Articles tagged with Liver Cancer
A new study predicts a 23% rise in metabolic dysfunction-associated steatosic liver disease (MASLD) in US adults from 2020 to 2050. The predicted increase is linked to rising obesity and diabetes rates, resulting in nearly twice as many liver cancers annually.
Men who are overweight or obese at age 18 have a higher risk of developing 17 different cancers later in life. Higher BMI is also associated with an increased risk of mortality after cancer diagnosis for certain types of cancer.
A new smartphone app using the APRI+ALBI score increases the safety of liver surgery by providing an individualized risk assessment for patients prior to resection. The score offers a cheaper and less invasive option with comparable predictive power compared to standard preoperative tests.
A collaborative study has identified key epigenetic targets for treating hepatoblastoma, the most common childhood liver cancer. The research found that the enzyme histone-lysine methyltransferase G9a plays a crucial role in epigenetic regulation and is a promising therapeutic target.
A clinical trial shows that a combination of atezolizumab and bevacizumab can reduce cancer recurrence in liver cancer patients by one-third after curative-intent resection or ablation. The therapy has improved recurrence-free survival rates compared to active surveillance, offering new hope for these patients.
Researchers at UC San Diego discovered that liver cells use vesicle exchange to share molecules and multiply, a process also found in various types of cancer cells. This mechanism could be a universal driver of resistance to cancer therapies targeting cell proliferation.
A University of Massachusetts Amherst team demonstrates a protein antigen from a childhood vaccine can be delivered into malignant tumor cells to refocus the immune system against cancer. The bacteria-based intracellular delivering system shows promise in treating pancreatic, liver, and metastatic breast tumors.
A University of Basel study reveals that high levels of arginine drive metabolic reprogramming to promote tumor growth. The findings suggest targeting the specific arginine-binding factor for effective liver cancer treatment.
A study published in the Chinese Medical Journal reveals that methotrexate can be an effective treatment for liver cancer with a specific genetic mutation. The drug works by disrupting nucleotide synthesis in cancer cells, making it a promising alternative to current first-line treatments.
A nationwide study from Karolinska Institutet in Sweden found that close relatives and partners of people with metabolic-associated fatty liver disease (MASLD) are at a higher risk of developing liver cancer and severe liver disease. This suggests that family members could benefit from the same lifestyle advice as patients with MASLD.
A new analysis of liver cancer identified racial and ethnic differences in cause, as well as emerging trends for this highly fatal disease. The study found that liver cancer disproportionately affects people of low socioeconomic status, immigrants, veterans, and incarcerated populations.
Researchers at HKUMed uncovered a novel intercellular interplay between tumour cells and endothelial cells initiated by sEV-vWF, facilitating liver cancer development and metastasis. The study suggests a potential therapeutic approach by blocking sEV-mediated tumour-endothelial communication.
A new gene therapy study has identified microRNA-22 as a potential treatment for liver cancer, achieving better survival outcomes and reducing inflammation compared to the current FDA-approved drug lenvatinib. The treatment was administered via a single intravenous injection and showed no observable toxicity.
Recent studies have identified molecular inflammatory mechanisms that trigger the growth and transformation of progenitor cells into cancer stem cells, a key step in liver cancer development. Maintaining progenitor cell compartment integrity could be an attractive therapeutic strategy, while targeting IL-17 production may eradicate CSC...
A large long-term study found that good cardiorespiratory fitness in young men is associated with a significantly lower risk of developing nine specific cancers, including a 40% reduced risk of liver cancer. Higher fitness was also linked to lower risks of rectal, pancreatic, and bowel cancers.
A study of 98,000 postmenopausal women found that daily consumption of sugar-sweetened beverages was associated with a higher incidence of liver cancer. The findings suggest a potential link between these beverages and chronic liver disease mortality.
A study published in JAMA found that consuming sugar sweetened beverages daily increased the risk of developing liver cancer and chronic liver disease by 85% and 68%, respectively. Researchers analyzed data from over 98,000 postmenopausal women and found a significant association between sugary drink consumption and liver health outcomes.
Researchers found all hallmarks of T cell exhaustion within six to 12 hours of tumor exposure, including dramatic changes in gene expression and chromatin accessibility. The study challenges existing ideas about how T cells become exhausted and has implications for cancer immunotherapies.
A new study by Boston University researchers found that the volume of liver resected during gallbladder cancer surgery does not significantly affect overall survival rate when all cancer is removed. In contrast, larger liver resections were associated with more complications and longer hospital stays.
Researchers at St. Jude Children's Research Hospital created a more accurate hepatoblastoma model to improve therapies, focusing on DNA damage repair pathways. The model identified potential targets and validated the effectiveness of PRKDC inhibition when combined with doxorubicin, enhancing treatment efficacy.
