Articles tagged with Measles
Mayo Clinic researchers used genetic sequencing to study the measles virus's spread in a human brain. The study found that the virus acquired distinct mutations that drove its spread from the frontal cortex outward. This knowledge may help develop effective antiviral drugs to combat SSPE, a rare and lethal brain disease caused by measles.
A new study by Texas A&M University researchers found a significant decrease in measles antibody concentrations with increasing urinary arsenic levels in children with low serum folate levels. Folate intake may mitigate the toxic effects of chronic arsenic exposure, but the unequal impact of arsenic by sex remains unclear.
A study will examine the cognitive function of older adults who were exposed to measles during childhood, shedding light on potential long-term benefits of routine childhood vaccinations. The research aims to better understand how childhood experiences shape health and well-being across the life course.
A new study published in JAMA Network Open found live vaccinations safe and effective for children who have received liver or kidney transplants, offering protection against life-threatening conditions. The study showed high antibody levels and minimal adverse events following vaccination.
Scientists have developed a trivalent vaccine candidate that provides broad and long-lasting protection against COVID-19 infection by delivering the vaccine via the nose. The vaccine triggers a strong neutralizing antibody response and protects mucosal areas, preventing disease symptoms.
A nationwide ecological study in Brazil found a significant decline in MMR vaccine coverage between 2006 and 2020, with approximately half of municipalities falling short of the 95% target. This decline may leave these areas vulnerable to future outbreaks.
A third of under-fives attending Paediatric Emergency Departments have unmet vaccination need, with tetanus and MMR vaccination coverage levels below target. Researchers call for catch-up campaigns to reach this vulnerable group.
A London hospital recently took swift action to contain a potential measles outbreak, highlighting the importance of vaccination and prompt contact tracing. The hospital identified nine patients at high risk, including pregnant women and those with severe immunosuppression, and administered post-exposure prophylaxis to those not immune.
Researchers found that measles virus mutations in its fusion protein allow it to infect nerve cells, leading to subacute sclerosing panencephalitis. The team's discovery sheds light on the evolutionary mechanisms of viruses like coronaviruses and herpesviruses.
A study conducted in Brazil reveals that only 75.8% of under-fifteen children in São Paulo have antibodies against measles, falling short of the ideal 94% target to prevent outbreaks. The finding is a warning sign that Brazilian children are not achieving herd immunity, making them susceptible to infection.
A Queen Mary University of London study found that only 75% of children receive the first MMR vaccine on time, with poorest neighborhoods most affected. The researchers call for increased investment in vaccination services to ensure all London children are protected from measles.
Researchers have reverse-engineered a virus linked to chronic kidney disease in cats and described its mechanism of infection. The feline morbillivirus, or FeMV, can spread from host to host through urine, similar to the zoonotic Nipah virus.
Researchers mapped the spread of pathogens in wild macaque populations near human settlements, finding that monkeys with high human interactions cause larger outbreaks. The study used computer simulations to predict disease transmission and identified key factors influencing outbreak size.
A new study by the University of Georgia finds that current vaccine approaches are unlikely to eradicate measles, with a basic reproduction number of 18 for measles. The researchers propose novel approaches to improve vaccine coverage equity and reevaluate cessation criteria to prevent outbreaks.
Public health researchers developed a global vaccine risk index (VRI) to predict vaccine coverage lapses worldwide. The VRI considers factors like measles incidence, vaccine confidence, climate change, education, and income, revealing countries at high risk of disease outbreaks.
Researchers have published the first-ever look at a key stage in the life cycles of measles and Nipah viruses, revealing how future therapies might stop these viruses. The study identifies how paramyxoviruses utilize a host cell lipid for viral spread, providing a new target for developing inhibitors of the assembly process.
A novel point-of-care biosensing device has been developed to detect measles virions in human saliva, potentially aiding in viral spread control. The device, smaller than a €1-cent coin or U.S. quarter, utilizes lab-on-a-chip technology and showed high accuracy in experiments.
A systematic review of 35 observational studies found that current immunisation coverage target of 95% may only be the minimum requirement for elimination. The analysis estimated average MCV2 vaccine effectiveness was 96.4%, indicating that a vaccination level of 95% should be considered a minimum requirement, not a goal.
Low MMR vaccine uptake is being blamed for a decline in protective immunity, with only 95% coverage needed to prevent outbreaks. Experts urge parents and healthcare professionals to improve awareness and uptake of the vaccine.
A new study by researchers from the Annenberg Public Policy Center finds that exposure to alternative health media can affect beliefs about consequential health-care issues like vaccination. After Dr. Mehmet Oz endorsed the MMR (measles-mumps-rubella) vaccine on a March 2019 episode of “The Dr. Oz Show,” significantly more people in hi...
