A UK study of over 420,000 adults reveals that those with existing cardiovascular disease and overweight or obesity are five times more likely to suffer a stroke and four times more likely to have a heart attack than those with extreme obesity. The study highlights the substantial impact of living with both conditions on individuals, p...
The National Institutes of Health is enrolling 10,000 participants in a landmark precision nutrition study. The study aims to develop algorithms predicting how individuals respond to different foods and diets based on genetic, lifestyle, and environmental factors.
A study found that muscle fat accumulation, known as myosteatosis, is associated with a higher risk of major adverse events and death in asymptomatic adults. The presence of muscle fat was comparable to the mortality risk associated with smoking or type 2 diabetes.
A study published in Cell Reports found that saturated fatty acids promote the immune escape of oral cancers in mouse models. Obesity helps establish a type of tumor microenvironment that promotes tumor progression by suppressing STING-type-I interferon pathway and NLRC3.
A new study found that ear acupuncture with beads can help reduce waist circumference, body fat, and BMI in men living with obesity. Participants who received auricular acupuncture with beads lost an average of 10.4cm off their waist circumference and 4% of total body fat.
Researchers at Indiana University School of Medicine discovered a strong association between obesity and clonal hematopoiesis of indeterminate potential (CHIP), a blood condition that increases the risk of blood cancer. The study found that obesity causes inflammation, which can lead to rapid growth of mutated blood cells.
Research reveals both metabolically healthy and unhealthy obesity types linked to increased risk of various obesity-related cancers, with stronger association in metabolically unhealthy obesity. Metabolically unhealthy women face higher risks for endometrial, liver, and kidney cancers.
Researchers discover that senescence-associated secretory phenotype (SASP) can induce neuroendocrine transdifferentiation (NED) in breast cancer epithelial cells, promoting tumor progression and aging-related features. SASP's dual role in cancer involves both antitumoral and tumorigenic effects.
Researchers found that fatty liver cells secrete proteins and genetic material that promote the spread of colorectal cancer to the liver. This condition is likely underdiagnosed, affecting over 40% of patients with colorectal cancer, according to a new study published in Cell Metabolism.
Researchers found that high-fat diets increase levels of gut-derived bacterial toxins and systemic inflammation, promoting atherosclerosis. The study suggests targeting interventions for individuals at risk of developing heart disease.
A recent study found that a vast majority of tweets about obesity are negative, with only 8.25% containing positive sentiments. The analysis suggests that Twitter activity spiked around significant political events, including comments from influential politicians and celebrities.
A new UK study found that people who believe individuals are to blame for living in poverty are more likely to oppose weight discrimination laws. The researchers also discovered a connection between stigmatizing views on weight and greater prejudice towards larger-bodied individuals.
Researchers found that people with severe obesity have a higher risk of severe COVID-19 outcomes and may need more frequent booster doses. Immunity declines faster in obese individuals, putting them at greater risk of infection over time.
Overweight and obesity in early adulthood are associated with increased risks of colorectal cancer and non-colorectal gastrointestinal cancers. The study highlights the need for further exploration into the mechanisms driving these associations.
A new study found that being overweight or obese during early and middle adulthood increases the risk of gastrointestinal cancers in later life. The research also suggests that frequent aspirin use does not modify this increased risk.
Researchers at McMaster University have found that solriamfetol is the most effective treatment for excessive daytime sleepiness (EDS) in individuals with obstructive sleep apnea (OSA). A systematic review of 14 clinical trials and analysis of data from various databases revealed solriamfetol to be the best option.
Maynooth University research finds that the obesity treatment drug GLP-1 can restore the body's natural cancer-killing defences by boosting NK cell function. The study shows independent benefits of GLP-1 on cancer risk, beyond its weight loss effects.
A study in Kenya's Nairobi city found that preadolescents' diets are shifting towards unhealthy Western patterns, leading to increased obesity. Researchers suggest interventions using peer counselors and lay health educators to promote healthy lifestyles.
Recent cluster analyses identify novel risk stratification concepts to better implement precision medicine in clinical practice. Metabolically unhealthy individuals, regardless of weight, face a higher CVD risk compared to obese, metabolically healthy peers.
A new study published in JMIR Diabetes found that Fitterfly's diabetes digital therapeutics program improved glycemic control and weight management in participants with type 2 diabetes. The 90-day program led to significant reductions in hemoglobin A1c levels and body weight.
A recent study published in PLOS ONE found that patients with Type 2 diabetes who have full chewing function have significantly lower blood glucose levels compared to those with impaired chewing ability. The research highlights the importance of dental care and occlusal function in managing blood sugar levels.
