A new strain of vaccinia virus has been developed to induce immunogenic cell death in tumor cells, increasing immunogenicity and reducing toxicity. The virus shows high efficiency in activating immune responses against various types of cancer, including melanoma, colon, and kidney cancer.
A survey of Australian citizens reveals growing support for changing Australia Day date due to respect for First Nations people. Reconciliation Day on May 27 is the most popular alternative date, with younger respondents more likely to support a change.
A new study suggests the D-layer may be a unique composition leftover from Earth's earliest days, potentially holding clues to the planet's formation. The D-layer is believed to contain iron-rich peroxide with strong affinity for iron, which could explain its heterogeneous structures.
Researchers have identified genetic changes that can leave children born with little to no immune defense against infection. The study links mutations in the NUDCD3 gene to Severe Combined Immunodeficiency and Omenn syndrome, rare and life-threatening immunodeficiency disorders.
Researchers found that hyaluronic acid with a specific molecular weight improves host inflammation by modulating the gut microbiota and metabolites. The optimal molecular weight range of hyaluronic acid to improve host inflammation has been identified, providing new strategies for alleviating inflammation.
Researchers found 45% of TikTok videos promoting age-verification-free sales, highlighting a loophole in local and federal laws. Small business owners used hashtag challenges like #discreetshipping to circumvent regulations, selling products via Instagram or Telegram.
Researchers have discovered a new class of light-sensitive proteins that can turn off brain cells with light, providing an unprecedentedly effective tool to study brain function. This breakthrough offers exciting opportunities for applying optogenetics to understand the underlying mechanisms of neurodegenerative and psychiatric disorders.
Researchers from the UChicago Pritzker School of Molecular Engineering have found a way to manipulate water molecules to make CO2R more efficient, achieving nearly 100% efficiency under mildly acidic conditions. The new method uses either gold or zinc as catalysts and can be scaled up using cheaper, more abundant materials.
Defective autophagy in pancreatitis allows damaged organelles to accumulate, disrupting cellular function and potentially leading to cell death. Researchers identified therapeutic targets within the autophagy pathway, including VMP1 and TFEB.
Researchers investigated the reproductive cycle of Michigan's threatened freshwater mussels, finding that pregnant females use mantle lures to attract fish and infect them with larvae. The study identified two distinct lure morphs in one mussel species, which elicit different responses from potential host fish.
A team of researchers from Okayama University developed a novel phenothiazine-based organic photoredox catalyst with enhanced stability and recyclability. The new catalyst, PTHS, features a spiral structure that provides improved stability and can be recycled multiple times without losing catalytic activity.
Researchers at Okayama University developed a novel AAK1 inhibitor using Kinobeads technology, shedding light on its inhibitory mechanism and targeting various neurological disorders and viral infections. This breakthrough paves the way for rapid and cost-effective enzyme inhibitors with clinical applications.
The detection and management of borderline hepatic nodules, particularly those hypointense in the HBP without APHE, are critical in preventing overt hepatocellular carcinoma progression. Advances in imaging technologies have improved detection and characterization of these nodules, leading to better patient prognosis.
Researchers at La Jolla Institute for Immunology found that people who experienced breakthrough COVID-19 infections develop T cells better equipped to recognize and target SARS-CoV-2. The study also discovered that B cells produce more diverse antibodies targeting common epitopes between the vaccine and variants.
The DRIVE-RM consortium, led by UMC Utrecht, aims to develop smart materials that assist the body in healing and regenerate tissues and organs using regenerative medicine. The project focuses on treating chronic diseases such as heart failure, kidney failure, and worn joints.
The study highlights the importance of protease-activated receptors (PARs) in cancer growth and development, with PH-binding motifs identified as a key platform for drug design. The researchers suggest that targeting PARs could provide an alternative to current oncogenic pathways.
Researchers identified TP63 as a master regulator promoting immune evasion and affecting immunotherapy efficacy in squamous cell carcinoma. Inhibition of TP63 improves CD8+ T cell infiltration and tumor killing, offering a potential strategy to enhance anti-tumor immunotherapeutic effects.
A cross-sectional study found that COVID-19 surges are associated with declines in hospital quality, emphasizing the importance of maintaining care standards during periods of high hospital use. The study highlights the need for effective strategies to mitigate these declines and ensure continued high-quality care.
A recent study from Lund University suggests that tattoos may be a risk factor for cancer in the lymphatic system. Researchers found that individuals with tattoos had a 21% higher risk of developing lymphoma compared to those without tattoos.
