Articles tagged with Fatty Liver Disease
Researchers found that microcystin can significantly amplify non-alcoholic fatty liver disease even at low levels. The toxin was processed differently in the kidneys of mice with pre-existing liver disease, suggesting a need for special preventative guidelines.
Researchers discovered that a common type of gut bacteria, Klebsiella pneumoniae, produces high levels of alcohol in the body and can cause liver damage even in non-drinkers. The study found that 60% of patients with non-alcoholic fatty liver disease (NAFLD) had high- and medium-alcohol-producing K. pneumonia in their gut.
Researchers at Massachusetts General Hospital developed a lab-on-a-chip platform to study non-alcoholic fatty liver disease (NAFLD) progression. The platform allows for detailed studies of NAFLD's effects on liver cells and evaluates the potential of investigational drugs.
Researchers from The Westmead Institute for Medical Research have discovered how fatty liver disease develops in lean people. Lean patients tend to have worse outcomes due to an 'obesity-resistant' profile, despite having higher levels of bile acids and FGF19, which increase energy expenditure.
Researchers at the University of Pittsburgh School of Medicine have successfully grown genetically modified miniature human livers in a laboratory setting. These mini livers mimic non-alcoholic fatty liver disease progression and can be used to test therapeutics, providing a valuable tool for understanding and treating diseases.
Research from the University of Sydney found that electric fans lowered core temperature and cardiovascular strain in hot, humid conditions, but were detrimental in very hot, dry conditions. The study highlights the limitations of using heat index values to recommend fan use during heat waves.
Michelle Long, MD, MSc, assistant professor of medicine at Boston University School of Medicine, has been awarded a three-year, $495,000 Doris Duke Clinical Scientist Development Award to investigate the relationship between physical activity and NAFLD. The study aims to identify biomarkers of early disease and risk for progression.
A study by Clemson researchers found that the Cyp2b gene is associated with obesity and fatty liver disease in male mice, regardless of diet. The discovery suggests that enzymes involved in detoxification may play a role beyond diet and exercise in weight management and metabolic health.
A new blood test shows promise in replacing liver biopsies for children with Non-Alcoholic Fatty Liver Disease (NAFLD), a condition affecting one in 10 children. The test detects different types of fats in the blood, indicating inflammation and scarring.
Researchers at Cincinnati Children's Hospital Medical Center develop human liver organoids that accurately mimic key features of fatal liver diseases. The study reveals molecular secrets of deadly ailments and tests a potential therapy for Wolman disease, reversing an often-fatal childhood condition.
Researchers at Duke-NUS Medical School and NHCS found that deactivating IL11 with therapeutic antibodies reverses inflammation and scarring in patients with non-alcoholic steatohepatitis (NASH). This breakthrough has implications for the development of drugs to treat NASH, a common condition affecting millions worldwide.
A 30-day Ramadan fast has shown promising implications for timing and duration between meals, increasing proteins that play a crucial role in improving insulin resistance. The study suggests dawn-to-sunset fasting could provide a cost-effective intervention for those struggling with obesity-related conditions.
A study of 18 million people across Europe found that people with type 2 diabetes are at particular risk of non-alcoholic fatty liver disease (NAFLD) and its aggressive form NASH. The study suggests that targeted interventions and treatments can be effective in preventing life-threatening disease progression.
A recent study published in Clinical Gastroenterology and Hepatology found a significant association between glyphosate exposure and nonalcoholic fatty liver disease (NAFLD) in human subjects. The study, led by Paul J. Mills, PhD, examined urine samples from patients with NAFLD and healthy individuals, revealing higher levels of glypho...
Researchers found a connection between intrahepatic cholestasis of pregnancy and non-alcoholic fatty liver disease, suggesting impaired bile acid metabolism as a potential link. Women with ICP were 5.7 times more likely to have a diagnosis of fatty liver disease than controls.
A study examining national survey data found that approximately 10.9 million Americans have alcoholic fatty liver disease, highlighting the need for awareness and prevention efforts. The study's findings also suggest a significant association between heavy drinking and the development of this condition.
A team at IRB Barcelona has identified Mitofusin 2 as a protein that protects against non-alcoholic fatty liver disease. Early diagnosis and treatment options for this condition are limited, but researchers hope to enhance levels of Mitofusin 2 without side effects.
A study published in the journal Obesity found that nonhuman primates on a Mediterranean diet ate fewer calories, had lower body weight, and less body fat compared to those on a Western diet. The findings suggest that a Mediterranean diet may protect against obesity-related diseases.
A study of over 4,000 young adults in the UK found that nearly 20% had nonalcoholic fatty liver disease, and one in 40 had advanced fibrosis. The condition is linked to obesity, diabetes, and hyperlipidaemia, highlighting the need for greater public health awareness.
