Articles tagged with Hypoglycemia
A study by researchers at Institute of Science Tokyo has identified a key gene, DOCK10, involved in abnormal insulin secretion in insulinomas. The findings pave the way for novel diagnostic biomarkers and treatment options.
A landmark trial is underway to test new treatments that restore the body's natural warning signs for low blood glucose in people with type 1 diabetes. The CLEAR trial compares innovative treatments, including an artificial pancreas system and bespoke psychoeducational programs, to find the most effective way to prevent severe episodes.
Research highlights preventable harms of intensive diabetes and hypertension treatment in frail older adults, calling for personalized care approaches that prioritize patient safety. Guidelines recommend cautious individualized care, but complications remain alarmingly common.
A study of nearly 5 million Chinese women found that those with low blood sugar levels prior to conception had a higher risk of adverse pregnancy outcomes, including preterm birth and low birth weight. The study also showed varying risks associated with different body mass indices.
Researchers at Kyoto University have developed a new non-invasive diagnostic method for insulinomas, which achieved 100% diagnostic accuracy in a Phase II clinical trial. The new method using positron emission tomography (PET) probe successfully detected cases difficult to diagnose through existing methods.
The Dexcom G7 CGM device demonstrated an accuracy of 8.0% in a study involving 130 adults with type 1 or type 2 diabetes, setting a new standard for continuous glucose monitoring devices.
The INHALE-3 extension study found that a regimen of inhaled technosphere insulin and insulin degludec reduced post-meal hyperglycemia in adults with type 1 diabetes. The treatment showed significant improvements in mean time in range, with 43% of participants expressing interest in continuing the regimen.
A Japanese study found that CGM devices with low-glucose alerts reduced hypoglycemic incidents and increased confidence among diabetic drivers. The findings suggest that such systems can make driving safer for people with diabetes.
A study comparing hybrid closed-loop and open-loop systems in young people with type 1 diabetes found that hybrid closed-loop systems offered improved long-term blood sugar values, a lower risk of hypoglycemic coma, but a higher rate of diabetic ketoacidosis. The results suggest that hybrid closed-loop therapies may be beneficial for i...
A Brazilian researcher at Harvard identified serotonin as the central role in postprandial hypoglycemia, a common complication of bariatric surgery. The study found that serotonin levels increase significantly after meals in affected individuals, unlike those without symptoms.
Researchers developed glucose-responsive micelles that encapsulate and protect glucagon, releasing it when blood sugar levels drop below a certain threshold. The micelles prevented hypoglycemia in mouse trials, achieving normal blood sugar levels within 40 minutes.
Researchers at University of Gothenburg propose inhibiting somatostatin to restore glucagon release and prevent dangerous blood sugar levels. This approach has the potential to save lives and is supported by experimental results in mice with type 1 diabetes.
A new class of weekly insulin, efsitora alfa, has been shown to be non-inferior to daily injections in managing blood sugar levels in patients with type 1 diabetes. However, the study found higher rates of hypoglycaemia, highlighting the need for vigilance in dose initiation and optimization.
A new study found that interval exercise is better suited for men with low blood sugar levels, while continuous exercise is more effective for women. The research suggests that gender-specific recommendations should be considered when prescribing aerobic exercise to patients with type-1 diabetes.
A recent study found that long-term use of sulfonylureas increases the risk of impaired awareness of hypoglycemia in patients with type 2 diabetes. The longer the patient uses sulfonylureas, the higher the risk. Researchers suggest using newer classes of medications to reduce this risk.
A new study led by researchers at UC San Francisco found that a virtual emotion-centered program called TunedIn can reduce diabetes distress by half and improve glucose control. The program incorporates elements of Acceptance and Commitment Therapy and was delivered virtually to 276 adults with Type 1 diabetes.
Administration of antenatal corticosteroids to late preterm babies was not linked to increased risk of neurodevelopmental problems by age 6. Long-term follow-up study suggests the medication may be safe for these high-risk infants.
In a randomized clinical trial, weekly tirzepatide showed greater reductions in HbA1c levels and body weight compared to prandial insulin as an additional treatment in people with inadequately controlled type 2 diabetes. The study also found less hypoglycemia with tirzepatide.
A new quality improvement study shows a primary care intervention reduced the number of older adult patients at risk for hypoglycemia by almost 50%. The tool facilitated shared decision-making and improved patients' daily lives, leading to de-escalation of diabetes medications causing hypoglycemia in 20% of participants.
A recent study published in the Journal of Diabetes Science and Technology found that HbA1c levels are markedly higher in young black youth compared to whites with type 1 diabetes. This disparity can lead to increased risk of hypoglycemia and long-term complications if primarily used for insulin management.
