Articles tagged with Hypoglycemia
A new type of insulin called i-insulin was developed by UCLA researchers to help regulate blood sugar levels and prevent hypoglycemia. The smart insulin works like a 'smart key,' allowing glucose to enter cells while blocking excessive entry when blood sugar is normal.
A nationwide study found patients with diabetes discharged with low glucose values have a higher risk of death and rehospitalization; physicians should avoid discharging patients until glucose levels are above 100 mg/dl
Researchers are developing novel derivatives of glucagon to improve rescue kits for hypoglycemia, which can be life-threatening if left untreated. The new solutions aim to enable easy delivery methods like an EpiPen-like device and potentially intranasal delivery.
Researchers discovered a protein called neuronostatin that protects against low blood sugar and causes the pancreas to release less insulin. By understanding how neuronostatin works, scientists may develop new ways to treat and prevent hypoglycemia, potentially saving lives.
A new automated drug delivery system can detect impending low blood sugar and deliver glucagon to prevent severe hypoglycemia in patients with post-bariatric hypoglycemia. The study found the system was effective in improving blood glucose levels after meals and reducing severe hypoglycemia.
Researchers found that older adults with type 1 diabetes spend more than an hour per day in the hypoglycemic range, increasing their risk of severe complications. This study highlights the need for interventions to reduce the risk of severe hypoglycemia in this age group.
Researchers found that patients with biochemical hypoglycemia are at increased risk of severe hypoglycemic events. The study analyzed the DCCT data set and used two levels of biochemical hypoglycemia to determine the relationship to severe hypoglycemic events.
Patients with diabetes are more likely to experience hypoglycemia after fasting, which can lead to faintness, confusion, and loss of consciousness. The study suggests that routine fasting guidelines may not be necessary anymore, and proper education about fasting and diabetes is lacking.
A new study suggests that antioxidants can reduce cognitive impairments caused by low blood sugar in diabetic patients. The research found that stimulating antioxidant defenses with sulforaphane improved cognitive ability in mice, indicating potential benefits for humans.
Researchers found that switching to real-time continuous glucose monitoring (RT-CGM) significantly reduced time spent in hypoglycemia among adults with type 1 diabetes at high risk of hypoglycemia. The study also showed that continuing RT-CGM for an additional 8 weeks maintained the benefits of this option
A recent study found that people with both diabetes and dementia are 67% more likely to die after experiencing dangerously low blood sugar. The researchers call for strategies to prevent and reduce hypoglycaemia in older adults with these conditions, prioritizing continuous glucose monitoring devices.
Researchers at the University of Guelph found that a sudden drop in glucose levels can have a lasting effect on mood. The study, published in Psychopharmacology, examined the impact of hypoglycemia on emotional behavior in rats.
A new LSU Pennington Biomedical study reveals a novel biomarker that may help diagnose hypoglycemia-associated autonomic failure (HAAF) in diabetics. The biomarker measures how well the brain uses acetate, which could indicate if someone is at risk for developing HAAF or has already suffered from it.
A new LSU Pennington Biomedical Research Center study suggests a novel biomarker may help create a diagnostic tool for hypoglycemia-associated autonomic failure. Measuring brain adaptation after low blood sugar episodes could detect increased risk of HAAF, allowing for targeted treatment.
A study by Yale School of Medicine researchers found that human insulin is comparable to insulin analogs in terms of safety and effectiveness. The use of more expensive analog insulins did not result in better blood sugar control or reduced risk of hypoglycemia, suggesting they may be unnecessary for many patients with type 2 diabetes.
A SLU scientist is using a $150,000 grant to research human pancreas cells and develop new therapies for people at risk of life-threatening hypoglycemia. The goal is to mimic a protein that drives glucagon release in response to low blood sugar.
A Phase 3 clinical trial funded by the National Institute of Allergy and Infectious Diseases found consistent and dramatic improvements in quality of life among participants with type 1 diabetes who had frequent severe hypoglycemia. Islet recipients also reported better overall health status despite needing lifelong treatment.
Researchers developed a wearable heart rate monitor that detected hypoglycemia using beat-to-beat variation in heart rate. The device showed promise for timely detection of impending hypoglycemia, but requires further refinement to increase accuracy and precision.
Researchers found that hospitalized patients with coronary artery disease who developed low blood glucose levels during their stay had higher mortality rates, longer hospital stays, and increased healthcare costs. Frequent glucose monitoring could potentially save lives and decrease hospital length of stay and healthcare expenses.
A new analysis from the Endocrine Society finds that clinicians struggle to identify and manage patients at risk of hypoglycemia, a common but underappreciated threat among type 2 diabetes patients. The study suggests that improving clinical care for these individuals could help reduce hospital admissions and mortality.