Researchers from the University of Copenhagen have solved the mystery of how the Hepatitis C virus evades the human immune system. The virus uses a molecule called FAD as a 'mask', cloaking itself in a form that is already present in cells, making it invisible to the immune system.
A study found disparities in Hispanic cancer mortality rates, with higher rates for men in certain age groups and women for liver, pancreatic, and uterine cancers. The researchers highlight the need for targeted education and screening efforts to address these disparities.
Researchers have developed a new technique to generically treat several kinds of cancer, showing tumors grew almost three times less and survival rates reached 100% after just one injection. The method targets cancer cells with alpha radiation, sparing healthy tissue.
A new study found that obesity is associated with an increased risk of certain cancers, with stronger links in female patients for gallbladder and endometrial cancer. The study also revealed differential effects between sexes on colorectal, esophageal, and liver cancer.
Researchers found that distant cancers alter liver function by inducing fat accumulation and inflammation in liver cells. The process involves secretion of extracellular vesicles containing fatty acids, which reprogram the liver to resemble fatty liver disease.
Researchers analyzed 28 samples of curd cheese and mozzarella from Brazil and found aflatoxins in all, with levels below the European Union's upper limit. The study highlights the need for improved production practices throughout the dairy industry to minimize contamination.
Researchers have discovered that HER3 plays a crucial role in promoting cell survival in metastatic colorectal and pancreatic cancer. The surrounding liver microenvironment activates HER3, making it an emerging therapeutic target for these types of cancer.
Researchers found that B cells in the gastrointestinal tract play a crucial role in promoting liver cancer by activating autoaggressive T cells and producing IgA antibodies. When B cells are turned off, inflammation and fibrosis regress in mice, suggesting new ways to prevent NASH and liver cancer.
A study by Dr. Manel Esteller's team has identified a key epigenetic alteration in liver cancer that makes tumors more vulnerable to a specific class of anticancer drugs. This discovery may lead to improved treatment options for patients with liver cancer, particularly those with intact NSUN7 gene function.
SpaceMarkers, a new machine learning software, can identify molecular interactions among distinct cell types in and around tumors. By analyzing spatial transcriptomics data, it reveals genes overexpressed due to cell-to-cell interactions, providing new avenues for understanding cancer progression and treatment responses.
A new study from the USC Norris Comprehensive Cancer Center found that immigrant adults with liver cancer have a significantly higher five-year survival rate compared to those born in the US. The study identified disparities in survival rates across different racial and ethnic groups, with immigrants demonstrating better outcomes.
Researchers used human liver organoids to study fibrolamellar carcinoma, a rare childhood liver cancer. They found that different genetic mutations underlie different degrees of aggressiveness in the tumors, and uncovered the probable cell-of-origin as hepatocytes.
Researchers at West Virginia University found that bariatric surgery significantly reduces the risk of major cardiovascular events and death in patients with NAFLD. The study included 9,374 adult patients with NAFLD and obesity, who underwent either Roux-en-Y gastric bypass or sleeve gastrectomy.
Jeong Min Lee, KSR President and professor at Seoul National University Hospital, is honored with ARRS membership. He has published over 470 scientific articles and serves on the editorial board of several publications.
The National Cancer Centre Singapore has strengthened its position as a leader in shaping local and international clinical trials targeted at improving outcomes for Asian cancers. A pivotal phase III trial co-chaired by a NCCS clinician scientist delivered positive results, increasing recurrence-free survival of patients with hepatocel...
Researchers have identified a genetic signature in pre-malignant liver cells, which could help determine the future risk of developing liver cancer. The discovery has significant implications for staging and monitoring chronic liver disease patients.
Researchers found that a protein associated with liver cancer, ATF4, protects the liver by promoting the expression of SLC7A11, which suppresses ferroptosis and slows liver cancer progression. This unexpected result could inspire new treatments for preventing liver disease and cancer.
Scientists have created a new method to model liver cancer tumor subtypes using CRISPR-Cas9, discovering that specific gene isoforms can lead to different cancer subtypes. This platform could help researchers develop new therapeutic interventions for treating cancer and other diseases.
Researchers created the integrated-gut-liver-on-a-chip platform to examine how gut and liver cells interact, particularly in relation to non-alcoholic fatty liver disease. The study showed significant changes in gene expression and DNA damage when free fatty acids were introduced, leading to cell death similar to severe cases of NAFLD.
A new study by Cedars-Sinai investigators found that ChatGPT can provide easy-to-understand information about basic knowledge, lifestyle, and treatments for cirrhosis and liver cancer. The AI system has the potential to play a role in clinical practice and empower patients with knowledge about their disease.
