Articles tagged with Influenza
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Johns Hopkins researchers study nasal spray flu vaccine in human nasal tract cells to determine optimal weakening or strengthening of the virus. They find that by adjusting nine mutations, a stronger vaccine can be created for older adults while still protecting children under two, offering new hope for effective flu vaccines.
A new study published in PLOS Computational Biology has developed a flu forecasting system that can predict the timing and intensity of influenza outbreaks in subtropical climates. The system was able to forecast peak timing and magnitude for 44 epidemics in 16 years, with an accuracy rate of 93%.
A new study found that UK investment in pneumonia research was less than £43.08 per death, despite rising substantially since 2010. Total funding for pneumonia between 2011-2013 exceeded total investment across the previous 14 years for tuberculosis and influenza.
A study in PLOS Medicine predicts that vaccinating Thai children with seasonal flu vaccine will reduce approximately 3,000 deaths annually. The policy is considered cost-effective according to WHO criteria.
A study led by Mount Sinai researchers compares flu viruses to the measles virus to identify key genes that can't be changed. This could lead to the development of universal flu vaccines and improved protection against emerging viral threats.
A new Veterans Affairs study found that the high-dose flu vaccine provides stronger protection against flu-related hospitalizations and deaths for those 85 and older, while standard vaccines may be effective for younger seniors. The study included over 165,000 patients and tracked hospitalization and death rates.
Research published in Occupational & Environmental Medicine found that children whose parents regularly used bleach to clean the home had higher rates of respiratory and other infections. The risk of flu, tonsillitis, and any infection was significantly higher among these children, with risks of 20% and 35% respectively.
Researchers discovered a rare genetic mutation that prevents certain children from producing a protein necessary to fight off the flu. This mutation can lead to life-threatening symptoms and has been found in only one case, but clinicians now have a potential treatment option for children with severe flu cases.
A new flu vaccine that includes four strains of inactivated influenza has been found to be more protective than a similar vaccine containing only three strains. The addition of the fourth strain increases the chance the vaccine will match the circulating flu B strains without compromising protection against other strains.
Researchers at Scripps Research Institute analyzed two influenza strains, H10N8 and H6N1, and found that they have not acquired changes allowing them to infect humans easily. However, the viruses' versatility in attaching to host cells suggests continued caution against potential pandemics.
A new study suggests that adults over 30 only get the flu about twice a decade, according to researchers who analyzed blood samples from volunteers in Southern China. The study found that flu-like illnesses can be caused by many pathogens, making it difficult to assess infection frequency.
Research at Henry Ford Hospital found that patients whose physicians recommended flu vaccination were more likely to receive it, with higher rates among white and Asian patients. The study suggests that improving communication between doctors and patients about the benefits of flu vaccination is crucial.
Scientists at the University of Oxford have built a complete model of the outer envelope of an influenza A virion using a coarse-grained molecular dynamics simulation. The simulation reveals various characteristics about the membrane components, including the separation of spike proteins and their interactions with host cells. This res...
UC San Diego researchers use social network analysis to combine Google Flu Trends' 'big data' with CDC data, improving predictions. The study refines Google's predictions by weighting them with a social network derived from CDC reports on laboratory-tested cases of flu.
A new analysis of human influenza B viruses sheds light on the pathogen causing seasonal flu, suggesting targeted vaccines and potential eradication of a slower-evolving lineage by expanding quadrivalent vaccine use.
Researchers at McMaster University have discovered a new class of antibodies that can neutralize a wide range of influenza A viruses, paving the way for a universal flu vaccine. The vaccine would only need to be given once and could protect against all strains of flu, even when the virus mutates.
Sepsis can be a complication of almost any type of infection, including influenza. Mayo Clinic expert Dr. Steve Peters explains the difference between severe sepsis and septic shock, symptoms to watch for, and treatment options.
A study found that the high-dose flu vaccine significantly improves immune response to flu virus in frail, older residents of long-term care facilities. The vaccine provided superior protection against laboratory-confirmed influenza illness compared to the standard vaccine.
A randomized controlled trial found the high-dose flu vaccine produced a stronger immune response in frail older adults living in long-term care facilities. The study suggests the high-dose vaccine may be the better option for this population to protect against flu.
Researchers have discovered a mutation in ferrets that shares similarities with humans, potentially leading to improved therapies for influenza and other diseases. This finding opens up a novel approach to tackling human diseases.
