Articles tagged with Fatty Liver Disease
A new review highlights the risks of fatty liver disease caused by metabolic dysfunction, characterized by fat accumulation in liver cells and oxidative stress. The progression of the disease can lead to inflammation, fibrosis, and cirrhosis with a high risk of hepatocellular carcinoma.
A new study found that lean individuals with non-alcoholic fatty liver disease (NAFLD) have a higher prevalence of cardiovascular disease compared to those who are overweight or obese. Despite having lower risks for other metabolic and cardiovascular conditions, lean patients with NAFLD were more likely to develop cardiovascular disease.
A study led by the University of Barcelona found that 69% of patients with non-alcoholic fatty liver disease perceive stigmatization in their daily lives, affecting stereotypes, discrimination, shame, and social isolation. The perceived stigma is associated with impaired quality of life and can lead to human and social rights issues.
Researchers investigate how enzymes regulate metabolism, weight gain, and liver disease, revealing diet's significant role in obesity and altered lipid profiles. The study also shows that age affects metabolic processes, leading to weight gain, increased fat storage, and unhealthy liver changes.
A new study published in Scientific Reports reveals that regular high-intensity interval training exercise can significantly decrease fasting glucose levels and waist circumference, while improving oxygen consumption rates in patients with non-alcoholic fatty liver disease. Exercise also modifies amino acid metabolism in adipose tissue...
A new study systematically reviews data on PFAS exposure and liver damage, linking three commonly detected PFAS to elevated levels of a liver enzyme, ALT. The research suggests a potential link between PFAS and non-alcoholic fatty liver disease (NAFLD), a growing public health crisis affecting 25% of adults worldwide.
Non-alcoholic fatty liver disease (NAFLD) is a common condition that can lead to chronic liver damage and cardiovascular disease. Early diagnosis and treatment are crucial, as lifestyle changes can help prevent or reverse the condition.
A modified version of the hormone kisspeptin has been shown to protect against the development of fat in the liver and reduce inflammation and fibrosis in a mouse model. This could potentially favorably impact the health and lives of millions of patients around the globe.
A breakthrough discovery has identified a novel approach to tackle metabolic diseases by inhibiting a liver enzyme that regulates appetite and energy expenditure. The treatment, which stabilizes key proteins in the blood, resulted in significant weight loss and improved insulin sensitivity in obese mice.
A preclinical study found that mice fed a high-fat diet and given the mineral supplement Aquamin did not develop liver cancer, unlike those without the supplement. The researchers observed a dramatic reduction in late-stage consequences of non-alcoholic steatohepatitis (NASH) in animals receiving the supplement.
Even normal weight individuals are susceptible to severe fatty liver disease due to various risk factors including diet, genetics, and ethnicity. Nonalcoholic fatty liver disease can progress to nonalcoholic steatohepatitis and cirrhosis if left undiagnosed or untreated.
A retrospective study found that cases of metabolic dysfunction-associated fatty liver disease increased since before the COVID-19 pandemic. Late-night meals and higher alcohol intake were identified as independent predictors of developing MAFLD, especially among working-age individuals.
Researchers identified three NAFLD subtypes with unique lipidomic profiles and varying cardiovascular disease risk. Subtype A shows a lower CVD risk profile, differing from other subtypes, which may explain variation in hepatic versus cardiovascular outcomes.
Researchers found that female mice produce more of the FPR2 protein, which helps prevent NAFLD, and that estrogen mediates its production. This discovery highlights the need for sex-balanced animal experiments and could lead to novel treatments and gender-based therapies for NASH
A new study reveals that liquid fructose intake, even in high-fat diets, can accelerate liver fat accumulation and hypertriglyceridemia. The study found that fructose induces an increase in the synthesis of fatty acids in the liver and inhibits lipid oxidation, leading to the emergence of non-alcoholic fatty liver disease (NAFLD).
Researchers found that long or irregular menstrual cycles in young women are associated with an increased risk of nonalcoholic fatty liver disease (NAFLD). NAFLD is a chronic condition where excess fat builds up in the liver, increasing the risk of death. Lifestyle changes can help reduce the risk of NAFLD in these women.
Research by the University of Queensland found that male livers with hepatic diseases undergo a sex change as part of a self-protective mechanism. The study suggests that this transformation may be driven by the female hormone oestrogen, which helps to slow down disease progression.
NAFLD and diabetes are linked through subclinical inflammation, insulin resistance, and dysregulated liver-derived proteins. Integrating knowledge from childhood to older age can help personalize prevention and treatment.
A nationwide study in Germany found that liver cirrhosis has the highest mortality rate among chronic diseases, with 0.94% of hospital admissions affected. The study also showed a decline in mortality rates due to improvements in Hepatitis C treatment, but an increase in non-alcoholic fatty liver disease cases.
A comprehensive review highlights recently discovered associations between lncRNAs and specific diseases, including fatty liver disease and liver cancer. The study suggests that a diverse group of molecules known as long noncoding RNAs could emerge as biomarkers for liver disease.
