Articles tagged with Obesity
Researchers found that P2-HNF4α expression is associated with p-STAT3 and c-Myc expression in NAFLD patients, suggesting potential biomarkers for hepatocellular carcinoma (HCC) risk. Additionally, p-STAT3 expression was linked to hypertension, while c-Myc expression was associated with advanced fibrosis.
Research highlights importance of long-term screening and healthy lifestyle behaviors in reducing cardiovascular disease risk among young cancer survivors. Factors such as sociodemographic status, income, education, smoking status, and physical activity levels are associated with increased or decreased CVD risk.
A new study shows that paying cash to people with obesity for losing a specific amount of weight works better than offering free tools like weight-loss programs and wearable fitness trackers. Incentives tied to actual weight lost were most effective in the short term, while goal-focused financial rewards performed better in the long run.
Researchers developed a new method to target and treat visceral adiposity using positively charged P-G3 nanomaterials, which inhibit unhealthy lipid storage in enlarged fat cells. This approach also rejuvenates healthy fat cells, promoting metabolically healthy fat cell formation.
A recent study led by the University of Nevada, Reno and the Pan American Health Organization suggests that the adoption of front-of-pack nutrition labeling can help reduce poor-nutrition related non-communicable diseases in the region. Improved FOPNL systems have been associated with improved diet quality and reduced risk of NCDs.
A new study from the University of East Anglia found that overweight women are more likely to experience symptoms of long Covid. The research also shows that people with long Covid are much more likely to need additional and lasting NHS care than those who make a swift recovery.
A low-cost prenatal intervention benefits mothers’ mental health up to eight years later. The eight-week class intervention supported healthier stress responses in their children, and cut their short-term risk of depression and diabetes.
Researchers review myeloid-derived suppressor cells' phenotypes, mechanisms of immunosuppression, and roles in cancer treatment. Studies on non-malignant diseases, such as autoimmune disorders and obesity, are lacking, highlighting the need for further investigation.
Researchers found that excess fat triggers immune cells to overeat serotonin in the brain of developing male mice, leading to depression-like behavior. Female mice are not affected in the same way, with higher levels of oxytocin linked to social withdrawal.
A recent study found metabolic perturbations in young nonhuman primates' liver and skeletal muscle after maternal obesity during pregnancy, even after a normal diet was introduced post-weaning. The study identified 58 altered metabolites in the liver and 46 in skeletal muscle, suggesting long-term health consequences.
Researchers explore the interactions between adipose tissues and surrounding blood vessels in connection with lipid metabolism and associated diseases. Targeting angiogenesis may provide a gateway for treating obesity, while its inhibition or promotion depends on the specific disease context.
A new smartphone healthcare app called CALO mama Plus has been found to lead to significant reductions in body weight. The study, conducted by researchers from the University of Tsukuba, tested the efficacy of a comprehensive behavior modification app and found it to be as effective as established interventions.
A UK Biobank study found that screening all adults aged 40-70 years for type 2 diabetes using HbA1c could detect up to 250,000 undiagnosed cases, bringing diagnoses forward by 2.2 years on average.
Researchers found that metabolic disease affects blood vessels in different organs, leading to vascular dysfunction and increased risk of diseases. A healthy diet can partially reverse this damage, but some blood vessels may retain the disease signature, making it difficult to fully reverse.
A new study from the University of South Australia found that eating 30-50 grams of almonds can help people cut back on kilojoules consumed each day. This leads to a reduced energy intake by 300 kilojoules, mostly coming from junk food.
A new study by Cedars-Sinai investigators has identified risk factors for developing diabetes in people with chronic pancreatitis, including smoking and being overweight. The findings suggest that models can be built to predict diabetes risk, allowing clinicians to connect patients with weight loss or smoking cessation programs.
Research finds that increased body weight is associated with higher levels of inflammation, signs of gut permeability, and poorer asthma control. The study suggests that targeting the gut could be an effective treatment target for improving asthma control in patients with obesity. Weight loss may also improve symptoms for these patients.
Rates of complications, death, and subsequent surgery were similar for gastric bypass and sleeve gastrectomy in adolescents with severe obesity. Adolescents who underwent sleeve gastrectomy had lower emergency room visits and hospital admissions compared to those who had gastric bypass surgery.
A Rutgers study of 86,964 adults with obesity and NAFLD found that bariatric surgery reduced the risk of major cardiovascular events by 49% compared to nonsurgical care. This is significant because heart disease is a leading cause of death in the US, and NAFLD can lead to liver damage and inflammation.
A study by Okayama University researchers found that neuromedin U (NMU) is involved in metabolic processes but its 'anti-hunger' function may not be crucial for rats. Unlike mice, NMU expression is restricted in the rat brain and does not suppress feeding behavior.
