Articles tagged with Infectious Diseases
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers report that apratoxin S4, an anticancer drug candidate, can interfere with viral replication in human cells. The compound was effective against multiple viruses, including SARS-CoV-2, influenza A, and Zika virus. Further studies are needed to confirm its potential as a broadly acting antiviral.
Researchers found no association between social behavior and parasite infection in Asian elephants, despite studying three key aspects of their social life. The study suggests that social benefits may outweigh the costs of sociality for these animals.
Researchers from Dartmouth's Geisel School of Medicine found a significant rate of new TB infections among Tanzanian adolescents. The study used serial testing and identified transient, persistent, and irregular conversions between positive and negative IGRA test results.
A team of researchers created an in vitro human model of environmental enteric dysfunction (EED) using the Human Organ Chip technology. The EED Chips recapitulate features of EED found in biopsies from human patients, including inflammation and intestinal barrier dysfunction. The study sheds light on the complex interplay between malnu...
Researchers will evaluate COVID-19 vaccination safety in 1,800 pregnant participants and monitor immune response. The study aims to provide information on vaccine efficacy for mothers and babies.
A UC San Diego study suggests COVID-19 rebound symptoms after taking Paxlovid are likely caused by insufficient drug exposure, not resistance or impaired immunity. The study found the virus remained sensitive to the drug and no relevant mutations were detected.
Researchers discovered how Mycobacterium tuberculosis can evolve efficiently by forming complex biofilms due to genetic mutations. The study sheds light on the bacterium's robustness and identifies potential vulnerabilities for developing more effective treatments.
The European Society of Gynaecological Oncology and four international medical societies have published consensus statements on the treatment of pre-invasive vulvar lesions. These guidelines highlight the need for specific attention to these lesions, which can cause symptoms such as burning and itching, and may progress to invasive can...
Researchers discovered that nano-sized electrostatic atomized water particles damage SARS-CoV-2 viral envelope, protein, and RNA, reducing its infectivity. The particles' reactive oxygen species (ROS) are responsible for this damage, posing a promising alternative disinfection method.
Scientists detect a highly resistant strain of Neisseria gonorrhoeae in Austria, causing treatment failure with current antibiotics. The discovery highlights the urgent need for enhanced antimicrobial surveillance and development of novel treatments to combat this growing public health concern.
A study in the Netherlands estimates a mean incubation period of monkeypox at 8.5 days, with most cases developing symptoms within 13 days after exposure. The findings support the current 21-day quarantine recommendation for preventing infectious contacts.
A new study led by UCSF found that routine screening for and removal of precancerous anal lesions can significantly reduce the risk of anal cancer. The study, known as ANCHOR Study, showed a 57% reduction in anal cancer among people with HIV who underwent treatment for high-grade squamous intraepithelial lesions (HSIL).
Researchers used bacteriophage therapy to treat 20 complex, antibiotic-resistant lung infections in a clinical trial, resulting in no adverse reactions. More than half of treated patients experienced symptom improvement or reduced bacterial presence. The study's findings advance the promise of phage therapy as an alternative to traditi...
Monkeypox is a viral disease caused by the monkeypox virus, typically spread through contact with infected animals or humans. Symptoms include a rash and fever, and treatment involves antiviral medications.
The CDC has published a new report detailing the county-level distribution of seven diseases spread by blacklegged ticks. The map highlights areas with reported infections and those without, emphasizing the need for public awareness and prevention measures.
A study analyzing 17 million patient GP records in England found that people with certain inflammatory immune conditions were at higher risk of dying or needing hospital care from COVID-19. The analysis suggests that targeting prevention strategies and early interventions towards those most at risk can help inform evidence-based policy.
The article reports on the rapid transmission of monkeypox in Europe, with cases detected in Italy, Portugal, the UK, and Australia. Human-to-human transmission has been confirmed, particularly in sexual networks, raising concerns about the virus's epidemiology and control.
The US Army Medical Research Institute of Infectious Diseases has made a breakthrough in understanding Crimean-Congo hemorrhagic fever virus (CCHFV) disease process. The study found that the host inflammatory response is a significant driver of CCHFV-mediated disease, and that modulating this response could help prevent severe disease....
A new study reveals which bird species are driving the global spread of avian influenza, identifying ducks and geese as super-spreaders. The research also highlights the crucial role of gulls in transmitting the virus over long distances, with their ability to fly over oceans playing a significant role in its rapid spread.
A Japanese study found that older patients are significantly more likely to become long-haulers compared to those aged 40 and below, with persistent symptoms affecting over half of participants at a median of 29 days after onset. Long-haul COVID-19 was also associated with psychological distress, stigma, and discrimination.
