Articles tagged with Microbial Infections
A new study proposes using AI algorithms to diagnose and treat diseases related to gut microbiota in cancer patients. The technology has the potential to identify new associations and improve understanding of the human microbiota.
Researchers successfully transplanted beneficial microbes from a healthy, related species to a critically endangered Hawaiian plant, Phyllostegia kaalaensis. The treatment provided significant protection against powdery mildew disease, allowing the plants to thrive in the wild for the first time.
Studies show that gut-derived metabolites may prevent neurodegeneration, while probiotic treatment corrects memory problems in an Alzheimer's mouse model. The research suggests targeting the gut could be a promising angle to tackle brain disorders across the lifespan.
A novel transdisciplinary study has uncovered microbes that may one day deter major grape disease, Pierce's disease. The researchers used next-generation sequencing and modern bioinformatics tools to analyze microbial communities in grapevines, finding a link between beneficial bacteria and reduced disease severity.
Researchers developed a 3D spatial visualization tool to understand the effects of chemicals on diseased organs in context of microbes. The tool helps advance targeted drug delivery for cystic fibrosis and other conditions where medications struggle to penetrate, revealing new insights into microbial anatomy.
Researchers at the Francis Crick Institute have identified an enzyme that disrupts vital cell processes in intestinal worms, potentially leading to new vaccine or drug development. The discovery could also help combat emerging drug-resistant worm infections.
A new study suggests that diet may be a crucial factor in the development of liver injuries in mice bred to consume high amounts of alcohol. The research found that mice on a diet of alcohol and water consumed less alcohol than those on an artificial sugar diet, resulting in greater liver injury.
A recent study has uncovered millions of previously unknown genes from microbial communities in the human gut, skin, mouth, and vaginal microbiome. The research triples the amount of data previously analyzed and provides new insights into the role these microbes play in human health and disease.
A new study analyzes thousands of new measurements of microbial communities from various sites in the body, providing insights into how microbes work together to maintain human health. The research identifies differences unique to an individual's microbes and tracks them across the body over time.
A team of 106 Concordia undergraduate students co-authored a review article on human gut microbiota and its interactions with the host. The project, led by affiliate assistant professor Chiara Gamberi, aimed to improve students' writing and editing skills.
Researchers identified specific gut microbes associated with multiple sclerosis, suggesting they play a role in regulating immune responses and potentially contributing to disease progression. The study found that certain bacteria can trigger pro-inflammatory or anti-inflammatory responses in the immune system.
Scientists have identified an early predictor of Inflammatory Bowel Disease (IBD) through a groundbreaking collaboration. By analyzing the microbiome, researchers found parallel changes in gut bacteria that may indicate disease onset.
Scientists found caterpillars have only 50,000 times fewer microbes than human guts, suggesting most are ingested from surroundings. Caterpillars can grow and develop without microbes, challenging the idea of a universal microbiome among animals
Researchers suggest that plant hormones produced by plants can be synthesized by gut microbes, influencing inflammatory diseases. Consuming ABA-rich fruits and vegetables may help alleviate aspects of diabetes.
Children with low gut microbiome diversity are more susceptible to severe Entamoeba histolytica infection. The study found that antibiotic disruption of the gut microbiome in mice led to decreased white blood cell activity and increased severity of colon inflammation.
The 2017 Massry Prize recognizes the groundbreaking research of Knight, Gordon, and Pace on the human microbiome. Their work has led to a deeper understanding of microbes' role in human health and disease, with applications in fields such as medicine and environmental science.
Researchers at Mayo Clinic and University of Iowa found a human gut microbe, Prevotella histicola, that effectively suppresses immune disease in a mouse model of MS. The study suggests that this microbe may play a role in treating MS, an autoimmune disease caused by the immune system's attack on the myelin sheath.
Researchers have successfully developed a new method to analyze soil microbial communities and their role in the development of Sudden Death Syndrome (SDS) disease in soybean. By profiling microbes, scientists found significant differences between healthy and diseased areas, suggesting that biological factors play a key role in determi...
A study led by Bernd Schnabl found that chronic alcohol intake increases fungal populations in the intestine and levels of β-glucan in the bloodstream, leading to liver inflammation. Treating mice with anti-fungal agents prevented liver disease, supporting further research into the fungal microbiome's role in alcohol-related liver damage.
Researchers have found that microbes manipulate the molecular machinery of animal cells, triggering patterns of gene expression associated with health and disease. The study suggests ancient parts of the genome and interactions with microbes are relevant to modern-day human diseases.
