Articles tagged with Pandemic Influenza
A large multicentre study found that early antiviral treatment reduced hospitalization and intensive care admissions among transplant recipients with H1N1. Vaccination and preventive measures may also provide protection for this high-risk population.
Researchers have discovered a monoclonal antibody that is effective against multiple strains of influenza, including Avian H5N1, seasonal H1N1, and the 2009 Swine H1N1 influenza. The antibody targets a conserved region of the viral coat protein, providing broad-spectrum protection against various flu strains.
A 2009 H1N1 pandemic influenza vaccine has been found to protect mice from the 1918 Spanish flu virus. The study's results suggest that people vaccinated against 2009 H1N1 or exposed to the virus may have cross-protective antibodies against the 1918 strain, providing potential protection.
The article identifies six key public health challenges and data needs to prepare for future pandemics, including measuring age-specific immunity and accurately quantifying severity. Serological surveys and monitoring time-sources are crucial for gathering valuable pandemic data.
A recent study in Hong Kong found that fear of the H1N1 virus prompted residents to adopt preventive behaviors such as frequent hand-washing (47% reported washing hands >10 times/day) and wearing face-masks. These behaviors can play a crucial role in controlling pandemic influenza.
A Singaporean study analyzed trends and symptoms among patients during the 2009 pandemic, finding that pandemic influenza was milder than seasonal flu, with fewer cases of fever and upset stomach. The study also found that pandemic influenza affected younger individuals more often than older adults.
A study of 18 patients with H1N1 infection found increased risks of obstetrical complications, including fetal distress and premature delivery. The study suggests that early antiviral treatment may improve maternal outcomes and highlights the need for further research on the impact of H1N1 on pregnant women.
The study found that patients with mild disease responded favourably to oseltamivir treatment, reducing viral clearance and transmission. Containment measures may have delayed large-scale transmission by at least three weeks in Vietnam.
Researchers reconstructed the initial 2009 H1N1 influenza outbreak in Ho Chi Minh City, finding that containment efforts may have delayed establishment of infection but did not prevent community spread. The study also showed that treatment clearance times varied depending on treatment timing and patient characteristics.
A study by the University of Washington found that Google Flu Trends is less accurate in estimating laboratory-confirmed influenza cases compared to CDC surveillance. The analysis revealed a 25% error margin during the 2003-04 flu season, with greatest deviations occurring during periods of high media attention or unexpected activity.
A study found that older children hospitalized with pandemic H1N1 influenza had more severe medical conditions than those with seasonal influenza. Vaccination is crucial for this age group and those with pre-existing conditions to prevent hospitalization.
A PLOS Medicine article examines the challenges of increasing global access to influenza vaccines, citing disagreements between developed and developing countries as a major obstacle. The author calls for further research on ways to address these issues through collective action.
A study shows that public fear of disease can lead to overcrowding in emergency departments, even when the actual disease is not present. The American Academy of Pediatrics calls for responsible media coverage of public health emergencies to prevent unnecessary strain on medical facilities.
A new study published in the American Journal of Infection Control suggests that hand-washing, mask-wearing, and cough etiquette can limit the transmission of pandemic flu. The study found that while these measures show promise, further research is needed to fully understand their effectiveness and address gaps in knowledge.
Researchers at St. Jude Children's Research Hospital found that individuals who received the 1976 vaccine mounted a stronger immune response against both the 2009 pandemic H1N1 virus and a different H1N1 strain. The study suggests that routine vaccination against seasonal flu might confer broader-than-realized protection.
Scientists discovered that chicken antibodies from vaccinated hens can prevent H5N1 and H1N1 infections in mice, raising hope for an affordable and effective alternative to control influenza outbreaks.
Researchers in Canada investigated whether seasonal flu vaccination increased the risk of getting pandemic H1N1 flu. Four studies involving over 2,700 people found that prior vaccination was associated with a 68% increased likelihood of pH1N1 illness, but not with hospitalization.
The Scripps Research Institute team solved the structure of the 'swine flu' virus, revealing similarities with earlier human flu viruses. This discovery helps explain why older individuals were less severely affected by the recent outbreak than younger ones.
The Norwegian Influenza Study (NorFlu) aims to understand the effects of influenza in pregnancy on maternal health and childhood development. Pregnant women in Bergen and Oslo will participate in the study, providing a blood sample and completing a questionnaire.
Researchers found that pandemic influenza viruses from 1918 and 2009 share a structural detail that makes them susceptible to neutralization by the same antibodies. Vaccination with either virus can generate cross-reactive antibodies capable of neutralizing the other virus.
