Articles tagged with Obesity
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Scientists have created mice that can eat rich, high-fat diets without accumulating fat or risking diabetes. The mice lack the SCD-1 gene, which produces an enzyme required for fat tissue production. Instead of storing excess fat, the mice metabolize it, increasing energy expenditure and oxygen consumption.
A study by researchers at the University of Southern California found that obesity and weight gain in Hispanic women are associated with a nearly two-fold increased risk of breast cancer. The risk was elevated regardless of menopausal status, and particularly among those who gained substantial weight after age 18.
Diet-induced thermogenesis is an intricate system of communications masterminded by the brain that produces heat and helps prevent obesity. By removing beta adrenergic receptors, researchers found that mice fed a high-fat diet grew massively obese, highlighting the importance of this pathway in preventing weight gain.
A study found that high whole-grain consumption was associated with lower rates of type 2 diabetes and cardiovascular disease. Participants who consumed more whole grains had healthier lifestyle habits, including a lower waist-to-hip ratio, less saturated fat, and more fruits and vegetables.
A study finds that a lack of physical activity disrupts normal homeostatic mechanisms, leading to an increased risk of chronic conditions. The research highlights the importance of physical activity in preventing common chronic diseases, including cancer, cardiovascular diseases, and metabolic disorders.
A study found that over 90% of patients experienced significant improvement in GERD symptoms after gastric bypass surgery. Patients also saw a decrease in medication use, including proton pump inhibitors and histamine 2 blockers.
A brain-imaging study found that obese individuals have enhanced metabolic activity in specific regions involved in sensory processing of food. This suggests a heightened sensitivity to food palatability, potentially driving overeating in obese individuals.
Researchers found Xenical significantly improved HbA1c and fasting plasma glucose levels in patients with type 2 diabetes. Additionally, treatment with Xenical showed post-prandial glucose benefits and cost-effectiveness as an adjunctive therapy to oral anti-diabetic medications.
A US study found that 26% of men and 28% of women were obese by age 35-37, with black women and Hispanic men at higher risk. Obesity is linked to various health problems, including heart disease, diabetes, and stroke.
A 12-month study of 430 overweight men and women showed a significant weight loss of 11.6 kg with Xenical, with improvements in blood pressure, cholesterol levels, and waist circumference. The results demonstrate the efficacy of Xenical in a real-life clinical practice setting.
A study published in the journal Diabetes found that a ginseng berry extract completely normalized blood glucose levels, improved insulin sensitivity, lowered cholesterol levels, and decreased weight in diabetic mice. The extract also reduced appetite and increased activity levels in treated mice, leading to significant weight loss.
A recent study has found that low-calorie dieting raises ghrelin levels, while gastric bypass surgery sharply reduces them, making it a potential key to unlocking the secrets of successful weight loss. The research also suggests that this mechanism may be why gastric bypass surgery is often more effective than dieting.
A study from the Centers for Disease Control and Prevention found that obesity and smoking significantly increase asthma risk in adults. Women were 94% more likely than men to have asthma, while people in lower socioeconomic groups were 30% more likely to be affected.
Declining physical activity levels are strongly associated with increasing obesity rates. A 15-year study found that higher intensity physical activity was inversely related to obesity, suggesting a physically active lifestyle can help prevent weight gain.
A Virginia Tech study found that obesity, heavy alcohol consumption, and age are strongly associated with hypertension in both men and women over 40. Losing weight can reduce the risk of hypertension, particularly for African-American women, who are at a greater risk due to their body mass index and lifestyle factors.
The U.S. Preventive Services Task Force emphasizes the importance of personalized advice from doctors to motivate patients to change unhealthy behaviors. Effective methods include engaging patients in self-management practices and shared decision-making, prioritizing patient autonomy and choice.
A new study found that sedentary men with higher levels of abdominal visceral fat have lower cardiovagal baroreflex gain, increasing their risk of cardiovascular disease. The study suggests that weight loss may improve cardiovagal baroreflex gain and reduce the risk of cardiovascular disease.
Researchers found that diets rich in soy protein and flaxseed can decrease total cholesterol, triglycerides, and glucose levels in obese rats. Flaxseed also showed a greater effect on various parameters than soybean, suggesting potential benefits for humans.
A new research study identifies a protein called PTP1B that helps overcome leptin resistance, a common issue in obese individuals. The knockout mice lacking PTP1B displayed increased energy expenditure and were resistant to high-fat diets.
The American Physiological Society hosts a series of briefings on the physiology and pathophysiology of obesity, featuring renowned experts who examine gene-environment interactions, neurobiology, endocrine/metabolic consequences, and cardiovascular regulation. The conference aims to advance understanding of human health and disease.