A new 'smart' glucagon delivery system has been developed to treat post-bariatric hypoglycemia. The system combines a continuous glucose monitor, rapid glucagon delivery, and a mobile platform with a hypoglycemia prediction algorithm, successfully alerting investigators to impending hypoglycemia and reducing episodes.
A new review of studies suggests that tight sugar control during labour and delivery may reduce newborn hypoglycaemia. The evidence is currently limited, emphasizing the need for high-quality investigations.
A study published in the Journal of Clinical Endocrinology & Metabolism found that continuous glucose monitors can protect against hypoglycemia episodes, even when the body's defense mechanisms are impaired. The devices raised awareness of low blood sugar threats and reduced severe episodes.
A study published in JAMA found that insulin pump therapy among young patients with type 1 diabetes was associated with lower rates of severe hypoglycemia and diabetic ketoacidosis compared to traditional injections. This innovative treatment approach offers improved clinical outcomes for this vulnerable population.
Researchers at Binghamton University have created a wearable, single-use biosensor that integrates a paper-based glucose/oxygen enzymatic fuel cell into a standard Band-Aid adhesive patch. This device allows for non-invasive monitoring of glucose in human sweat during exercise, providing an attractive alternative to conventional methods.
A new tool developed by Kaiser Permanente researchers can identify diabetes patients at high risk of severe hypoglycemia-related emergency department or hospital visits. The tool categorizes patients into three risk levels based on six variables, and has been validated with data from over 1.3 million members.
Patients with diabetes who experience severe dysglycemia are at highest risk for recurrent episodes and readmission. Discharge planning and post-hospital follow-up can help prevent readmissions.
Two studies found that insulin degludec reduced hypoglycemic episodes and severe hypoglycemia in patients with Type 1 or 2 diabetes, compared to insulin glargine U100. The trials involved over 800 adults and had mixed results.
A recent study by UT Southwestern researchers reveals ghrelin's role in preventing hyperglycemia and hypoglycemia in Type 1 and Type 2 diabetes. The hormone helps regulate blood sugar levels when glucagon activity is blocked, suggesting a potential new treatment approach for diabetes.
A new study compares blood glucose control and hypoglycemia rates between type 1 diabetes patients using insulin pumps versus multiple daily injections during Ramadan. Researchers report improved glucose variability and reduced hypoglycemic episodes with insulin pump therapy.
A new study by Johns Hopkins Bloomberg School of Public Health found that severe hypoglycemia is associated with nearly double the risk of cardiovascular disease or death in older adults with type 2 diabetes. Within three years of a dangerously low blood sugar episode, one-third of those in the study died.
Researchers found that a $100 increase in SNAP benefits decreases the likelihood of an ER visit for hypoglycemia by about 13 percent. More generous SNAP benefits could help low-income families manage household budgets to avoid nutritional fluctuations leading to fewer ER visits.
A new study found that low blood sugar in hospitalized patients is associated with increased short- and long-term mortality risk. The study's authors recommend increasing awareness of hypoglycemia and improving quality of care for patients who experience it.
A single dose of dextrose gel can lower the risk of developing neonatal hypoglycaemia in newborns, according to a randomized study. The study found that babies who received one dose of 200 mg/kg dextrose had the lowest risk of hypoglycemia compared to placebo.
A new meta-analysis suggests that antenatal corticosteroids can improve lung development and reduce severe respiratory distress in preterm babies. The study found a significant reduction in respiratory distress syndrome among babies born between 34-37 weeks, including those delivered via scheduled C-section.
Research at UT Southwestern Medical Center found that beta 1 adrenergic receptors mediate ghrelin release, which prevents hypoglycemia. The study suggests that suppression of ghrelin release by beta blockers may be responsible for low blood sugar levels in children taking these drugs.
A new systematic review found that gliclazide confers the lowest risk of hypoglycemia when added to metformin. This suggests prescribing a medication with a lower risk of low blood sugar may be a rational and affordable alternative for patients with type 2 diabetes.
A new study published in JAMA Internal Medicine found that over 25% of adults with type 2 diabetes received intensive glucose-lowering therapy, which increased the risk of severe hypoglycemia. Patients with advanced age and co-existing illnesses were at higher risk.
A new study found that intensive glucose treatment can nearly double the risk of severe hypoglycemia in older patients and those with serious chronic conditions. Patients taking multiple medications to lower HbA1C levels were at higher risk of experiencing severe low blood sugar episodes.
A clinical trial found that islet transplants effectively prevented severe hypoglycemic events and restored awareness in patients with Type 1 diabetes. The study also demonstrated excellent glycemic control, with nearly 88% of subjects remaining free from severe hypoglycemia at one year.