Research found that mothers with metabolic syndrome can switch on an imprinted gene in their mice offspring, leading to liver disease. The study suggests a key role for imprinted genes in the development of non-alcoholic fatty liver disease (NAFLD).
A new Chinese Medical Journal study explores the risks of non-alcoholic steatohepatitis (NASH) turning into liver cancer. Early detection through simple medication and lifestyle changes can prevent NAFLD from progressing to more severe conditions, such as cirrhosis and hepatocellular carcinoma.
Researchers found that alterations in the RNF43 and ZNRF3 genes lead to an accumulation of lipids and inflammation in the liver, increasing the risk of developing non-alcoholic steatohepatitis (NASH) and fatty liver disease. These genetic changes also affect liver cell proliferation, contributing to the progression of liver diseases.
A study by Kanazawa University researchers found that the chemokine CCL3 plays a significant role in inducing inflammation as nonalcoholic fatty liver disease develops. The presence of CCL3 increased liver macrophage accumulation, leading to liver inflammation and scarring.
Exercise modifies the adaptation of the liver to increased energy intake, regulating enzymes for glucose and fructose degradation. Regular physical activity also improves glucose control and reduces fat storage in the liver, offering a comprehensive insight into molecular adaptations to high-energy diets.
A new study by Keck Medicine of USC found that food insecurity increases the risk of death among patients with nonalcoholic fatty liver disease and advanced liver disease. The study, which analyzed data from over 34,000 individuals, suggests that eradicating food insecurity could eliminate up to 7% of nonalcoholic fatty liver disease d...
Scientists at Kumamoto University have developed a novel peptide vaccine that improves obesity-related dyslipidemia and may be cost-effective. The vaccine targets angiopoietin-like protein 3 (ANGPTL3) and has been shown to reduce dyslipidemia in mice, producing antibodies that last for six months.
A large-scale epidemiologic study in China identified links between long-term exposure to ambient air pollution and metabolic-associated fatty liver disease (MAFLD). Long-term exposure to air pollution may increase the risk of MAFLD, especially in individuals with unhealthy lifestyles and central obesity.
A team of researchers at UC Davis Health has developed a novel PET imaging-based tool to detect liver inflammation in non-alcoholic fatty liver disease. The tool uses dynamic PET imaging and mathematical modeling to measure glucose transport from blood to liver tissue, allowing clinicians to quantify liver inflammation.
Researchers found that video-based, telehealth-delivered exercise and weight loss programs improved pain and function in people with knee osteoarthritis and overweight or obesity. The intervention with dietary component led to substantial weight loss and additional benefits.
A study found that D-glyceric acid treatment improved metabolism, blood parameters, and reduced low-grade inflammation in healthy volunteers aged 50-60 years. The compound's activation of mitochondrial metabolism may help interrupt the spiral of persistent systemic inflammation and improve liver function.
Researchers found that albino mice with a mutated tyrosinase gene are more susceptible to non-alcoholic steatohepatitis (NASH) than black mice. This study provides new insights into the genetic factors contributing to NASH and its progression.
Researchers have identified a novel estrogen compound that provides benefits similar to hormone replacement therapy but without the risk factors associated with it. The compound has been shown to reduce excess lipid deposition in the liver and prevent the progression of fibrosis, which can lead to liver failure and metabolic problems.
A VCU study found that people with advanced liver scarring caused by obesity and diabetes are dying from liver disease, underscoring the need for new treatments. The research provides a roadmap for future therapies to prevent liver transplants and save lives.
Researchers identified five genes mutated in people with liver disease, affecting insulin sensitivity and fat metabolism. These mutations reduce the liver's ability to respond to dietary sugars and fats.
A new center will address individual, familial, societal and environmental factors contributing to health disparities in the Latino/a/x community. The center will support research projects and interventions aimed at reducing obesity and chronic disease risk in Latino/a/x families.
A multidisciplinary taskforce developed a Clinical Care Pathway for NAFLD/NASH, outlining practical guidance from screening to patient care management. The pathway aims to provide efficient, safe, and value-based care for patients with NAFLD and NASH, highlighting the importance of early interventions and shared decision-making.
A new study found that every extra 1cm in waist circumference increases the odds of advanced fibrosis by 5% in people with type 2 diabetes. Advanced fibrosis is a late stage of non-alcoholic fatty liver disease (NAFLD), which can lead to serious liver damage.
Researchers found that DNA methylation patterns at specific genomic sites correlated with levels of fibrosis in non-alcoholic fatty liver disease (NAFLD). The study suggests that these patterns could be used to diagnose the severity of this condition, potentially leading to earlier treatment and improved outcomes.
A 34-year follow-up study found that the coexistence of hypertension and fatty liver disease did not exceed their separate effects on mortality. The study suggests a negative interaction between the two conditions on cardiovascular death in non-diabetic men.