A population-based study found that waist-to-hip ratio was a stronger predictor of stroke risk than body mass index (BMI), especially among normal and overweight individuals. The study recommends incorporating education about waist-to-hip ratio into stroke prevention programs.
Scientists have found a potential mechanism for obesity resistance in mice lacking the fat-making enzyme DGAT1. These mice are more sensitive to leptin and insulin, leading to lower tissue triglyceride levels and increased sensitivity to insulin, resulting in weight loss despite high-fat diets.
Scientists at Michigan Medicine have discovered that leptin is linked to blood clot formation, particularly in obese individuals. Knowing how to block this interaction could help prevent heart attacks and strokes.
A recent study published in JCI Journals reveals a significant connection between the brain and bone health, with implications for osteoporosis treatment. The findings suggest that certain neurological factors contribute to the development of bone disorders, opening up new avenues for therapy.
A study of 206 men and 135 women found that waist circumference and BMI are both strong predictors of nonabdominal, abdominal subcutaneous, and visceral fat stores. Combining these two measures is more effective at predicting abdominal obesity and its associated health risks than using either variable alone.
A recent study found that heightened depressive symptoms, emotional eating, and low self-esteem can predict binge-eating disorders in teenage girls. The research also revealed that low peer support increases the risk of binge eating, while parental support has no effect on this issue.
A new study finds that lifestyle factors, including obesity and stress, significantly predict healthcare costs among young employed adults. Participants with high-risk scores for overall wellness, stress, or obesity used more healthcare services and incurred higher costs.
The study found that restrained eating behavior was associated with lower risk of adult-onset obesity, whereas disinhibition was linked to increased weight gain. A high level of restraint attenuated weight gain even when there were high levels of disinhibition, suggesting a protective effect.
A study published in the American Journal of Clinical Nutrition found that women who gained weight after weight loss had significantly lower energy expenditure due to physical inactivity. To match their initial weight, these individuals would need to engage in at least 80 minutes of moderate-intensity physical activity per day.
C75 blocks fatty acid synthase, a key enzyme in energy storage, to alter brain messengers regulating appetite. Lean mice quickly regain normal eating habits after treatment, while obese mice fail to recover.
The study, conducted in Olmsted County, Minnesota, found that only a small percentage of people utilize recommended approaches to weight loss. The efforts being undertaken by CardioVision 2020 aim to reduce cardiovascular disease burden through diet and exercise changes. Meanwhile, another study on breast cancer patients highlights the...
The Look AHEAD trial will examine the effects of a lifestyle intervention program on cardiovascular health in people with type 2 diabetes. The study, which began screening participants in July, aims to enroll 5,000 volunteers and follow them for up to 11.5 years.
A recent study reveals a critical link between obesity and type 2 diabetes through the AMPK pathway and leptin hormone. Researchers found that AMPK activation, triggered by leptin, inhibits an enzyme involved in fat metabolism, increasing fat burning.
Research suggests that a single enzyme, 11beta hydroxysteroid dehydrogenase type 1 (11 beta HSD-1), is involved in the accumulation of visceral fat and metabolic symptoms. Increasing this enzyme's activity in fat cells leads to obesity, diabetes, and other diseases.
A study published in the American Journal of Clinical Nutrition found that obese women converted carbohydrates to fat at a faster rate than lean women. This increased conversion was observed even when both groups were overfed with carbohydrate-rich diets, suggesting an intrinsic genetic potential for de novo lipogenesis.
A study of 633 HIV-positive participants found that sociodemographic factors significantly affect their nutritional adequacy. Gay men, those with higher household incomes and educational attainment, were more likely to meet the Recommended Daily Allowances for nutrients. In contrast, individuals with lower incomes, fewer children at ho...
Individuals with normal low-density lipoprotein (LDL) cholesterol may still be at increased risk of coronary artery disease (CAD), particularly if they carry additional risk factors like central obesity and insulin resistance. Targeting atherogenic dyslipidemia, including abdominal obesity, is recommended to prevent CAD risk.
Middle-aged women with obesity, stress, financial struggles, and certain medical conditions are more likely to experience daily functional limitations. A national survey of 16,000 women aged 40-55 found that these factors significantly impact physical function.
A recent study published in American Journal of Health Promotion reveals that military personnel struggle more with weight gain than tobacco use, hindering successful smoking cessation rates. Active-duty participants were four times more likely to relapse if they anticipated gaining 5-10 pounds after quitting smoking.
Research suggests that leptin, a hormone involved in weight regulation, may be more closely tied to mental factors than previously thought. Studies have found that alterations in brain structure and function may play a key role in leptin-related obesity.