The 'Low Oxygen and Weight Status' study will investigate the effects of low oxygen levels on weight loss and health outcomes in adults with obesity. Participants will be randomized to sleep in an altitude tent or normal conditions, while following a weight loss diet. The study aims to inform new strategies for improving metabolic health.
A study by researchers at Umeå University found that diet plays a much stronger role in shaping the intestinal microbiota composition than previously thought. The study also suggested that intestinal defense molecules may help protect against metabolic disorders when consuming an unhealthy Western-style diet.
Researchers at West Virginia University found that bariatric surgery significantly reduces the risk of major cardiovascular events and death in patients with NAFLD. The study included 9,374 adult patients with NAFLD and obesity, who underwent either Roux-en-Y gastric bypass or sleeve gastrectomy.
A study supported by the National Institutes of Health found that younger women are nearly twice as likely to be rehospitalized after a heart attack as men. The disparity is largely due to higher rates of risk factors such as obesity and depression among women, which contribute to more adverse outcomes.
New research published in the journal SURGERY found that obesity is associated with increased risk of complications following surgery, including infection, blood clots, and kidney complications. Patients with overweight or obesity had higher risk-adjusted odds of developing these post-operative outcomes compared to those of normal weight.
A study found that young women are more likely to experience adverse outcomes and rehospitalization after a heart attack, with non-cardiac hospitalizations showing the most significant disparity. Researchers highlight the need for public awareness and sex-specific post-heart attack care.
A Maynooth University study published in Science Signaling has found that the MYC protein is essential for MAIT cell growth, proliferation, metabolism, and function. The researchers also discovered that MYC is defective in people with obesity, providing a mechanism to explain why MAIT cells are impaired in this condition.
The grant aims to develop accurate household food waste measurement methodologies and metrics. Innovative technologies will help create impactful interventions to minimize and eliminate food waste in the United States and globally.
Researchers found that long siestas (30+ minutes) increased the risk of obesity, metabolic syndrome, and high blood pressure. In contrast, short siestas were associated with improved systolic blood pressure levels.
A large national study found that preteens carrying excess weight have notable differences in cognitive performance, brain structures, and brain circuitry. The association is concerning as it suggests that excess BMI may impact brain development and function.
A comprehensive review of 169 clinical trials found that the effect of fructose-containing sugars on adiposity varies among food sources and energy control. High doses of certain sources, like SSBs, lead to increased body weight, while others, such as fruit and honey, show moderate beneficial effects when consumed in moderation.
A study published in Scientific Reports found that rats exposed to high-fat diets during pregnancy and early life developed a preference for salty taste. This preference was linked to increased levels of AT1 protein in the taste buds, which can lead to higher sodium intake and potentially contribute to obesity and diet-linked diseases.
Researchers found deaths from gallstone disease increased in younger populations and those with Medicaid after Medicaid expansion, highlighting the need for proactive prevention over reactive emergency care. A new healthcare model emphasizing primary care and prevention is proposed to address these inequities.
Researchers found that maternal overweight compromises the placenta's antiviral response, weakening its ability to protect the fetus. The study suggests that adequate antenatal care is crucial in preventing complications from Zika infection.
A study found that sleeve gastrectomy decreases bone mineral density and strength in adolescents and young adults. Participants who underwent weight loss surgery lost significant amounts of weight and experienced reductions in abdominal fat tissue and muscle mass.
A study from Tufts University researchers estimates that menu calorie labels can prevent at least 28,000 obesity-associated cancer cases and 16,700 cancer deaths over a lifetime, saving $2.8 billion in healthcare costs. The policy is expected to have the greatest impact on young adults and Hispanic/Black individuals.
A modelling study suggests that specifying menu calorie counts is likely to reduce obesity-related cancers and healthcare costs in the US. The policy could prevent 28,000 new cancer cases and 16,700 cancer deaths, as well as save $1.48 billion in medical costs.
A mouse study suggests that a specific brain receptor, the leptin receptor, may be involved in the development of PCOS symptoms. Researchers found that mice exposed to excess androgens prenatally had improved estrous cycles and regulation of their menstrual cycles, offering potential therapeutic targets for people with PCOS.
The CHEST journal April issue features cutting-edge research on asthma, chronic obstructive pulmonary disease (COPD), and sarcoidosis. Key findings include the potential of efzofitimod as a treatment for managing sarcoidosis. The journal also showcases innovative approaches to clinical practice and education in chest medicine.
A machine learning model has been developed to predict a patient's risk for a sleep disorder using demographic, lifestyle, physical exam results, and laboratory values. The model identified depression, weight, age, and waist circumference as the greatest predictors of a sleep disorder diagnosis.
