Articles tagged with Hiv Infections
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Researchers found that viruses like HIV and Ebola hijack the same protein complexes as archaea and humans, using ESCRT machinery for cell division. The study presents a new model system to understand virus-host interactions.
A new study suggests that universal HIV testing in India could be a cost-effective strategy to save millions of lives. The study found that testing every five years would be the most cost-effective option, with a price tag of $1,900 per year of life saved in the general population and $1,300 per YLS among high-risk groups.
A study analyzed 275 endoscopes and found 30% to fail cleanliness ratings, with duodenoscopes failing at the highest rate. The study highlights the need for improved cleaning protocols and guidelines to prevent infections.
Researchers found a strong association between low vitamin D levels and high HBV replication in patients with chronic HBV. The study suggests that vitamin D may help control HBV levels and proposes further investigation of its therapeutic potential.
Scientists at NIH discover how HIV kills immune cells by triggering a signal that causes infected cells to die. Treating HIV-infected individuals with drugs blocking viral replication may improve CD4+ T cell survival and immune function.
In the UK, healthcare staff cannot test unconscious patients for HIV without consent, despite the risk of infection and potential psychological impact. Experts argue that changing the law would protect both patients and healthcare workers.
Mathematical analysis reveals that viral blips occur naturally due to infection rate saturation, not external triggers. Models propose a 5-dimensional immunological model that can generate blips, applicable to various viral diseases and autoimmune disorders.
A new study finds that HIV-positive transgender individuals have similar rates of retention, antiretroviral therapy coverage, and HIV suppression as nontransgender peers. Advances in HIV treatment and increased attention to LGBT health may contribute to the improvement in outcomes.
Theoretical mathematical models can help analyze viral dynamics in the early phase following exposure to HIV, providing insights into therapeutic and prevention strategies. The models suggest that reverse transcriptase inhibitors are more effective than protease inhibitors for PrEP, while fast initiation of treatment is crucial for PEP.
Researchers used computer simulations to study how HIV-1 virus creates its capsid, a protective armor around the viral genome. The simulations provide new insights into the process, which could lead to better understanding and prevention of infection.
Researchers at OHSU have discovered a strategy to increase the number of viral peptides that T cells recognize, allowing them to more effectively respond to HIV. The method uses cytomegalovirus (CMV) to generate SIV-specific T cells that can target multiple viral peptides, providing a better targeting system for the immune system.
A new microsphere-based detection system uses multiple antibodies at once for early HIV detection and vaccine efficacy assessment. The novel multiplex immunoassay approach significantly improves sensitivity over standard ELISA techniques.
A global consensus statement establishes standardized definitions and measurements for drug-resistant tuberculosis in children. Research findings highlight the importance of colonization pressure as a predictor of healthcare-associated MRSA infections.
A new meta-analysis of seven trials in Bangladesh, India, Malawi, and Nepal found that grassroots women's groups can dramatically reduce maternal and newborn deaths. Additionally, an analysis of official development assistance for reproductive health reveals that less than a tenth of funding is directed towards family planning.
The new tool uses neutralization fingerprinting to identify specific types of HIV antibodies present in a blood sample. This approach is particularly useful when other methods are not feasible and can significantly reduce the time required for analysis.
Researchers developed a mathematical model to represent HIV-infected cell reproduction, revealing significant uncontrolled replication in sanctuary sites. The discovery implies current antiretroviral therapies may not be as complete in suppressing HIV as previously thought.
Researchers at the University of Pittsburgh have discovered a potential treatment for deadly, drug-resistant bacterial infections that uses the same approach as HIV to infect cells. The new antibiotic, called engineered cationic antimicrobial peptides (eCAPs), has shown rapid destruction of bacteria resistant to standard antibiotics.
Researchers found that stimulating the CB2 receptor in white blood cells weakens HIV-1 infection. Synthetic compounds may make current therapies more effective and provide protection against certain complications. The discovery holds promise for fighting other viral diseases.
A study of 804 HIV-infected children found that those on nevirapine-based treatment had a longer time to virological failure compared to efavirenz-based treatment. The authors conclude that nevirapine may be a cost-effective option for pediatric antiretroviral treatment programs in resource-limited settings.
A study of HIV-infected children and adolescents found that highly active antiretroviral therapies do not impair heart function. Instead, the therapies appear to be cardioprotective, reducing the risk of heart failure in these patients.
