Researchers have developed a novel drug therapy for obstructive sleep apnea (OSA), which has shown significant improvements in reducing breathing interruptions and improving overall health. The treatment targets both respiratory and metabolic complications, providing a promising alternative to existing therapies.
A randomized clinical trial found that an intermittent fasting plan consisting of two nonconsecutive fasting days and five days of meal replacement diet improved glycemic outcomes and weight loss in the short term compared to metformin or empagliflozin. The study suggests a promising initial intervention for type 2 diabetes management.
Researchers are exploring inflammation caused by COVID-19 as a trigger for Long Covid, a condition characterized by persistent symptoms like fatigue, brain fog, and shortness of breath. The study aims to identify potential causes and treatments for Long Covid, with findings that could lead to enhanced immune function in patients.
A Cleveland Clinic study finds bariatric surgery cuts the risk of major cardiovascular events by 42% and all-cause mortality by 37% in patients with obesity and moderate to severe obstructive sleep apnea. The study analyzed data from 13,657 adult patients who underwent weight loss surgery between 2004 and 2018.
A new genetic cause of obesity has been discovered, linking it to the SMIM1 gene variant. People with this variant tend to expend less energy when at rest, leading to excess weight and increased risk of obesity.
A study found that overexpressing a gene responsible for amino acid transport in the placenta can cause fetal growth to increase by 27%, while also providing insights into pregnancy complications like IUGR and obesity. The research has therapeutic implications, potentially informing treatments to prevent or treat these conditions.
A new study found that regular snoring is associated with elevated blood pressure and uncontrolled hypertension, particularly in overweight middle-aged men. The research used multiple night home-based monitoring technologies and objective assessments to explore the connection between snoring and hypertension.
The USPSTF recommends providing or referring children and adolescents with a high body mass index (BMI) to comprehensive behavioral interventions. Approximately 19.7% of US children aged 2-19 have a BMI at or above the 95th percentile, with higher prevalence among Hispanic/Latino, Native American/Alaska Native, and lower-income families.
A new study found that Americans are eating better, but disparities in diet quality persist among marginalized communities. The proportion of adults with poor dietary quality decreased from 48.8% to 36.7% between 1999 and 2020, while those with intermediate diet quality increased.
Researchers from the University of Granada found that accumulating moderate-to-vigorous physical activity in the evening improves glucose regulation in overweight and obese adults. The study's results have significant implications for individuals at risk of developing insulin resistance or type 2 diabetes, highlighting the importance o...
A Vanderbilt University Medical Center-led research team discovered a connection between obesity and cancer, revealing that macrophages play an unexpected role in the complicated connection. Obesity increases macrophage frequency in tumors and induces PD-1 expression, which can contribute to both increased cancer risk and enhanced resp...
Research shows people with obesity are more sensitive to price when buying unhealthy foods, while those with normal weight are not. A 10% price hike on these categories can lead to a significant reduction in consumption, such as decreased frozen pizza purchases.
The Pennington Biomedical Research Center is conducting a clinical trial to better understand lipedema. Participants will undergo comprehensive assessments and imaging techniques to help advance medical knowledge related to chronic disease. Compensation of up to $475 is offered for participation in the three-month study.
The study found that 1 in 5 children and adolescents experience excess weight, with rates varying by region. Excess weight is linked to multiple factors, including inherent, behavioral, environmental, and sociocultural influences.
In individuals with a diabetes duration of 10 years or less, bariatric metabolic surgery was associated with greater weight loss and reduced mortality compared to first-generation GLP-1RAs. No differences were observed between treatment modalities in patients with longer diabetes duration.
A recent study from the Women's Health Initiative found that both obesity and metabolic syndrome increase breast cancer risk, but in distinct ways for different subtypes. The research highlights the importance of controlling waist circumference and metabolic conditions to reduce breast cancer risk.
A meta-analysis of 15 randomized studies found that patients taking GLP-1 medications experienced only mild differences in gastric emptying, delaying solid food by about 36 minutes. The findings suggest it may be safe to continue these medications before surgery without a high risk of aspiration.
Current medical training neglects to educate future doctors on how to encourage healthier eating habits and focuses on weight loss and BMI. Researchers advocate for small changes in medical education to address anti-obesity bias and promote cardiometabolic health, a stronger predictor of overall well-being.
A study suggests that women who underwent sleeve gastrectomy before pregnancy had children who gained more weight per month in the first three years of life. In contrast, those born to mothers who had Roux-en-Y gastric bypass surgery experienced slower weight gain. Researchers found this difference after adjusting for various factors, ...