Cancer cells have been found to employ a strategy to evade the immune system's killer T cells by interacting with myeloid cells and suppressing type 1 interferon production. This natural pathway is crucial for recruiting killer T cells to combat cancer spread. Researchers hope to develop new therapeutic approaches, such as forcing tumo...
A new radiotracer successfully detected 100% of primary tumors across multiple cancer types, outperforming the current standard. It also showed promise in detecting lymph node and distant metastases, offering a promising alternative for diagnosis and treatment.
Researchers found an enzyme in liver cancer cells that can convert a group of compounds into anticancer drugs, killing cells and reducing disease in animals. The enzyme SULT1A1 activates compounds like YC-1, making them toxic to tumor cells.
Researchers at City University of Hong Kong identified lysyl hydroxylase 1 (LH1) as a key factor in promoting confined migration of liver and pancreatic cancer cells. The study found that LH1 promotes metastasis by stabilizing Septin2, which enhances the actin network.
Researchers have developed a new imaging approach to diagnose advanced non-alcoholic fatty liver disease (NASH). The enzyme-sensitive nanoprobe emits signals that can be detected by MRI techniques, providing more accurate and sensitive data for diagnosis. This breakthrough aims to improve the treatment outcomes of NASH patients.
The use of AI is improving diagnostic accuracy for digestive cancers, but challenges in data sharing and standardization hinder its widespread application. Researchers surveyed recent applications of AI to these deadly cancers, finding that AI can automate complex processes and detect patterns not visible to humans.
A study by researchers at TUM found that gut bacteria play a crucial role in liver regeneration. The microbiome produces short-chain fatty acids, which are essential for liver cell growth and division. In mice treated with antibiotics, liver regeneration was delayed or not possible, but a
Researchers discovered that combining ferroptosis induction with immune checkpoint inhibition reduces liver tumour growth and metastases, offering a promising new approach for treating liver cancer
Researchers explore CEACAM1, CEACAM5, and CEACAM6's pathological significance in cancer biology and immunology. The review highlights their interactions with pathogens and potential avenues for cancer therapy.
Researchers at the Francis Crick Institute created a comprehensive map of metabolic pathways in mice, then gathered data to put into a model predicting diet effects on liver cancer. The study found specific changes in metabolism associated with unhealthy diets promote cancer cell growth.
Researchers found a molecular staple called NIHCOLE that helps liver cancer cells repair broken DNA, making them resistant to radiotherapy. Understanding this mechanism may lead to the development of new strategies to combat liver cancers with poor prognosis.
A UK study found that people with type 2 diabetes have substantially higher cancer mortality rates than the general population. Breast cancer mortality in younger women with T2D is rising, highlighting the need for extended screening, better management of diabetes and its complications, and improved cancer treatments.
Researchers successfully applied AlphaFold AI to an end-to-end platform, discovering a novel target and developing a potent hit molecule for liver cancer. The study demonstrates the potential of AI-powered drug discovery to accelerate treatment development.
Researchers found that inhibiting HSF1 signaling reduces hepatoblastoma growth and induces apoptosis, suggesting it as a viable pharmacologic target. The study also identified HSF1's role in tumor aggressiveness and its potential association with mortality.
A phase II clinical study has found that nearly 50% of patients with inoperable locally advanced liver cancer can be cured using the tri-modality therapy. The 'Reduce and Remove' approach, which combines TACE, SBRT, and immunotherapy, results in a 90% two-year survival rate with minimal side effects.
Researchers from prominent institutions discuss hepatocellular carcinoma's pathogenesis, genomic heterogeneity, and targeted therapy options. The review aims to characterize HCC's complexities and develop clinically relevant biomarkers for better management.
Researchers at USC Keck School of Medicine found that liver cancer cells hijack circadian clock proteins to replicate and spread. Inhibiting these proteins can prevent cancer cell multiplication and potentially improve outcomes for patients with liver cancer.
A study by Sanford Burnham Prebys found that misfolded proteins in liver cells contribute to liver cancer development, potentially increasing the risk of certain patients receiving gene therapies for hemophilia. Improving FVIII folding could decrease this risk and develop safer treatments.
Researchers found that P2-HNF4α expression is associated with p-STAT3 and c-Myc expression in NAFLD patients, suggesting potential biomarkers for hepatocellular carcinoma (HCC) risk. Additionally, p-STAT3 expression was linked to hypertension, while c-Myc expression was associated with advanced fibrosis.
A team of researchers has developed a bioorthogonal molecular system that selectively transports nitrite ions to the endoplasmic reticulum, where they are released, triggering cell death in cancer cells. The system demonstrates synergistic effects with various cancer therapy drugs.