Researchers found that even unrelated vaccines can provide cross-protection against multiple pathogens, reducing caseloads and hospital usage. Vaccinating vulnerable populations with other vaccines during the pandemic can have a substantial impact.
The study suggests that COVID-19 eradication is technically possible due to the availability of safe vaccines, lifelong immunity, and effective government management. However, securing high vaccine coverage and responding quickly to variants are major challenges.
High-quality vaccination programs protect people of all ages, from infants to the elderly, but many adults remain under- or unvaccinated. The article highlights the importance of vaccines in preventing life-threatening diseases and discusses challenges in ensuring equitable access to vaccines.
A Kaiser Permanente study found that child vaccination rates declined significantly during the COVID-19 pandemic, with measles vaccination coverage remaining substantially reduced in many age groups. The decline was more severe and persistent in older children, highlighting concerns about vaccine-preventable diseases.
A new SARS-CoV-2 vaccine candidate has shown strong immune responses and prevented infection in multiple animal studies. The vaccine uses a modified measles vaccine platform to stimulate immunity, potentially offering advantages over existing vaccines.
A new modelling study estimates that without vaccination, mortality in children under five would be 45% higher in low-income and middle-income countries. Vaccination has prevented 69 million deaths between 2000-2030.
A new study estimates that vaccination against 10 major pathogens will have prevented 69 million deaths in low-income and middle-income countries between 2000 and 2030. Vaccination programs are expected to reduce mortality from these diseases by 72% for those born in 2019, with the greatest impact on children under five.
A new scientific study examines vaccine delivery in low- and middle-income nations, finding higher vaccination rates in urban areas than rural communities. The study highlights the need for policymakers to target both urban and remote locations to equitably vaccinate all children.
Major measles outbreaks will occur globally in 2021 due to widespread vaccination delays caused by the COVID-19 pandemic. Malnutrition and vitamin A deficiency worsen measles severity, leading to increased deaths and blindness.
Local spatial clustering of non-vaccinated individuals can lead to large measles outbreaks even at high overall vaccination coverage. The study highlights the importance of fine-scale vaccination data for effective targeted interventions in high-risk areas.
A new study from the University of Michigan suggests that localized data on childhood vaccination coverage can help predict and prevent measles outbreaks. The research found that when people who are not vaccinated cluster geographically, the probability and size of an outbreak increase.
A new study suggests that localized vaccination surveillance can help predict and prevent measles outbreaks by analyzing geographic clustering of non-vaccinators. The researchers found that even at high overall vaccination coverage, clustering of non-vaccinators increases the probability and size of an outbreak.
A study found that vaccination with the measles-mumps-rubella (MMR) vaccine reduced the severity of COVID-19 in high-risk patients. Out of 36 cases, none required supplementary oxygen or respiratory insufficiency.
Research in Niger links measles outbreaks to rainfall and temperature patterns, revealing a strong annual cycle associated with agricultural labor migrations. Vaccination strategies targeting migrating populations during the rainy season may break this pattern, reducing outbreaks.
Scientists at Georgia State University have identified a potent and well-tolerated antiviral compound, GHP-88309, that targets paramyxovirus polymerases. The compound is effective against both human parainfluenzaviruses and the measles virus.
Researchers propose that MMR vaccination could provide protection against COVID-19 in children, based on sequence similarity between SARS-CoV-2 and measles viruses. Experimental research is needed to support this hypothesis and confirm the duration of protection.
A new study suggests the measles virus emerged in humans around 528 BCE, thousands of years earlier than previously thought. Researchers used lung samples and genome sequencing data to reconstruct the virus's evolutionary history, tracing its emergence from a cattle-infecting relative.
A team of researchers sequenced a measles genome from 1912 and found it likely arose in human populations around the 6th century BCE. This finding suggests that large cities may have played a role in the emergence of the virus. Understanding the origins of COVID-19 could help protect against and fight the pandemic.
A recent study found that delayed vaccinations and increased contact among young children, likely through 'measles parties', fueled the 2019 measles outbreak in NYC. Vaccination campaigns averted a huge spike in cases, but experts warn of potential future outbreaks as vaccination rates plummet.
Researchers modeled measles dynamics using 40 years of English and Welsh data, revealing local town spread contributes to virus persistence before vaccination. After introduction, unidentifiable sources became main reintroduction pathway.
