 3.5 years.
Researchers discovered a link between serum amyloid alpha (SAA) and future cardiovascular events, with increased levels predicting a 3% higher risk of heart attack or stroke over three years. SAA appears to respond specifically to active heart disease, making it a potential more accurate predictor than C-reactive protein.
The DEFINITE study found that implantable cardioverter-defibrillators (ICDs) can reduce the risk of sudden cardiac death and improve overall survival in non-ischemic cardiomyopathy patients. The study, which followed 458 participants for two years, showed a statistically significant reduction in arrhythmic deaths and all-cause mortality.
A study of 352 patients found that sirolimus-eluting stents significantly improved minimum coronary artery diameter at 8 months, reducing restenosis rates by 42% and major cardiac events by 23%. The technology offers promising results for endoluminal therapy, potentially rivaling bypass surgery.
Researchers study women's midlife health, focusing on intra abdominal fat and its impact on heart disease risk. The WISH project examines the mediating role of stress on cardiovascular risk among post menopausal women.
A study by Mary A. Whooley and colleagues found that depressive symptoms are a better predictor of poor quality of life in patients with coronary disease than previously thought. The researchers measured depressive symptoms using the Patient Health Questionnaire (PHQ) and found that these patients were more likely to report lower healt...
Researchers compared MPI and CCTA scans to determine a more comprehensive assessment of coronary artery disease. Combining functional SPECT MPI and anatomic CT scans provided valuable information on severe myocardial perfusion defects and calcium deposits.
A study found that statin therapy combined with aggressive lifestyle modifications can significantly reduce coronary calcium scores and prevent disease progression. In the 12-year follow-up, nearly one-third of patients on statins and lifestyle changes showed reduced calcification scores, avoiding revascularization procedures.
A recent study from Johns Hopkins Medicine suggests that cognitive decline immediately after coronary artery bypass surgery is transient and reversible. The researchers tested patients before and after surgery using various neuropsychological tests to measure memory and other cognitive abilities.
A study of 95 premenopausal women found a significant link between low estrogen levels and an increased prevalence of coronary artery disease. Women with hypoestrogenemia were more likely to experience adverse coronary arterial dysfunction, suggesting a higher mortality risk.
A Stanford study finds that medications for heart disease, including warfarin, beta blockers, and ACE inhibitors, are underused in outpatient settings. The researchers urge improved education, quality-improvement practices, and patient involvement to address this issue and reduce complications.
A recent study found that stent-assisted angioplasty reduced the need for repeat revascularization by 14% compared to CABG. Additionally, patients who received angioplasty experienced a lower risk of subsequent heart attack (5%) than those given CABG (8%).
The CYPHER Sirolimus-eluting Stent demonstrated significant reductions in angiographic in-stent restenosis (94% less than control) and late lumen loss. The stent also showed excellent safety results, with a low event-free survival rate and no cases of acute or subacute thrombosis.
Researchers at Duke University Medical Center have found that revascularization procedures can improve outcomes for lung transplant patients with severe coronary artery disease. The study analyzed 350 lung transplants and showed a 88% survival rate for patients who received combined heart bypass, lung transplant surgeries.
A new intracoronary gene therapy has shown promising results in treating stable angina, a condition affecting nearly 7 million people nationwide. The study, led by the University of Vermont, involved 79 patients and demonstrated improved exercise ability compared to placebo groups.
A Mayo Clinic study found that sildenafil does not worsen symptoms of inadequate blood supply to the heart muscle during exercise in men with coronary artery disease. The study, which involved 105 patients, suggests that sildenafil can be safely prescribed for these patients without increasing their risk of heart attacks.
A clinical trial of 109 patients found that coronary magnetic resonance angiography (MRA) accurately diagnosed coronary artery disease with an accuracy rate of 72% and specificity of 87%. The non-invasive test eliminates radiation exposure, infection risk, and hospital stay time, making it a promising diagnostic tool.
A study by Northwestern University researchers found that men who smoke are more likely to experience erectile dysfunction due to the negative effects of smoking on blood vessels. The prevalence of erectile dysfunction in former smokers was similar to that of never-smokers, highlighting the long-term risks of tobacco use.
