Articles tagged with Liver Cancer
Researchers engineered mini liver tumours co-cultured with endothelial cells to investigate their crosstalk. The team found that endothelial cells promote the production of CXCL1, a protein associated with poor survival outcome in liver cancer patients.
A new interactive web portal, SpUR, catalogues over 1,000 splicing events found in cancers, highlighting their role in tumor development and progression. The database provides a platform for researchers to study RNA dysregulations in cancer and develop RNA-based anti-cancer drugs.
A new review highlights the risks of fatty liver disease caused by metabolic dysfunction, characterized by fat accumulation in liver cells and oxidative stress. The progression of the disease can lead to inflammation, fibrosis, and cirrhosis with a high risk of hepatocellular carcinoma.
A new combination therapy using a tumor-suppressing lipid molecule and an antibody for cytotoxic T-lymphocyte antigen 4 has been shown to significantly slow tumor growth and enhance the strength of tumor-attacking T cells in liver cancer. This promising approach offers hope for patients with limited treatment options.
A study by Osaka University found that fat accumulation in liver tumors can predict patient response to immunotherapy. The researchers identified a unique tumor immune microenvironment, known as steatotic HCC, which is associated with high infiltration of immune cells but exhaustion of nearby T cells.
A new study from University of Gothenburg found that men with high childhood BMI are at an elevated risk of obesity-related cancer, even if their weight is normal in young adulthood. The study analyzed data from 6,565 men born between 1945 and 1961 and found a persistently increased risk of adult obesity-related cancer.
Researchers have found a way to partially reset liver cells to more youthful states, allowing them to heal damaged tissue at a faster rate than previously observed. The use of reprogramming molecules improves cell growth and leads to better liver tissue regeneration in mice.
A new study has identified a strong predictor for the development of clinically important liver problems in people with Hemochromatosis. Researchers found that 84% of those with advanced liver fibrosis also had arthritis, highlighting the importance of early detection and monitoring.
Researchers at MD Anderson have made significant advancements in treating neuroendocrine tumors with combination therapy, identified consensus subtypes for hepatocellular carcinoma to improve treatment selection, and found a targetable vulnerability in urothelial cancer due to MTAP loss.
The American Gastroenterological Association (AGA) has issued new clinical practice guidelines on systemic therapy for HCC, emphasizing the importance of consulting a multidisciplinary team of healthcare professionals. The guidelines provide specific patient scenarios and treatment options to help hepatologists make informed decisions.
A comprehensive analysis of over 2,200 patients in Europe reveals the complexity of cholangiocarcinoma, a rare cancer often diagnosed at an advanced stage. The study highlights the need for education programs to raise awareness and improve early diagnosis, survival, and quality of life.
A team of researchers has reprogrammed the tumor microenvironment of liver cancer by using mRNA nanoparticles, restoring the function of the p53 master regulator gene. The approach increased antitumor immune responses in hepatocellular carcinoma laboratory models and shows promise for treating HCC and other cancers.
Scientists at Cold Spring Harbor Laboratory have developed a way to interfere with the energy pathway that allows liver cancer to grow and spread by targeting the pyruvate kinase protein. This approach uses antisense oligonucleotides, which reduce tumor development in mouse models, offering a potential treatment for liver cancer.
A new Chinese Medical Journal study explores the risks of non-alcoholic steatohepatitis (NASH) turning into liver cancer. Early detection through simple medication and lifestyle changes can prevent NAFLD from progressing to more severe conditions, such as cirrhosis and hepatocellular carcinoma.
A new algorithm can determine patients' liver cancer risk in a single examination, providing an efficient screening method for those at high risk. The tool uses blood values and liver stiffness to identify individuals with a higher likelihood of developing hepatocellular carcinoma after hepatitis C treatment.
A study of 1,000 patients found that some recoverees from hepatitis C still face liver cancer risks after treatment. Researchers propose a 2-step strategy combining FIB-4 and transient elastography/ultrasound to predict high-risk cases.
Researchers at HKUMed have discovered a stepwise upregulation of polymeric immunoglobulin receptor (pIgR) in circulating extracellular vesicles from liver cancer patients, suggesting its potential as a non-invasive diagnostic marker. The study also found that pIgR-enriched EVs promote cancer stemness and tumorigenesis in mouse models, ...
Researchers at Osaka University have made a breakthrough in understanding the molecular mechanisms behind Intrahepatic cholangiocarcinoma (ICC), a deadly form of liver cancer. By identifying TRAF3 and NIK as key players, they have uncovered potential therapeutic targets for novel ICC treatment.
A new review suggests that moderate coffee consumption can stimulate digestive processes and help movement through the colon. The study also found a possible association between coffee consumption and reduced risk of gallstones and certain liver diseases. However, further research is needed to confirm these findings.