Researchers discovered how tiny ions move within a complex network of pores, simulating and predicting ion movement in just a few minutes. This breakthrough could lead to more efficient energy storage devices like supercapacitors.
A Chinese team reveals how acetylation of Bub1 by TIP60 regulates proper chromosome congression and segregation. Impaired Bub1 acetylation causes chromosome missegregation, leading to genomic instability.
Research highlights varied associations between social isolation and mortality risk across demographic groups, including socioeconomic disparities. The study emphasizes the importance of considering sociodemographic heterogeneity in understanding the impact of social isolation on health outcomes.
Researchers at Penn Engineering have developed an adjustable filter that can prevent interference and enable the use of higher-frequency bands in wireless communications. The filter, made from a unique material called yttrium iron garnet, is tiny and requires minimal power, making it suitable for future mobile devices.
New research from the University of Notre Dame reveals that protest movements against political parties can inadvertently empower politicians who use them to disrupt the status quo. The study analyzed 12 case studies across Europe, Asia, and North and South America between 2008 and 2016, finding varying outcomes including factional cha...
Researchers will design a digital intervention to harness existing social relationships and promote sustained behavior changes related to physical activity. A five-year R01 grant will be used to study the effectiveness of this approach in increasing long-term increases in physical activity among U.S. adults.
A study published in the New England Journal of Medicine found high H5N1 virus levels in mice administered raw milk from infected dairy cows. The results suggest that consuming raw milk may pose a risk for H5N1 infection, highlighting the need for further research into pasteurization and its effectiveness.
A team of researchers has discovered a method to create the Leidenfrost effect at lower temperatures using engineered surfaces. By creating micropillars on a surface, they can increase the temperature at which water droplets hover, improving heat transfer applications.
Researchers demonstrate a way to describe spin-boson systems and efficiently configure quantum devices in a desired state. Non-Gaussian states are used to retain powerful mathematical machinery while describing diverse quantum states.
A nationwide study found a high incidence rate of sepsis cases among non-child cancer patients in China, with males exhibiting higher rates than females. The study also revealed significant geographic variations in sepsis burden across China, with regions having lower and higher development levels exhibiting elevated rates.
Researchers created a novel composite material by adding Sm2O3 micron plates to boron-containing polyethylene, improving thermal stability, mechanical strength, and radiation shielding properties. The material showed excellent performance in blocking neutron and gamma radiation, with up to 98.7% blockage at 15 cm thickness.
A groundbreaking study reveals semaglutide significantly reduces the risk of major kidney disease events, cardiovascular outcomes, and all-cause mortality in patients with type 2 diabetes and chronic kidney disease. Semaglutide also shows improved safety and efficacy profiles.
A team of UC Santa Cruz researchers has identified a peptide in human RNA that plays a crucial role in regulating inflammation. The discovery provides a promising target for developing new treatments for inflammatory diseases such as arthritis and lupus.
A cohort study found that heat waves were associated with increased rates of preterm and early-term deliveries, especially among vulnerable populations. The results suggest that extreme heat events pose a significant threat to perinatal health.
A research team led by UCF's Mário Nascimento De Prá and Noemí Pinilla-Alonso discovered carbon dioxide and carbon monoxide ices on 59 trans-Neptunian objects using the James Webb Space Telescope. The findings suggest that carbon dioxide was abundant in the protoplanetary disk, while the origin of carbon monoxide remains uncertain.
Researchers found predictable, repeatable evolutionary patterns in populations of stick insects, with fluctuations in color frequency influenced by bird predation and natural selection. The study provides evidence for the existence of 'up-and-down' dynamics in evolution based on standing genetic variation.
African researchers are urging fair collaboration in microbiome studies to explore unique populations and environments, addressing a significant knowledge gap. The proposed framework emphasizes community involvement, capacity building, and multidisciplinary collaboration for sustainable outcomes.
Researchers discovered that sperm in insects can adapt to sexually transmitted microbes, with fertility reduced by 1/5th when sperm and microbes are unfamiliar. This finding may explain mixed results from human studies on the impact of microbes on male fertility.
A study by UCLA Health Jonsson Comprehensive Cancer Center researchers found that combining experimental immunotherapy drugs with chemotherapy significantly improves progression-free survival and overall survival for patients with metastatic colorectal cancer. The median progression-free survival was 6.2 months compared to 2.1 months f...
Researchers at KIT have developed a novel polymer-based metamaterial that combines properties of light diffusion, self-cleaning, and radiative cooling while maintaining transparency. The material can optimize indoor lighting, provide passive cooling, and reduce reliance on air conditioning.