New research presents preliminary results of a study on Xenical's effectiveness in promoting rapid and sustained weight loss. The medication has been shown to improve cardiovascular risk factors and maintain weight loss for up to two years, resulting in significant health benefits.
A new study reveals that 12% of Indian women are overweight and 2% obese, with urban areas showing higher rates of overweighness. The research highlights the need for targeted health education programs for high socioeconomic groups to combat obesity.
Researchers found that adding leptin to sibutramine increased weight loss in obese rats, as it prevented a decrease in leptin levels that normally occurs with weight loss. This study provides new clues on how to overcome the plateau effect and may lead to successful treatments for obesity.
A study found that leptin treatment reduced appetite and increased feelings of fullness in obese men. However, the participants did not experience significant weight loss, suggesting that reduced appetite may not be representative of overall food intake.
A study published in Obesity Research found that bupropion, an antidepressant approved for depression and smoking cessation, is effective for long-term weight loss in obese women. Women who took bupropion combined with a 1,600-calorie diet lost significantly more weight than those on placebo, with sustained effects for up to two years.
A groundbreaking study has found that Avandia can prevent the development of Type 2 diabetes in patients with impaired glucose tolerance, a condition affecting millions worldwide. The results have provided proof of concept for a larger prospective study to establish the effectiveness of Avandia in preventing Type 2 diabetes.
A Mayo Clinic study found that over one-third of adults aged 45+ had plaque buildup on their aortic valves, increasing the risk of hardening and narrowing of the aorta. Lifestyle changes can help prevent life-threatening complications. Risk factors include male gender, high blood pressure, obesity, and elevated homocysteine levels.
The American College of Physicians-American Society of Internal Medicine has released a comprehensive guide for primary care doctors on obesity diagnosis and management. Obesity rates increased by 30% between 1980 and 1994, carrying significant direct health care costs for the United States. The guide addresses key aspects of medical a...
A 2-year study found that brief counseling by health professionals significantly increased physical fitness and activity levels in inactive adults, particularly women. The interventions were equally effective for men and women, with a 5% improvement in cardiorespiratory fitness.
A Mayo Clinic study found that overweight or obese patients had their first heart attacks at a younger age, with obese patients experiencing an average of 8.2-year gap compared to normal-weight patients. The study also revealed similar in-hospital outcomes among the three groups.
Researchers found a correlation between lower dopamine receptor availability and higher BMI in severely obese individuals compared to control subjects. Exercise is recommended as the most practical application for improving dopamine receptors and reducing pathological overeating.
Scientists found obese individuals have fewer dopamine receptors than normal-weight subjects, with the number decreasing as body mass index increases. Exercise has been shown to increase dopamine release and raise dopamine receptors in animal studies, suggesting it may help stimulate dopamine pleasure circuits.
A study by Raben et al. found that postobese women have different metabolic profiles than never obese women, with greater insulin sensitivity and more efficient triacylglycerol storage. This suggests that weight loss may not entirely eliminate the risks associated with obesity.
A new study from the University at Buffalo reveals that obese individuals carry a massive oxidative load that increases their risk of heart disease. Severe calorie restriction decreases free radical production by over 50%, reducing the risk of developing heart disease without medication.
A Penn State study found that restricting foods has negative effects on children's self-esteem, particularly among overweight girls as young as 5 years old. The research suggests that parents' concern about their daughter's weight and restriction of food access can lower perceived physical and cognitive ability.
A study published in The American Journal of Clinical Nutrition found that two major US dietary patterns, prudent and Western, result in distinct health risks. The prudent diet was associated with a favorable biomarker profile, while the Western diet was linked to higher plasma levels of biomarkers for cardiovascular disease risk and l...
Researchers found that obese individuals were twice as likely to be diagnosed with asthma, but not more responsive airways. Underweight individuals, on the other hand, experienced increased airway responsiveness and reduced lung function.
A study found that pneumatic compression and extended anticoagulant drug therapy lower the risk of developing symptomatic blood clots after hip replacement surgery, with overweight patients most at risk. Pneumatic compression was effective in normal-weight patients, while warfarin therapy benefited all patients.
A study analyzing health data from nearly 3,000 patients found that obesity is associated with lower physical functioning levels and worse perceptions of health. Patients with higher BMI values were also limited in basic activities due to their weight, according to lead author David A. Katz.
Researchers at Baylor College of Medicine have identified perilipin as a crucial protein that protects fat cells from breakdown. By eliminating this protein, mice lost weight despite consuming more food and gained increased muscle mass. The findings hold promise for developing new anti-perilipin drugs to combat obesity.