Researchers at UC San Diego School of Medicine found that COVID-19, MIS-C and Kawasaki disease share similar underlying molecular patterns. The study reveals that MIS-C is a more severe version of the immune response than KD, with potential implications for improved disease diagnosis and treatment.
A new analysis of nationally representative data reveals a significant increase in the impact of HPV vaccination efforts, leading to decreased prevalence of cancer-causing HPV infections among both vaccinated and unvaccinated females. The study found that vaccination has directly protected individuals and generated herd effects, reduci...
Two projects aim to vaccinate 40,000 and 60,000 people in Ethiopia against cholera, using the OCV vaccine developed by IVI. The mass vaccination campaign will also establish a disease monitoring system to strengthen local public health capabilities.
Researchers found that a single mRNA vaccine booster shot can provide the same level of protection as three doses, making it a promising investment for resource-poor countries. The study suggests that this strategy could benefit billions of people worldwide and help combat emerging COVID-19 variants.
A new study found that states with higher funding for public health programs reported more foodborne illnesses and were better equipped to investigate them. The researchers hope their findings will lead to increased investment in public health programs nationwide.
Researchers developed a novel 'Wikiguideline' approach to establish medical guidelines, leveraging online collaboration and high-quality data. The method was tested using osteomyelitis, an infection of the bone, and found sufficient data for only two recommendations: increasing oral antibiotic therapy and limiting therapy duration.
Researchers developed a new test method to detect tuberculosis (TB) progression from latent infection in elephants using IgG antibodies against Antigen 85B. High levels of IgG against ESAT6/CFP10 remained constant, while IgG against Ag85B increased before disease onset and declined with treatment.
A regional COVID-19 prevention system in Ibaraki Prefecture, Japan did not substantially alter user behavior despite being associated with some positive health behaviors. The study aimed to investigate factors that make these systems effective and identify areas for improvement.
A new study predicts climate change will lead to a viral jump to humans, increasing the risk of the next pandemic. Rising temperatures will have a devastating impact on bats, allowing them to travel long distances and share viruses with unprecedented rates.
Researchers analyzed 451 bacterial strains of C. difficile, identifying 9,924 distinct gene clusters and categorizing them into 176 genetically distinct groups. The study provides new insights into the genetic diversity and evolution of this pathogen, shedding light on its virulence factors and antimicrobial resistance determinants.
A new study published in the Canadian Medical Association Journal found that unvaccinated individuals pose a significant risk to vaccinated people, even when vaccination rates are high. The research suggests that mixing between unvaccinated and vaccinated populations can lead to substantial new infections among the vaccinated.
Two fatal cases of airport malaria were reported in Belgium, highlighting the need for healthcare awareness near airports. The most likely route of transmission was through an imported infectious exotic Anopheles mosquito that was possibly brought via the international airport or military airport.
Researchers at Gwangju Institute of Science and Technology (GIST) have developed a new technique to easily visualize viruses using an optical microscope, called the Gires-Tournois immunoassay platform. The platform uses 'slow light' technology to detect coronavirus particles by slowing down light that gets reflected around them.
New research suggests that ADCC responses and strain susceptibility influence HIV-1 mother-to-child transmission during breastfeeding. Enhancing ADCC through a vaccine may not be sufficient to prevent transmission due to chronically infected individuals' ADCC-resistant strains.
Key signalling pathways blocking by existing drug candidates limit CCHF virus reproduction. The findings offer hope for patients affected by this deadly disease, which has a high mortality rate in humans.
A new study found that people with psychiatric conditions, especially those over 65, have a higher risk of breakthrough COVID. The researchers tracked data from over 250,000 VA patients and found increased risks for breakthrough infections among those with substance abuse, psychotic disorders, bipolar disorder, adjustment disorder, and...
A five-year, $13 million grant will investigate the molecular and cellular mechanisms of prion transmission in CWD. The researchers aim to understand the inter-species transmission potential of the disease and its ability to spread from animals to humans.
Researchers characterized viral protein binding to sialic acids on animal and human coronaviruses, revealing host-specific patterns. This adaptation enables coronaviruses to quickly jump species, driving cross-species transmission.
A recent study found that COVID-19 spreads extensively in households, with approximately 50% of household members infected from the first-infected individual. Children were less likely to spread the virus but equally likely to become infected as adults, highlighting their potential role in transmission.
Researchers at Tokyo University of Agriculture and Technology discovered that double-stranded RNA molecules can activate the immune system response leading to bone deterioration in gum disease. The study found that dsRNA triggers the differentiation of osteoclasts, cells responsible for breaking down bone, leading to increased bone ero...