Two studies presented at The International Liver Congress highlight the increasing burden of non-alcoholic fatty liver disease (NAFLD) in people with HIV infection, leading to a risk of progressive liver disease. NAFLD prevalence is higher in HIV-infected individuals than the general population.
Two independent studies found high rates of liver disease progression and mortality among patients with non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH), highlighting the importance of early detection and treatment to prevent progression and reduce mortality. Advanced liver diseases progressed in up to 11% o...
A new molecule, EPB-53, has been discovered to increase FGF21 levels in the liver and plasma through oral administration. This could lead to new therapeutic strategies for treating type 2 diabetes and non-alcoholic fatty liver disease.
A new study has uncovered important differences in the biological pathways that lead to cancer for alcoholic fatty liver disease compared to non-alcoholic fatty liver disease. The findings could benefit the more than 3 million people diagnosed with fatty liver disease each year, potentially leading to new cancer prevention strategies.
Scientists found that platelets play a key role in the development of fatty liver disease and liver cancer. Blocking platelet function or attaching to specific molecular sites may help prevent the condition.
Researchers at UC San Diego identified unique bacterial features in the stool of people with nonalcoholic fatty liver disease and their twins, allowing for 92% accurate diagnosis of liver cirrhosis. The test also showed promise in detecting previously undiagnosed cases with 87% accuracy.
Researchers discovered a novel molecular pathway for PAI-1 inhibition that reversed diet-induced obesity and its related health problems in mice. The investigational drug TM5614 showed significantly improved fasting levels of blood sugar, insulin, and LDL cholesterol, as well as a reduction in fatty liver disease.
Researchers have identified six proteins associated with early-stage non-alcoholic fatty liver disease (NAFLD), a condition that can progress to end-stage liver cirrhosis. The discovery of protein PIGR as a candidate biomarker for liver damage tests offers a promising new diagnostic tool.
A team of researchers has identified biomarkers in the blood that can predict the accumulation of toxic fats in the liver, a sign of early fatty liver disease. The discovery has the potential to lead to a blood test to detect those at risk of advanced fatty liver disease and could represent a new approach in precision medicine.
Researchers discovered 27 new molecules with significant therapeutic potential for treating fatty liver disease and obesity by activating the PPAR-delta protein. These molecules are currently undergoing pharmaceutical evaluations and show promise in improving physical endurance and reducing waistlines.
Researchers found that a low-sugar diet resulted in significant improvement in nonalcoholic fatty liver disease (NAFLD) in adolescent boys. The study showed a 31% reduction in liver fat in the low-free sugar diet group compared to the typical diet group.
A randomized clinical study found that a diet low in free sugars significantly improved nonalcoholic fatty liver disease (NAFLD) in adolescent boys. The study showed a reduction in NAFLD from 25% to 17% in the intervention group, compared to a 20% reduction in the usual diet group.
Researchers have developed a new model to study the health effects of metabolic protein AMPK, revealing its potential as a treatment for nonalcoholic fatty liver disease and other diseases. By activating AMPK in mice with fatty liver disease, scientists found that it lowered liver fat and protected against weight gain and obesity.
Research suggests that PCSK9 inhibitors can protect against NAFLD by inducing degradation of hepatic HNF1a protein, insulin resistance, and other mechanisms. The use of PCSK9 inhibitors also ameliorates NAFLD independently of low-density lipoprotein cholesterol level reduction.
A new study by USC researchers reveals that a fatty diet can trigger changes in the immune system leading to non-alcoholic steatohepatitis (NASH), a serious form of non-alcoholic fatty liver disease. The study identified a novel type of reparative macrophage that counteracts inflammation, offering potential pathways for future therapies.
Researchers at the University of Minnesota Medical School have made a groundbreaking discovery about how liver cell communication affects disease progression. By studying the dialogue between hepatocytes and macrophages, they found that a specific ketone body metabolite helps protect against tissue fibrosis in non-alcoholic fatty liver...
Researchers at CU Anschutz Medical Campus discover that infant gut microbes altered by maternal obesity increase the risk of obesity and non-alcoholic fatty liver disease later in life. The study suggests that altering the microbiome through probiotics or supplements may help reduce this risk.
Researchers from George Washington University aim to understand the role of brain endoplasmic reticulum stress in the development of non-alcoholic fatty liver disease. The study, funded by $2.4 million from the National Institutes of Health, will examine the link between ER stress and transcription factor activation in NAFLD development.
Researchers found three genetic variations linked to increased liver fat, which could lead to new treatment options for non-alcoholic fatty liver disease (NAFLD). The study, led by Westmead Institute for Medical Research, identified the mechanisms behind hepatic steatosis, a major risk factor for NAFLD.
Researchers discovered that breastfeeding for over six months lowers the risk of non-alcoholic fatty liver disease (NAFLD) in mothers. Women who breastfed one or more children for longer periods had a lower risk compared to those who did not breastfeed or breastfed for under one month.
