Articles tagged with Obesity
Research published in JAMA Network Open found that individuals with higher genetic risk of obesity need to walk more steps per day than those with lower risk to avoid becoming obese. Participants with a higher polygenic risk score required significantly more physical activity, with some needing up to 11,020 steps per day.
Researchers have identified two plant compounds with potential as GLP-1 agonist weight loss pills, derived from common plants and potentially offering fewer side effects than current medications. The discovery was made using high-performance artificial intelligence techniques to analyze over 10,000 compounds.
A new study evaluates the use of tirzepatide in overweight/obese adults with type 1 diabetes, showing significant weight loss and improved glucose control. Tirzepatide also reduces insulin dose and increases time-in-range on continuous glucose monitoring.
A European randomized controlled trial found that replacing sugar with sweeteners improved weight loss control for at least one year after rapid weight loss in adults. The study also showed greater diet satisfaction and lower cravings for sweet foods among participants who consumed low/no-energy sweetened products.
Researchers have identified the unique nutritional profile of Canadian sea buckthorn berries, which are rich in polyphenols with potential health benefits for cardiovascular protection and anti-inflammatory properties. The study found that geographical factors influence the polyphenolic profile of the berries, making them a promising s...
A study published in Nature Metabolism reveals that the diabetes drug metformin and solid foods increase a hunger-reducing factor called Lac-Phe, while sugary drinks have minimal effect. This discovery could lead to new anti-obesity treatments and help explain why liquid calories drive obesity.
Researchers found obese individuals exhibit distinct walking patterns, characterized by shorter strides and modified ankle muscle activation. This study suggests these differences may increase the risk of falls and musculoskeletal disorders.
Recent medications for Type 2 diabetes and weight loss have positive effects on cardiovascular and kidney health but are not always prescribed or accessible to those who need them. The studies highlight the need to address barriers to access and equity, particularly among Black adults with severe obesity.
Researchers found that Kallistatin expression increases after weight loss, improving hepatic insulin sensitivity in obese mice. This protein may be an interesting therapeutic target for treating obesity and type 2 diabetes.
Researchers at Flinders University have discovered a bedtime nasal spray that can reduce the severity of sleep apnea in people and lower their blood pressure. The study found that the spray, which blocks potassium channels, improved oxygen levels and reduced markers of OSA severity in 7 out of 10 participants.
A new study published in the Journal of the Endocrine Society found significant cardiometabolic improvements in patients who underwent bariatric surgery, including lower blood pressure and cholesterol levels. The study analyzed over 7,800 patients and showed that younger females and whites experienced greater post-surgery cardiometabol...
New research shows tirzepatide consistently reduces bodyweight and waist circumference, with greater reductions in participants with longer disease durations. Tirzepatide also achieves higher weight loss targets and reduces waist circumference more significantly than placebo across all disease duration categories.
Researchers found that middle-age obesity is caused by age-related changes in the shape of neurons in the hypothalamus, a region controlling metabolism and appetite. A protein called MC4R detects overnutrition and regulates metabolism to prevent obesity. Dietary restriction may help maintain brain anti-obesity systems as we age.
A new study reveals that adults living in extreme poverty in LMICs have high rates of hypertension, diabetes, smoking, obesity, and dyslipidemia, yet are often untreated for these conditions. The findings challenge the common assumption that poverty protection against cardiovascular disease risk factors.
A new analysis shows that tirzepatide effectively reduces body weight across different BMI subgroups, achieving significant weight loss of 5% or more in up to 100% of participants. The treatment also demonstrated superior weight reduction compared to placebo in patients with type 2 diabetes.
A collaborative study found that patients with end-stage renal disease who undergo weight loss surgery can experience significant improvements in BMI, hypertension, and diabetes management. This enhancement of overall health and transplant viability offers hope for previously ineligible patients.
Research reveals oestrogen's protective role in preventing fatty liver disease by targeting the TEAD1 protein. The discovery could lead to a new treatment for fatty liver and liver cancer, as well as earlier detection methods.
New Norwegian research reveals a strong association between parental BMI and offspring's obesity status, even after adulthood. Individuals with both parents living with obesity have six times higher odds of developing obesity in middle age.
A genetic mutation in a quarter of all Labradors hard-wires them for obesity, making them hungrier between meals and burning fewer calories. Owners must be strict with feeding and exercising their dogs to keep them slim.
A large study found that people with class I obesity had double the risk of stillbirth at 39 weeks' gestation compared to those with normal BMI. The risk further increased with gestational age, with a more than fourfold risk at 40 weeks. Researchers hope that these findings will improve care for pregnant individuals with obesity.