Researchers used EBCT to screen coronary arteries for calcium deposits in former Kawasaki patients. Four out of 18 participants showed positive results, indicating moderate to high risk of coronary artery disease. The study suggests that EBCT can be an effective non-invasive screening method for detecting artery disease in these patients.
A new study by Johns Hopkins Medicine suggests that nitroglycerin relief does not accurately predict coronary artery disease, challenging the long-held assumption. The study found that only 28% of patients with heart disease experienced chest pain relief from nitroglycerin.
A UCSF study found that patients with substance abuse-related medical conditions benefit from integrated medical and addiction treatment, leading to improved abstinence rates and reduced inpatient use. The two-year study showed no significant differences in total abstinence rates between the integrated and independent care groups.
A study found that invasive management improves quality of life and reduces major adverse cardiac events in elderly patients with CAD. Patients aged 75 or older with chronic angina benefit from revascularisation procedures.
A Phase Ib clinical trial led by Duke University Medical Center cardiologists has cleared its first hurdle for a potential new treatment that prevents the formation of blood clots earlier than other agents. The drug inhibits Factor Xa, a pivotal clotting factor involved in blood clot formation.
Researchers analyzed data on over 1,200 cardiac patients and found that negative affect and hopelessness were strong predictors of survival. These symptoms were linked to a 40% increased risk of death compared to those with little negative affect.
A new blood marker, MIRF (Myocardial Ischemia Rating Function), has been found to be highly correlated with the incidence and severity of coronary artery disease. Combining this marker with age and gender can enhance disease predictability, allowing for a simple screening test.
A study by the American Heart Association found that individuals with heart attacks are more likely to have periodontal disease, a type of gum tissue inflammation. The researchers believe that high blood levels of C-reactive protein may be linked between the two conditions.
Researchers found that children with a parent who had a premature heart attack showed structural and functional abnormalities in their arteries as young as 6 years old. These changes included thickened vessel walls and decreased reactivity, which can lead to atherosclerosis and increase the risk of heart disease.
The NHLBI has launched a 10-year study to find new ways of detecting heart disease early, before symptoms appear. The $68 million Multi-Ethnic Study of Atherosclerosis (MESA) will collect data on various risk factors, including calcium deposits in coronary arteries and pulse waves at the radial artery.
A recent study review suggests that elderly smokers who quit can significantly reduce their risk of lung cancer, chronic obstructive pulmonary disease (COPD), and coronary artery disease. Additionally, quitting at an older age can still lead to improved life expectancy and a lower risk of smoking-induced mortality.
A study found that young women with heart disease experience worsening exercise performance and angina pain in the early follicular phase, just after menstruation, but improved performance and slower pain onset in mid-cycle. Sex hormones may play a role in these fluctuations.
Researchers from Penn University School of Medicine investigated the safety of Viagra in men with severe coronary artery disease. The study revealed no direct adverse cardiovascular effects from Viagra use, but a small beneficial effect on coronary blood flow reserve was observed.
A new study links high hostility levels to an increased risk of coronary artery calcification and heart disease in young adults. The researchers found that those with higher hostility scores were nearly 3 times more likely to develop coronary artery calcification than those with lower scores.
Patients awaiting coronary artery bypass grafting (CABG) in Ontario face higher mortality risk compared to the general population. However, a new study found that those on the waitlist may actually have similar or decreased vital risk when compared to patients living with coronary artery disease.
Despite evidence supporting aspirin's effectiveness in preventing future heart problems, low usage rates were found among patients with coronary artery disease. The study, published in Circulation: Journal of the American Heart Association, highlights the need for optimal use of life-saving medications.
A study found that women with unstable angina had significantly higher neopterin levels, indicating worsening of the condition. High neopterin levels were also seen in women with stable angina experiencing acute exacerbations, suggesting a potential marker for disease progression.
A new study published in the Archives of Internal Medicine found that treatment rates for patients with a history of heart disease were low, but women were disproportionately under-treated. Only 12% of women with high LDL levels achieved an acceptable level, compared to 31% of men.
A new scoring system used in treadmill testing has been found to improve the accuracy of diagnosing heart disease, with 77% accuracy overall compared to 69% for expert cardiologists. This method is more accurate than expensive diagnostic equipment and can provide a second opinion for physicians.