A new study found that people exposed to higher levels of airplane noise were more likely to have a higher body mass index, an indicator for obesity that can lead to cardiometabolic diseases. The study highlights the role of environmental factors in shaping health outcomes.
Researchers found that GLP-1 receptor agonists and SGLT-2 inhibitors lower the risk of major cardiovascular events, such as heart attacks, and severe liver complications compared to other diabetes treatments. These medications also showed no significant increase in severe adverse events.
A study found that nearly 20% of breast cancer survivors experience excess weight gain of more than 10% over six years. Factors associated with this weight gain include lower body weight, younger age, hormone-positive breast cancer, and certain genetic mutations.
A comprehensive study found that living with obesity for 10 years or more significantly increases the risk of heart attacks and strokes. The research, published at ENDO 2024, analyzed data from over 109,000 participants and revealed a 25-60% increased risk in younger adults.
A recent study funded by tirzepatide maker Eli Lilly Inc. found that the medication resulted in significant weight loss regardless of the number of obesity-related complications patients had at the outset. The study combined data from four trials involving over 4,700 subjects with obesity or overweight conditions.
A new study found that children who are sedentary for more than six hours a day have a significantly increased risk of severe fatty liver disease and liver cirrhosis by young adulthood. Engaging in light-intensity physical activity for at least 3 hours a day can reverse premature liver damage.
A new study found that tirzepatide significantly reduced weight in Chinese adults with obesity, with both 10mg and 15mg doses showing clinical benefits. The treatment also demonstrated an acceptable safety profile.
A mouse study found that heart failure with preserved ejection fraction (HFpEF) differs between male and female mice, with females exhibiting altered heart filament proteins and males showing slowed calcium removal. This may lead to different treatment strategies for women compared to men with HFpEF.
Researchers emphasize the importance of addressing socioeconomic, cultural, and epigenetic factors in the Latin American obesity epidemic. The study suggests that public policies and strategies must acknowledge these drivers for effective weight loss.
A new study highlights the benefits of intermittent fasting and protein-pacing on gut health, weight loss, and metabolic responses. Participants showed improved diversity of the gut microbiota, decreased symptoms of gastrointestinal problems, and increased beneficial microbes linked to a lean body type.
A new study reveals TNIK's role in various diseases, including fibrosis, cancer, obesity, and Alzheimer's. The protein has been found to drive cancer cell proliferation and treatment resistance, while also regulating metabolic processes.
Researchers at USask have discovered a new peptide that lowers lipid accumulation in human liver cells, offering new avenues for treating metabolic diseases. The finding is hopeful news as there's a lack of new therapies available for these diseases.
A new study reveals that a cancer drug can improve insulin sensitivity and lower blood glucose levels, but eliminating a specific gene related to fat metabolism worsens insulin resistance. The research highlights the interconnectedness of fat metabolism in organs and the need for simultaneous treatment of obesity and insulin sensitivity.
Dr. George Bray's paper tracks the development of obesity research over 100 years, from early explorations to modern medication interventions. The study highlights the chronic and relapsing nature of obesity as a disease process.
Research published in the Journal of Investigative Dermatology reveals that UV exposure increases energy expenditure by inducing the 'browning' of subcutaneous fat, thereby preventing weight gain. This breakthrough discovery opens up new possibilities for treating obesity and metabolic disorders.
A new study from Flinders University found that feeling connected to a social group can lead people to make healthier food choices. The research tested the idea that people are more likely to adopt healthy eating habits if they feel like they belong to the same group as those promoting healthy eating.
A nationwide study in Spain found that high summer temperatures increase the risk of hospital admission for metabolic disorders, obesity, renal failure, urinary tract infections, and sepsis. The study also revealed differences in vulnerability among age groups, sexes, and pre-existing health conditions.
Researchers at the State University of Campinas found that daily consumption of jaboticaba peel improved glucose metabolism even after meals. The study showed lower post-prandial glycemia and less inflammation in volunteers with obesity and metabolic syndrome.
The Endocrine Society will unveil new research on male birth control and anti-obesity medications during ENDO 2024 news conferences. The society's Vitamin D Clinical Practice Guideline is also being shared publicly for the first time, featuring discussions on its recommendations.
A new American Heart Association scientific statement reveals significant gaps in the application of obesity research to patient care, with widespread adoption varying by healthcare professional and institution. The statement emphasizes the need for better implementation of evidence-based treatments and strategies, such as lifestyle mo...
Adolescents with overweight or obesity may be more vulnerable to negative cognitive effects following sleep restriction. Improved sleep hygiene and duration can positively impact their cognitive health.