A study found that household discussions about influenza prevention reduced the risk of secondary cases by 40%. Transmission was rapid, with half of cases occurring within three days and nearly 90% within one week.
A new study published in Pediatric Critical Care Medicine found that children with chronic illnesses are more likely to develop severe H1N1 infections. With careful management, pediatric ICUs can meet increased demands during a pandemic. Researchers also modeled PICU surge capacity and found it should be adequate with adaptable planning.
Research at Ohio State University suggests that pandemic H1N1 flu strains may become resistant to Tamiflu, the primary antiviral drug used to treat the disease. The study found that mutations in the neuraminidase protein of seasonal and pandemic H1N1 viruses drove the development of resistance to Tamiflu.
A new study found that genetic interactions between avian H5N1 influenza and human seasonal influenza viruses can create hybrid strains with increased virulence. The researchers identified a key gene segment, PB2, which is responsible for the increased pathogenicity.
Carlos Castillo-Chavez analyzes Mexico's response to the 2009 H1N1 outbreak, highlighting the impact of social distancing measures and diagnostic infrastructure on disease spread. His research aims to inform optimal public health policies for non-wealthy nations and address the limited access to antiviral drugs and vaccines.
A Canadian study analyzed 1479 hospital admissions for H1N1, finding that delays in seeking care increased the risk of death. Patients with underlying medical conditions and those over 20 years old were most susceptible to severe outcomes.
A new study found that critically ill patients with H1N1 influenza do not need increased Tamiflu dosages, contrary to international guidelines. The study showed that the 75 mg twice daily dosage of Tamiflu was well absorbed in these patients.
A Queen's University study found that one quarter of Ontario hospitals lack pandemic plans, with few existing plans having been tested. Small and rural hospitals are particularly vulnerable due to staff expertise shortages.
A new study predicts the impact and cost-effectiveness of different vaccination options for pandemic influenza, revealing that prioritizing high-risk individuals is likely very cost-effective. The model was applied to the 2009 H1N1 outbreak and accurately predicted when the epidemic would peak and who should be vaccinated.
A researcher at Virginia Tech is developing a unified mathematical framework to study the spread of pandemics, malware, and power grid failures. The framework aims to improve robustness in healthcare, computer networking, and power grid controls, addressing concerns for workers and policy planners.
The pandemic H1N1 influenza virus replicates efficiently in lung cells and infects conjunctiva, suggesting a potential route of transmission; however, it does not induce cytokine dysregulation like highly pathogenic avian flu viruses.
A study of college students found that wearing face masks and practicing hand hygiene reduced influenza-like symptoms by 35-51%. The use of hand sanitizer did not add significant benefit, suggesting that mask-wearing alone is enough to limit the spread of flu.
The BC Centre for Disease Control has launched a genomic surveillance project to study the evolution of the pandemic H1N1 flu virus in British Columbia. Researchers will compare the genetic sequences of BC's influenza viruses with those from other regions to understand how mass gatherings like the Olympics impact the virus' evolution.
A study found the proportion of children in high-risk areas infected with H1N1 during the first pandemic wave was 10 times higher than estimated from clinical surveillance. This suggests that children play a key role in transmission and are a target group for vaccination.
Scientists tested 2009 and 1918 H1N1 virus strains on chickens and ducks without causing disease or symptoms. The results suggest that birds played no role in the spread of these pandemic viruses.
Scientists in Vienna have developed a new technique using insect cells to produce vaccines for H1N1 'swine flu', which can meet the demand of a global flu pandemic. This method is faster than traditional egg-based production and offers a safe alternative with reduced biosafety issues.
A study found a strong correlation between the presence of Streptococcus pneumoniae and increased risk for severe H1N1 pandemic influenza virus infections. The bacteria were present in most severe cases, with a 125-fold increased risk of severe disease among individuals aged 6-55.
A new study from the University of Pittsburgh suggests that short-term school closures can increase infection rates and prolong an epidemic. The research found that sustaining closures for at least eight weeks is crucial in decreasing the spread of infection.
A new study published in the New England Journal of Medicine found that young people under 18 are more susceptible to catching swine flu from an infected person in their household. However, the risk of transmission does not vary by age, with household contacts over 50 being the least likely to get infected.
Researchers at Medical College of Wisconsin develop rapid semi- and fully-automated multiplex real-time RT-PCR assays for detecting human H1N1, H3N2, and swine-origin H1N1 viruses. The tests can distinguish between influenza A, B, and RSV infections, reducing technician and assay time.
