Articles tagged with Pancreatic Cancer
Researchers have identified a unique pattern of microRNAs in pancreatic tumor tissue, suggesting a new way to diagnose and treat the disease. The findings may lead to more effective early detection and treatment of pancreatic cancer.
Researchers found that 201 patients (23%) lived five years after surgery, with at least half being 65 years old or older. Of those survivors, 65% lived another five years, nearly matching the general population's survival rate.
Researchers at UT Southwestern Medical Center developed a new approach using an inexpensive tracing agent and ultrasound to monitor the effectiveness of cancer therapies. This non-invasive method showed significant results in controlling tumor growth and predicting treatment outcomes, offering hope for more effective treatment options.
A new study published in CANCER journal reveals that patients with pancreatic cancer are more likely to receive radiotherapy if the treating hospital has it available, while rectal cancer patients have equal access regardless of hospital radiation capacity. The findings suggest adjuvant radiotherapy for pancreatic cancer may be over-ut...
A study at the University of Texas M.D. Anderson Cancer Center found that combining cromolyn with chemotherapy reduced pancreatic tumor growth by 85% compared to control animals. The combination also increased the effectiveness of standard chemotherapy.
Researchers found that breast cancer stem cells are relatively resistant to radiotherapy and can even increase in number after multiple treatments. In contrast, statin use is associated with a decreased risk of advanced prostate cancer, according to a large prospective study.
A University of Washington-led team has identified a mutated form of the Palladin gene as the cause of familial pancreatic cancer. The discovery reveals that this genetic abnormality causes cancer cells to move abnormally, invading surrounding healthy tissue.
A gene discovered by UNC researchers, palladin, has been associated with two forms of pancreatic cancer, according to a study. Palladin is involved in the formation of scar tissue on nerve cells and is overexpressed in people with sporadic, non-familial pancreatic cancer.
Researchers identify palladin as the first familial pancreatic cancer gene, linked to a large family with 18 members affected by the disease. The mutated gene is associated with overexpression and disruption of cytoskeletons in cancer cells.
A new bile duct stent called Dua Anti-Reflux Valve has been shown to improve the quality of life for patients with pancreatic and bile duct cancers. The stent's anti-reflux valve reduces backflow of intestinal contents, resulting in fewer repeat procedures and better outcomes.
Researchers at Thomas Jefferson University found that common blood pressure medications can reduce tumor-feeding blood vessels in laboratory studies. High levels of angiotensin II have been linked to poor cancer prognosis and early recurrence, making these drugs a potential treatment option for pancreatic cancer.
A study found that BRCA1 and BRCA2 mutations are more common in the general population than previously reported, increasing the risk of ovarian, breast, testicular, and pancreatic cancers. The study also showed that these mutations are associated with higher risks of specific types of cancer.
Researchers at Vanderbilt University Medical Center have developed a new animal model for pancreatic cancer that exhibits aggressive characteristics similar to human tumors. The genetically-engineered mice can be used to investigate targeted drug therapies and identify potential screening methods for early detection.
Research found that men with periodontal disease had a 63% higher risk of pancreatic cancer, while those who reported recent tooth loss showed a 2.5-fold increase in risk. Obesity also impairs immune responses to vaccines.
Scientists at the American Association for Cancer Research have developed a novel method to detect DNA methylation in exhaled breath, which may help predict lung cancer development. The test has also shown promise in identifying patients with pancreatic cancer, raising hopes for early detection and treatment.
A new study from Karolinska Institutet found that consuming fizzy drinks and sugary foods significantly increases the risk of developing pancreatic cancer. The study followed almost 80,000 healthy individuals over eight years, discovering that those who drank high-sugar beverages regularly had a 90% higher risk of developing the disease.
A new approach uses mouse tests to predict which chemotherapy drugs work best for each patient, offering a promising way to individualize therapy earlier in treatment. The method involves implanting tiny bits of patient tumor into mice, allowing researchers to test multiple drugs simultaneously.
Researchers at SUNY Downstate Medical Center have found that PNC-28, a human protein, can destroy pancreatic tumor cells in animals without harming healthy cells. The study's results are encouraging and suggest PNC-28 may be an effective agent in treating cancers, particularly when delivered directly to the tumor.
A large study found that Japanese adults with diabetes have a higher risk of developing certain types of cancer, including liver, kidney, and pancreatic cancers. Men with diabetes had a significantly higher risk of cancer than men without diabetes.
Researchers discovered how Myc oncoprotein drives tumor angiogenesis in pancreatic cancer by inducing IL-1beta expression. Blocking IL-1beta activity can thwart tumor angiogenesis, offering experimental evidence for cancer drug therapies targeting this pathway.
