Research on HIV infection and how the virus behaves. Covers viral persistence, prevention policy, adolescent consent, and how HIV infects cells.
Caucasians 55+ are at greatest risk of a deadly lung infection caused by nontuberculous mycobacteria (NTM), which affects over 2,990 people in the US each year. The infection is treatable but expensive antibiotic therapy can take up to two years.
Scientists discovered that Pichia holds at bay a harmful fungal yeast Candida by secreting material that controls Candida's growth and biofilm formation. This finding holds promise for therapeutic agents to stave off not only thrush but also other life-threatening systemic fungal infections.
A study published in PLOS Pathogens found that a family of fungi called Pichia suppresses the growth of disease-causing fungi like Candida. This antagonism is thought to be responsible for reducing the severity of oral candidiasis in HIV-infected individuals.
Research finds that HIV transmissions within communities are often facilitated by sexual contact with partners from outside the community. The study, conducted in Uganda, analyzed data from 46 communities and found that most new infections occur through sex with an outsider.
Researchers have discovered potent antibodies in a KwaZulu-Natal woman's blood that can kill multiple strains of HIV. The study, published in Nature, could lead to new HIV vaccine strategies and improve treatment options.
A study of high-achieving young physician-researchers reveals pronounced gender differences in domestic activities among those married with children. Additionally, single-patient trials may help determine statin tolerability, while a US survey reports 2.7 million living with chronic Hep C virus.
A scientific team discovered how the immune system makes a powerful antibody that blocks HIV infection of cells by targeting a site on the virus called V1V2. The new findings point toward a potentially more effective vaccine that would generate V1V2-directed HIV neutralizing antibodies.
Researchers tested anti-HIV drugs for their ability to suppress cell-to-cell transmission of the virus. The results show that NNRTIs, ENT-Is, and PIs remained highly effective against HIV cell-to-cell transmission.
Women living in world regions with high HIV rates are at high risk of acquiring HIV during pregnancy and postpartum. The combined HIV incidence rate among pregnant/postpartum women was 3.8/100 person-years, significantly higher in African countries than non-African countries.
A new study suggests that a strengths-based social/behavioral intervention can help injecting drug users avoid injection-related HCV and HIV infections. The 'Staying Safe Intervention' program, developed by NYU researchers, showed substantial improvements in motivation and planning to avoid injection risks.
A study by Royal Holloway University found that younger people, men, and childless individuals are more prone to abandoning HIV treatment in South Africa. This can lead to the spread of the disease, putting not only their own lives at risk but also those of others.
A new study aims to identify the causes of oral health problems in HIV-positive patients, including tooth decay, gum disease, and yeast infections. The researchers are analyzing samples from 440 patients to compare their microbiota with uninfected individuals.
Hepatitis C affects 160 million worldwide, with 3.2 million Americans infected. The Rutgers study identifies the virus's outer protein structure, which enables evasion of the immune system.
Chronic THC administration has been shown to increase survival of T cell populations and reduce overall cell death in the gut of monkeys infected with simian immunodeficiency virus (SIV). This finding suggests that marijuana may have a protective effect against HIV-related inflammation and disease progression.
Researchers have identified how dengue virus enters cells using the DC-SIGN protein. Strong neutralization antibodies block this process, offering hope for vaccine development to combat the global mosquito-borne disease. The study's findings could lead to improved prevention and treatment of dengue fever.
A new Penn Medicine study found that mental health patients are up to four times more likely to be infected with HIV than the general population. Researchers tested over 1,000 patients in care and detected several new HIV cases, highlighting the need for routine testing in mental health settings.
Researchers have shown that boosting broadly neutralizing antibodies can protect humanized mice from both intravenous and vaginal HIV infection. The study used a novel technique called vectored immunoprophylaxis, which enabled the production of antibodies for extended periods.
A Caltech-developed method for delivering HIV-fighting antibodies has been shown to be effective in preventing vaginal transmission of the virus in mice, a breakthrough that could potentially lead to new prevention strategies for humans.
A safe and effective HIV vaccine is necessary to control and end the AIDS pandemic, according to a new commentary by NIAID Director Anthony S. Fauci. Recent advances in understanding broadly neutralizing antibodies and T-cell responses offer promising areas for further exploration.
A safe and effective HIV vaccine is necessary to control and potentially end the HIV/AIDS pandemic. Recent scientific advances offer promising areas for further exploration, including the discovery of broadly neutralizing antibodies and improved understanding of T-cell responses.