A study published in Journal of the Academy of Nutrition and Dietetics found that women with HIV have an elevated resting energy expenditure compared to healthy women. The study also showed that this effect persists even among those on effective antiretroviral therapy, suggesting a direct impact of HIV infection on metabolism.
A study found that circumcision significantly alters the penis microbiome, with a reduced bacterial load and fewer anaerobic bacteria. This change may explain why circumcision offers protection against HIV and other viral infections.
A mathematical model developed by Yale researchers predicts that combining multiple interventions could prevent up to two-thirds of future HIV infections and reduce prevalence from 19% to 10% in 10 years. The study suggests increasing male circumcision, more frequent screening, and antiretroviral therapy as the most effective strategies.
Researchers found that temporarily blocking a critical protein helps the immune system fight off chronic infection, reversing many immune problems. The discovery suggests new approaches to treating persistent viral infections like HIV and hepatitis C.
Researchers found high numbers of HPV type 53 in normal cervical smears from HIV positive women, but not in cervical cancers. This sub-type may inhibit progression to cervical cancer, potentially providing a simple biological therapy for prevention.
The Johns Hopkins researchers developed a Web-based mathematical model to predict which patients would benefit from taking a possibly infected organ. The tool considers factors such as waiting list duration, previous transplants, age, and diabetes status.
Researchers found that women with HIV are at risk of acquiring cancer-causing forms of HPV, including types 52 and 58, which are not covered by current vaccines. Treating HIV may also protect women from HPV-related cancers.
A study has identified a broadly cross-reactive neutralizing antibody in an infected HIV-1 patient, providing insights into effective vaccination strategies. The researchers hope that a vaccine mimicking the development of this potent antibody response may trigger similar protective antibodies.
Researchers have identified a key player in the development of broadly neutralizing antibodies against HIV, paving the way for potential vaccine discovery. By studying the co-evolution of HIV and an individual's immune response, scientists can identify target proteins to include in vaccines.
The review highlights the risks of sharps injuries, including high costs related to contracting serious infectious diseases, with nearly 400,000 incidents occurring annually in the US. Engineered safety devices and proper protocols can prevent many injuries, but clinician compliance remains a crucial factor in reducing their impact.
A systematic review confirms HIV self-testing is effective in removing fear and stigma associated with testing, leading to higher acceptability rates. Self-tests are non-invasive, convenient, and can provide results within 20 minutes, paving the way for early detection and treatment.
Researchers at LSU Health Sciences Center discovered that a common sexually transmitted infection-causing parasite cultivates bacteria beneficial to it, changing the thinking about which comes first–infection or bacteria. The study found two unique bacterial communities strongly associated with trichomonas infection.
Researchers deciphered previously unknown properties of transmitted HIV-1 viruses, revealing they are highly infectious and contain more envelope protein. The findings provide new insights into the biology of viral/host dynamics and may inform vaccine design.
A study published in PLoS Pathogens suggests that removing the viral infectivity factor gene from HIV allows the innate human immune system to destroy the virus. The researchers used a humanized mouse model and found that APOBEC3 proteins effectively restrict HIV growth when vif is removed.
Researchers have discovered that broadly neutralizing antibodies (bNAbs) can handle HIV's high mutation rate, offering a promising strategy for vaccine development. The study found that mutations in framework regions strengthened the antibodies' antiviral activity while conserving key structural features.
A new study by Michigan State University found that about four percent of HIV-positive individuals also have hepatitis, highlighting the need for stronger protections against co-infection. The study reveals that behaviors putting people at risk of HIV also increase their risk of getting hepatitis B or C.
Researchers at Albert Einstein College of Medicine have discovered a new approach for stopping herpes infections by identifying the molecular key that herpes viruses use to infect cells. The finding could lead to new drugs for treating or suppressing herpes virus infections.
A new study reveals that immune cells can recognize and respond to mutated HIV, paving the way for an effective vaccine. The research suggests that a vaccine targeting key mutant forms of the virus could be effective in preventing HIV infection and AIDS.
Researchers will study the effectiveness of a mobile phone app/game in improving antiretroviral treatment adherence among HIV-infected youth and young adults. The goal is to enhance CD4+ cell count, reduce HIV viral load, and decrease transmission risk.
A new study published in Hepatology found that hepatitis C transmission from an infected partner during sex is extremely rare in monogamous heterosexual relationships. The researchers recruited 500 couples and found a maximum incidence rate of 0.07% per year, equivalent to roughly 1 case per 190,000 sexual contacts.
