Articles tagged with Pancreatic Cancer
A Northwestern University-developed optical technology has been found to be effective in the early detection of colon cancer, now appearing promising for detecting pancreatic cancer. The technique can detect abnormal changes in cells lining the duodenum without touching or imaging the pancreas.
A new optical technology has been developed to detect early signs of pancreatic cancer, allowing for earlier diagnosis and potentially improving treatment outcomes. The technique uses a minimally invasive procedure that can identify cancerous tissue with high accuracy, even in patients with chronic pancreatitis or family history.
Researchers have identified IL6 as a protein that stimulates tumor growth when activated by Ras, leading to increased blood vessel formation. Suppressing IL6 activity has shown promising results in fighting tumor formation in preclinical models.
Researchers at the University of Texas M. D. Anderson Cancer Center have developed a gene therapy that selectively targets and eliminates pancreatic cancer cells, inhibiting metastasis and prolonging survival with minimal toxicity. The therapy, called VISA-BikDD, has shown significant promise in preclinical trials, with treated mice su...
A study led by University of Cincinnati scientists has found that the RON receptor is overexpressed in pancreatic cancer cells, suggesting a link between the receptor and disease development. The researchers believe blocking the receptor's signaling pathways could lead to new therapies for this deadly disease.
Scientists create a new adenovirus that selectively targets cancer cells with high dNTP concentrations, potentially delivering genetic materials to destroy malignant cells. The approach has shown promise in testing mice and human pancreatic cancer cells.
Researchers found that consuming high amounts of vitamin B6, B12, and folate from food reduced the risk of pancreatic cancer by 59%, 73%, and 81% respectively. In contrast, multivitamin use was associated with a higher risk of developing the disease.
Recent research evaluates the progress made to date in diagnosing and treating pancreatic cancer, highlighting promising new applications of technology that will improve survival rates. The studies also identify key predictors of malignancy, including age, gender, symptoms, and radiographic features.
A recent study evaluated the incidence of malignancy in small pancreatic tumors and identified predictors such as age, gender, symptoms, and radiographic features. The findings suggest that very small tumors with no other symptoms or radiographic indicators have a low risk of malignancy.
A large cohort study found that using Swedish moist snuff (snus) increases the risk of developing pancreatic cancer by twice the rate of non-users. The study, conducted on almost 300,000 male construction workers, suggests that while the risks are small, snus use can still be a concern for overall health.
A recent study published in The Lancet found that Swedish snus is associated with a higher risk of pancreatic cancer, despite being less harmful than smoking. However, switching from cigarettes to snus can potentially lead to significant health benefits for smokers.
Scientists discovered a global expression pattern of microRNAs that can differentiate between pancreatic cancer and normal pancreas with high accuracy. The study found that specific miRNA expressions were associated with long-term survival and poor prognosis, offering potential for personalized treatment.
Researchers at Ohio State University Comprehensive Cancer Center have discovered a way to distinguish pancreatic cancer from non-cancerous tissue using microRNA molecules. The study found that specific miRNAs can predict patient survival rates, with correlations seen in just a few miRNAs that were not previously associated with the dis...
A new study identified genetic markers that can distinguish between chronic pancreatitis and pancreatic cancer, as well as predict patient outcomes. The discovery represents a significant advancement in cancer diagnostics and may lead to improved therapy options.
A new stent has been shown to relieve GI upper cancer distress by incorporating an anti-reflux valve, which reduces backflow of intestinal contents into the bile duct. The study found that patients with the Dua stent had a longer median of 145 days without complications compared to those with standard stents.
A study from the University of Pittsburgh Cancer Institute found that triphala extracts can prevent or slow pancreatic cancer tumor growth in mice by inducing apoptosis. The herb was shown to activate tumor-suppressor genes, supporting the generation of proteins that promote cell death in cancer cells.
A new pancreatic cancer vaccine has successfully stalled disease progression in a handful of patients three years post-vaccination, offering new insights into how the vaccine could be made more effective. The study found that the vaccine triggered an active immune response and slowed down cancer growth in four patients.
New cancer vaccine studies are making progress in developing vaccines that can attack cancerous cells by stimulating the immune system. Researchers have found that a human papillomavirus vaccine continues to protect against HPV types 16 and 18, as well as other related viruses, with significant cross-protection.
A new computer software tool, PancPRO, helps genetic counselors and physicians predict the chance of carrying a gene for hereditary pancreas cancer and the lifetime risk of developing the disease. The model, developed by Johns Hopkins Kimmel Cancer Center researchers, calculates a percentage score of probability that a person carries a...