Research links low birthweight (<2.5 kg/5 lbs 8oz) to increased risk of early type 2 diabetes (59 years or younger) when combined with overweight at aged 20 years, with a 10 times greater risk compared to normal weight peers.
A University of Cincinnati study found liraglutide to be efficacious and safe for weight loss in individuals with stable bipolar disorder, without destabilizing the illness. The drug reduced binge eating behavior and significantly lowered hemoglobin A1C levels.
The study highlights the urgent need to tackle obesity and underweight globally, particularly in poor countries. Obesity rates have surpassed one billion, with combined rates of underweight and obesity being more common than malnutrition in many countries.
A 12-year study published in JAMA found that bariatric surgery significantly improved blood glucose control and type 2 diabetes remission compared to medical management alone. Participants who underwent bariatric surgery experienced greater weight loss, reduced medication use, and higher rates of diabetes remission.
Recent research shows that many mechanisms contributing to obesity affect the brain, particularly dopamine pathways. This insight may impact treatment approaches, including medication and initiatives to make fattening foods less accessible. Society must also take responsibility for destigmatizing obesity.
Researchers at the University of Pennsylvania School of Engineering and Applied Science have invented a new way to synthesize key components of lipid nanoparticles, simplifying their manufacture while boosting efficacy. The new method involves combining three chemicals to create branched lipidoids that promote mRNA delivery to target c...
Researchers found that obesity increases allosteric regulation during feeding and decreases it when fasting in mice livers. This disruption may lead to metabolic disorders like nonalcoholic fatty liver disease and Type 2 diabetes.
A new mouse study reveals that the gut microbiome interacts with the loss of female sex hormones to exacerbate metabolic disease. The research suggests that the gut microbiome contributes to weight gain, fat in the liver, and inflammation, particularly in women after menopause.
A one-year interdisciplinary therapy program reduced inflammation and cardiometabolic risk in obese adolescents, improving insulin resistance and weight management. The semi-intensive model produced better results than previous intensive models, reversing hyperlipidemia and promoting energy balance.
A new study in tens of thousands of people with obesity shows the impact of different weight management treatments on achieving a 5% weight loss. Effective treatment options include nutrition counseling, medically supervised meal replacements, anti-obesity medications, and bariatric surgery.
A new study published in LANCET eClinicalMedicine found that regular exercise can help individuals maintain weight loss after completing medical weight loss treatment. The study showed that exercising just two hours a week can lead to better quality of life, improved mental health, and reduced fatigue.
A study has identified 1,289 genetic markers associated with Type 2 diabetes, including 145 newly discovered markers. The research provides risk scores for diabetes complications and suggests potential genetic targets for new treatments.
A new Danish study finds that a protein-rich breakfast increases satiety and improves concentration, but eating the same meal in larger quantities may lead to consuming more calories. The study's results suggest that replacing a carbohydrate-rich diet with a protein-rich diet can have a positive impact on preventing weight gain.
Weight loss treatments such as nutrition counseling and bariatric surgery increased the patient-level probability of achieving significant weight loss. Current treatment utilization rates are insufficient to impact the population level, highlighting a need for improved access.
A study published in the Journal of the American College of Surgeons found that gastric bypass surgery results in high rates of Type-2 diabetes remission five years after the operation, even after patients regain a significant amount of weight. In contrast, patients who underwent sleeve gastrectomy and regained their weight were five t...
Researchers found that bariatric surgery led to improved cognition and overall well-being two years after the procedure. The study revealed changes in blood vessel efficiency and cortical thickness of the temporal cortex, offering new treatment options for patients with obesity and dementia.
A new study published in the American Heart Association journal Hypertension found that tirzepatide significantly lowered systolic blood pressure levels in nearly 500 adults with obesity. The results suggest treating obesity with this weight loss medication may be an effective strategy for preventing or treating high blood pressure.
A five-year study shows that bariatric surgery maintains normal blood pressure levels without medications, while reducing BMI compared to medical therapy alone. Participants who underwent bariatric surgery had fewer medications and lower blood pressure rates than those on medication alone.
A recent study published in PNAS suggests that impaired macrophage function plays a key role in the development of type 2 diabetes in obese individuals. The research found that collagen breakdown is handled by macrophages, which become deactivated in obesity and insulin resistance, leading to the accumulation of collagen fragments.
Researchers at Karolinska Institutet developed a method to study liver function and disease using the cornea of mice eyes. They transplanted liver cells into the eyes, creating a non-invasive platform to monitor liver health over time.