Researchers found that altering the gut microbiome may be an effective therapy for CCMs, a cerebrovascular disease causing stroke and seizures. Genetic variations affecting TLR4 signaling linked to higher numbers of CCM lesions.
The World Obesity Federation experts argue that obesity is a chronic, relapsing, progressive disease process driven by environmental and genetic factors. This recognition can lead to improved treatment options and reduced stigma around the condition.
A new study found that certain bacterial species and fungal families are present in both land-based sources and coral reefs, suggesting invasion. The researchers used high-throughput DNA sequencing to analyze water samples from coastal inlets, sewage treatment plants, and coral tissues.
Panos N. Papapanou, a Columbia University dental scientist, has received the International Association for Dental Research (IADR) Award for his diverse and prolific contributions to periodontal disease research.
Researchers at University of Utah Health Sciences found that a common yeast species exacerbates Inflammatory Bowel Disease (IBD) symptoms in mice. Allopurinol, a generic drug, showed promise in reducing inflammation and potentially offering relief to patients with high yeast antibodies.
A team of international researchers analyzed dental plaque from four Neandertals, revealing a complex picture of their behavior, diet, and evolutionary history. The study found that Neandertals had a good knowledge of medicinal plants and used them to self-medicate, including the use of poplar trees for pain relief.
A study published in Cell Reports found that genetic variation in mice shapes their gut microbiome, which regulates insulin secretion and contributes to the onset of metabolic disease. The researchers observed a correlation between specific bacteria in the microbiome and metabolic traits such as body weight and glucose levels.
Klebsiella pneumoniae is a multi-drug resistant microbe causing severe infections with mortality rates of 25-60 percent. Researchers have identified the underlying molecular explanations preventing treatment, highlighting the need for innovative solutions to counteract its effects.
Research using mutant zebrafish models human disease to show that changes in certain gut bacteria can cause intestinal inflammation. Transplanting beneficial bacteria and restoring gut neurons also cured the disease.
Researchers from Canadian and international institutions discuss the impact of microbes on human health, disease, and society, as well as the neural basis of emotional memories. They also explore quantum computing and its potential to revolutionize cybersecurity.
Patients with inflammatory bowel disease exhibit highly fluctuating gut microbiomes, unlike healthy individuals, who display more consistent microbial communities over time. The research highlights the dynamic nature of IBD and its relationship to the human gut microbiome.
A new computational method, FishTaco, integrates taxonomic and functional approaches to identify bacterial species responsible for functional imbalances in the microbiome. Researchers found that diverse combinations of species drive functional imbalances in diseases like type 2 diabetes and inflammatory bowel disease.
A study found that gut microbes exacerbate motor symptoms in a mouse model of Parkinson's disease, but antibiotic treatment and germ-free environments reduced motor deficits. The research could lead to new treatments for the neurodegenerative disease.
Researchers at Caltech discovered a novel link between the gut microbiome and Parkinson's disease, finding that gut bacteria promote hallmark pathology, neuroinflammation, and motor dysfunction. The study suggests targeting the gut microbiome may provide a new approach for diagnosing and treating PD.
Researchers at New York University discovered that ATM keypads harbor a range of human skin microbes, as well as microorganisms from food and environmental sources. The study's findings suggest that ATMs can serve as a repository for understanding a city's microbial community.
Research by Dr. Przemyslaw Sapieha and colleagues suggests that a diet rich in fat can alter the gut microbiome, leading to inflammation and increased risk of wet AMD, a blinding form of age-related macular degeneration. The study provides new insights into the role of gut microbes in disease prevention.
A recent study links a disease-associated microbial state to increased risk of developing IBD in genetically- and environmentally-susceptible individuals. Another study found that exposure to high altitude conditions triggers local acid sensing pathways leading to disease progression in IBD patients. Meanwhile, research highlights the ...
Researchers analyzed fecal samples from dogs with and without IBD, discovering a pattern of microbes indicative of the disease. The team used 16S rRNA sequencing to predict IBD diagnosis in dogs with high accuracy.
A study by researchers at UC San Francisco found that a particular pattern of microbes in newborns' guts triples their risk of developing asthma by age four. The abnormal gut microbiome produces molecules that reduce the abundance of key immune cells, leading to a hyperactive immune system and chronic inflammation.
A study reveals that nicotine triggers the release of neutrophil extracellular traps (NETs), which can harm tissue and contribute to conditions like COPD. The discovery provides a new link between nicotine consumption and inflammation, emphasizing the importance of quitting tobacco products.