Researchers have discovered a biological mechanism whereby two compounds in broccoli and soy reduce the invasive and metastatic potential of breast and ovarian cancer cells. Studies also suggest that a diet high in flavonols may help reduce pancreatic cancer risk, especially in smokers.
A protein called tissue transglutaminase (TG2) protects human pancreatic cancer cells from autophagy, a form of programmed cell death, researchers found. Inhibiting TG2 led to a drastic reduction in its expression and telltale signs of autophagy in the cancer cells.
A study published in Cancer Cell reveals that a specific sequence of genetic mutations determines the behavior of cystic pancreatic cancer, which has a 50% long-term survival rate. The research found that cells with this mutation are resistant to TGFb's tumor-promoting properties, contributing to their improved survival.
Researchers at Michigan State University found that polycyclic aromatic hydrocarbons (PAHs) produced by burning tobacco interfere with cell communication, promoting pancreatic cancer. PAHs do not initiate cancer but contribute to its promotion.
Researchers identified a small number of cells in pancreatic cancer capable of fueling tumor growth, which are thought to be the cancer stem cells. These cells can replicate and produce new tumors, making them a crucial target for therapy.
Researchers identified human pancreatic cancer stem cells, which can produce tumors in half of mice tested. These stem cells are highly tumorigenic and resistant to traditional therapy, making them a promising target for new treatments.
Researchers at Mayo Clinic Cancer Center found that giving patients both radiation and chemotherapy after completely removing invasive pancreatic cancer significantly improves patient survival rates. More than half of the 454 patients who received adjuvant therapy survived two years, with a five-year survival rate of 28%.
A new study by Harvard researchers has linked periodontal disease to an increased risk of pancreatic cancer. Men with periodontal disease had a 63% higher risk of developing the disease compared to those without it, after adjusting for other factors.
A new study found that calcium supplements can reduce the risk of colorectal adenoma recurrence by up to 5 years after stopping supplementation. In contrast, antioxidant supplements did not show a significant effect on gastric cancer risk.
A study found that chemotherapy with gemcitabine significantly delayed cancer recurrence in patients following pancreatic cancer surgery. The estimated median disease-free survival was 13.4 months for the gemcitabine group compared to 6.9 months for those without chemotherapy.
Researchers have identified a unique pattern of microRNAs in pancreatic tumor tissue, suggesting a new way to diagnose and treat the disease. The findings may lead to more effective early detection and treatment of pancreatic cancer.
Researchers found that 201 patients (23%) lived five years after surgery, with at least half being 65 years old or older. Of those survivors, 65% lived another five years, nearly matching the general population's survival rate.
Researchers at UT Southwestern Medical Center developed a new approach using an inexpensive tracing agent and ultrasound to monitor the effectiveness of cancer therapies. This non-invasive method showed significant results in controlling tumor growth and predicting treatment outcomes, offering hope for more effective treatment options.
A new study published in CANCER journal reveals that patients with pancreatic cancer are more likely to receive radiotherapy if the treating hospital has it available, while rectal cancer patients have equal access regardless of hospital radiation capacity. The findings suggest adjuvant radiotherapy for pancreatic cancer may be over-ut...
A study at the University of Texas M.D. Anderson Cancer Center found that combining cromolyn with chemotherapy reduced pancreatic tumor growth by 85% compared to control animals. The combination also increased the effectiveness of standard chemotherapy.
Researchers found that breast cancer stem cells are relatively resistant to radiotherapy and can even increase in number after multiple treatments. In contrast, statin use is associated with a decreased risk of advanced prostate cancer, according to a large prospective study.
A University of Washington-led team has identified a mutated form of the Palladin gene as the cause of familial pancreatic cancer. The discovery reveals that this genetic abnormality causes cancer cells to move abnormally, invading surrounding healthy tissue.
A gene discovered by UNC researchers, palladin, has been associated with two forms of pancreatic cancer, according to a study. Palladin is involved in the formation of scar tissue on nerve cells and is overexpressed in people with sporadic, non-familial pancreatic cancer.
Researchers identify palladin as the first familial pancreatic cancer gene, linked to a large family with 18 members affected by the disease. The mutated gene is associated with overexpression and disruption of cytoskeletons in cancer cells.
A new bile duct stent called Dua Anti-Reflux Valve has been shown to improve the quality of life for patients with pancreatic and bile duct cancers. The stent's anti-reflux valve reduces backflow of intestinal contents, resulting in fewer repeat procedures and better outcomes.
Researchers at Thomas Jefferson University found that common blood pressure medications can reduce tumor-feeding blood vessels in laboratory studies. High levels of angiotensin II have been linked to poor cancer prognosis and early recurrence, making these drugs a potential treatment option for pancreatic cancer.
