Researchers from Tianjin Medical University General Hospital review sarcopenic obesity's impact on liver disease, including nonalcoholic fatty liver disease and cirrhosis. The study aims to clarify the pathogenesis of sarcopenic obesity and identify potential therapeutic avenues.
SourceCactus Communications·JournalPortal Hypertension & Cirrhosis·TypeLiterature review·DateJul 6, 2022
A comprehensive study found that prenatal exposure to endocrine-disrupting chemicals is associated with non-alcoholic fatty liver disease in children. The researchers measured 45 chemicals in pregnant women and found elevated levels of biomarkers indicating risk for liver disease in children who were more highly exposed.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalJAMA Network Open·DateJul 6, 2022
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
A new method using ethyl glucuronide in hair and urine has improved the diagnosis of fatty liver disease, revealing a high rate of harmful alcohol consumption in patients with presumed non-alcoholic fatty liver disease. The study found that about 30% of patients were at risk of alcohol-related liver damage.
SourceMedical University of Vienna·JournalJournal of Hepatology·DateJul 5, 2022
Researchers found multiple gene variants contributing to pediatric NAFLD risk and disease severity, including novel SNPs associated with liver fibrosis. These genetic associations may guide future therapeutics for pediatric NAFLD, a chronic childhood disease linked to increased cardiovascular risk and mortality.
SourceUniversity of California - San Diego·JournalHepatology·DateJun 27, 2022
A MedUni Vienna study team has identified a specific subtype of macrophages as a protective function against fibrosis in non-alcoholic fatty liver disease. TREM2-positive macrophages have been shown to prevent fat accumulation, inflammatory processes and progression to liver fibrosis.
SourceMedical University of Vienna·JournalJournal of Hepatology·DateJun 21, 2022
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A study found that COVID-19 leads to progressive cholestasis, cholestatic liver failure, and secondary sclerosing cholangitis in 15% of patients with pre-existing liver disease. These patients often require intensive care and may experience irreversible bile duct damage.
SourceMedical University of Vienna·JournalHepatology·DateJun 15, 2022
A new study found that growth hormone reduces liver fat and inflammation in patients with nonalcoholic fatty liver disease, improving liver function tests and markers of inflammation. The study showed significant improvements in liver health after administering growth hormone to 41 participants for 6 months.
A new study has found that nonalcoholic fatty liver disease (NAFLD) in children significantly increases the risk of developing type 2 diabetes. The study, published in Clinical Gastroenterology and Hepatology, revealed that among 892 children with NAFLD, 6.6% developed type 2 diabetes, with the incidence rate rising by 3% annually.
SourceUniversity of California - San Diego·JournalClinical Gastroenterology and Hepatology·DateJun 13, 2022
Scientists at CNIC discovered a complex network between liver tissue connections that allows the liver to regulate body temperature. The secretion of IL-12 by liver-infiltrating macrophages blocks FGF21 production, reducing heat generation by brown fat in mice.
SourceCentro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)·JournalHepatology·TypeExperimental study·DateJun 13, 2022
Research suggests that high fructose consumption is associated with a higher chance of developing non-alcoholic fatty liver disease (NAFLD), especially among Mexican Americans and non-Hispanic Blacks. The study analyzed data from over 3,200 participants and found that those consuming the highest amount of fructose were at greatest risk.
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GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
Researchers developed a machine learning model to predict NAFLD development based on gut microbiome data, showing 90% of subjects who developed the disease had subtle differences in their samples. The model combines easily measurable information from blood and microbiome data with high accuracy.
SourceLeibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute -·JournalScience Translational Medicine·TypeComputational simulation/modeling·DateJun 9, 2022
The primary causes of liver cancer are changing globally, with advances in hepatitis B vaccinations and antiviral therapies reducing HBV-associated liver cancer. However, alcohol consumption and obesity are rising, leading to increased liver cancer deaths. The incidence of NASH is projected to increase further due to rising obesity rates.
SourceUniversity of California - San Diego·JournalCell Metabolism·DateJun 6, 2022
A new review analyzes the efficacy of current non-invasive methods for assessing non-alcoholic fatty liver disease (NAFLD) and associated conditions. Blood-based biomarker tests and imaging methods are explored, with some showing promise in early diagnosis and staging liver disorders.