A University of Florida study found that vaccinating school-aged children from flu can protect other age groups, including non-school-aged residents, with significant reductions in influenza-like illness rates. This effect is profound, both on students and the community.
A Dartmouth/Univ. of Exeter study found that correcting myths about the flu vaccine did not effectively promote immunization among vaccine skeptics, and in some cases even reduced intention to vaccinate among those with high concerns about side effects.
A systematic review found that premature birth, neurological disorders, and multiple medical conditions significantly increase the risk of hospitalization in children with influenza. The study highlights the need for clearer guidelines on which children should be prioritized for seasonal flu vaccination.
A team of researchers has discovered that 'back boosting' the immune system by pre-emptively vaccinating against likely future strains of the influenza virus can significantly improve vaccine effectiveness. This approach would allow for more targeted and effective vaccination campaigns, potentially saving millions of lives worldwide.
A new algorithm called Above Local Elevated Respiratory Illness Threshold (ALERT) uses routinely collected data to signal the start of elevated influenza activity. The tool allows users to customize results based on their institution's historical data, helping them determine when to declare flu season and take extra precautions.
Hospital admissions for acute aortic dissection increased during peak flu season in the US, according to research. Researchers found a notable correlation between flu activity and AAD admissions from 2001-2013.
Researchers discovered flu infection prompts immune cells to migrate to gut, altering bacterial composition and causing inflammation that promotes tissue injury. Blocking inflammatory molecules or antibiotics attenuates intestinal injury, suggesting relief options for flu-induced gastrointestinal symptoms.
A new analysis of over 12,000 outbreaks affecting 44 million people worldwide reveals a rising trend in global infectious disease outbreaks, with 65% caused by zoonoses. Despite this increase, the impact of outbreaks is declining on a per capita basis.
Researchers discovered flu virus exploits aggresome, a cellular waste bundle, to release genetic material. The process takes 20-30 minutes and is gradual, with the virus tricking the waste pickup and disposal system.
A new study reveals how flu vaccines prevent heart attacks by stimulating the immune system to produce antibodies that protect the heart. The research identifies a protein called BKB2R as the key mechanism behind this protective effect, and suggests it could be harnessed to develop a vaccine against heart disease.
Research shows that influenza A potentiates pneumococcal co-infection by enhancing the bacterium's ability to colonize the nasopharynx and infect the middle ear. This interaction leads to increased inflammatory responses, allowing pneumococci to flourish in the host environment.
A flu shot is crucial for pregnant women to prevent serious illness and protect their babies from influenza. Vaccinated moms also have a lower risk of flu-related hospitalizations for chronic asthma, heart conditions, diabetes, and other health issues.
A mandatory employee vaccination policy at Henry Ford Health System resulted in a significant increase in flu vaccination rates, reaching 99% among health care workers. The system's success can be attributed to effective communication, education, and sufficient vaccine availability.
A new single-dose influenza drug, peramivir, shows promise in alleviating flu symptoms, including fever and viral shedding, when administered within 48 hours of symptom onset. It effectively reduces median time to alleviation of symptoms by 22 hours and is generally safe and well-tolerated.
Racial and ethnic minorities are less likely to get vaccinated against flu due to missed opportunities by healthcare professionals. Offering flu shots more frequently could increase adult vaccination rates to 50% or above for all groups.
Researchers discovered that club cells, which normally protect against inhaled microbes, contribute to prolonged inflammation during flu infection. Targeting these cells may help shorten flu symptoms by reducing lung damage.
A Vanderbilt-led study published in the New England Journal of Medicine found that the high-dose flu vaccine is 24% more effective than the standard-dose vaccine in protecting persons ages 65 and over against influenza illness. The study, which enrolled 31,989 participants, showed that the high-dose trivalent vaccine induces significan...
A study of 6,800 outpatients found antiviral therapy was given to only 19% of those at high risk for complications, while antibiotics were prescribed to 30%. The findings suggest a need for increased education on appropriate use in outpatient settings.
Researchers found that prior colonization by Streptococcus pneumoniae protected mice from severe disease and pneumonia. The protective effect was linked to the bacterial virulence factor pneumolysin, which reduced inflammation in the lungs.