A systematic review of 13 modelling studies found that pre-exposure prophylaxis with antiretroviral drugs is the most cost-effective strategy for preventing HIV infection in people at risk. The cost-effectiveness of this approach depends on factors such as drug costs, epidemic context, and individual adherence levels.
Albert Einstein College of Medicine researchers have been awarded a $12 million grant from the National Institutes of Health to develop a drug-impregnated intravaginal ring to prevent HIV infection in women. The device aims to provide safe and effective prevention strategies for women at increased risk of HIV infection.
Researchers at Washington University School of Medicine have developed nanoparticles carrying melittin, a toxin found in bee venom, that can destroy human immunodeficiency virus (HIV) while leaving surrounding cells unharmed. This finding offers an important step towards developing a vaginal gel that may prevent the spread of HIV.
A new study found that community-based HIV-prevention efforts can significantly increase testing rates and reduce new infections. The trial demonstrated a 14% reduction in new HIV infections compared to control communities.
The study demonstrates that community efforts can significantly increase HIV testing rates, especially among men and young individuals. The intervention communities showed a 45% higher rate of testing for men compared to control communities, leading to a 14% reduction in new HIV infections.
A large study of veterans found that HIV infection is independently associated with an increased risk of acute myocardial infarction (AMI or heart attack), even after adjusting for standard risk factors. The study also identified other risk factors, including low CD4 cell count and hepatitis C virus, as contributing to the increased risk.
A NIH/NIAID study found that antiretroviral-based strategies to prevent HIV infection among women were not effective due to low adherence rates. The VOICE trial showed that nearly half of participants, particularly young and unmarried women, failed to use their assigned products daily.
A study led by Katherine Luzuriaga and Deborah Persaud shows that early ART can curtail the formation of hard-to-treat viral sanctuaries. Five HIV-infected teenagers who started ART within two months of exposure had lower copy numbers of viral DNA compared to those who started later.
Researchers found that co-infection with HIV speeds up the progression of liver disease in individuals infected with hepatitis C, increasing the severity of scarring and cirrhosis by nearly a decade. The studies identified two genetic mutations that may help the immune system fight off the HCV virus more effectively.
A two-year-old child was treated with antiretroviral drugs from birth and later showed no detectable levels of virus or disease symptoms without treatment. Researchers are exploring the possibility of replicating this outcome in clinical trials involving other HIV-exposed children.
A team of researchers describes the first case of a functional HIV cure in an infant, achieved through prompt antiviral therapy within 30 hours of birth. The infant remained virus-free for over a year without treatment.
A Monash Institute of Medical Research team has identified a protein called Interferon epsilon (IFNe) that protects females against infections, including STIs. The discovery could lead to new therapeutic opportunities and boost protective immunity.
Scientists at Johns Hopkins Medicine have identified 25 human proteins that may be critical to HIV-1's ability to infect new cells. These proteins are found in viruses from two different types of infected cells, providing a potential target for diagnosis and treatment.
Research suggests a significant proportion of HIV positive patients are not disclosing their infection to NHS staff, potentially skewing estimates of undiagnosed HIV. This phenomenon may be linked to fear of judgment or stigma, highlighting the need for further study and education.
TB infection rates are forecasted to surge as antibiotics become less effective against the disease. The lack of progress in combating TB is attributed to increasing drug resistance, reminiscent of the 1930s when dedicated sanitaria and invasive surgery were common treatments.
A study published in PLOS Pathogens found that HIV exploits a human cytokine called interleukin 7 (IL-7) in semen to promote its own transmission. The researchers discovered that the increased concentration of IL-7 in semen facilitates HIV transmission to cervical tissue ex vivo.
A new study finds that extra-couple transmission accounts for 30% of new HIV infections in men and 10% in women within stable partnerships. Targeting all heterosexual routes of transmission with test-and-treat strategies could be key to fighting the epidemic.
A study found that conditional cash transfer programs can improve behavior among gay men and male sex workers in Mexico City. Gay men would participate at a rate of over 75% if offered $7-8.75/month, while male sex workers would participate for significantly less, $156/year.
A UK study found that improved prevention measures failed to reduce HIV levels among men who have sex with men in England and Wales, despite increased testing and treatment rates. The researchers suggest that targeting the most-at-risk groups and initiating treatment earlier may be necessary to bring about a drop in HIV incidence.
A new study suggests that early diagnosis and treatment of Hepatitis C in intravenous drug users can prevent many transmissions by identifying 'super-spreaders' who are highly infectious. By understanding how the virus spreads in these individuals, researchers hope to develop targeted interventions to stop its spread.