Researchers have identified a molecular mechanism underlying liver cirrhosis, a deadly disease poorly understood. The discovery, made using genetically modified mice, reveals that the lack of MCRS1 protein leads to bile acid accumulation and fibrosis, opening new avenues for treatment.
Researchers found that alterations in the RNF43 and ZNRF3 genes lead to an accumulation of lipids and inflammation in the liver, increasing the risk of developing non-alcoholic steatohepatitis (NASH) and fatty liver disease. These genetic changes also affect liver cell proliferation, contributing to the progression of liver diseases.
Researchers at UT Southwestern Medical Center have developed a promising liver-specific microRNA drug that shows minimal toxicity in mice, preventing cancer cells from establishing themselves in the liver. The new treatment has potential as a candidate for companies developing mRNA vaccines for COVID-19.
The American Society for Radiation Oncology (ASTRO) has released a new clinical guideline outlining the use of external beam radiation therapy (EBRT) to treat adult patients with primary liver cancers. The guidelines emphasize multidisciplinary care and provide evidence-based recommendations on indications, dosing, techniques, and trea...
Researchers at Karolinska Institutet have identified a specific connection between a protein and an lncRNA molecule that can help decrease fat depots in tumor cells, leading to cell division cessation and cancer cell death. The study contributes to increased knowledge of liver cancer diagnosis and future treatments.
The new technology can reliably distinguish between cancerous and healthy liver tissue, aiding diagnosis and potentially reducing errors in biopsies. The researchers plan to continue measuring fluorescence lifetime parameters in patients with different types of tumors to generate real-time diagnostic classifiers.
Researchers have developed a CRISPR/Cas9 gene editing system to enhance the effectiveness of sonodynamic therapy, allowing tumors to be effectively shrunk in a mouse model of liver cancer. The technology reduces antioxidant defense systems, increasing cancer cell death from the treatment.
Researchers at University of California San Diego found a way to boost innate immunity in liver cancer, making tumors highly responsive to immunotherapy. The combination of anti-PD-L1 antibody and polyIC molecule showed remarkable synergistic effects in liver tumor inhibition.
Researchers at Princeton University have discovered a new compound that can disable the MTDH gene, which is essential for cancer progression and metastasis. The compound shows promise in treating major human cancers, including breast, prostate, lung, and colon cancers.
A cohort study of 165 patients with hepatitis C-related hepatocellular carcinoma found that treating the virus with direct-acting antivirals reduces tumor progression and metastasis. The study showed a 72% reduction in tumor progression and an 88% reduction in risk of death from HCC.
A new analysis of US national data finds that external-beam radiation therapy is a proven treatment option for patients with unresectable liver cancer but is rarely prescribed, with only 3.6% of patients receiving it. The study suggests that institutional and regional practice patterns play a key role in driving treatment decisions.
A study published in The Journal of Nuclear Medicine found that PSMA PET/CT is more accurate than conventional CT in detecting hepatocellular carcinoma metastases. This led to a change in management plans for nearly half of the patients, enabling them to receive effective treatment.
Scientists use modern imaging technology to determine liver cancer subtypes, identifying specific sugar structures that correlate to different subtypes. This approach could lead to earlier detection and more personalized therapies for hepatocellular carcinoma.
A study at Hiroshima University analyzed 160 pediatric liver cancer cases, identifying molecular markers that help understand treatment outcomes. The research found that ASCL2 and IGF2 production play a crucial role in the disease's development, with 'cell of origin' being a premature hepatoblast.
The most common form of liver cancer is on the rise in rural areas, with men aged 60-69 and non-Hispanic Blacks disproportionately affected. Urban areas, however, have seen a decline in HCC rates since 2013, including among younger individuals and certain ethnic groups.
Researchers identified a minimal set of defined factors that can convert normal human fibroblast cells to liver cancer cells, providing a mechanistic proof-of-principle for understanding why certain mutations cause cancer in particular tissues.
Researchers have found that viruses like hepatitis B and C do not always kill infected cells, but instead cause long-term changes. These changes can affect genes related to cell division and metabolism, potentially contributing to increased risk of liver cancer in cured patients.
A novel approach to improve fitness for surgery, known as 'prehabilitation', has been shown to reduce cancer patients' hospital stay by 1.8 days compared to standard care. This study suggests that prehabilitation can benefit patient outcomes and potentially confer a survival advantage.
A Korean population-based cohort study found that cancer, particularly multiple myeloma and leukemia, is associated with an increased risk of kidney failure. The study included approximately 825,000 patients with cancer compared to twice as many without cancer, matched on other characteristics.
A new study by Salk scientists found that time-restricted eating (TRE) confers multiple health benefits, including reduced risk of type 2 diabetes, fatty liver disease, and sepsis, regardless of age and sex. TRE may also protect against infectious diseases like COVID-19 and improve insulin resistance.
