Articles tagged with Prostate Cancer
A team from the University of Washington has developed a non-destructive 3D imaging method that can help doctors more accurately diagnose borderline cases of prostate cancer. The new approach uses 3D images to identify complex features in tissue samples, which can increase the likelihood of correctly predicting a cancer's aggressiveness.
After the 2012 US Preventive Services Task Force (USPSTF) statement discouraging routine prostate-specific antigen (PSA) testing, rates of prostate cancer screening and biopsy decreased across racial groups. However, Black men had higher rates of local and metastatic prostate cancer despite similar screening rates.
Researchers at Princeton University have discovered a new compound that can disable the MTDH gene, which is essential for cancer progression and metastasis. The compound shows promise in treating major human cancers, including breast, prostate, lung, and colon cancers.
A study at Tampere University in Finland found that statin users had lower rates of low-risk prostate cancers detected through screening, but no difference in high-risk cancer detection. Statin use also reduced prostate cancer mortality in screened men compared to unscreened men.
Researchers have developed a new approach to studying prostate cancer, allowing them to track the behavior of individual cancer cells from birth to organ spread. The technique uses whole-organ imaging and artificial intelligence to create a 3D reconstruction of the organ at single-cell resolution.
Researchers produce large quantities of powerful cancer-fighting iNKT cells using stem cell engineering and organoid technology, offering a potential solution for mass-producing an off-the-shelf immune cell therapy. The therapy, which uses hematopoietic stem cell-engineered iNKT cells, has been shown to be effective in killing multiple...
Researchers found that dysregulation of enzymes in the glucuronidation pathway is associated with castration-resistant prostate cancer. The study suggests that reducing UGDH expression and/or activity can reverse castration resistance, potentially preventing or delaying therapeutic resistance.
A study of over 1,100 prostate cancer patients found that androgen deprivation therapy did not increase the risk of death within 30 days after a COVID-19 infection. Researchers concluded that men receiving androgen deprivation therapy had similar mortality rates as those who did not receive this treatment.
A new study in mice found that PFAS exposure reprograms the metabolism of benign and malignant human prostate cells to a more energy efficient state. Consuming a high-fat diet significantly accelerated development of tumors in PFAS-exposed mice, suggesting a synergistic interaction between the two.
Researchers developed a blood test that can detect prostate cancer patients who are resistant to chemotherapy drug docetaxel, enabling early detection and personalized treatment. The test analyzes circulating tumor cells in the bloodstream, revealing patterns that predict disease progression and survival.
A recent study found that Black, Hispanic, and Asian men are less likely to receive an MRI exam after a prostate-specific antigen (PSA) blood test. The study suggests racial and ethnic disparities in the use of prostate MRIs following elevated PSA results.
A study analyzing 93 precision oncology studies revealed significant underrepresentation of racial and ethnic minority populations in cancer research. These disparities affect the representation of diverse patient groups in clinical trials, which can impact treatment efficacy and outcomes.
Researchers found that restoring NXTAR expression can suppress prostate tumor growth, suggesting a new approach to treating hormone-resistant prostate cancer. The study identified an RNA molecule called NXTAR that plays a key role in regulating the androgen receptor, a protein driving prostate tumor growth.
A phase III clinical trial found that a trio of drugs, apalutamide, abiraterone, and prednisone, slowed the progression of metastatic castration-resistant prostate cancer by 24 months compared to 16.6 months with abiraterone and prednisone alone.
A new pilot study reveals a prostate cancer urine test can identify men with intermediate-risk disease, allowing them to opt for active surveillance instead of immediate treatment. The test assesses the amount of aggressive cancer in the prostate without needing a biopsy.
Researchers found diet-associated molecules in the gut are associated with aggressive prostate cancer, linking them to higher levels of metabolites like phenylacetylglutamine and nutrients choline and betaine. The study's findings may have clinical implications for diagnosing and preventing lethal prostate cancer.
A new international meta-analysis of randomized clinical trials found that adding androgen deprivation therapy (ADT) to definitive radiotherapy improves metastasis-free survival by 8% and overall survival by 7%. Prolonging adjuvant ADT for 18-36 months also shows similar benefits.
The NRG-RTOG 0815 trial found that adding androgen suppression to dose-escalated radiotherapy did not improve overall survival, but reduced rates of biochemical failure and distant metastases. Future studies are needed to identify subsets of patients who may benefit from this intervention.
A recent clinical trial found that a shortened course of radiation therapy after prostate removal surgery does not increase long-term side effects or lower quality of life compared to conventional treatment. Patients who underwent hypofractionated, post-operative radiation therapy experienced comparable genitourinary and gastrointestin...