University of Chicago scientists have developed new multiscale simulations that reveal the proton permeation mechanism in influenza A, a crucial step in viral replication. This breakthrough could lead to the development of more effective and targeted treatments against the flu.
A California-based study reveals a strong connection between hospital healthcare personnel influenza vaccination and the rate of influenza-like illnesses in surrounding communities. For every 15 vaccinated healthcare workers, one fewer case of flu is reported in the community.
Researchers found that SOCS4 suppresses the immune system's runaway reaction to flu infection, reducing the risk of cytokine storms and related deaths. The discovery provides a potential means of minimizing the impact of flu pandemics.
A new study from the University of Liverpool surveyed 1,821 people in Guangdong to understand how diseases such as bird flu spread among communities. The research found that people met around ten others each day and spent between five and ten hours a day with other people.
A study by University of Houston researchers found that Google Flu Trend overestimated flu cases in the US by up to 50% and failed to accurately predict levels in previous seasons. The researchers suggest combining big data with traditional methodologies for a more accurate understanding of human behavior.
A global inventory of flu strains in birds has identified over 116 avian flu strains in wild birds, twice the number found in domestic birds. The study also reveals patterns of flu diversity in different bird hosts, with some strains specific to certain species.
A new study suggests that self-administration of the flu vaccine via a microneedle patch could be feasible and increase vaccination rates. The study found that nearly all participants were able to accurately apply the patches, with significant increases in willingness to receive the vaccine.
A new study published in Nature Climate Change found no link between warmer winters and reduced excess winter death rates in the UK. Instead, flu activity was identified as the main cause of year-to-year variation in winter mortality.
A study by St. Jude Children's Research Hospital identified an immune signature that predicts poor flu outcomes in patients, who are more likely to develop severe symptoms and suffer from complications. The findings also explain why infants and toddlers are at elevated risk for flu-related issues.
A new study published in Diabetologia confirms that working-age adults with diabetes are at a higher risk of influenza compared to non-diabetic individuals. The research suggests that vaccinating this group could be cost-effective and mitigate healthcare costs associated with flu-related hospitalizations.
Researchers found that a new adjuvant improved flu vaccine effectiveness in mice and showed promise for the elderly. The study also highlighted the importance of characterizing immune responses following intra-nasal vaccinations, particularly with novel adjuvants.
The new website provides weekly predictions for US seasonal flu rates in 94 cities, based on a scientifically validated system. Flu cases are forecast to peak in January, with some areas already experiencing the worst of the outbreak.
Researchers at the University of Melbourne have identified a genetic marker that signals increased susceptibility to emerging influenza strains. This breakthrough allows clinicians to develop early intervention strategies for high-risk patients.
Researchers at Tufts University found that wolfberries can increase immune system activity and protect against the flu virus in older mice who received the flu vaccine. The study suggests potential benefits for humans as well, where age-related weakening of the immune system reduces vaccine effectiveness.
Scientists successfully predicted the timing of the 2012-2013 influenza season up to nine weeks in advance, providing actionable information for officials and the public. The flu forecasting system, using combined data from Google Flu Trends and CDC reports, outperformed alternate schemes and showed regional differences in accuracy.
Researchers at UC Davis and University of Rochester found that having health insurance increases use of preventive services like flu shots and health screenings, but does not affect risky health behaviors. The study contradicts a common concern that expanding healthcare coverage may encourage riskier behavior.
Researchers have identified that seasonal flu escapes immunity by making just a single amino acid substitution, occurring at seven specific places on its surface. This new understanding could lead to more effective flu vaccines.
A study found that Amphotericin B, a widely used anti-fungal medicine, neutralizes an important anti-viral protein IFITM3, making cells more susceptible to flu infection. This increases the risk of flu infections in patients with already compromised immune systems.
A social media program by San Diego State University professor Ming-Hsiang Tsou analyzed tweets for keywords 'flu' and 'influenza' to identify outbreaks. The algorithm detected daily correlations between tweet patterns and regional reports, with five cities showing the strongest correlations.
Research suggests that northern China conduct annual vaccinations starting in October, while southernmost provinces vaccinate in February. The study aims to optimize the timing of future vaccination programs and provides a clear picture of influenza seasonally across China.
Diagnosing influenza with a rapid test reduces the need for unnecessary antibiotics, lab tests, and antiviral medications. It also increases the prescription of antiviral drugs, leading to more targeted and efficient care in emergency departments.