A comprehensive review reveals how excessive fructose intake can disrupt metabolic pathways, leading to diseases such as diabetes, fatty liver disease, and heart disease. The study highlights the role of protein transporters, gluconeogenesis, and gene-level changes in regulating fructose metabolism.
A new study by Salk scientists found that time-restricted eating (TRE) confers multiple health benefits, including reduced risk of type 2 diabetes, fatty liver disease, and sepsis, regardless of age and sex. TRE may also protect against infectious diseases like COVID-19 and improve insulin resistance.
Researchers at Skoltech have discovered structures called apical bulkheads in liver cells that are responsible for the narrow shape of bile canaliculi. The discovery reveals a key role for the Rab35 protein in regulating hepatocyte lumina formation and suggests potential avenues for medical applications in fatty liver disease and fibrosis
Researchers linked World Trade Center dust exposure to increased risk of liver disease in responders. Analysis of lung scans found evidence of hepatic steatosis, a condition associated with chemical exposures.
Patients with obesity or type 2 diabetes are at a higher risk of developing NAFLD and NASH. Effective screening, diagnosis, and treatment strategies are urgently needed for this growing population.
A novel 3D imaging technique reveals the degeneration of nerves in the liver, correlating with the severity of liver pathology in non-alcoholic fatty liver disease. The study suggests a 'vicious cycle' where compromised nerve function contributes to disease progression and worsens metabolic challenges.
Researchers found that a chemical modification called m6A may offer protection against non-alcoholic fatty liver by slowing down the accumulation of fat in the liver. The study also suggested that this modification occurs at a different rate in females than males, potentially explaining sex differences in liver fat content.
A new noninvasive biomarker, thrombospondin-2, can identify patients at risk of NAFLD complications using a simple blood test. The biomarker was found to parallel clinical indicators used to categorize pathological changes in liver cells.
A two-year study found that testosterone therapy normalised testosterone levels, reduced NAFLD, and suppressed symptoms of hypogonadism in obese men. Testosterone therapy may help obese men with functional hypogonadism and type-2 diabetes reduce the prevalence of non-alcoholic fatty liver disease.
A new study found that blocking ABCB10 protein in liver cells protects against insulin resistance and fatty liver disease. Increased bilirubin content inside mitochondria driven by ABCB10 activity contributes to fatty liver disease. The findings could inspire the development of therapies targeting ABCB10 or mitochondrial bilirubin.
A team of scientists at Cincinnati Children's Hospital Medical Center has discovered a promising new approach to preventing obesity-driven liver damage. By controlling a subgroup of immune system cells that trigger non-alcoholic fatty liver disease (NAFLD), researchers have identified a potential treatment target.
A new registry study linked non-alcoholic fatty liver (NAFLD) to a 17-fold increased risk of liver cancer, particularly hepatocellular carcinoma. NAFLD patients were also found to have a higher risk of other cancers, emphasizing the need for targeted interventions and personalized screening strategies.
Researchers developed a chimeric mouse model that accurately reproduces human non-alcoholic fatty liver disease (NAFLD) by combining both human and murine cells. The study reveals striking differences in liver cell behavior, metabolism, and gene expression, providing new insights into the disease's mechanisms.
Researchers at the University of Tsukuba found that exercise regimen reduced liver steatosis by 9.5%, liver stiffness by 6.8%, and FibroScan-AST Score by 16.4%. Exercise preserved muscle mass, independent of weight loss, and induced anti-inflammatory responses.
A study published in International Journal of Environmental Research and Public Health found that exercise can alter the oral environment, favoring less harmful bacteria in people with NAFLD and gum disease. This shift may help reduce inflammation and improve overall health outcomes.
A review of studies links excessive fructose intake to NAFLD in children, suggesting restricting added sugars may reduce risk; current diagnosis methods are inadequate, and better tools are needed.
Researchers at Tokyo University of Science have developed a new method to quantify fat content in liver tissue using near-infrared hyperspectral imaging. The study found that this technique can accurately visualize lipid distributions within the liver and identify fatty liver-associated liver diseases, including cancer.
A new study from the University of Minnesota Medical School suggests that disease-driving B cells contribute to the development of non-alcoholic fatty liver disease (NAFLD). The research, led by Fanta Barrow, found that a Western diet and changes in gut microbes activate these pathogen-fighting B cells into 'disease-promoters',
Researchers have identified CNNM4 protein as key regulator of magnesium in the liver and potential therapeutic target for non-alcoholic fatty liver disease. High expression of CNNM4 protein is associated with inflammation and liver fibrosis in patients with non-alcoholic steatohepatitis.
Researchers developed a stem cell-based cell culture model for nonalcoholic fatty liver disease (NAFLD), revealing key findings on gene expression, lipid droplet morphology, and metabolic networks. The model also showed promising results with AdipoRon, a synthetic analogue that positively influences hepatocyte metabolism.