SourceCactus Communications·JournalChinese Medical Journal·TypeLiterature review·DateJun 2, 2022
Researchers from NTU and NUS found a link between NAFLD and blood vessel damage, leading to increased risks of cardiovascular diseases. High levels of chemokines attract immune cells into blood vessels, causing inflammation and damage.
SourceNanyang Technological University·JournalEMBO Reports·DateMay 25, 2022
Researchers discovered that lean individuals with non-alcoholic fatty liver disease (NAFLD) are at a higher risk of developing cardiovascular diseases compared to those who are overweight or obese. Despite lower rates of other health conditions, lean patients with NAFLD exhibited increased prevalence of cardiovascular disease.
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A new review highlights the risks of fatty liver disease caused by metabolic dysfunction, characterized by fat accumulation in liver cells and oxidative stress. The progression of the disease can lead to inflammation, fibrosis, and cirrhosis with a high risk of hepatocellular carcinoma.
SourceCactus Communications·JournalChinese Medical Journal·TypeLiterature review·DateMay 19, 2022
A new study found that lean individuals with non-alcoholic fatty liver disease (NAFLD) have a higher prevalence of cardiovascular disease compared to those who are overweight or obese. Despite having lower risks for other metabolic and cardiovascular conditions, lean patients with NAFLD were more likely to develop cardiovascular disease.
SourceAmerican Gastroenterological Association·DateMay 13, 2022
A study led by the University of Barcelona found that 69% of patients with non-alcoholic fatty liver disease perceive stigmatization in their daily lives, affecting stereotypes, discrimination, shame, and social isolation. The perceived stigma is associated with impaired quality of life and can lead to human and social rights issues.
SourceUniversity of Barcelona·JournalPLOS ONE·TypeObservational study·DateMay 12, 2022
Researchers investigate how enzymes regulate metabolism, weight gain, and liver disease, revealing diet's significant role in obesity and altered lipid profiles. The study also shows that age affects metabolic processes, leading to weight gain, increased fat storage, and unhealthy liver changes.
SourceClemson University·JournalJournal of Lipids·TypeExperimental study·DateMay 11, 2022
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Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
A new study published in Scientific Reports reveals that regular high-intensity interval training exercise can significantly decrease fasting glucose levels and waist circumference, while improving oxygen consumption rates in patients with non-alcoholic fatty liver disease. Exercise also modifies amino acid metabolism in adipose tissue...
SourceUniversity of Eastern Finland·JournalScientific Reports·DateMay 3, 2022
A new study systematically reviews data on PFAS exposure and liver damage, linking three commonly detected PFAS to elevated levels of a liver enzyme, ALT. The research suggests a potential link between PFAS and non-alcoholic fatty liver disease (NAFLD), a growing public health crisis affecting 25% of adults worldwide.
SourceKeck School of Medicine of USC·JournalEnvironmental Health Perspectives·TypeMeta-analysis·DateApr 27, 2022
Non-alcoholic fatty liver disease (NAFLD) is a common condition that can lead to chronic liver damage and cardiovascular disease. Early diagnosis and treatment are crucial, as lifestyle changes can help prevent or reverse the condition.
SourceAmerican Heart Association·JournalArteriosclerosis Thrombosis and Vascular Biology·DateApr 14, 2022
A modified version of the hormone kisspeptin has been shown to protect against the development of fat in the liver and reduce inflammation and fibrosis in a mouse model. This could potentially favorably impact the health and lives of millions of patients around the globe.
SourceRutgers University·JournalJournal of Clinical Investigation·DateApr 7, 2022
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Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
A breakthrough discovery has identified a novel approach to tackle metabolic diseases by inhibiting a liver enzyme that regulates appetite and energy expenditure. The treatment, which stabilizes key proteins in the blood, resulted in significant weight loss and improved insulin sensitivity in obese mice.