SourcePLOS·JournalPLOS ONE·TypeComputational simulation/modeling·DateApr 12, 2023
Researchers found that higher selenium levels were associated with lower blood pressure and HDL concentration in middle-aged women. The study suggests that selenium may moderate the effect of genetic variants on MetS components, such as waist circumference.
A study of 308 adults found that people displayed more active and healthy behaviors during a three-day holiday, with increased physical activity and decreased sedentary behavior. The extra time off also led to improved sleep patterns, with participants gaining an average of 21 minutes of sleep per day.
A new study published in Metabolism reveals that the hormone neurotensin is released in greater amounts by people who successfully maintain weight loss after a low-calorie diet. This suggests that neurotensin may play a key role in regulating appetite and weight management.
Research explores how social norms and culture influence food preferences, physical activity behaviors and future hopes for community development. Key themes include the importance of creating interventions aligned with cultural norms to create effective and sustainable programs.
SourceElsevier·JournalJournal of Nutrition Education and Behavior·TypeData/statistical analysis·DateApr 11, 2023
A study published in Diabetologia found that bariatric surgery can regenerate damaged nerves and improve metabolic risk factors related to diabetes. Peripheral neuropathy, a condition affecting over 30 million Americans, showed improvements two years after the procedure.
The new American Heart Association scientific statement emphasizes the importance of including non-biological factors and social determinants in CVD risk assessment for women. These factors include economic stability, neighborhood safety, education level, and access to quality healthcare, which disproportionately affect women from dive...
The University of Texas at El Paso will study the role of obesity and inflammation in pancreatic cancer development, a disease with high mortality rates. The grant aims to develop targeted treatments and preventives, potentially transforming understanding of pancreatic cancer.
Researchers from Karolinska Institutet found that people with obesity due to genetic predisposition have a lower risk of cardiovascular disease. The study analyzed data from over 15,000 twins and medical registries, suggesting that genetics may play a role in mitigating the risk of cardiovascular disease.
Researchers found that obstructive sleep apnea (OSA) can cause premature cognitive decline in middle-aged men, including poorer executive functioning and social cognition. The study suggests that OSA itself is sufficient to cause these deficits, rather than being solely attributed to co-morbidities.
New research suggests a way to ward off age-related weight gain by stimulating beige fat cells. Beige fat has thermogenic properties that can reduce blood sugar and fatty acids causing heart disease. The study identifies a specific signaling pathway responsible for suppressing beige fat formation in older mice.
A new UCLA study identifies sex-specific brain signatures associated with obesity in men and women, revealing differences in brain networks related to early life adversity, mental health, and sensory stimulation. The findings suggest the need for tailored interventions based on an individual's sex.
Researchers successfully add purified curcumin to probiotic yogurt, preserving its dissolved form and enhancing its health properties. The study shows that the curcumin inhibits yeast, fungi, and bacteria growth while maintaining the recommended levels of beneficial lactic acid bacteria.
Research shows that higher Body Mass Index (BMI) in the oldest old is associated with a range of health issues. The study also found significant differences between women and men in terms of mental health concerns related to BMI.
Children born to mothers infected with COVID-19 during pregnancy may experience altered growth patterns and increased weight gain in early life, which can lead to a higher risk of obesity, diabetes, and cardiovascular disease. The study highlights the importance of long-term follow-up and prevention strategies for pregnant individuals.
A new class of compounds reduces weight dramatically and lowers blood glucose in lab animals, boosting calorie burn and avoiding nausea. The injectable treatments activate multiple gut hormone receptors, including GLP-1 and PYY, to signal fullness and curb appetite.
Researchers aim to understand the allure of highly processed foods, which make up 58% of US calories. By studying their processing and added ingredients, they hope to identify underlying variables driving consumption.
A team of researchers from Ohio University discovered that CIDEC protein improves vascular and metabolic dysfunction, reducing insulin resistance and lipid levels in high-fat diet-induced mice. The study contributes to understanding the role of the vascular endothelium in regulating systemic metabolism.
Research highlights that intensive behavioral weight loss programs significantly reduce cardiovascular disease and Type 2 diabetes risk factors, which persist for at least five years. Participants who lost weight through such programs had lower risk factors compared to those in less intensive or no weight loss programs.
A new study suggests that age, not weight, should be used to screen for diabetes, capturing the greatest number of people in all racial and ethnic groups. The approach identifies the greatest proportion of adults with prediabetes and diabetes and maximizes equity across racial and ethnic groups.