A study by Columbia University's Mailman School of Public Health found that HIV-positive men are more likely to engage in safer sex practices when their moods improve, compared to weeks with worsening moods. Depression was linked to an increased risk of unprotected sex.
A Johns Hopkins study found nearly half of HIV-infected teenagers and young adults delay treatment until their disease is advanced, putting them at risk for serious infections and long-term complications. Males and members of minority groups are more likely to show up in clinic with advanced infections.
Researchers used a defective form of HIV to track CD4+ T cells in HIV patients, distinguishing dividing cells from dying ones and discovering they can persist for at least 17 years. The study sheds light on the lifespan of effector memory T cells, which were previously thought to last only days or weeks.
Researchers at Caltech used high-resolution electron microscopy to visualize HIV infection in the gut of an infected mouse model. The study revealed novel observations about HIV behavior, including semisynchronous wave patterns of virus release from infected cells and transmission through free pools of virus.
A new study reveals the 3D structure of HIV infection in the gut, showing how the virus infects immune cells and spreads through tissue. The researchers used electron tomography to visualize the architecture of infected parts of the gut, revealing details on viral transmission events.
Researchers from Helmholtz Munich demonstrate that geranium extracts inhibit HIV-1 virus replication by blocking attachment to host cells. The extracts contain polyphenols with high anti-HIV-1 activity, making them a promising lead for phytomedicine against HIV-1.
CONRAD has been awarded the USAID Science and Technology Pioneers Prize for its work on the first vaginal gel proven to reduce HIV and HSV-2 infections. The gel, containing tenofovir, was tested on 889 women in South Africa and showed successful results.
Scientists at UC Berkeley and NIH have captured a high-resolution snapshot of the Nef protein, which hijacks host proteins to facilitate HIV's lethality. By blocking a promising target on host protein AP2, researchers aim to slow or stop HIV.
Researchers found that women in violent relationships fear asking their partners to use condoms due to concerns about violent consequences, leading to inconsistent condom use. The study suggests that health providers should address IPV and fear of IPV when providing HIV prevention services.
Researchers from the University of Pennsylvania conducted a large-scale HIV intervention project in South Africa, involving nearly 1,200 individuals. The program showed significant improvements in condom use and reductions in unprotected sex among men, with participants reporting increased discussions about safe sex and condom use.
A USC study has identified a viral microRNA cluster responsible for causing Kaposi's sarcoma, the most common cancer among HIV-infected people. The cluster targets key cellular pathways associated with cancer development, offering potential targets for new therapeutics.
Researchers discover a subgroup of memory T-cells that are resistant to HIV killing and can survive for years, making them a key target for developing a true 'cure' for HIV infection. This finding could also lead to the development of new cancer therapies targeting stem-cell metabolic pathways.
A recent study identified a population of stem-like T memory cells where HIV persists despite treatment. These cells have the ability to regenerate new HIV-infected cells, fueling the virus's persistence in the human body. The findings suggest that targeting these cells could lead to novel interventions for future treatment.
A new approach targeting persistent HIV-infected cells could complement antiretroviral therapy to achieve sustained disease remission. The immunotoxin 3B3-PE38 significantly reduced the number of infected cells and viral load in a mouse model.
Researchers at Gladstone Institutes have identified the precise chain of molecular events driving CD4 T cell death in HIV-infected individuals, leading to AIDS. They also discovered an existing anti-inflammatory drug that blocks this process, paving the way for a Phase 2 clinical trial.
A recent animal vaccine study has provided valuable insights that may lead to the development of more effective HIV vaccines. The study found that antibodies targeting SIV spikes can prevent infection and identified clear measures of immune responses that predict protection.
A new study confirms that regular Truvada use can reduce one's risk for contracting HIV without leading to increased sexual risk behavior. The research provides further proof of the effectiveness of Truvada as an HIV prevention strategy.
The National Institute of Allergy and Infectious Diseases (NIAID) has named leadership groups and clinical trials units to lead the restructuring of HIV/AIDS clinical trials networks. The new structure aims to increase collaboration, expand research scope to include co-infections, and create transparent mechanisms for idea solicitation.
A recent study published in the Journal of Infectious Diseases found that HIV-infected women have a greater prevalence of noncalcified coronary artery plaques, which are more vulnerable to rupture. Immune system activation is also increased in these women, particularly with age.
Researchers have mapped every salmonella gene's response to human body environments, providing a detailed picture of the bacterium's choreographed infection process. This knowledge could lead to targeted therapies and vaccines specifically designed to combat salmonella's strategies for survival within the human body.