A new video game, Colony B, helps scientists analyze how microbes relate to lifestyle habits and health. The game correlates player data with survey information from the American Gut project, revealing potential links between microbial composition and human health.
Researchers have discovered two distinct growth forms of Candida auris, a fungus resistant to multiple antifungal drugs, which can cause fatal infections in hospital patients. The strain's ability to cause disease is surprisingly high, rivaling that of the most invasive Candida species.
The study found a small number of species associated with periodontitis, but not gingivitis, including Prevotella, Treponema, and Selemonas. This research may lead to an inexpensive and rapid point-of-care test based on distinguishing the two conditions' microbiomes.
A recent Cornell University study suggests that circulating trimethylamine N-oxide (TMAO) may be a biomarker of differences in the gut microbiome rather than a cause of heart disease. Researchers found that healthy men with elevated TMAO levels after consuming eggs and beef also had high counts of firmicutes, a type of bacteria that co...
Researchers found that infants' airways are colonized with bacteria or bacterial DNA at birth, which could predict severe lung disease. The 'healthy' pattern of colonization seen in BPD-resistant infants is protective, with increased abundance of Lactobacillus.
Researchers found that tomatoes can detect a parasitic vine's peptide, triggering an immune response and increased resistance. This discovery could lead to new strategies for mitigating crop losses caused by parasitic plants worldwide.
A new study by University of Maryland School Medicine researchers has identified key aspects of the Mucorales fungi that may lead to treatment development. The fungus invades weakened immune systems, causing sometimes-deadly mucormycosis infections.
Researchers at Brigham and Women's Hospital found altered gut microorganisms in patients with multiple sclerosis, including those treated with therapy. These changes correlated with immune system gene activity and breath methane levels. The study supports the connection between gut microbiome and immunological disorders like MS.
A new study from UTSA professor Mark Eppinger describes innovative strategies to track disease-causing pathogens like E. coli, featuring whole genome sequence typing of outbreak strains. By analyzing subtle traits among outbreaks, researchers can pinpoint the origin and severity of an outbreak.
Researchers have discovered that a variety of normally harmless bacteria can cause bleaching disease in seaweeds when stressed. Three new pathogens from the Alteromonas, Aquimarina and Agarivorans genera were identified as the culprits.
A study published in mSystems journal found that Boston's subway system is heavily colonized by microbes from human skin, with surface type being the major driver of variation. The majority of microbes found were from normal human skin and were harmless, but some samples showed low levels of gut and oral microbes.
Researchers at Cornell University have identified biological markers of chronic fatigue syndrome in gut bacteria and inflammatory microbial agents in the blood. This breakthrough discovery offers a new approach to diagnosing ME/CFS through stool samples and blood work.
Researchers are studying how microbes control ant behaviors using $2.56 million in grants from the National Institutes of Health and the National Science Foundation. The goal is to understand the complex collective behavior of fungi, which can precisely control their hosts' actions.
A new study examines the role of diet in promoting cooperation or conflict between gut microbes and human cells. The research proposes a framework for understanding the subtle interplay of diet and health, with potential implications for the management of inflammatory and metabolic disease.
Research found that crows on a university campus carried high rates of Campylobacter jejuni, suggesting they could play a role in transmitting the bacteria to humans. The study tracked crow movements and behavior, revealing that their foraging habits often bring them into close proximity with livestock and humans.
A recent study reveals differences in gut bacteria between children with and without multiple sclerosis. Key findings include an association between MS and increased inflammatory bacteria, as well as decreased anti-inflammatory bacteria. The discovery may pave the way for new therapeutic approaches by identifying novel drug targets.
Recent CMGH articles suggest that targeting gut microbial populations may help prevent or treat Crohn's disease. A new study also identifies a potential therapy for chronic pancreatitis by reducing fibrosis and damage to the pancreas.
A new study tracks bacteria strains in stool transplants, suggesting donor-patient compatibility is crucial for success. The research could improve treatment options for conditions like ulcerative colitis and metabolic syndrome.
The pandemic E. coli strain H30 causes persistent and deadly infections, often undetected until severe complications arise. Researchers found that patients with underlying conditions and those in healthcare facilities are at higher risk for infection.
Researchers discovered that neutrophils can internalize C. neoformans in the brain vasculature and circulate them back into the bloodstream for removal. This process enables the prevention of cryptococcal meningoencephalitis, a deadly brain infection.