Researchers at Johns Hopkins Medicine discovered a combination therapy that allows some advanced liver cancer patients to undergo successful surgical removal of their cancer. The treatment, involving cabozantinib and nivolumab, has shown promising results in shrinking tumors and reducing the risk of recurrence.
A global study estimates that 4% of all newly diagnosed cancers in 2020 are associated with drinking alcohol, with men accounting for more than three-quarters of those cases. Moderate drinking was found to be problematic, contributing to over 103,000 cases.
Bariatric surgery significantly reduces the risk of cancer in individuals with severe obesity and nonalcoholic fatty liver disease (NAFLD), especially obesity-related cancers. The study found a 25% reduction in risk for obesity-related cancers.
Research found that immunotherapy using checkpoint inhibitors does not benefit patients with NASH-related liver cancer, and may even promote tumor growth. The study identified a biomarker to assess treatment efficacy in these patients.
Researchers discovered that varying levels of a DNA repair enzyme called AAG can lead to different outcomes after exposure to NDMA, a probable carcinogen. High levels of AAG can cause tissue damage and cell death, while low levels can result in more cancer mutations.
Advanced liver fibrosis worsens cancer-specific and overall survival in iCCA patients, regardless of surgical resection. Patients with advanced fibrosis are at increased risk of mortality across follow-up periods.
A study published in Cancer found that nearly one-third of Black patients would not have qualified for liver cancer screening using common cirrhosis measures. The researchers also discovered that the tumors in Black patients tended to be larger, more numerous, and more invasive at diagnosis.
A global survey revealed significant disruptions to liver cancer care during the COVID-19 pandemic, including delayed screenings and treatments. The survey found that 87% of participating cancer treatment centers modified their clinical practices, highlighting the need for continued investment in liver oncology nurses and education.
Researchers found a distinctive gut microbiome profile in people with liver cancer linked to non-alcoholic fatty liver disease (NAFLD) that modulates the immune response, promoting cancer survival. This discovery could lead to more effective preventative and therapeutic treatments for NAFLD-related liver cancer.
Researchers developed a risk score to prioritize liver cancer patients for transplantation, accounting for both cancer-related and non-cancer-related factors. The LiTES-HCC score predicts post-transplant survival for hepatocellular carcinoma patients, leading to more efficient allocation of livers.
Researchers at Massachusetts General Hospital have found that reprogramming the connective tissue microenvironment of a liver cancer can inhibit its progression and resistance to chemotherapy. Blocking placental growth factor (PlGF) with antibodies reduces production of connective tissue and increases survival in mice with liver cancer.
A new study found that tumors in the liver siphon off critical immune cells, rendering immunotherapy ineffective. However, coupling immunotherapy with radiotherapy restored immune cell function and led to better outcomes in mice. Researchers are now exploring potential clinical trials to understand the mechanisms at play.
A new treatment combination combining radiofrequency ablation and chemotherapy drug sunitinib significantly reduces tumor growth and extends the life span of mice with liver cancer. The therapy triggers an immune response to target and destroy liver cancer cells.
Osaka University researchers developed a technique to study liver cancer genes in lab mice, identifying a serum biomarker for effective treatment. The study found that FGF19-driven HCC is susceptible to lenvatinib treatment and a specific protein, ST6GAL1, can be used as a biomarker.
A major new study found that men with two copies of the faulty haemochromatosis genes are 10 times more likely to develop liver cancer by age 75 compared to the general population. Researchers call for routine early testing for the iron overload condition.
A recent study published by Shinshu University found that eating less can significantly reduce the risk of liver cancer caused by fatty liver. The research team observed a 41% decrease in liver tumors in mice with hepatitis C virus core gene, simply through dietary restriction.
A study analyzing US cancer data reveals patients from rural regions and lower-income households often have advanced liver cancer at diagnosis and face higher mortality rates. This highlights the need for targeted quality improvement interventions to address healthcare disparities affecting these populations.
Researchers discovered that liver tumors can harness the liver's powers to retrain the immune system and exert its influence on distant cancer cells. Adding a second checkpoint inhibitor in combination therapy may overcome this resistance and increase immunotherapy effectiveness.
Researchers used nationwide cancer mapping statistics to develop a mathematical model that reveals patterns of cancer incidence by remoteness. The study found cancers having higher incidence in remote areas include head and neck, liver, lung, oesophageal, cervical, and uterine cancers.
Researchers have identified a protein PPARα that regulates bile acid metabolism and suppresses the growth of cholangiocarcinoma in mice. The study provides new insights into liver cancer development and suggests potential therapeutic targets.
Scientists have identified a microRNA in obese mouse mothers that increases the odds of liver cancer in their offspring and throughout future generations. The study found that maternal obesity causes susceptibility to liver cancer in offspring, with the severity increasing over generations.