A newly discovered connection between two brain regions may help regulate how much we eat, according to a Northwestern University study. The weaker the connection between these regions, the higher a person's BMI, suggesting that individuals with weak brain circuits may overeat even when full.
A study published in JAMA Surgery found that bariatric surgery significantly reduces the risk of breast cancer in women with obesity, particularly those with high blood insulin levels. The results show a 32% lower risk overall and a 52% lower risk for women with high insulin levels at the start of the study.
Researchers have developed a new weight loss drug that combines GLP-1 with molecules blocking the NMDA receptor, exploiting its effects on appetite control and neuroplasticity. This approach shows promise for greater weight loss in mice than existing medications.
Researchers at Tokyo University of Science developed menthyl esters with potent anti-inflammatory and anti-obesity effects. The compounds outperformed menthol in inflammatory assays and suppressed genes involved in immune responses. They also inhibited adipogenesis, showing promise for addressing metabolic disorders.
A new UK-based trial found that text messages with financial incentives can help men with obesity lose weight, with an average of 4.8% body weight loss over 12 months. The study, which involved 585 men living with obesity, suggests that text messaging alone may not be as effective in promoting weight loss.
A wireless feedback system is comparable to a similar system with added coaching in achieving meaningful weight loss. The study suggests that technology alone may not produce clinically acceptable weight loss for most individuals, highlighting the need for stepped care with human coach support.
A new study suggests a lower BMI threshold of 27 kg/m² may be more appropriate than the existing WHO BMI threshold (30 kg/m²) for middle-aged and older adults. This could lead to improved health outcomes for millions of older adults, as body fat percentage is a more accurate indicator of obesity.
A new Northwestern University study found that technology alone resulted in worse weight loss compared to a combination of tech and telehealth coaching for obesity treatment. The study suggests that while technology has its benefits, it cannot replace the human touch for meaningful weight loss.
A new study shows that text messaging with financial incentives significantly improves weight loss in men with obesity compared to traditional methods. The intervention combines personalized text messages with cash rewards, resulting in a 5% weight loss threshold, and could be an effective low-cost solution for health services.
Two studies based on the SELECT trial show semaglutide leads to sustained weight loss of 10% body weight and 7cm waist reduction after 4 years, regardless of starting weight or BMI. The medication also delivers cardiovascular benefits, with a lower risk of heart attack, stroke, or death.
A new Italian study has found that people living with obesity often conceal their bodies in WhatsApp profile pictures, indicating potential body dysmorphic disorder. The study suggests that such images could provide valuable insights into patients' psychological states.
A recent analysis of WHI findings indicates that MetS and obesity each have different associations with breast cancer subtypes and mortality risk. Women with higher MetS scores are at a higher risk of poor-prognosis, estrogen receptor-positive, progesterone receptor-negative breast cancers.
The European Association for the Study of Obesity highlights TikTok's potential in addressing childhood obesity. Analysis of Dr Anthos' TikTok account reveals popular videos on obesity medication and stigma combating, with live Q&A sessions generating significant discussion.
A UK survey found that only 13% of respondents would be willing to regularly consume insects, highlighting the need to overcome the 'disgust factor' for entomophagy to become mainstream. The study suggests that incorporating insect flours into processed foods may help reduce disgust and increase consumer acceptance.
Researchers found that Kallistatin expression increases after weight loss in individuals with overweight and obesity. Additionally, human Kallistatin improves hepatic insulin sensitivity in diet-induced obese mice. The study suggests that Kallistatin may be an interesting therapeutic target for people with obesity and type 2 diabetes.
Researchers found that smokers skip meals more often, go longer without eating, and are more likely to snack between meals. They also tend to eat fewer sweet foods, but more fried foods, salt, and sugar than non-smokers.
A Danish study found that patients who tapered off semaglutide slowly and focused on lifestyle changes maintained their weight loss for at least 6 months. Lower doses of the drug were as effective as higher ones, with a tailored approach minimising side-effects.
A randomized trial found that aerobic exercise significantly reduced inflammatory markers in adults with obesity, including IL-6 and IFN-γ levels. Exercise combined with liraglutide treatment showed no additional benefits in reducing inflammation compared to placebo or liraglutide alone.
Food and drink advertisements on videogame livestreaming platforms (VGLSPs) like Twitch are associated with more positive attitudes towards and purchases of unhealthy foods. Researchers call for stronger regulations to protect young viewers from the potential harms of digital food marketing.
Researchers found that men with obesity have increased adipose tissue insulin resistance and higher levels of free fatty acids in the blood. This may partly explain why type 2 diabetes is more common in men. The study suggests that sex differences in adipose tissue insulin sensitivity could be a key factor in this disparity.