Articles tagged with Pancreatic Cancer
Researchers have made breakthroughs in understanding the molecular mechanisms driving pancreatic cancer's rapid growth and resistance to treatment. They've identified new targets for therapy, including a protein sponge that suppresses tumor growth and a novel mechanism for chemoresistance.
Researchers found that administering opioid growth factor (OGF) to patients with advanced pancreatic cancer improved their quality of life and survival rates. OGF was shown to be non-toxic and did not cause common side effects associated with chemotherapy, such as hair loss or nausea.
A study found that the anti-inflammatory drug nimesulide triggered angiogenesis and increased pancreatic cancer cell growth in COX-2 negative tumor cells, but inhibited tumor growth in COX-2 positive cells. Researchers plan to test other COX-2 inhibitors for similar effects.
A Mayo Clinic study of 100 patients with advanced pancreatic cancer found that a nerve block technique, combined with pain-relieving medications, provided a 50% reduction in pain and improved quality of life. The study suggests that this treatment option could be beneficial for patients with pancreatic cancer, allowing them to live mor...
A study of over 88,000 women found no significant difference in pancreatic cancer risk between aspirin users and non-users. However, extended regular aspirin use was associated with a 58% increased risk, while higher doses were linked to an 86% increased risk.
A new animal model of pancreatic cancer has been developed, which mimics both non-invasive and invasive forms of the disease. The study identified a unique protein signature in the blood of animals with precancerous lesions, offering potential for early detection and therapeutic targets.
Researchers have developed a mouse model that mimics human pancreatic cancer, enabling the discovery of biomarkers for early detection and potential therapeutic targets. The model replicates the disease's progression and is poised to facilitate rapid testing of novel treatments.
Researchers have made significant progress towards a vaccine for pancreatic cancer, with one patient out of ten remaining disease-free after five years and two others surviving over two years. While the study's findings are promising, caution is advised due to the small sample size and potential biases in the selection process.
Researchers found that pancreatic cancer growth can be arrested by blocking the Hedgehog signaling pathway, which is active in human embryonic development. This pathway has been linked to several other types of cancer and may offer a new treatment avenue for pancreatic cancer.
Researchers at Johns Hopkins Medicine found that pancreatic cancer may be triggered by the reactivation of a growth signal normally turned off in adult tissues. By blocking this pathway, they hope to prevent the early cellular changes leading to cancer.
Researchers at Michigan Medicine have identified 158 genes specific to pancreatic cancer in a new study, providing a more accurate accounting of the disease's molecular makeup. The team hopes to use this knowledge to develop new diagnostic tests and treatments tailored to individual patients.
Researchers have identified a genetic link between Fanconi's Anemia and pancreatic cancer, finding that faulty FA-related genes can make cancer cells susceptible to certain treatments. This discovery may lead to improved treatment options for patients with early-onset pancreatic cancer caused by gene mutations.
Researchers identified BRCA2 germline mutations in 19% of families with familial pancreatic cancer. The presence of specific frameshift mutations was found in 12% of the families studied. These findings suggest an important role for BRCA2 mutations in a subpopulation of families with familial pancreatic cancer.
A study suggests that a high-starch diet may increase the risk of pancreatic cancer in overweight and sedentary women. Women with diets heavy in starchy foods were found to be more than two-and-a-half times more likely to develop pancreatic cancer than those with low glycemic loads.
A study found no association between carbohydrate and sucrose intake and pancreatic cancer risk, but a diet high in glycemic load increased the risk among overweight women. Dairy product consumption was not associated with reduced breast cancer risk among postmenopausal women, but may be protective in premenopausal women.
Researchers found that MMP-9 expression contributes to angiogenesis in human ovarian tumors, while dense breasts compromise diagnostic mammography sensitivity. Aspirin users have a lower risk of developing pancreatic cancer, according to the study.
A study of over 7 years found that women taking aspirin two to five times per week had a lower risk of pancreatic cancer compared to those not taking it. The researchers estimate that aspirin use might prevent up to 43% of pancreatic cancer cases in women who do not normally take aspirin.
The study demonstrated that gemcitabine was well-tolerated in patients with superficial bladder cancer, with no or very low levels of the drug found in plasma samples. The results suggest that gemcitabine may be a suitable alternative to current standard treatments, which often cause toxic side effects.
Researchers have identified a region of chromosome 4 associated with pancreatic cancer, which may lead to earlier identification and treatment. The discovery has potential implications for understanding the disease's causes and developing new treatments.
A large family study identified a specific genetic marker on chromosome 4 associated with inherited pancreatic cancer. The discovery sheds light on the disease's development and may lead to new prevention and treatment strategies.
African-American patients with non-small-cell lung cancer have a significantly lower one-year survival rate compared to non-African-American patients. Despite similar disease stages and health care disparities, researchers found no difference in outcomes after adjusting for factors such as performance status and socioeconomic status.
Researchers investigate DNA repair capacity and its association with melanoma risk, while also exploring the predictive value of HPV testing in managing equivocal Pap tests. Additionally, a study on breast cancer biomarkers finds that measuring uPA and PAI-1 levels may help predict disease course and inform treatment strategies.
Researchers at Columbia University Irving Medical Center have discovered a combination of two genes that selectively kill pancreatic cancer cells in test tube experiments. The mda-7 protein and K-ras antisense DNA combination prevents tumor growth in animals, offering a potential new treatment option for this aggressive disease.
A clinical trial found that marimastat produced comparable one-year survival rates to chemotherapy drug gemcitabine in patients with localized pancreatic cancer. Fewer toxic side effects were reported in patients taking marimastat compared to gemcitabine.
A long duration of regular aspirin use is associated with a significant increase in pancreatic cancer risk among women. Women taking 14 or more tablets per week experience nearly an 86% increased risk, while those taking six to 13 tablets per week see a 41% higher risk.
A new pancreatic cancer vaccine has been found to be safe and successful in reaching immune system cells, with several patients remaining disease-free over 30 months after diagnosis. The vaccine uses lab-grown pancreatic cancer cells genetically-modified with the immune-boosting gene GM-CSF.
A new study by Northwestern University Medical School researchers found that high blood sugar levels are associated with an increased risk of pancreatic cancer death. The study analyzed data from nearly 40,000 men and women who were screened for cardiovascular disease risk and followed up for an average of 25 years.
The Seattle Gastrointestinal Program Project will investigate the role of oxidative damage in pancreatitis and chronic ulcerative colitis. Researchers aim to develop screening tests for pancreatic cancer and more sensitive early detection methods for colon cancer.
Researchers found that tumors with a specific BRCA2 mutation are more sensitive to radiation and certain chemotherapy drugs. This suggests genetic screening could be used to tailor treatment for patients with this mutation, potentially improving outcomes.
Researchers at Ohio State University have developed a technique to help surgeons determine the extent of tumor spread in pancreatic cancer patients. This method uses an antibody labeled with radioactivity to detect cancer cells, potentially improving treatment outcomes and reducing harm from extensive surgery.
Researchers found that patients who received chemotherapy and radiation after surgery lived longer than those who did not. Additionally, 7% of patients had inherited mutations in the BRCA2 gene, which is linked to breast and ovarian cancer.
Researchers are testing a promising new vaccine against pancreatic cancer, which boasts one of cancer's poorest survival rates. The vaccine targets an abnormal variant of the ras gene, designed to stimulate an immune response against mutant ras protein.