SourceUniversity of Texas Health Science Center at San Antonio·JournalCell Metabolism·TypeExperimental study·DateApr 5, 2022
A preclinical study found that mice fed a high-fat diet and given the mineral supplement Aquamin did not develop liver cancer, unlike those without the supplement. The researchers observed a dramatic reduction in late-stage consequences of non-alcoholic steatohepatitis (NASH) in animals receiving the supplement.
A retrospective study found that cases of metabolic dysfunction-associated fatty liver disease increased since before the COVID-19 pandemic. Late-night meals and higher alcohol intake were identified as independent predictors of developing MAFLD, especially among working-age individuals.
SourceOsaka City University·JournalLiver International·TypeMeta-analysis·DateMar 24, 2022
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GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
Even normal weight individuals are susceptible to severe fatty liver disease due to various risk factors including diet, genetics, and ethnicity. Nonalcoholic fatty liver disease can progress to nonalcoholic steatohepatitis and cirrhosis if left undiagnosed or untreated.
SourceThe Translational Genomics Research Institute·JournalDiabetology & Metabolic Syndrome·TypeLiterature review·DateMar 24, 2022
Researchers identified three NAFLD subtypes with unique lipidomic profiles and varying cardiovascular disease risk. Subtype A shows a lower CVD risk profile, differing from other subtypes, which may explain variation in hepatic versus cardiovascular outcomes.
Researchers found that female mice produce more of the FPR2 protein, which helps prevent NAFLD, and that estrogen mediates its production. This discovery highlights the need for sex-balanced animal experiments and could lead to novel treatments and gender-based therapies for NASH
SourcePusan National University·JournalNature Communications·TypeExperimental study·DateMar 17, 2022
A new study reveals that liquid fructose intake, even in high-fat diets, can accelerate liver fat accumulation and hypertriglyceridemia. The study found that fructose induces an increase in the synthesis of fatty acids in the liver and inhibits lipid oxidation, leading to the emergence of non-alcoholic fatty liver disease (NAFLD).
SourceUniversity of Barcelona·JournalMolecular Nutrition & Food Research·TypeExperimental study·DateMar 4, 2022
Researchers found that long or irregular menstrual cycles in young women are associated with an increased risk of nonalcoholic fatty liver disease (NAFLD). NAFLD is a chronic condition where excess fat builds up in the liver, increasing the risk of death. Lifestyle changes can help reduce the risk of NAFLD in these women.
SourceThe Endocrine Society·JournalThe Journal of Clinical Endocrinology & Metabolism·DateMar 3, 2022
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
Research by the University of Queensland found that male livers with hepatic diseases undergo a sex change as part of a self-protective mechanism. The study suggests that this transformation may be driven by the female hormone oestrogen, which helps to slow down disease progression.
SourceUniversity of Queensland·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateFeb 21, 2022
NAFLD and diabetes are linked through subclinical inflammation, insulin resistance, and dysregulated liver-derived proteins. Integrating knowledge from childhood to older age can help personalize prevention and treatment.
SourceDeutsches Zentrum fuer Diabetesforschung DZD·JournalThe Lancet·TypeLiterature review·DateFeb 18, 2022
A nationwide study in Germany found that liver cirrhosis has the highest mortality rate among chronic diseases, with 0.94% of hospital admissions affected. The study also showed a decline in mortality rates due to improvements in Hepatitis C treatment, but an increase in non-alcoholic fatty liver disease cases.
SourceGoethe University Frankfurt·JournalThe Lancet Regional Health - Europe·TypeObservational study·DateFeb 11, 2022
A comprehensive review highlights recently discovered associations between lncRNAs and specific diseases, including fatty liver disease and liver cancer. The study suggests that a diverse group of molecules known as long noncoding RNAs could emerge as biomarkers for liver disease.
SourceThe Translational Genomics Research Institute·JournalAnnual Review of Pathology Mechanisms of Disease·TypeLiterature review·DateFeb 8, 2022
Research found that mothers with metabolic syndrome can switch on an imprinted gene in their mice offspring, leading to liver disease. The study suggests a key role for imprinted genes in the development of non-alcoholic fatty liver disease (NAFLD).