Researchers found that people with hemophilia infected with HIV for decades have increased levels of immune cells targeting HIV. This cellular response, combined with antiretroviral therapy, enables patients to long-term survive despite HIV activity. The study provides new insights into the reasons behind clinical stability in these pa...
A study found that HIV infection occurred in 68% of HIV-positive transplant recipients' new organs despite undetectable blood levels. Researchers developed a new, simple urine test to diagnose kidney infections in these patients, which could improve diagnosis and treatment.
Researchers used RIT to destroy HIV-infected cells in blood samples, reducing infection levels to undetectable. The treatment also showed effectiveness in targeting brain and central nervous system infections.
Researchers found that HIV-1-specific antibodies and low pH enhance transcytosis of the virus across epithelial cells. This process was enhanced by the FcRn receptor and is influenced by whether or not the antibody neutralizes the virus.
CONRAD and Eastern Virginia Medical School will receive $80 million in funding to develop new HIV prevention products, including microbicides and objective measures of adherence. The project aims to address the high risk of HIV infection among young women in South Africa.
A novel, multipurpose pod-intravaginal ring (pod-IVR) delivers up to five different antiretroviral drugs and two hormonal contraceptives, showing promise in preventing HIV and unintended pregnancy. This innovative device could empower women in resource-poor areas to protect themselves from infections.
A recent study published in PLOS ONE found that HIV-positive men who have sex with men are at a higher risk of developing anal cancer due to Human Papillomavirus (HPV) infection. The researchers discovered that taking antiretroviral therapies as prescribed can lower the risk of HPV infections among HIV-infected men.
Researchers found a protein, Sprouty-2, that causes loss of function in immune cells combatting HIV, but disabling it restored their ability to fight the virus. Disabling both Sprouty-2 and PD-1 in exhausted T cells reversed exhaustion completely.
Researchers have determined the high-resolution atomic structure of E2 envelope glycoprotein, a crucial part of the hepatitis C virus. The new data reveal unexpected structural features and should greatly speed efforts to make an effective hepatitis C vaccine.
A study published in the Journal of the American Medical Association found that only 1.45% of new inmates in North Carolina prisons tested positive for HIV, with most having previously been diagnosed. The findings suggest that screening incoming prisoners may not be an effective strategy for detecting new undiagnosed cases.
A study analyzing 23,373 inmates entering a state prison system in North Carolina found that only 0.09% were HIV seropositive and not previously known to be infected. This suggests that incarceration may not be a high-risk environment for new cases of undiagnosed HIV infection.
A large-scale study found that government grants in South Africa significantly reduce the risk of sugar daddy relationships among teenage girls, which is a major cause of HIV infection. The study suggests that providing financial security to girls through child support grants can empower them to make safer choices.
A recent study published in Clinical Infectious Diseases suggests that even those with low viral loads are at risk of treatment failure. Patients with persistent viral loads between 50-999 copies/mL have a significantly higher risk of virologic failure, which can lead to disease progression.
A recent study by Uppsala University researchers mapped nearly 90,000 ERVs from 60 host genomes, revealing a host reservoir for one group of retroviruses with rampant host switching throughout history. This finding adds credence to the possibility that many additional retroviruses may remain to be discovered in vertebrate species.
Research by Case Western Reserve University found that younger individuals with HIV are more likely to experience social isolation and stress due to stigma and limited support networks. In contrast, older adults with HIV were found to have developed social connections and coping mechanisms that helped mitigate these effects.
Researchers uncover how HIV-1 evades detection by the immune system and triggers protective responses against HIV-2 infection. Modifying the virus to be recognized by the immune system could lead to effective vaccines.
A University of Tennessee professor has received a $100,000 grant from the Bill and Melinda Gates Foundation to develop an improved condom design that enhances pleasure while preventing disease and unplanned pregnancies. The new condom incorporates superelastomers, allowing for thinner, more comfortable designs.
The Los Alamos National Laboratory team has developed a novel approach to estimating epidemic dynamics, capturing the full infection history and social network interactions. The model allows for realistic simulation of epidemics with known parameters of human interactions.
Researchers found that HIV protein Tat alters synaptic connections between nerve cells, leading to neurocognitive impairment in infected patients. The changes appear to be a protective response resulting from the over-excitation of the network by Tat.
The updated HIV care guidelines recommend focusing on preventive care, including screening for high cholesterol, diabetes, and osteoporosis. Primary care physicians should also be familiar with HIV care recommendations to provide comprehensive care to patients with HIV infection.