Research recognizes significant association between unhealthy behaviors and conditions like obesity, diabetes, smoking, leading to poorer COVID-19 outcomes. Experts emphasize promoting healthy lifestyles to combat syndemics, particularly impacting underserved communities.
The study highlights the importance of the gut microbiome in metabolic conditions like obesity and neurological diseases such as Parkinson's. Pesticide exposure is also found to disrupt the gut microbiota, leading to brain-gut alterations that can exacerbate these conditions.
A University of Gothenburg study found that severe obesity at age 18 is associated with a three- to fourfold increased risk of developing atrial fibrillation in younger middle age. The study analyzed data from over 1.7 million men in Sweden and found that higher BMI was linked to mortality risk, heart failure, and ischemic stroke.
Researchers identified a genetic variant that predisposes people to being slim, carried by 60% of Europeans. The variant affects the amount of fat stored in the body and is associated with the biochemical signalling pathway that tells cells what nutrients are available.
A recent UK-based experiment found no significant change in the overall number of calories purchased when food and drink labels showed physical activity calorie-equivalent values. The study suggests that PACE labelling may not be effective in reducing energy intake, contradicting previous expectations.
A genetic variant associated with a 10-15% reduction in fat storage has been identified in 60% of Europeans. Researchers studied the effect of this variant in mice and found it to be linked to leanness, highlighting the complex interplay between genetics and obesity.
A new comprehensive guideline, C-CHANGE, offers 83 actionable recommendations to prevent and treat cardiovascular disease in Canadian adults. The updated resource incorporates new or revised recommendations from 11 guideline groups, addressing key risk factors such as dietary habits, smoking, and physical activity.
A recent study shows that eight weeks of exercise can restore the brain's insulin sensitivity in severely overweight adults, leading to improved metabolism and reduced visceral fat. This opens up new therapeutic possibilities for reducing obesity and diabetes risk factors.
A large-scale Australian study found that highly processed and refined foods are the primary contributor to rising obesity rates. The 'Protein Leverage Hypothesis' suggests that people overeat fats and carbohydrates due to their strong appetite for protein, leading to an increased risk of chronic disease.
A new study published in the New England Journal of Medicine found that semaglutide, an approved obesity drug for adults, also helps adolescents with obesity lose weight and have healthier hearts. After 68 weeks, 72.5% of participants who received semaglutide had achieved at least 5% weight loss compared to just 17% on placebo.
Researchers argue that obesity should be recognized as a disease and treated early on to prevent complications. Culinary medicine is proposed as an effective intervention, combining nutrition and cooking skills to promote healthy eating habits.
A UMass Amherst epidemiologist is investigating how physical and mental health during pregnancy can predict cardiovascular and mental health disorders in middle age. Pregnancy complications may be associated with poorer cardiometabolic health and mental health status in middle adulthood among Puerto Rican women.
A study of over 1.3 million young Asian American adults hospitalized for atrial fibrillation found a significant increase in obesity and other modifiable cardiovascular disease risk factors. Young adults with at least one cardiovascular risk factor were almost three times more likely to be hospitalized for atrial fibrillation.
Neighborhood walkability is associated with lower cardiovascular disease burden and risk, according to two preliminary studies. The analysis found that even after considering other factors, walkability alone was linked to a 0.1% decrease in cardiovascular disease for each one-point increase in walkability score.
Researchers at Johns Hopkins Medicine have identified TRPM7, a cation channel in carotid bodies and bloodstream, as a promising therapeutic target for sleep apnea. Blocking or eliminating this channel may offer a new treatment option for obesity-related breathing disorders.
A one-year lifestyle intervention with a digital app and group counselling improved diet quality, reduced abdominal obesity and insulin resistance among 2907 Finnish adults at risk of type 2 diabetes. The study suggests that commitment to lifestyle counselling supports positive changes.
A new study from the University of Missouri School of Medicine found that short-term exposure to reduced physical activity and increased sugar consumption disrupts insulin response in blood vessels, with men more prone to vascular insulin resistance. In contrast, young women are protected against this condition.
Researchers at Tulane University have discovered that following a low-carbohydrate diet can lead to reduced hemoglobin A1c levels and improved fasting glucose levels among individuals with unmedicated diabetes and prediabetes. The study suggests that a low-carb diet may be a useful approach for preventing and treating Type 2 diabetes.
Researchers explore the role of nutrition in cancer development, finding that precise nutritional strategies can be used to supplement treatment and treat cancer. Intermittent fasting is being studied as a promising approach to fight cancer, with studies showing it may increase toxicity on tumour cells and reduce side effects.