A team of scientists, led by Warren Booth, solved the 250-year-old mystery of the German cockroach's origin by analyzing genomic data from over 280 specimens across 17 countries and six continents.
A recent study combines experimental data with state-of-the-art calculations to reveal new details on the origins of proton spin. The research shows that gluons, which hold protons together, contribute significantly to the proton's spin, contradicting earlier findings.
Researchers from the University of Bath have created a deformable screen called DeformIO, which can be deformed through finger pressure. The surface becomes softer or stiffer in direct response to force applied, allowing users to interact with digital objects in a more tactile way.
A new study published in JAMA Network Open found that virtual scribes can significantly reduce the time physicians spend on electronic health records. The study analyzed data from 144 physicians across specialties who used real-time or asynchronous virtual scribe services for at least three months, resulting in reduced time spent on no...
Researchers investigated the effectiveness of systemic thrombolysis for acute portal vein thrombosis (PVT) in liver cirrhosis patients. After a 7-day treatment period, 60% of patients achieved full recanalization of the portal vein, with no significant side effects.
A study suggests that reducing plastic pollution by 5% per year can stabilize the level of microplastics in surface oceans. However, even a 20% reduction may not significantly impact existing microplastics levels, which will persist in oceans beyond 2100.
Researchers created a topological quantum simulator device that operates at room temperature, allowing for the study of fundamental nature of matter and light. The device has the potential to support the development of more efficient lasers.
Researchers have developed a method to print adaptive and eco-friendly sensors directly onto biological surfaces, including human skin. The new approach uses 'electronic spider silk' that can conform to surfaces while providing high-quality sensor performance.
Researchers developed a new technique to view living mammalian cells using ultrafast pulses of illumination from a soft X-ray free electron laser. The microscope captured images of carbon-based structures in living cells with high spatial resolution and a wide field of view, revealing new insights into cellular biology.
A Wayne State University team, led by Dr. Arash Javanbakht, will study augmented reality-enhanced exposure therapy for post-traumatic stress disorder (PTSD). The technology aims to provide immersive real-life environments for patients to practice comfort and interaction with diverse characters.
The new assembly toolkit PMAT addresses the limitations of traditional methods by utilizing highly accurate long-read HiFi sequencing data. It successfully assembled the mitogenomes of 13 plant species with minimal sequencing data, making it a cost-effective solution for large-scale genomic studies.
Researchers at the University of Michigan have developed a new thermophotovoltaic cell that can recover significantly more energy from heat batteries, increasing efficiency to 44%. The device uses air bridges to trap photons with the right energies, allowing for the recycling of useless photons and improving overall performance.
A new study reveals that Black Americans trail white Americans in financial stability, which may impact brain health. The study found that lacking low-cost debt constrains Black Americans' ability to accumulate wealth, leading to lower cognitive function and increased risk of Alzheimer's disease.
The study found a 5.7% blood culture positive rate among eligible Hem-Onc patients, with 56% having an absolute neutrophil count greater than 500 µL at presentation. Gram-positive organisms were the most common isolates, highlighting the diversity of bloodstream infection causes in this patient population.
A new study reveals that a cancer drug can improve insulin sensitivity and lower blood glucose levels, but eliminating a specific gene related to fat metabolism worsens insulin resistance. The research highlights the interconnectedness of fat metabolism in organs and the need for simultaneous treatment of obesity and insulin sensitivity.
Studies led by the University of Texas at Austin researchers found that bird song and human voice share a common genetic link, with the syrinx and larynx having similar developmental programming. This discovery highlights the shared ancestry between birds and humans in terms of vocal organ structure.
A recent study has cataloged gene-isoform variation in the developing human brain, providing crucial insights into neurodevelopmental and psychiatric disorders. The research found thousands of isoform switches that occur during brain development, implicating previously uncharacterized RNA-binding proteins.
Researchers from the Polish Academy of Sciences find that wave phenomena, like sound waves, may be responsible for heat transport in complex systems. The study uses the telegraph equation to describe how electric current propagates with attenuation along one spatial dimension.
After living kidney donation, donors experience a slower rate of estimated glomerular filtration rate (eGFR) decline compared to non-donors. However, donors are more likely to have an eGFR between 30-60 mL/min/1.73 m2 at least once during follow-up.
The study identified over 150 genetic variants linked to disease and showcased the utility of using organoids for brain research. Machine learning was used to predict gene activity, enabling faster and more efficient research.
A study of 1,126 participants in Beijing found significant changes in gut microbiomes after the pandemic. The team discovered a decrease in bacterial loads and less mature gut microbiomes in children and infants.