Researchers identified Sav1, a component of the Hippo pathway, as a key mutated gene in fatty liver-associated liver cancer. This discovery may lead to new liver cancer treatments targeting the Hippo pathway.
Patients with non-alcoholic fatty liver disease (NAFLD) who consume moderate amounts of alcohol have a 36% decreased risk of early death, while heavy drinking increases the risk by 45%. The study suggests that moderate drinking may be beneficial for these patients.
A new study found that a web-based intervention is an effective approach to manage lifestyle changes in patients with NAFLD, reducing weight, and improving dietary intake. The web-based program was compared to group counseling and showed similar effectiveness after two years.
A new six-year single-center study found a web-based program to be an effective approach to manage lifestyle changes in patients with NAFLD, comparable to group-based interventions. The web program reduced weight loss and improved liver health, suggesting counseling as a key therapeutic option until drugs are approved.
Two recent studies reveal that mitochondrial proteins are broken down more quickly in fatty liver cells, reducing their activity. Meanwhile, liver cells with fatty liver disease show signs of overworking, using triglycerides instead of glucose to make energy and increasing reactive oxygen byproducts, which can damage proteins.
Researchers identified caspase-2 as a critical driver of non-alcoholic steatohepatitis (NASH), a chronic and aggressive liver condition. The study found that an inhibitor of caspase-2 could provide an effective way to treat or prevent NASH, possibly even reversing early symptoms.
A new test predicts advanced fibrosis in NAFLD patients, accurately identifying 92% of those at risk. The tool uses the PRO-C3 biological marker and combines it with clinical information for highly accurate results.
Fatty liver disease is a complex condition that can lead to severe complications like type 2 diabetes and cardiovascular disease. A new review article proposes the use of new diagnostic and therapeutic approaches to enable specific risk prognosis and individualized treatment.
A TGen-led study has found a link between DNA methylation and non-alcoholic fatty liver disease (NAFLD) in obese patients. The research identified four genes that may represent potential targets for new therapeutics.
Nonalcoholic fatty liver disease (NAFLD) has a significant impact on the US healthcare system, with estimated annual costs of $32 billion. The prevalence of NAFLD mirrors the rising trend of obesity in the United States, affecting roughly 100 million Americans.
Researchers identified a compound called phenylacetic acid (PAA) produced by gut bacteria linked to the early onset of Non-Alcoholic Fatty Liver Disease (NAFLD). The study suggests PAA could be used as a biological marker in the clinic to identify patients at increased risk of disease.
Researchers identified plasma lipid species as signatures of healthy or unhealthy metabolic states, including fatty liver disease. They also pinpointed genetic regulators of lipid species and their physiological functions using systems genetics approaches.
Scientists at the University of Edinburgh have developed a lab-based system for studying Non-Alcoholic Fatty Liver Disease (NAFLD), the most common cause of liver disease in the developed world. The new tool enables researchers to investigate biological mechanisms and develop effective treatments.
A recent study found that UK children with non-alcoholic fatty liver disease have insufficient vitamin D levels throughout the year, particularly during winter months. Genetic variations in the vitamin D metabolic pathway are also associated with increased liver fat and inflammation.
Researchers identified two tryptophan metabolites produced by gut bacteria that modulate inflammation, potentially reducing the severity of non-alcoholic fatty liver disease. The study found that these metabolites reduce cytokine levels and macrophage activity, which are key contributors to inflammation.
Researchers at Bar-Ilan University have identified a family of indoline compounds with potent activity against pro-inflammatory cytokines and ROS toxicity. These novel substances show promise in treating acute pancreatic inflammation, fatty liver damage, and diabetes.
Patients with NAFLD achieved similar weight loss and normalized liver enzymes through a web-based lifestyle modification programme. The study suggested that the degree of weight loss was likely to have resulted in fibrosis regression.
A new study has reported a good correlation between an automated image analysis system and an expert reviewer for the identification of key markers of NASH disease activity in a pre-clinical model. The study used deep-learning algorithms applied to open-source pathology software (QuPath1) to accurately identify cell histology patterns ...
A study analyzed outcomes and costs for German patients with NAFLD/NASH who developed compensated cirrhosis, finding significant increases in comorbidities, mortality, and healthcare costs. The study highlights the need for new treatment options to improve patient outcomes.
A new study published in the Journal of Pediatrics found that children as young as 8 years old with obesity are at risk for nonalcoholic fatty liver disease. Elevated waist circumference at age 3 and increased weight gain between ages 3 and 8 are associated with higher levels of a liver enzyme called ALT.
Research found that women with PCOS are two to three times more likely to develop non-alcoholic fatty liver disease, regardless of their weight. High testosterone levels also increase the risk, even in normal-weight women.