Articles tagged with Microbial Infections
Researchers developed a new method using Microbiome Search Engine to analyze health data, identifying disease-associated microbe outliers for quicker diagnoses. The approach outperforms traditional models, providing promising results for microbiome-based big data-based diagnosis.
A new article provides guidance on allocating stockpiled ventilators to healthcare facilities during a severe pandemic, considering factors such as need assessment and access to vulnerable populations. The strategies outlined are crucial for state and local planners to make informed decisions under difficult conditions.
Researchers found that premature babies can catch up with their immune systems after birth, equivalent to those born at term. The study suggests that preterm and term infants converge in a similar time frame for immune development, and that early identification of infection risk can lead to improved outcomes.
Researchers have designed new quinazolinone derivatives that effectively kill brain-eating amoebae, including Naegleria fowleri and Balamuthia mandrillaris. The compounds' low toxicity for human cells makes them promising candidates for drug development.
A new study has found that researchers can accurately predict a person's chronological age using machine learning algorithms and microbiome samples. The study analyzed data from over 4,400 participants across various body sites, including skin, saliva, and feces, and found significant gender-specific differences in gut microbiome results.
Researchers at University of Montreal found that human cells scramble their membrane fat to fix holes caused by microbes, preventing cell damage. The discovery identifies a molecule, TMEM16F, that can repair these holes and protect humans from certain diseases.
The study uses mathematical models to predict metabolites generated by microbial species within the gut, revealing a four-level trophic organization. The findings suggest that species composition changes along the gut, with bacteria near the end forming the lowest trophic level.
Researchers at Princeton University have developed new computational and experimental tools to identify microbial small molecules encoded in clinical samples. This allows scientists to explore microbial-host interactions and mine the human microbiome for drug discovery, revealing potential antibiotics and insights into human-microbe in...
Researchers found that probiotic yeasts derived from food can reduce the virulence of non-albicans Candida species by up to 53% and prevent biofilm formation. The study suggests that these food-derived yeasts could be a safe and cost-effective alternative to current antifungal medications.
A recent study by the University of Helsinki found a significant link between increased use of antibiotics and an elevated risk of developing Parkinson's disease. The study suggests that excessive antibiotic use can disrupt the gut microbial ecosystem, leading to pathological changes in the intestine years before typical symptoms appear.
Researchers led by Dr. Stanley Hazen will explore how gut microbes convert digested nutrients into chemical signals, affecting cardiovascular and metabolic diseases. The team aims to identify specific microbial pathways linked to atherosclerosis, thrombosis, and obesity.
Researchers have gained insights into how nanoparticles can be used to identify invasive microbes and deliver targeted treatments, potentially preventing deadly diseases contracted on medical equipment. The study, conducted by Monash University researchers, found that nanoparticles bound to fungal cells but were non-toxic to them.
A study from Texas A&M University found that dogs with chronic enteropathy and exocrine pancreatic insufficiency have similar bacterial outputs, suggesting a common underlying mechanism. This discovery could lead to the development of more targeted treatments for both canine and human GI diseases.
Researchers at the University of Pittsburgh have developed a novel electrochemical therapy to treat metal-based implant infections, which are a persistent problem with five to 10 percent failure rates. The new approach damages the microbe cell membrane, increasing susceptibility to antibiotics and eradicating drug-resistant cells.
A study published in Mucosal Immunology reveals that ASC and NLRP3 are key players in maintaining innate immune homeostasis in the airway, independent of caspase-1. This alternative mechanism may provide a new understanding of different possible mechanisms involved in airway protection against microbial infections.
A Dartmouth study reveals that the way human fungal pathogens form colonies can significantly impact their ability to cause disease. The researchers identified a specific mutation that causes key changes in gene function, leading to improved virulence and host damage. Understanding these characteristics is crucial for developing effect...
A study published in Nature suggests that certain strains of gut microbes, particularly Akkermansia muciniphila, may slow the progression of amyotrophic lateral sclerosis (ALS) in mice. The researchers found that supplementing ALS-prone mice with this strain significantly improved their survival and reduced disease symptoms.
Scientists at the University of Virginia Health System are creating a new industry of microbe 'microbreweries' to produce customized probiotics. By optimizing gut microbiome growth and resource sharing, researchers aim to create tailored blends for various diseases, including autism, cancer, and depression.
A new study has identified 40 crucial genes in Cryptococcus that impact human disease outcomes, offering a potential breakthrough in treatment. The findings could lead to personalized medicine approaches and reduced reliance on toxic antifungals.