Researchers found that combining chemotherapy with radiation therapy after surgery significantly improves survival rates for patients with advanced pancreatic cancer. The study showed a median survival time of 18.3 months, compared to the national average of 11 months.
A new study finds that high cadmium levels may increase breast cancer risk, while silibinin has been shown to inhibit lung tumor blood vessel formation. Additionally, researchers have identified a potential anticancer compound in milk thistle and explored the role of KGF and FGFR2b in cancer treatment.
A recent study found that major pancreatic cancer surgery can be successfully performed on patients in their 80s, 90s, and older with comparable five-year survival rates to the general population. This challenges common misconceptions about the suitability of elderly patients for such surgery.
Researchers report improved survival rates with RP101, a novel compound being investigated as a potential therapeutic for advanced pancreatic cancer. In two studies, patients showed significant improvements in median survival and time to progression, offering hope for patients affected by the disease.
A new combination therapy after surgery has improved survival rates for pancreatic cancer patients by 50%, increasing median survival from 16.9 to 20.6 months. The study found significant benefits for patients with pancreatic head adenocarcinoma, a type of cancer that affects the pancreas.
Research suggests that diabetes may be a marker of early pancreatic cancer, with studies showing increased rates of colon, pancreatic, and esophageal cancers in patients with diabetes. Additionally, women with type 2 diabetes are at higher risk of developing colorectal adenomas and advanced adenoma.
Researchers discovered capsaicin significantly reduces tumor size and induces apoptosis in human pancreatic cancer cells, with no harm to normal pancreatic tissue. The compound's potential use as a novel agent for prevention and treatment of pancreatic cancer is being explored.
A new study suggests that high dietary folate intake may be associated with a reduced risk of pancreatic cancer. The research followed over 81,000 men and women for an average of 6.8 years and observed 135 cases of pancreatic cancer during this time. Men and women with higher folate intakes had lower incidence rates of the disease comp...
Researchers have identified the stage-specific roles of individual cathepsins in tumorigenesis, revealing that inhibiting cathepsin B, L, and S suppresses cancer development. The study found that these cathepsins promote tumor invasion by cleaving E-cadherin.
A cohort study found that higher insulin concentrations and insulin resistance were associated with an increased risk of pancreatic cancer in male smokers. The study suggests that lifestyle changes to decrease glucose and insulin levels may help prevent pancreatic cancer development.
Researchers developed a new treatment that reverses traditional treatment steps, reducing tumor size and increasing surgical removal options. The treatment has shown significant success in shrinking tumors, with no progression or recurrence observed after surgery.
Researchers have developed an immune-boosting vaccine that combines with surgery and chemotherapy to treat pancreatic cancer. Early results show improved survival rates, surpassing previous studies, and the team hopes to refine the vaccine's targets through further analysis.
Researchers found that vasostatin, a protein gene incorporated into an adenovirus vector, effectively blocks the formation of new blood vessels and curbs tumour growth in mice with pancreatic cancer. This approach may represent a promising therapeutic option for malignancy with a poor prognosis.
A phase III clinical trial found that combining gemcitabine with capecitabine significantly improves overall survival for patients with locally advanced or metastatic pancreatic cancer. The combination of treatments resulted in a median survival of 7.4 months compared to 6 months with gemcitabine alone.
Researchers found a possible genetic link between cystic fibrosis gene mutations and young-onset pancreatic cancer. The study showed that individuals carrying the CFTR gene mutation are at increased risk for pancreatitis, which may also increase the risk of developing pancreatic cancer.
Researchers found no link between breast-feeding and adult cancer risk, but high red meat consumption is associated with increased pancreatic cancer risk. A new vaccine approach may enhance tumor-specific immune response when combined with chemotherapy.
A novel screening method for pancreatic cancer has been developed by scientists at the University of Liverpool. The method analyzes genetic mutations in pancreatic juice to determine an individual's risk of developing cancer, with results ranging from a 0.1% chance to a 90% certainty.
A high-vegetable diet rich in onions, garlic, beans, and yellow vegetables was associated with a 50% reduced risk of pancreatic cancer. Fruits were also found to be protective, but to a lesser extent.
A study published in American Journal of Roentgenology found that 3D MRI can detect pancreatic cancer in patients with severe mid-abdominal pain and other symptoms. The study suggests that radiologists should look for pancreatic cancer even if the patient didn't have an examination for that purpose.
A study by Rutgers University researchers found that combining TPA, a compound from the croton plant, with all-trans retinoic acid (ATRA) effectively inhibits growth of pancreatic cancer cells. The combination also showed increased apoptosis and reduced mitosis in tumors.