A study found that 15% of dental patients with periodontal disease have undiagnosed diabetes, while 56% have high cholesterol. The study highlights the importance of routine physical examinations and preventative care for patients with risk factors.
A new study suggests that estrogen supplementation in postmenopausal women may slow the progression of periodontal disease, protecting their teeth. The research found that estrogen deficiency and osteopenia/osteoporosis speed oral bone loss following menopause, leading to tooth loss.
The study found that aggressively lowering 'bad' cholesterol with atorvastatin reduced ischemic events by 36% compared to balloon angioplasty, delaying cardiac events in patients with stable coronary artery disease. Researchers concluded that this therapy is a safe and effective initial strategy for reducing ischemic events.
A new study by researchers from the University of Washington reveals that depression significantly impairs heart disease patients' ability to work and perform daily activities. Patients with both major and minor depression were found to function less well than nondepressed patients, reporting more heart disease symptoms.
A University of Pittsburgh team used electron beam computed tomography and carotid ultrasounds to assess heart disease in living people. They found that pre-menopausal risk factors such as smoking and low-density cholesterol strongly predict the development of coronary artery disease after menopause.
Researchers at the University of Pittsburgh found that HbA1 levels predict mortality from coronary artery disease in women with Type 1 diabetes. However, this association was not seen in men with the same condition. The study analyzed data from over 600 subjects and suggests a gender-specific link between hyperglycemia and CAD risk.
A new UCSF study reveals that women are as likely as men to agree to a doctor's recommendation for an invasive cardiac procedure after testing positive for heart disease. The study also found that men and women reported similar willingness to accept recommendations for coronary angioplasty or coronary artery bypass graft surgery.
Researchers suggest a clear connection between periodontal disease and cardiovascular disease, with bacteria and toxins traveling through the bloodstream. Periodontal bacteria contain lipopolysaccharides that can cause illness and damage blood vessel linings.
A lifetime of poor health can start with conditions in the womb, according to Cornell University researcher Peter W. Nathanielsz. He argues that adults may suffer diseases due to incompletely formed organs during vulnerable periods of development. The book emphasizes the importance of prenatal care and nutrition for future generations.
Researchers found that heart patients with high levels of social support show fewer symptoms of depression, while those with low social support tend to have higher levels of depression. Interventions that decrease hostility and increase social support may also benefit heart disease patients.
The Azithromycin and Cardiac Events Study (ACES) investigates the role of Chlamydia pneumoniae in atherosclerosis. Researchers aim to determine if antibiotics can prevent complications of coronary artery disease, enrolling approximately 4,000 volunteers.
The new guidelines provide recommendations for diagnosing and treating heart valve disease, covering common disorders such as mitral valve prolapse and aortic stenosis. It also addresses rare ailments, provides advice on evaluating and treating adults, teens, and pregnant women with defective valves.
A new study finds that Enhanced External Counterpulsation (EECP) is effective in reducing angina in individuals with coronary artery disease. EECP, a non-invasive therapy, has been proven to improve exercise tolerance and reduce angina attacks, offering relief for patients who suffer from this condition.
A Johns Hopkins study has found that depression is an independent risk factor for coronary artery disease in men, with those experiencing clinical depression twice as likely to develop the condition. Symptoms of CAD appeared on average 15 years after the first episode of depression.
A study by Cornell University Medical College researchers suggests that atherosclerosis and some forms of cancer may be linked to a single-cell mutation in the Type II TGF-beta receptor gene. This finding could provide new avenues for understanding cardiovascular disease progression and developing diagnostic and therapeutic strategies.
A new national health database allows researchers to measure the long-term benefits of biomedical research on the entire US population. The database, created using data from National Long Term Care Surveys, shows significant declines in chronic disability and institutionalization among older Americans.
Two Duke University studies suggest that diabetics with severe coronary artery disease do equally well if they receive either angioplasty or coronary artery bypass surgery. The studies recommend considering factors other than diabetes when choosing a treatment.
A study by Johns Hopkins Medicine reveals that boosting production of the molecule arginine can restore normal blood vessel responses in people with coronary artery disease. By increasing nitric oxide production, researchers were able to improve blood flow and reduce the risk of ischemia and heart attack.