Researchers at Universitat Pompeu Fabra and S-Biomedic demonstrated the use of living bacteria to temporarily modulate skin microbiome composition. The study, published in Microbiome, found that probiotic solutions from donor microbiomes can be applied to recipients, leading to a shift towards a healthier microbiome state.
Research reveals high levels of antibiotic resistance among E. coli and other Enterobacteriaceae species in Ghana, posing a significant threat to the healthcare system. The spread of these resistant bacteria through contact with contaminated surfaces and person-to-person contact is a major public health concern.
A new hypothesis, the Coevolution Effect, proposes that habitat loss facilitates the emergence of infectious diseases in humans by increasing diversity of disease-causing microbes. This research could provide a new perspective on the association between habitat fragmentation and disease spillover.
Researchers at Beth Israel Deaconess Medical Center have identified novel combinations of antifungal and antibacterial drugs that demonstrate activity against multidrug resistant Candida auris. The study used a modified inkjet printer to test multiple combinations, finding three effective treatments in under two hours.
A Montreal-based research team has found a correlation between gut bacteria and chronic pain in people with fibromyalgia. Variations in the microbiome composition of approximately 20 different species of bacteria were observed in individuals with fibromyalgia compared to healthy control subjects.
Experts warn that leaving microbes out of the climate conversation has major consequences. Microbes are crucial in regulating climate change, supporting animal and human health, agriculture, and the global food web. Climate change impacts microbial populations, exacerbating disease spread and threatening global food supplies.
A recent study published in Nature Medicine Letters reveals that specific microbiome organisms are linked to the early stages of colorectal cancer development. The researchers found increases in these microorganisms in fecal samples from patients, which could potentially provide vital diagnostic clues.
Researchers have made an important advance in understanding the role of gut bacteria in human health, including diagnostic methods and therapies. The study found that patients with certain diseases had a smaller number of protein families in their microbiome compared to healthy individuals.
A new study from Harvard T.H. Chan School of Public Health and the Broad Institute of MIT and Harvard found that changes in the gut microbiome during IBD trigger an unhealthy inflammatory reaction. The research, part of the Human Microbiome Project, identified specific chemicals and microbial shifts that contribute to disease activity.
A new study found FMT safe and effective in treating children with C. difficile, with success rates of 87% and predictors including fresh stool, colonoscopy, and recent treatment. The procedure was associated with fewer complications compared to adults, paving the way for future research.
Researchers have identified a drug that can reverse hyperactivity induced by Toxoplasma gondii infection, reducing inflammation rather than parasite reduction. The study suggests the immune system plays a key role in behavioral changes caused by the parasite.
A new study found no major differences in gut microbiomes of people infected with roundworms or hookworms and uninfected peers. However, curing hookworm infections resulted in specific changes to the microbiome, while deworming had minimal effects.
A new diagnostic classification technique enables stratification of pediatric patients with IBS, allowing for tailored nutritional and targeted therapies. Researchers identified correlations between certain microbes and metabolites with abdominal pain, providing insights into novel treatment approaches.
Women may be at greater risk of developing surgical site infections after coronary bypass surgery, re-vascularization of arterial occlusion, and hernia repair. Men are more likely to develop infections after orthopaedic and trauma procedures.
Researchers from University of Copenhagen and EMBL found consistent changes in gut bacteria across seven countries, providing a universal signature for colorectal cancer. These microbiome changes may play a role in developing the cancer and could be used as biomarkers for diagnosis and therapeutic targets.
Replanting urban environments with native flora could help address chronic health problems by promoting healthy microbial diversity. Restoration of urban biodiversity is estimated to have generational health benefits and huge savings for healthcare sectors.
Researchers found that TB drugs alter gut microbiota, compromising immunity and increasing susceptibility to Mtb infection. Transplanting healthy feces restored immunity in treated mice.
Researchers from UC Davis found that the majority of microbes growing in sugar water from hummingbird feeders are unlikely to cause disease in hummingbirds. Regular cleaning of feeders is encouraged to minimize potential risks.
A new study reveals that climate change could lead to declines of underwater kelp forests, impacting fisheries and potentially affecting food security. The research found that ocean warming and acidification can cause disease-like symptoms in kelp, leading to degradation and photosynthesis impairment.
Research found differences in gut microbiota between patients with and without dementia, with higher levels of ammonia and indole associated with increased dementia risk. Lower levels of beneficial Bacteroides organisms were also observed in dementia patients.
Researchers found that Candida albicans exploits lack of oxygen to cause disease by evading immune cells and thriving in deep-seeded body sites. The fungus uses low oxygen environments to become more virulent and causes life-threatening, systemic disease.