SourceNorth Carolina State University·JournalHepatology·TypeExperimental study·DateFeb 7, 2022
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
A new Chinese Medical Journal study explores the risks of non-alcoholic steatohepatitis (NASH) turning into liver cancer. Early detection through simple medication and lifestyle changes can prevent NAFLD from progressing to more severe conditions, such as cirrhosis and hepatocellular carcinoma.
SourceCactus Communications·JournalChinese Medical Journal·TypeLiterature review·DateFeb 2, 2022
Researchers found that alterations in the RNF43 and ZNRF3 genes lead to an accumulation of lipids and inflammation in the liver, increasing the risk of developing non-alcoholic steatohepatitis (NASH) and fatty liver disease. These genetic changes also affect liver cell proliferation, contributing to the progression of liver diseases.
SourceMax Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)·JournalNature Communications·TypeExperimental study·DateJan 17, 2022
A study by Kanazawa University researchers found that the chemokine CCL3 plays a significant role in inducing inflammation as nonalcoholic fatty liver disease develops. The presence of CCL3 increased liver macrophage accumulation, leading to liver inflammation and scarring.
SourceKanazawa University·JournalMetabolism·DateDec 26, 2021
Exercise modifies the adaptation of the liver to increased energy intake, regulating enzymes for glucose and fructose degradation. Regular physical activity also improves glucose control and reduces fat storage in the liver, offering a comprehensive insight into molecular adaptations to high-energy diets.
SourceDeutsches Zentrum fuer Diabetesforschung DZD·JournalMolecular Metabolism·DateDec 20, 2021
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Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
A new study by Keck Medicine of USC found that food insecurity increases the risk of death among patients with nonalcoholic fatty liver disease and advanced liver disease. The study, which analyzed data from over 34,000 individuals, suggests that eradicating food insecurity could eliminate up to 7% of nonalcoholic fatty liver disease d...
SourceUniversity of Southern California - Health Sciences·JournalClinical Gastroenterology and Hepatology·TypeData/statistical analysis·DateDec 16, 2021
Scientists at Kumamoto University have developed a novel peptide vaccine that improves obesity-related dyslipidemia and may be cost-effective. The vaccine targets angiopoietin-like protein 3 (ANGPTL3) and has been shown to reduce dyslipidemia in mice, producing antibodies that last for six months.
SourceKumamoto University·JournalCell Reports Medicine·TypeExperimental study·DateDec 13, 2021
A large-scale epidemiologic study in China identified links between long-term exposure to ambient air pollution and metabolic-associated fatty liver disease (MAFLD). Long-term exposure to air pollution may increase the risk of MAFLD, especially in individuals with unhealthy lifestyles and central obesity.
SourceElsevier·JournalJournal of Hepatology·TypeData/statistical analysis·DateDec 6, 2021
A team of researchers at UC Davis Health has developed a novel PET imaging-based tool to detect liver inflammation in non-alcoholic fatty liver disease. The tool uses dynamic PET imaging and mathematical modeling to measure glucose transport from blood to liver tissue, allowing clinicians to quantify liver inflammation.
SourceUniversity of California - Davis Health·JournalClinical Gastroenterology and Hepatology·DateNov 30, 2021
Researchers found that video-based, telehealth-delivered exercise and weight loss programs improved pain and function in people with knee osteoarthritis and overweight or obesity. The intervention with dietary component led to substantial weight loss and additional benefits.
SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeRandomized controlled/clinical trial·DateNov 29, 2021
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Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
A study found that D-glyceric acid treatment improved metabolism, blood parameters, and reduced low-grade inflammation in healthy volunteers aged 50-60 years. The compound's activation of mitochondrial metabolism may help interrupt the spiral of persistent systemic inflammation and improve liver function.
SourceUniversity of Jyväskylä - Jyväskylän yliopisto·JournalFrontiers in Aging·DateNov 15, 2021
Researchers found that albino mice with a mutated tyrosinase gene are more susceptible to non-alcoholic steatohepatitis (NASH) than black mice. This study provides new insights into the genetic factors contributing to NASH and its progression.