A Phase III clinical trial found no significant increase in genitourinary or gastrointestinal toxicity with hypofractionated post-operative prostate bed radiotherapy compared to conventional radiotherapy. However, dose-escalated radiation therapy was not shown to be superior to conventional RT.
Research suggests that regular PSA testing from age 40 could detect life-threatening prostate cancer in men with genetic hallmarks of Lynch syndrome, increasing the chances of earlier diagnosis and treatment. Men with MSH2 gene faults were eight times more likely to be diagnosed with prostate cancer at a younger age.
Scientists at Osaka University developed a novel system for targeted cancer radiation therapy using gold nanoparticles labeled with astatine-211. The nanoparticles are highly toxic to cancer cells while remaining localized, minimizing damage to healthy tissues.
A new study found that common gut bacteria can drive prostate cancer growth and treatment resistance by providing an alternative source of growth-promoting androgens. Researchers identified specific bacterial 'fingerprints' linked to prostate cancer outcome, which could help identify men who could benefit from strategies to manipulate ...
The ARAMIS phase III clinical trial found that darolutamide improved metastasis-free survival and overall survival in Black/African American patients. Darolutamide-treated patients had a higher three-year overall survival rate and longer time to disease progression compared to placebo-treated patients.
A clinical trial found that obese prostate cancer patients who underwent regular exercise training for 12 weeks had increased levels of anti-cancer myokines, which suppressed tumour growth and helped fight cancerous cells. The study suggests exercise may be a key weapon in cancer patients' battle against the disease.
Researchers mapped cancer through protein interactions, revealing biomarkers and potential new treatments for breast and head and neck cancers. The study provides a new definition of biomarkers based on large, multi-protein complexes, offering a more precise way to explain mutation effects.
Researchers identified two subtypes of metastatic prostate cancer that respond differently to hormone treatment. Luminal tumors responded better to testosterone-blocking treatments, while basal tumors did not benefit as much from this hormone treatment.
A novel combination of abiraterone acetate and prednisolone has been shown to prolong survival in patients with hormone/castration-sensitive prostate cancer. Studies PEACE-1 and STAMPEDE found that the addition of these drugs to standard therapy lengthened survival compared to standard therapy alone.
Novartis presents Phase III MONALEESA-2 study results demonstrating improved overall survival with Kisqali (ribociclib) in combination with letrozole. The analysis shows a statistically significant and clinically meaningful improvement in survival, with median OS of 63.9 months.
A new study found that genome-wide association studies (GWAS) results from people with European ancestry can still be applied to predict breast and prostate cancer risk in diverse groups. However, the findings emphasize the need for more diverse participants in GWAS analyses to realize the full potential of polygenic risk scores.
A study analyzing 6,775 patients with low-risk prostate cancer found that cancer-related factors such as tumor grade and size are key risk factors for conversion to active treatment. The study also found that higher Gleason grade, PSA level, tumor stage, and number of positive biopsy cores are related to shorter conversion times.
Firefighters who worked at the World Trade Center site after 9/11 are 13% more likely to develop cancer, particularly prostate and thyroid cancer. They were also diagnosed at a younger age, on average, with early-stage disease. The exact cause of this increased risk is unclear.
Researchers identify molecular targets for improved prostate cancer therapy by comparing genomic changes in cancer cells eradicated and resistant to treatment. The study also finds L1 retrotransposition as a dynamic source of cancer heterogeneity.
Research finds prostate cancer risk among 9/11 responders is 24% higher, with highest risk among earliest responders. The study also reveals a shorter latency period from exposure to disease development compared to other studies.
Researchers at Tampere University identified a specific population of treatment-resistant cells that persists in prostate cancer tissue. This finding suggests that the presence of these cells can predict patient responses to treatment and may help tailor treatment for different subgroups of patients.
Researchers at Flinders University have identified a protein called 6PGD that supports the survival of prostate cancer cells when challenged with hormonal therapy. The study found that 6PGD inhibitors can kill cancer cells in lab dishes and real tumours, offering new hope for targeted therapies
A population-based study found that nearly half of men with low-risk prostate cancer transitioned from active surveillance to definitive treatment within five years after diagnosis. The study, published in The Journal of Urology, analyzed data from 8,541 men and identified factors associated with the likelihood of transition, including...
Monash University researchers have established a vast collection of living prostate cancer tumors from patients, enabling the testing of new treatments and advancing patient care. The PDX collection comprises 59 tumors collected from 30 patients between 2012-2020, providing a unique resource for scientists and pharmaceutical companies.
A recent study reveals that some prostate cancer survivors experience a persistent fear of cancer recurrence (FCR) even many years after diagnosis and treatment. The study identified patient and clinical risk factors linked with FCR, highlighting the need for ongoing monitoring and psychosocial care.