Research suggests that infant mice need a higher dose of bacterial LPS to prevent asthma, while adult mice can tolerate lower doses. This mechanism supports the hygiene hypothesis, which proposes that decreased exposure to microorganisms in childhood leads to increased allergies.
This special issue of Clinical Gastroenterology and Hepatology delves into the relationship between the gut microbiome and specific digestive diseases. Key findings include the role of the microbiome in inflammatory bowel disease, functional gastrointestinal diseases, colorectal cancer prevention, and pancreatic disease.
A new study from the University of Kent has found that a common gut parasite, Blastocystis, can survive under conditions with increased oxygen levels, contrary to previous thinking. This discovery could provide insights into its role in intestinal diseases such as irritable bowel syndrome.
A research study shows that the microbiomes of sea stars play a critical role in the progression of the disease. The study found that an imbalance of beneficial and disease-causing bacteria contributes to the severity of the illness, with healthy animals hosting more helpful microbes.
Infants born at home have more diverse bacteria in their guts and feces, which may influence their developing immunity and metabolism. The study suggests that revamping hospital environments for non-high risk births could be beneficial.
Researchers found that infants with higher levels of Bifidobacterium had reduced antimicrobial resistance genes and lower frequency of resistant bacteria. This suggests that colonization by the microbe can help guard the infant intestine.
A new study found all ESBL-producing E. coli isolates from US retail meat were resistant to at least three antimicrobial classes, carrying various types of CTX-M type ESBL genes. The presence in food-producing animals and retail meat supplies may contribute to a greater incidence of infections.
A team of researchers at the University of Illinois has developed a system that harnesses the power of bubbles to destroy microbial biofilms. The system uses diatoms loaded with an oxygen-generating chemical, which creates microbubbles that propel tiny particles through the surfaces of tough films and deliver an antiseptic deathblow to...
New research shows that the timing and order of introduction of gut bacteria after birth significantly impact the development of the microbiome. This discovery could eventually allow doctors to establish beneficial gut bacteria in infants right after birth, potentially warding off serious chronic diseases.
Research published in Applied and Environmental Microbiology found that probiotics increased the severity of cryptosporidiosis in mice, defying initial hypotheses. The study suggests that manipulating gut microbiota may hold potential for developing probiotics to mitigate the disease.
The US Department of Energy has awarded a $1.1 million grant to the University of Illinois for sorghum disease resistance research. The project aims to develop host resistance in sorghum, a key trait for lignocellulosic bioenergy production, by leveraging knowledge from corn.
Researchers identified a compound called phenylacetic acid (PAA) produced by gut bacteria linked to the early onset of Non-Alcoholic Fatty Liver Disease (NAFLD). The study suggests PAA could be used as a biological marker in the clinic to identify patients at increased risk of disease.
An OSU biologist argues that chronic diseases require a restoration ecology approach, similar to natural habitats. By removing unhealthy diets and promoting symbiotic gut microbes, patients can improve their health. The study's findings highlight the importance of personalized medicine and active interventions in treating chronic disease.
Tsetse flies transmit Nagana disease to livestock by injecting trypanosomes into the skin, which then invade the bloodstream and cause severe illness. Understanding how these microbes develop inside the fly may lead to new methods of controlling the spread of the disease.
Researchers found that gorillas' and chimpanzees' gut microbes fluctuate seasonally in response to diet changes, similar to those observed in human hunter-gatherers. This study highlights the importance of dietary fiber on microbiome diversity and may have implications for intestinal health and disease.
Scientists have found a way to target specific gut bacteria using chemical compounds, potentially regulating diseases such as type I diabetes. The research suggests that this approach could lead to the development of drugs that permanently alter the composition of the microbiome.
Researchers found that liverworts can be infected by Phytophthora palmivora and respond with proteins similar to those in flowering plants. The discovery reveals early land plants were genetically equipped to respond to microbial infections, indicating an ancient relationship between plants and microbes.
Researchers isolated a novel oral microbe, Desulfobulbus oralis, in adults with periodontitis, shedding light on its adaptations and evolution. Meanwhile, scientists at ORNL also developed a new cast aluminum alloy for engine cylinder heads, aiming to boost fuel efficiency without sacrificing performance.
A new study found that antibiotics used to treat Chlamydia in koalas can alter the balance of gut microbes necessary for digestion, according to researchers at UC Davis. The study suggests a need to develop antibiotic-free treatments, such as a vaccine, to address this issue.
Researchers found oral pathogens in colon specimens of polybacterial-infected mice, affecting the microbiome and NO synthesis. The study suggests a link between periodontitis and colon health, potentially impacting motility and antioxidant defenses.