Researchers found that islet transplantation prevents severe hypoglycemic events in people who experienced episodes despite expert care. After one year, 88% of participants were free of severe hypoglycemic events and had restored hypoglycemic awareness.
Researchers investigated how hypoglycemia affects cardiovascular autonomic control, finding a clear change in the body's responses to cardiovascular stress. The study suggests that hypoglycemia may compromise the heart's function.
Researchers have found that treating hypoglycemia in newborns according to current recommendations is safe and appears to prevent brain damage. The study suggests that maintaining stable blood glucose levels without significant fluctuations may be crucial for preventing neurosensory impairments.
Researchers are developing a breathalyzer-type device to detect hypoglycemia in people with diabetes. The device will identify signature odorants produced in human breath by specific volatile organic compounds created by metabolic processes leading to low blood sugar.
A recent study suggests that early transient newborn hypoglycemia may be associated with lower fourth-grade achievement test scores. The research, published in JAMA Pediatrics, found that newborns who experienced low blood sugar levels had decreased literacy and mathematics proficiency rates at age 10.
In silico experiments show that more accurate continuous glucose monitoring (CGM) systems can detect dangerously low blood sugar and reduce the frequency of hypoglycemic episodes. The technology improves glycemic control by providing more precise measurements, enabling better decision-making for individuals with diabetes.
A pilot study found that daily oral insulin administration induced an immune response without hypoglycemia, supporting the need for a phase 3 trial to prevent islet autoimmunity and diabetes. The study enrolled genetically at-risk children and showed varying responses to different doses of oral insulin.
A nationwide study found glyburide associated with increased risk of hospitalization, respiratory distress and hypoglycemia in newborns. In contrast, insulin showed lower risk for these outcomes.
Researchers have identified a novel brain pathway that produces the hormone cholecystokinin (CCK), which acts as a crucial sensor of blood glucose levels. The discovery may lead to new treatments for hypoglycemia and its side effects, particularly in patients who suffer from unawareness due to repeated bouts of low blood sugar.
A Canadian-Japanese research team has identified a shared genetic mutation responsible for an inherited metabolic disorder, glycogen storage disease type IIIa, in Inuit populations in northern Quebec. The mutation affects approximately 1 in 2500 people in Nunavik and can cause enlarged livers, hypoglycemia, and muscle weakness.
A new study by Yale University researchers found that older diabetes patients often receive aggressive treatment despite questionable benefits. The study suggests a one-size-fits-all approach may be over-treating a substantial proportion of the population, increasing the risk of hypoglycemia.
A study found that nearly two-thirds of older adults with complex or very complex health status maintained tight blood sugar control, suggesting potential overtreatment. This vulnerable population is unlikely to benefit from intensive glucose management and may experience harms such as hypoglycemia.
Researchers at the University of Pennsylvania School of Medicine have successfully restored type 1 diabetics' ability to recognize low blood sugar levels after receiving islet cell transplantation. The treatment has nearly abolished time spent in a hypoglycemic state and improved response to experimental insulin-induced hypoglycemia.
Researchers at McGill University found that tramadol use is associated with a two-fold increased risk of hospitalization for severe hypoglycemia. The study also suggests that this risk is particularly high in the first 30 days of tramadol use.
Researchers found that tramadol use was associated with an increased risk of hospitalization for hypoglycemia, especially in the first 30 days. The study analyzed data from over 334,000 patients and found that tramadol was linked to a higher risk of severe hypoglycemia compared to codeine.
A clinical trial confirms the external artificial pancreas system improves glucose control and reduces the risk of hypoglycemia compared to conventional diabetes treatment. The dual-hormone artificial pancreas provides additional reduction in hypoglycemia, offering a promising treatment option for type 1 diabetes patients.
A genetic variant once aiding Arctic survival now linked to increased risk of hypoglycemia in modern populations. Researchers analyzed genomes from Northern Siberians, Europeans, and East Asians, finding the CPT1A gene variant was prevalent in Northern Siberians but absent in other populations.
A study of 37,539 children and young adults with type 1 diabetes found that the link between low average glucose blood levels and severe hypoglycemia declined substantially between 1995 and 2012. The relative risk for severe hypoglycemia decreased from 1.28 to 1.05 per 1% decrease in HbA1c levels, corresponding to a drop in risk of 1.2...
The American Diabetes Association lowers its target recommendation for blood glucose levels in children with type 1 diabetes to lower than 7.5 percent, reflecting research showing prolonged hyperglycemia can lead to early development of serious complications such as cardiovascular disease and kidney disease.
A post-hoc analysis of patients with type 2 diabetes found that intensification of insulin therapy with Januvia (sitagliptin) 100 mg once-daily resulted in lower incidence of nighttime hypoglycemia compared to placebo. This is a positive finding for treatment approaches aimed at lowering nocturnal hypoglycemia.