Children and teenagers with diabetes frequently employ inaccurate CGM alarm settings, which may lead to reduced usefulness of these devices. Research highlights the importance of following recommended alarm best practices to ensure patients receive real-time glycemic data while minimizing alarm fatigue.
A qualitative case series study provides the first published examples of medication deprescribing protocols for patients with type 2 diabetes. The results highlight the importance of de-escalating glucose-lowering medications when patients achieve remission through lifestyle medicine interventions.
Dr. David McDougal's research project aims to find better therapies to prevent hypoglycemic episodes in people with type 1 diabetes, focusing on the role of leptin in regulating blood sugar responses. The grant-funded study seeks to identify novel treatments for preventing low blood glucose in these patients.
Low blood sugar levels trigger an increase in retinal cell proteins, leading to overgrowth of abnormal blood vessels and worsening diabetic eye disease. The study suggests that keeping glucose levels stable is crucial for preventing vision loss in people with diabetes.
Researchers found that continuous glucose monitors and wearable devices pose challenges for patients and caregivers, including issues with hardware, software, and device use. Nearly three-quarters of participants experienced low blood sugar levels, highlighting the need for improved technology to manage diabetes effectively.
A new American Heart Association scientific statement emphasizes the importance of rapid evaluation for TIA, which can lead to full-blown stroke. The statement offers a standardized approach to evaluating people with suspected TIA, including guidance for hospitals in rural areas with limited resources.
A study aims to enhance accessibility and value of health information tools for older adults with both diabetes and Alzheimer's disease. The research focuses on developing a user-friendly technology to detect low blood sugar, which can cause dizziness, confusion, and even death.
Researchers at Nagoya University have discovered a new treatment for type 1 diabetes that uses leptin to improve insulin-alternative effects in mice. The combination of leptin and a PTP1B inhibitor normalizes blood glucose levels without the need for insulin, reducing hypoglycemia risk.
People with diabetes face higher risk of hospitalization during extreme heat events due to dehydration and blood glucose imbalance. Research reveals a link between extreme heat and emergency hospitalizations for hypo- and hyperglycemia-related conditions.
Researchers found that factory-calibrated continuous glucose monitors are sufficiently accurate for estimating blood-sugar levels in patients with end-stage renal disease on hemodialysis. The devices showed 'clinical reliability', with almost 99% of readings accurate enough to be used without confirmatory fingerstick blood sugar readings.
A new study at Stellenbosch University identified significant knowledge gaps among medical specialists regarding the emergency management of hyperkalaemia. The researchers recommend starting therapy when potassium levels reach 6 mmol/L or higher, performing an ECG on all patients, and monitoring for hypoglycaemia.
A study in rural Malawi found high mortality rates for children admitted to hospital with low blood sugar or oxygen levels. The findings suggest that earlier identification and prompt care-seeking could help reduce the risk of death, emphasizing the need for better clinical management of severely ill children.
CHOP researchers have developed a targeted treatment that controls blood sugar in patients with hyperinsulinism, a genetic disease. The study found exendin-(9-39) reduces likelihood of fasting hypoglycemia by 76% and protein-induced hypoglycemia by 82%
Research from the University of Waterloo and the University of Auckland found that stabilizing blood sugar levels in newborns with hypoglycemia prevents brain damage. Untreated low blood sugar can cause adverse effects on a child's neurodevelopment up to age 4.5 years old.
A study found that many nursing home residents continue to receive insulin and other medications despite blood test results suggesting tight control. Only 27% of overtreated and 19% of potentially overtreated residents had their medications adjusted within 2 weeks.
Two papers from the Liggins Institute have been published in JAMA, providing important new data on managing babies at risk of low blood sugar levels. The research found that regular screening and treatment can help achieve similar outcomes for children affected by hypoglycaemia compared to those not exposed.
A recent study of 480 children at risk of neonatal hypoglycemia found no significant association between exposure to hypoglycemia and lower educational achievement at ages 9-10. The researchers analyzed data from treated children, suggesting that early treatment may not have long-term effects on academic performance.
Researchers found minority groups were less likely to start newer diabetes medications, despite needing them most. The study used data from nearly 5,000 patients with type 2 diabetes and showed Black patients were 20% less likely and American Indian or Alaskan Native patients were 50% less likely to initiate treatment.
A new study published in Frontiers in Endocrinology has identified a promising target for an anti-hypoglycaemia drug by boosting the brain's AMPK fuel gauge. The researchers found that the compound increases the release of glucagon from the pancreas, defending against hypoglycaemia.