A Cochrane Review confirms the effectiveness of MMR vaccines in preventing infectious diseases such as measles, mumps, and rubella. The review found that one dose of vaccine was 95% effective in preventing measles and 89% effective in preventing rubella, with no association between the vaccines and autism or other conditions.
Research finds people with vaccine skepticism tend to overestimate the likelihood of rare negative events, including mortality-related causes. This suggests a possible explanation for their concerns: cognitive or affective variables influencing vaccine skepticism.
A study conducted in northwestern São Paulo found that nearly a third of the population under 40 lacked immunity against measles, with only 1% over 50 showing similar results. Vaccination remains essential in preventing transmission and controlling outbreaks.
Scientists have determined the 3D atomic structure of a key enzyme complex in paramyxoviruses, a family of RNA viruses that includes measles, mumps, human parainfluenza and respiratory syncytial virus (RSV). This discovery could lead to the development of new antiviral drugs for these viruses as well as coronavirus.
A study found that people exposed to vaccine content on social media were more likely to be misinformed about vaccines than those exposed to it on traditional media. Up to 20% of respondents were at least somewhat misinformed, with common claims including the link between vaccines and autism.
A recent study published in BMJ Case Reports highlights the serious complications of measles, including hepatitis, appendicitis, and viral meningitis. The authors report on three cases of adults treated for measles, highlighting the need for urgent efforts to ensure global coverage with two-dose measles vaccines.
A study found that almost 60% of eligible young travelers were not vaccinated due to clinician decision or guardian refusal, despite recommendations from the Advisory Committee on Immunization Practices. The researchers emphasize the urgent need for greater awareness of MMR vaccination benefits for international travelers.
A study by Harvard Medical School researchers found that the measles virus depletes antibody repertoires, erasing immune memory to most previously encountered pathogens. This supports the immune amnesia hypothesis, suggesting that the vaccine's extended protective effects stem from preventing measles infection.
A study by the Wellcome Sanger Institute and University of Amsterdam found that measles virus deletes part of the immune system's memory, removing immunity to other infections in humans and ferrets. This 'immunological amnesia' increases vulnerability to secondary diseases like flu, diphtheria, and tuberculosis.
In unvaccinated children, measles infection can cause a significant weakening of the immune system, leading to impaired immunity against viruses and bacteria for months or even years. This phenomenon, known as 'immune amnesia,' was observed in two separate studies published in Science Immunology and Science.
A recent study published in Science reveals that measles virus infection can eliminate up to 73% of a child's protective antibodies, rendering them defenseless against other viruses. The discovery underscores the importance of widespread vaccination and highlights the potential consequences of measles infection on the immune system.
A vaccine for Lassa fever, a hemorrhagic disease causing up to 6,000 deaths annually, is set to enter human clinical trials. The measles platform-based vaccine demonstrated the best protection against the virus in preclinical tests.
Experts discuss the importance of vaccination in preventing serious complications from diseases like measles, influenza, and cystic fibrosis. The panel emphasizes that vaccines are effective in keeping disease rates low when majority of people are vaccinated.
A simple epidemiological model accurately predicts measles transmission dynamics in London over almost a century, accounting for historical events like the 1918 pandemic. The study's findings suggest long-term disease dynamics can follow simple rules, with implications for understanding other ecological phenomena.
Research suggests that infection with measles in unvaccinated children increases their risk of other severe infectious diseases in the 2-3 years following infection. Measles can cause immune-amnesia, erasing immunity to other diseases and exposing children to re-infection. Vaccination is crucial for preventing measles-related infections.
A study published in PLOS ONE found that individuals' vaccination attitudes are shaped by their proximity to a disease outbreak, particularly for those who distrust government medical experts. On the other hand, people with high levels of trust in government experts are not affected by disease proximity.
The study identified a novel protein interface in the polymerase complex that is pivotal for regulating polymerase activity, providing a new objective for target-based antiviral drug discovery. The findings reveal a vulnerability in the viral genome that could be exploited as a target for small-molecule antiviral drugs.
A computer simulation reveals that a 5% decrease in vaccination rates could lead to massive measles outbreaks in Texas cities, with Austin and Dallas-Fort Worth particularly at risk. The study finds that even with current high vaccination rates, there's a significant chance of an outbreak involving over 400 people in some areas.
Growing measles outbreaks require strong regional public health systems and sustained immunization coverage to prevent disease spread. Public health experts emphasize the need for coordination at the local level to overcome challenges posed by anti-vaccination proponents.
The study found that measles-vaccinated children had significantly higher scores on cognitive tests and attended better schools than their unvaccinated peers. Long-term health benefits of measles vaccination were also observed in terms of improved growth parameters, such as height and weight.