SourceUniversity of Tsukuba·JournalScientific Reports·DateNov 10, 2021
Researchers have identified a novel estrogen compound that provides benefits similar to hormone replacement therapy but without the risk factors associated with it. The compound has been shown to reduce excess lipid deposition in the liver and prevent the progression of fibrosis, which can lead to liver failure and metabolic problems.
SourceUniversity of Illinois College of Agricultural, Consumer and Environmental Sciences·JournalNutrients·TypeExperimental study·DateOct 28, 2021
A VCU study found that people with advanced liver scarring caused by obesity and diabetes are dying from liver disease, underscoring the need for new treatments. The research provides a roadmap for future therapies to prevent liver transplants and save lives.
SourceVirginia Commonwealth University·JournalNew England Journal of Medicine·TypeObservational study·DateOct 20, 2021
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Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
Researchers identified five genes mutated in people with liver disease, affecting insulin sensitivity and fat metabolism. These mutations reduce the liver's ability to respond to dietary sugars and fats.
SourceWellcome Trust Sanger Institute·JournalNature·DateOct 13, 2021
A new center will address individual, familial, societal and environmental factors contributing to health disparities in the Latino/a/x community. The center will support research projects and interventions aimed at reducing obesity and chronic disease risk in Latino/a/x families.
A multidisciplinary taskforce developed a Clinical Care Pathway for NAFLD/NASH, outlining practical guidance from screening to patient care management. The pathway aims to provide efficient, safe, and value-based care for patients with NAFLD and NASH, highlighting the importance of early interventions and shared decision-making.
SourceAmerican Gastroenterological Association·JournalGastroenterology·DateOct 1, 2021
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
A new study found that every extra 1cm in waist circumference increases the odds of advanced fibrosis by 5% in people with type 2 diabetes. Advanced fibrosis is a late stage of non-alcoholic fatty liver disease (NAFLD), which can lead to serious liver damage.
Researchers found that DNA methylation patterns at specific genomic sites correlated with levels of fibrosis in non-alcoholic fatty liver disease (NAFLD). The study suggests that these patterns could be used to diagnose the severity of this condition, potentially leading to earlier treatment and improved outcomes.
SourceThe Translational Genomics Research Institute·JournalClinical Epigenetics·DateSep 20, 2021
A 34-year follow-up study found that the coexistence of hypertension and fatty liver disease did not exceed their separate effects on mortality. The study suggests a negative interaction between the two conditions on cardiovascular death in non-diabetic men.
SourceUniversity of Eastern Finland·JournalScandinavian Journal of Gastroenterology·DateSep 8, 2021
A comprehensive review reveals how excessive fructose intake can disrupt metabolic pathways, leading to diseases such as diabetes, fatty liver disease, and heart disease. The study highlights the role of protein transporters, gluconeogenesis, and gene-level changes in regulating fructose metabolism.
SourceCactus Communications·JournalChinese Medical Journal·TypeLiterature review·DateAug 30, 2021
A new study by Salk scientists found that time-restricted eating (TRE) confers multiple health benefits, including reduced risk of type 2 diabetes, fatty liver disease, and sepsis, regardless of age and sex. TRE may also protect against infectious diseases like COVID-19 and improve insulin resistance.
SourceSalk Institute·JournalCell Reports·TypeExperimental study·DateAug 17, 2021
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Researchers at Skoltech have discovered structures called apical bulkheads in liver cells that are responsible for the narrow shape of bile canaliculi. The discovery reveals a key role for the Rab35 protein in regulating hepatocyte lumina formation and suggests potential avenues for medical applications in fatty liver disease and fibrosis
SourceSkolkovo Institute of Science and Technology (Skoltech)·JournalJournal of Cell Biology·TypeExperimental study·DateAug 3, 2021
Researchers linked World Trade Center dust exposure to increased risk of liver disease in responders. Analysis of lung scans found evidence of hepatic steatosis, a condition associated with chemical exposures.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalAmerican Journal of Industrial Medicine·DateJul 30, 2021
Patients with obesity or type 2 diabetes are at a higher risk of developing NAFLD and NASH. Effective screening, diagnosis, and treatment strategies are urgently needed for this growing population.
SourceAmerican Gastroenterological Association·JournalGASTROENTEROLOGY·DateJul 26, 2021
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Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.