A study published in JAMA found that a single dose of the H1N1 vaccine may provide sufficient protection for infants and children, reducing transmission of the virus. The researchers assessed the effectiveness and safety of two doses of the vaccine in healthy infants and children, aged six-months to less than 9 years, living in Australia.
A digital checklist system can reduce fatigue in emergency drug administration during pandemics, according to a study. The use of personal digital assistants also shows promise in improving efficiency and accuracy in medication distribution.
Preliminary studies indicate that a single dose of H1N1 influenza vaccine provides sufficient protection for adults, while children under 9 years may require a two-dose vaccination schedule. The vaccine was found to be safe and acceptable in all age groups, with no serious adverse events reported.
Influenza is circulating in Africa, causing sporadic outbreaks and potentially severe epidemics due to inadequate surveillance. The authors argue that improved monitoring is needed to accurately assess the burden of influenza in tropical countries like Africa.
A new RAND Corporation study found that US adults are not being vaccinated against the seasonal flu more often than last year. Despite increased public discussion about the importance of influenza vaccines, only 32% of all U.S. adults and 37% of those recommended to receive a flu vaccination had been inoculated by mid-November.
A German research team found that a severe influenza pandemic could result in a 40-50% reduction of RBC transfusion units in Germany, with up to 100,000 units being denied due to urgent needs. The study highlights the need for better understanding of demand and prioritization schemes.
Autopsies show that the 2009 H1N1 virus causes damage to both upper and lower respiratory tracts, with evidence of secondary bacterial infection present in over half of victims. The study also highlights the impact on younger people and the importance of identifying and treating severe infections.
A new study estimates the severity of the H1N1 flu during the autumn-winter flu season in the US, finding it may be less severe than initially thought. The study suggests that young children and non-elderly adults are at higher risk of complications from the illness.
Researchers combined large datasets from Milwaukee and New York City to estimate swine flu severity, finding most deaths occur in non-elderly adults. The study suggests the autumn-winter pandemic wave should have a death toll only slightly higher than or lower than seasonal influenza.
Researchers found that targeting young adults between 20-59 years for vaccinations could help mitigate the impact of ongoing pandemic waves, resulting in a 37% reduction in hospitalizations and 42% reduction in deaths. The study's adaptive strategy was effective in reducing influenza-related deaths by 35% when compared to traditional s...
The study estimates that vaccination, social distancing and antivirals can blunt the impact of H1N1 influenza. The median incubation period was 4 days and symptoms lasted 7 days.
The article discusses the impact of the H1N1 pandemic on solid organ transplant patients and donors. Experts recommend testing for influenza-like illnesses, empiric antiviral therapy, and vaccination with at least one dose of H1N1 vaccine to prevent transmission and severe disease.
The Lancet Infectious Diseases commentary highlights the lack of understanding on influenza transmission and its impact on healthcare worker protection. The article emphasizes the importance of source control, personal protective equipment, and immune status in preventing H1N1 spread.
A new study found asthma to be a significant risk factor for severe disease in children with pandemic H1N1 compared to seasonal flu. Children with mild asthma also face risks and should be vaccinated for H1N1, according to researchers.
Bird flu viruses require two simultaneous genetic mutations to infect humans, making human-to-human transmission unlikely. The study suggests that H5N1's high mortality rate in humans is due to its inability to infect the right cells, increasing the odds of it being less likely to cause a pandemic.
The study found major genetic differences between pandemic H1N1 and seasonal flu strains, potentially explaining why children are more susceptible. This difference in molecular makeup may contribute to the lower incidence of H1N1 in older adults due to pre-existing immunity.
The Saudi Arabian Ministry of Health recommends postponing Hajj participation for high-risk groups, including elderly and pregnant individuals. The plan aims to minimize disease transmission and ensure optimal provision of health services.
A study of Mexican swine flu cases reveals that young people are most likely to get infected, while the elderly have the highest mortality rates. The study also found that vaccination significantly lowers infection risk and prompt treatment is crucial for pregnant women.
The UK research community has secured £7.5 million in funding to study the development and spread of pandemic influenza H1N1 2009. The projects aim to understand how the virus mutates, jumps species barriers, and causes disease in humans and pigs.
The International Forum for Acute Care Trialists (InFACT) H1N1 Collaboration aims to develop coordinated, long-term approaches to treating severe H1N1 infection. Clinical trials will evaluate corticosteroids and statins as potential treatments for patients with severe H1N1 infection.