A recent study published in mBio discovered that the SARS-CoV-2 viral gene ORF8 plays a crucial role in the severity and spread of COVID-19. Researchers found that mutations in ORF8 contribute to inflammation and disease outcomes, suggesting new treatment options for patients with severe cases.
A recent study published in ACS Omega analyzed protein levels in semen of men who recovered from COVID-19 and found significant reductions in sperm count, motility, and normally shaped sperm. The researchers also detected changes in fertility-related proteins such as semenogelin 1 and prosaposin.
PrEP users in Germany experienced infrequent testing, with 26.3% not following recommended frequencies for HIV, STI, and renal function testing. Regular testing is crucial to prevent missed diagnoses and manage asymptomatic STIs, particularly in MSM populations.
Researchers have discovered that P. malariae, a malaria parasite infecting humans, originated in African apes before evolving to infect people. This breakthrough reveals the evolutionary links between the two species and sheds light on how the parasite adapted to infect humans.
Researchers found that metal concentrations were particularly elevated in CWSs serving semi-urban, Hispanic communities, highlighting environmental justice concerns. Arsenic, barium, chromium, selenium, and uranium concentrations were also disproportionately elevated.
Researchers at UCF have identified 116 new gene variants in sea turtles that may protect them from a tumor-causing disease. The discovery sheds light on the role of MHC class I alleles in potentially safeguarding sea turtles against fibropapillomatosis.
Researchers discover medusavirus undergoes four stages of maturation within host cells, with unique particle structures and DNA-protein exchange mechanisms. The findings provide new insights into giant viruses' biology and behavior.
Researchers at Hiroshima University discovered that pathogenic mycobacteria, such as Mycobacterium tuberculosis, attach to and multiply within human red blood cells. This interaction may play a role in the spread of lung diseases like tuberculosis.
Researchers analyzed nearly 100,000 pregnancies and found no association between COVID-19 vaccination and poor birth outcomes. The study provides further evidence on the safety of mRNA vaccines for pregnant individuals.
A novel class of bed net that kills mosquitoes resistant to traditional insecticides by making them unable to move or fly significantly reduces malaria infection in children. The study found a 43% reduction in malaria prevalence and 44% reduction in clinical episodes over two years.
The COVID-19 pandemic has led to a setback in global efforts to meet SDG targets for tackling tuberculosis. TB mortality plateaued in Europe between 2019 and 2020, likely due to disruptions in essential TB services. Researchers highlight the need for continued commitment and investments to prevent further progress being reversed.
A recent viewpoint article highlights the need for open access to digital sequence information (DSI) to facilitate real-time responses to global crises. The authors propose community self-governance as a solution to enable international collaboration, improve benefit-sharing mechanisms, and promote equitable sharing of DSI benefits.
The 'Agency for All' project aims to develop social and behavioral research to understand how to promote local voices and agency in health and development programming. The five-year, $38 million grant will fund an international network across Africa, South Asia, and other regions.
A study in Botswana found that HIV transmission occurs primarily within and between same-age communities, rather than between distant communities. Community-based HIV testing and treatment can effectively curb the spread of the disease if targeted at high-risk populations.
Researchers found that sugar-decorated proteins in mucus can bind to the coronavirus, keeping it from infecting cells. This discovery may explain why SARS-CoV-2 is more likely to spread through airborne droplets rather than surface transmission.
A new study found that fungal infections result in significant healthcare spending, with direct costs of $6.7 billion and secondary infections contributing to a total of $37.7 billion in U.S. national health care expenses. Fungal infections doubled hospital costs, patient stays, and mortality risk.
The WHO European Region saw a decrease in reported cases of syphilis, gonorrhoea and chlamydia, but data availability varies widely among non-EU/EEA countries. Georgia had the highest syphilis case rate, while EU/EEA countries had lower rates.
The WHO European Region has seen significant success in diphtheria immunization, with high coverage rates and only a few reported cases. However, suboptimal surveillance systems and inadequate laboratory capacity may contribute to the persistence of sporadic cases.
A new study published in the New England Journal of Medicine found that babies born with Congenital Zika Syndrome are at an 11x greater risk of dying during their first three years of life compared to those born without. The study highlights the importance of protecting women, especially those pregnant or of child-bearing age, against ...
Researchers at the University of Texas at Austin found a new approach to impairing antibiotic resistance in deadly bacteria by inhibiting the protein DsbA. This method could potentially restore the effectiveness of existing antibiotics, addressing a global health crisis responsible for millions of deaths annually.