Researchers from University of South Australia found that porous silica can prevent fats and carbohydrates from being adsorbed in the body. Engineered particles of purified sand are designed to soak up digestive enzymes, fats, and sugars within the gastrointestinal tract.
The new guidelines, issued by the American Society for Metabolic and Bariatric Surgery (ASMBS) and the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO), recommend metabolic and bariatric surgery for individuals with a BMI of 35 or more, regardless of obesity-related conditions. The guidelines also endo...
A recent study published in Journal of Science and Medicine in Sport reveals that high aerobic fitness does not protect children from metabolic syndrome. In contrast, a lower risk was observed when considering body size and composition.
Research at Northwestern University finds that eating during the daytime is ideal for dissipating energy as heat, while nighttime eating disrupts this process. This study's findings have broad implications for dieting, sleep loss, and patient nutrition, particularly in cases of Type II Diabetes.
The American Gastroenterological Association releases new guidelines recommending medications paired with lifestyle changes for adults struggling to lose weight. The guidelines highlight the importance of treating obesity as a biological disease, reducing health complications like diabetes and fatty liver.
A team of researchers has identified specific neurons in the amygdala that drive mice to eat fatty or sugary foods, even when not hungry. Switching off these neurons reduced overeating and protected against obesity, while also boosting physical activity and improving metabolic health.
A recent analysis found that higher BMI in adolescent men is strongly associated with developing early atrial fibrillation, as well as subsequent worse clinical outcomes after diagnosis. Men with higher BMIs had significantly increased risks of mortality, heart failure, and ischemic stroke.
A new study by Johns Hopkins Medicine reveals that stress influences appetite in both obese and lean adults, with differences in brain responses to food. The research found that obese individuals show increased activation of the orbitofrontal cortex after stress, while lean adults exhibit lower activation of cognitive control regions.
A global study found that cardiovascular disease risk factors are largely the same for men and women, except for high LDL levels which affect men more. Women have a lower risk of heart attack and stroke due to their estrogen's effect on vessel walls and liver function.
Few studies utilize high-throughput screening (HTS) and high-content screening (HCS) techniques in anti-obesity drug discovery due to a lack of original data or experimental design information. This limits the development of effective pharmaceutical treatments for obesity-related diseases.
A team of scientists at Scripps Research and Calibr discovered a naturally occurring metabolite called myristoylglycine that can convert white fat cells into brown fat cells, potentially treating obesity and related diseases. The breakthrough uses a novel drug discovery method to identify endogenous metabolites with therapeutic potential.
A national study found that patients with cardiovascular disease had a higher mortality rate than those without, but this association was largely due to shared risk factors. Myocardial injury was common among critically ill COVID-19 patients and associated with poor outcomes.
Researchers have identified microRNA-7 as a non-classic genetic risk factor for hereditary obesity. The molecule affects energy balance and appetite regulation in humans and mice, highlighting the need to examine non-genetic factors in gene-based studies. This discovery may lead to new therapeutic approaches for treating obesity.
Research suggests e-bikes won't help users reach weekly moderate to vigorous physical activity targets due to fewer and less physically demanding trips. However, they may encourage older people to take up cycling who wouldn't otherwise do so.
Taking more than 8,200 steps per day may protect against obesity, sleep apnea, and other conditions. The study analyzed data from over 6,000 participants and found that increasing daily steps can reduce the risk of chronic diseases.
Researchers call for a shift in Australia's approach to obesity, advocating for weight-inclusive policies and challenging the conventional emphasis on personal responsibility. The study highlights the need to address weight stigma in schools, workplaces, healthcare, and social media.
A new study from UCLA found that students who attended high-performing charter schools had a 50% lower rate of alcohol use disorder compared to waitlisted students. Males in the intervention group also reported better physical health and lower obesity rates, while females did not show similar benefits.
A study of 1,270 youths found that attending a high-performing public charter high school was associated with lower rates of substance use disorder and delinquent behaviors. The study also showed that attendance at such schools was linked to better physical health outcomes for males but worse outcomes for females.
A clinical trial conducted by Salk Institute and UC San Diego Health found that time-restricted eating improved measures of health and wellbeing in firefighters. The study showed that a 10-hour eating window reduced VLDL cholesterol, improved mental health, and decreased alcohol intake.
A new study in mice has mapped the cells, genes, and pathways that respond to exercise and diet, offering potential targets for drugs that mimic exercise's benefits. Exercise was found to push these systems in the opposite direction of high-fat diets.
A randomized controlled trial found that combining time-restricted eating (TRE) and high-intensity interval training (HIIT) improved long-term glycemic control and reduced fat mass in women with overweight/obesity. The study also showed increased cardiorespiratory fitness.