Researchers discovered that fasting raises arachidonic acid levels, which inhibit the NLRP3 inflammasome and reduce chronic inflammation. This finding may explain how calorie restriction protects against diseases linked to Western diets.
A study of over 1,700 adult patients found that gastric bypass and sleeve surgeries have few short-term complications and are equivalent in terms of risk. The results suggest that patients and doctors can choose between the two procedures without worrying about short-term surgical risks.
A study of 115,726 Korean adults found that eating up to three daily servings of kimchi was associated with a lower prevalence of obesity and abdominal obesity. Radish kimchi was also linked to a lower risk of midriff bulge in both men and women.
Polycystic ovarian syndrome (PCOS) affects 10% of females, causing infertility, miscarriage, and pregnancy complications. Effective management includes weight loss support, hormonal contraceptives, and nonhormonal medication like metformin.
Researchers at Pennington Biomedical aim to investigate the effects of intermittent fasting and calorie counting on healthspan. Participants in the DiAL-Health study will be compensated up to $2,500 for their involvement.
Researchers identified two probiotic strains that promote weight loss in obese dogs. The strains, Enterococcus faecium IDCC 2102 and Bifidobacterium lactis IDCC 4301, reduced body fat percentage and improved intestinal microflora balance in dogs fed a high-fat diet.
A scoping review of 508 clinical studies found that most define a low-carb diet as limiting carbohydrate intake to 30% or less, with some using thresholds below 100 grams per day. The study highlights the need for a standardized definition to inform public health and nutrition activities.
A study published in Nature Metabolism reveals that obesity is associated with the fragmentation of mitochondria in fat cells, leading to reduced energy burning and weight gain. Researchers identified a single gene responsible for this process and found that deleting it protected mice from diet-induced weight gain.
Experts predict a significant increase in bowel cancer death rates among young adults in the EU and UK, driven by rising obesity and heavy alcohol consumption. Death rates are predicted to rise by 26% in men and nearly 39% in women in the UK, with similar increases seen in Italy and other European countries.
A recent study by University of Missouri researcher Mansoo Yu found that online weight loss interventions with counseling and social support are effective for middle-aged adults with obesity. The study identified two key features: professional health coaching and access to social support from other users, which led to significant long-...
A recent study found that exposure to multiple toxicants across generations can amplify health problems, such as obesity and kidney diseases. The study, published in Environmental Epigenetics, showed that epigenetic changes were greatly altered with each new generation of exposed animals.
A nationwide study from Karolinska Institutet found that GLP1 agonists like Ozempic reduce the risk of cirrhosis and liver cancer in people with type 2 diabetes and chronic liver disease. Those who continued taking the medication for ten years were half as likely to develop severe liver disease.
A study of 398,000 UK Biobank participants found that improving social isolation and loneliness in people with obesity can decrease their risk of obesity-related excess mortality. The findings support the importance of addressing social isolation as a potential factor in reducing obesity-related mortality.
Researchers have made a groundbreaking discovery that could lead to novel treatment for obesity and associated diseases. The growth hormone secretagogue receptor (GHSR) plays a critical role in chronic inflammation, which is a key reason obese individuals often have multiple chronic diseases.
Participants with diabetes remission had a 33% lower rate of CKD and a 40% lower rate of CVD compared to those without remission. The magnitude of risk reduction was greatest for participants with longer-term remission.
A recent meta-analysis published in PLOS ONE found that dancing is a highly effective intervention for reducing body fat in overweight and obese individuals. The study analyzed data from various dance interventions and concluded that they can lead to significant weight loss and fat reduction.
Researchers found that obesity is associated with a 73% higher odds of having monoclonal gammopathy of undetermined significance (MGUS), a benign blood condition that often precedes multiple myeloma. Lifestyle factors such as physical activity and smoking habits also play a role in the development of MGUS.
Obesity recognized as chronic health condition with specific pathophysiologic causes, requiring safe and effective treatments. A multifaceted approach to care is essential for older adults, involving professionals from various fields to address social, environmental, and economic risk factors.
Researchers discovered that fruit bats have a genetic system controlling blood sugar levels, allowing them to consume up to twice their body weight in sugary fruit daily. The study's findings may lead to the development of better insulin- or sugar-sensing therapies for people with diabetes.
Researchers found that cognition scores remained stable two years after bariatric surgery, while secondary executive function tests showed improvement. However, one memory assessment declined following surgery. Further studies are needed to confirm the findings and understand how best to treat cognitive decline associated with obesity.