A novel blood test, Stockholm3, can reduce the number of MRIs performed by a third while preventing the detection of minor, low-risk tumours. The addition of this test to MRI reduces overdiagnosis by as much as 69% and halves the number of biopsies.
A recent study published in European Journal of Epidemiology reveals that widowers are at a higher risk of being diagnosed with advanced prostate cancer. The research highlights the importance of social environment and lifestyle factors in the development of the disease.
Researchers have found a way to harness the power of immunotherapy for advanced prostate cancer by targeting a protein called PIKfyve. Blocking PIKfyve with the inhibitor ESK981 has been shown to increase tumor death and recruit immune T cells, offering new hope for patients with this challenging form of cancer.
The American Academy of Family Physicians is investigating an 'educational' session promoting dairy products linked to increased risk of prostate cancer and other diseases disproportionately affecting African Americans. The Physicians Committee for Responsible Medicine filed a complaint, citing standards set by the Accreditation Counci...
A new genomic test may help identify patients at high risk of prostate cancer progression. The Decipher Biopsy test showed that men with high scores needed active treatment sooner, and those who underwent surgery had shorter time until PSA levels increased or they were put on anti-androgen therapy.
A study of 647 patients with untreated nonmetastatic prostate cancer found that Black men underwent significantly fewer prostatectomies during the pandemic compared to white patients. Prior to the pandemic, there was no difference in treatment rates between the two groups.
New research suggests that closely monitoring low-risk prostate cancer can be as effective as active treatment in reducing mortality rates and preserving sexual function. This approach allows men to live with the disease for ten years or more without treatment, while still being unlikely to die from it.
A phase 3 trial found that Lu-PSMA-617 significantly improved survival and progression-free survival of patients with metastatic castration-resistant prostate cancer. The treatment delivered beta radiation directly to tumour cells, keeping them alive for longer than standard care.
A new 'nomogram' helps predict which men with advanced metastatic prostate cancer will respond favorably to LuPSMA, a targeted therapy. The tool analyzes imaging and clinical data to stratify patients into high-risk or low-risk groups, enabling more personalized treatments.
A new AI-powered diagnostic tool can spot asymptomatic prostate cancer in routine CT scans, allowing for earlier diagnosis and improved treatment outcomes. The technology, developed at RMIT University, has been shown to perform better than human radiologists in detecting cancerous growths.
Researchers developed a miniature 3D bone-like tissue model to investigate the effects of anti-androgen therapies on prostate cancer bone tumours. The study found that traditional therapy had limited effect, with interactions between cancer cells and the bone microenvironment significantly impacting disease progress.
Men with high-risk prostate cancer benefit from multimodality care, which includes hormone therapy and radiation. The study found significant differences in deaths when guideline-concordant multimodality care was not delivered.
A new study found that Black men are 11% less likely to receive advanced prostate cancer therapies compared to non-Black men. Despite equal access to healthcare services, the disparity persists, with Black men also being more likely to die from the disease than non-Black patients.
Researchers identified a subset of localized prostate cancers that exhibit characteristics typical of 'hot' tumors, which may respond to immunotherapies. The study found that about a quarter of high-risk prostate cancers have these immunologic traits, suggesting a substantial number of patients may benefit from immunotherapy.
Researchers identify lineage plasticity as a deadly identity switch in castration-resistant prostate cancers, which can behave like small cell lung cancer. BET bromodomain inhibitors show promise in blocking this switch and overcoming treatment-emergent neuroendocrine prostate cancer.
A phase III clinical trial validates the effectiveness of 18F-DCFPyL in detecting and localizing recurrent prostate cancer, achieving high positive predictive values across various regions. The study's results support the use of PSMA-targeted radiotracers as the most sensitive and accurate agents for imaging prostate cancer.
Abdominal obesity is associated with an increased risk of developing aggressive prostate cancer, while general obesity does not show the same correlation. The research team recommends prioritizing studies on obesity exposure over a lifetime and further analysis of body fat distribution to better understand the risks.
Researchers identified glypican-1 protein that prevents cancer cells from spreading to bone, reducing aggressiveness. The study provides a potential new target for future treatments and supports previous findings suggesting the protein's role in preventing tumor growth.
A new treatment option has been developed to improve survival and disease control in men with advanced prostate cancer. The targeted radioligand therapy significantly extended survival and delayed progression, with a substantial effect given the high progression of disease despite previous treatments.
A nationwide Swedish study found that men with a family history of prostate cancer reach the screening risk threshold up to 12 years earlier than previously recommended, suggesting personalized screening approaches. The research suggests refining age guidelines for early screening based on individual family history factors.
Researchers have identified a promising drug target for treating and preventing aggressive, drug-resistant prostate cancer. Inhibiting the protein H6PD leads to significantly reduced tumor sizes and improved survival among mouse models with drug-resistant prostate cancer.