A study found that BRCA1 and BRCA2 mutations are more common in the general population than previously reported, increasing the risk of ovarian, breast, testicular, and pancreatic cancers. The study also showed that these mutations are associated with higher risks of specific types of cancer.
Researchers at Vanderbilt University Medical Center have developed a new animal model for pancreatic cancer that exhibits aggressive characteristics similar to human tumors. The genetically-engineered mice can be used to investigate targeted drug therapies and identify potential screening methods for early detection.
Research found that men with periodontal disease had a 63% higher risk of pancreatic cancer, while those who reported recent tooth loss showed a 2.5-fold increase in risk. Obesity also impairs immune responses to vaccines.
Scientists at the American Association for Cancer Research have developed a novel method to detect DNA methylation in exhaled breath, which may help predict lung cancer development. The test has also shown promise in identifying patients with pancreatic cancer, raising hopes for early detection and treatment.
A new study from Karolinska Institutet found that consuming fizzy drinks and sugary foods significantly increases the risk of developing pancreatic cancer. The study followed almost 80,000 healthy individuals over eight years, discovering that those who drank high-sugar beverages regularly had a 90% higher risk of developing the disease.
A new approach uses mouse tests to predict which chemotherapy drugs work best for each patient, offering a promising way to individualize therapy earlier in treatment. The method involves implanting tiny bits of patient tumor into mice, allowing researchers to test multiple drugs simultaneously.
Researchers at SUNY Downstate Medical Center have found that PNC-28, a human protein, can destroy pancreatic tumor cells in animals without harming healthy cells. The study's results are encouraging and suggest PNC-28 may be an effective agent in treating cancers, particularly when delivered directly to the tumor.
A large study found that Japanese adults with diabetes have a higher risk of developing certain types of cancer, including liver, kidney, and pancreatic cancers. Men with diabetes had a significantly higher risk of cancer than men without diabetes.
Researchers discovered how Myc oncoprotein drives tumor angiogenesis in pancreatic cancer by inducing IL-1beta expression. Blocking IL-1beta activity can thwart tumor angiogenesis, offering experimental evidence for cancer drug therapies targeting this pathway.
Researchers found that combining chemotherapy with radiation therapy after surgery significantly improves survival rates for patients with advanced pancreatic cancer. The study showed a median survival time of 18.3 months, compared to the national average of 11 months.
A new study finds that high cadmium levels may increase breast cancer risk, while silibinin has been shown to inhibit lung tumor blood vessel formation. Additionally, researchers have identified a potential anticancer compound in milk thistle and explored the role of KGF and FGFR2b in cancer treatment.
A recent study found that major pancreatic cancer surgery can be successfully performed on patients in their 80s, 90s, and older with comparable five-year survival rates to the general population. This challenges common misconceptions about the suitability of elderly patients for such surgery.
Researchers report improved survival rates with RP101, a novel compound being investigated as a potential therapeutic for advanced pancreatic cancer. In two studies, patients showed significant improvements in median survival and time to progression, offering hope for patients affected by the disease.
A new combination therapy after surgery has improved survival rates for pancreatic cancer patients by 50%, increasing median survival from 16.9 to 20.6 months. The study found significant benefits for patients with pancreatic head adenocarcinoma, a type of cancer that affects the pancreas.
Research suggests that diabetes may be a marker of early pancreatic cancer, with studies showing increased rates of colon, pancreatic, and esophageal cancers in patients with diabetes. Additionally, women with type 2 diabetes are at higher risk of developing colorectal adenomas and advanced adenoma.
Researchers discovered capsaicin significantly reduces tumor size and induces apoptosis in human pancreatic cancer cells, with no harm to normal pancreatic tissue. The compound's potential use as a novel agent for prevention and treatment of pancreatic cancer is being explored.
A new study suggests that high dietary folate intake may be associated with a reduced risk of pancreatic cancer. The research followed over 81,000 men and women for an average of 6.8 years and observed 135 cases of pancreatic cancer during this time. Men and women with higher folate intakes had lower incidence rates of the disease comp...
Researchers have identified the stage-specific roles of individual cathepsins in tumorigenesis, revealing that inhibiting cathepsin B, L, and S suppresses cancer development. The study found that these cathepsins promote tumor invasion by cleaving E-cadherin.
A cohort study found that higher insulin concentrations and insulin resistance were associated with an increased risk of pancreatic cancer in male smokers. The study suggests that lifestyle changes to decrease glucose and insulin levels may help prevent pancreatic cancer development.
Researchers developed a new treatment that reverses traditional treatment steps, reducing tumor size and increasing surgical removal options. The treatment has shown significant success in shrinking tumors, with no progression or recurrence observed after surgery.