Researchers developed an experimental device to improve blood sugar control in HI patients. The bihormonal bionic pancreas (BHBP) helps maintain stable glucose levels without human error in calculating doses.
A synthetic hinge concept developed by Indiana University School of Medicine Professor Michael A. Weiss and his team could lead to a breakthrough in 'smart' insulin therapy. The invention exploits a natural mechanism that allows the insulin to adjust its activity based on blood glucose levels, which could transform diabetes care.
The study found that continuous glucose monitors reduced emergency department visits and hospitalizations for hypoglycemia, improving blood sugar control in selected insulin-treated type 2 diabetes patients. The monitors also showed comparable results to a new diabetes medication in terms of blood sugar control.
Researchers found that people with low blood sugar events had a 75% greater risk of developing dementia, while those with high blood sugar events had more than twice the risk. People experiencing both types of events faced the greatest risk, with an incidence rate of 98.5 cases for every 1,000 person-years
Experts and patients are urging medical textbooks to be rewritten due to the rare condition of unexplained low blood sugar. The new guidelines aim to diagnose and treat this condition as any other disease.
A new once-weekly basal insulin injection demonstrated similar efficacy and safety to daily basal insulin in patients with type 2 diabetes, achieving comparable blood glucose control and lower rates of hypoglycemia
The Omnipod 5 System shows significant average improvements in hemoglobin A1c and time spent within the recommended target glucose range. Children also experience improved blood sugar control after using the device.
Researchers at Johns Hopkins Medicine used autonomous AI to detect pediatric diabetic retinopathy in a study of 310 patients. The AI tool achieved high sensitivity, specificity, and diagnosability rates, leading to improved screening adherence and early diagnosis.
The American Diabetes Association has lowered the target HbA1C levels for children with type-1 diabetes to less than 7% to reduce acute and long-term organ damage. The new guidelines aim to improve immediate and long-term health outcomes, fewer complications, and reduced mortality rates in T1D children.
Researchers developed a novel photodynamic therapy to target insulin-producing lesions, showing promise in slowing tumor growth and inducing cell death. The treatment could provide a minimally invasive option for hyperinsulinemic hypoglycemia, improving patient management.
A six-month clinical trial found that continuous glucose monitoring devices can significantly reduce hypoglycemia and severe hypoglycemic events in older adults with type 1 diabetes. The study also showed improved overall glucose control without worsening glycemic outcomes.
A new study found that people with Type 2 diabetes in the US often receive treatment that is too aggressive or not aggressive enough, with those who are most likely to benefit from intensive therapy being underserved. The study suggests a fine line between effective treatment and increased risk of hypoglycemia.
Researchers have identified four novel genes related to glucose metabolism that appear to explain unexplained low blood sugar in at least four families. The discovery may lead to the development of a novel drug against diabetes. However, more studies are needed to confirm the exact functional significance of these genetic mutations.
Researchers developed an automated glucagon delivery system to treat post-bariatric hypoglycemia, reducing the risk of unpredictable low blood sugar levels. The closed-loop system, comprising a CGM and glucagon pump, provides patients with a safe and reliable treatment option.
The Endocrine Society and Avalere Health introduced quality measures to assess healthcare providers' ability to identify and care for older adults at risk of hypoglycemia. The measures focus on outpatient treatment for adults aged 65 and older with type 2 diabetes, highlighting key risk factors and emphasizing education to prevent futu...
Researchers at UMass Amherst and Stanford have designed a new framework for fairer, safer machine learning algorithms. The Seldonian framework allows users to specify safety and fairness constraints, enabling the development of more responsible AI applications.
Researchers found that carbohydrate content and meal type are the most important factors affecting carb-counting accuracy. Larger meals tend to have more errors, while smaller meals have fewer mistakes.
Research from University of California - San Diego found a significant association between tramadol use and an increased risk of developing hypoglycemia. The study analyzed over 12 million reports and identified a 10-fold greater risk compared to other opioids, with methadone being the only other drug with comparable effect.
A recent study by Mayo Clinic researchers found that over 2.3 million adult patients in the US are likely treated too intensively for their blood sugar levels, resulting in thousands of preventable hospitalizations and emergency department visits. This excessive treatment is linked to increased risk of hypoglycemia and other complicati...
Researchers developed a predictive risk model to identify patients with diabetes at high risk of low blood sugar. The model combines known risk factors, including recent infections, insulin use, and dementia, to help healthcare providers intervene and prevent serious adverse events.
A new type of insulin called i-insulin was developed by UCLA researchers to help regulate blood sugar levels and prevent hypoglycemia. The smart insulin works like a 'smart key,' allowing glucose to enter cells while blocking excessive entry when blood sugar is normal.