Researchers found that older patients with newly diagnosed diabetes are considered a high-risk group for developing pancreatic cancer. The study, conducted by the Mayo Clinic College of Medicine, included 2,122 patients aged 50 and older who were diagnosed with diabetes between 1950 and 1995.
A new study has identified older Americans with new-onset diabetes as a high-risk group for pancreatic cancer. The research found that patients with type 2 diabetes are at a significantly higher risk of developing pancreatic cancer compared to those without the condition, highlighting the need for early detection and screening.
Researchers at Dartmouth discovered a molecule called Smad7, found in half of all human pancreatic cancers, that interferes with pathways regulating cell growth. Smad7 suppresses the function of the retinoblastoma protein, enabling cancer cells to grow unchecked and increasing metastasis.
Researchers developed a mouse model that closely mimics human pancreatic cancer at multiple levels, including clinical presentation and histological changes. The model demonstrates distinct similarities to human pancreatic cancer, including metastasis to the liver and lungs.
A combination of chemotherapy drugs showed improved overall and progression-free survival rates compared to a single drug, gemcitabine. Patients treated with the combination regimen (PEGF) had a higher percentage alive without disease after 4 months than those on standard treatment.
Metal stents have been shown to be a safe and effective treatment for bile duct obstructions caused by pancreatic cancer. The study found that 90% of patients had open stents after three months and 80% after one year, with minimal complications.
A large cohort study found that high consumption of processed meats was associated with a significant increase in pancreatic cancer risk. The study, which followed over 190,000 participants, suggests that chemical reactions during meat preparation may be responsible for this link.
Researchers found that capsaicin, a compound in red chili pepper, exhibited anticancer activity against pancreatic cancer cells. Phenethyl isothiocyanate (PEITC), a constituent of cruciferous vegetables like broccoli, also showed therapeutic benefits in inhibiting ovarian cancer cell growth.
A Harvard School of Public Health study analyzed dietary habits and found no strong association between western or prudent diets and pancreatic cancer risk. Participants who adhered to the prudent diet had healthier lifestyle behaviors, suggesting individual dietary components may still play a role in risk.
A new study found that altering food schedules and light/dark exposure in mice modified the expression of circadian clock genes and genes involved in carcinogenesis and tumor progression. The authors conclude that the altered light/dark or feeding schedules may slow tumor growth in chronic jet-lagged mice.
Researchers at Mayo Clinic discovered a new pathway against pancreatic cancer by targeting the GSK-3 Beta molecule, which regulates NF Kappa B activity. This finding may lead to new drug development strategies for other cancers and improve treatment options for pancreatic cancer patients.
Researchers are evaluating the effectiveness of BAY43-9006 alone and paired with gemcitabine in a phase II clinical trial for metastatic pancreatic carcinoma. The trial aims to add much-needed treatment options for this aggressive cancer, which affects approximately 27,000 deaths annually in the US.
A recent study published in Annals of Internal Medicine found that high-quality CT scans can accurately determine which pancreatic cancers are treatable, rendering endoscopic ultrasound unnecessary. The study also revealed that CT scans were more accurate in detecting new cancers and determining the stage of the disease.
Researchers found that patients with a family history of pancreatic cancer are more likely to be diagnosed at an earlier age and have a smoking history. The study suggests that strong counseling against smoking is necessary for these patients, as well as smoking cessation programs.
Researchers at Université de Montréal found that diabetes patients are three times more likely to develop liver cancer and twice as likely to get pancreatic cancer. The study analyzed data from over 3,000 cancer patients and healthy individuals.
Researchers found a three-fold increased risk of liver cancer among diabetic patients, which rose to almost four-fold when medication was used. Diabetes did not increase risks for other types of cancer, such as melanoma or colon cancer.
Researchers have made significant progress in developing a therapeutic vaccine for pancreatic cancer, which appears safe and stimulates immune activity. In a recent study, 12 patients with pancreatic cancer received the vaccine, resulting in no reported toxicity and positive changes in antibodies against the tumor.
Cohen's team found that fibroblast activation protein (FAP) and focal adhesion kinase (FAK) are overexpressed in over 90% of pancreatic adenocarcinomas, suggesting they may contribute to poor outcomes. However, selective inhibition of these proteins shows promise in preclinical models.
A study of 138,307 men found exclusive pipe smoking increased risk for six cancers and three diseases, with highest risk in larynx, lung, and oropharynx. Pipe smoking was associated with smaller but similar risks to cigar smoking, while larger than cigarette smoking.
Researchers from Michigan Medicine have discovered a protein biomarker and cell-signaling pathway that may aid in the detection and treatment of pancreatic cancer. The study found that a specific protein called CEACAM 1 is elevated in the blood of pancreatic cancer patients, allowing for better differentiation from normal tissue.