Articles tagged with Prostate Cancer
Current studies show promise in reducing malignancies with 5-alpha reductase inhibitors and dietary fat impact on disease development. Other compounds like soy, selenium, and green tea offer additional possibilities for disease prevention.
A University of Minnesota study found no evidence that prostate cancer is more aggressive in black men, contradicting previous studies. The research matched patients by age, Gleason grade, clinical stage, and PSA levels before prostatectomy.
Researchers reanalyzed data from the Prostate Cancer Prevention Trial, finding that prostate shrinkage may be responsible for the excess prevalence of high-grade cancer in the drug-treated group. Adjusting for changes in gland size due to finasteride use eliminated all excess high-grade tumors.
A new study suggests that finasteride, a generic drug for enlarged prostates, improves early detection of fast-growing prostate cancers. Finasteride reduces prostate size and cancer risk by 25 percent, making it easier for physicians to detect high-grade tumors early.
Two studies found that finasteride reduces prostate cancer incidence, but increases detection of high-grade cancers. Analysis suggests increased detection rather than development of high-grade cancers. The findings have favorable implications for the clinical impact of finasteride.
A study found that men screened every two years had more detected cancers than those screened every four years, but aggressive cancer detection rates remained the same. The results suggest that more frequent screening may detect smaller, clinically insignificant cancers.
Researchers discovered B7-H3, an immune molecule that predicts prostate cancer progression and recurrence after surgery. The biomarker can help individualize treatment plans for patients.
A comprehensive study found that conventional prognostic factors do not adequately predict survival outcomes in Asian-American men with prostate cancer. Despite worse prognostic profiles, most Asian ethnic groups have better outcomes compared to white men.
Researchers found that gene fusions trigger cancer growth and could impact treatment choices, with some genes regulated by androgen. The discovery may lead to better diagnostics and targeted therapies for prostate cancer.
A recent study found a significant decline in breast cancer incidence in 2003, coinciding with a drop in hormone therapy use. Breast density and sex hormone levels are also independent risk factors for breast cancer in postmenopausal women.
A study published in the Journal of the National Cancer Institute found that experienced surgeons perform more successful prostate cancer surgeries, with a steeper learning curve. As surgeons gain experience, patient outcomes improve, but beyond 250 operations, additional experience has little influence on cancer recurrence rates.
A large study of over 17,000 men found that finasteride caused a small decrease in sexual function, but this effect diminished over time. The researchers concluded that finasteride is unlikely to cause significant sexual dysfunction for most men taking the drug.
The FDA review found no strong association between eating tomatoes and decreased cancer risk, but some limited evidence for associations with prostate, ovarian, gastric, and pancreatic cancers. The agency allowed qualified health claims for these four cancers, citing very limited and preliminary scientific research.
Researchers found that simple, low-literacy interventions increased discussions about prostate cancer and led to more men receiving screening tests. These findings suggest that empowering patients through patient interventions can effectively promote discussion of prostate cancer.
A study found that certain clinician demographics, such as age and specialty, are associated with higher rates of inappropriate PSA screening. Patient education and system-level changes can help reduce this misuse.
A new drug candidate, abiraterone, has shown significant anti-tumor activity in early trials for patients with advanced prostate cancer whose tumors have continued to grow despite medical or surgical castration. The drug reduced PSA levels and shrunk tumors in both pre- and post-chemotherapy patients.
Researchers at the University of Southern California have identified a common genetic risk factor for colorectal and prostate cancer. The study found that one variant previously associated with prostate cancer also increases the risk of developing colorectal cancer.
Research suggests that a diet high in omega-3 fatty acids may improve prognosis for men genetically prone to develop prostate cancer. The study found that mice with a genetic defect causing prostate cancer had reduced tumor growth, slowed disease progression and increased survival when fed a high-omega-3 diet.
A diet rich in omega-3 fatty acids found to reduce prostate tumor growth and increase survival in genetically predisposed mice. Omega-6 fatty acids had the opposite effects, highlighting a beneficial interaction between genes and diet.
Researchers at Rutgers and Penn are developing advanced imaging techniques to increase the accuracy of prostate cancer diagnoses. These methods use powerful MRI and computer-aided diagnosis tools to reveal previously hidden cancerous tissue and pinpoint concentrations of suspicious tissue.
A recent review examines the evidence supporting PSA testing for prostate cancer screening. Despite controversy over its effectiveness, many Canadian men are being tested due to widespread practice. The article also discusses finasteride's potential in reducing enlarged prostate risks and cancer risk.
BRCA2 mutation carriers have a higher risk of developing aggressive and lethal prostate cancer, with younger onset and advanced-stage disease, according to a study published in the Journal of the National Cancer Institute. The study suggests that studying gene expression patterns in prostate cancers may help predict progression.
Researchers at Institut Gustave Roussy found that a combination of radiation and angiogenesis inhibitors can overcome HIF-1–dependent tumor radioresistance in mice. This breakthrough suggests a new approach to treating cancer by shifting tumor resistance towards apoptosis, according to the study published online on June 7.
A study from the University of Chicago Medical Center found that African-American men radically underestimate the likelihood of a cancer diagnosis after a needle biopsy for suspected prostate cancer. This underestimation can lead to delayed diagnoses and poorer outcomes.
A trial found that circulating tumor cells in the blood of patients with metastatic prostate cancer can predict how well they will respond to chemotherapy. Patients with more than five tumor cells per blood sample had a worse prognosis, while those whose CTC number went down fared better.
A new study reveals that patients with localized prostate cancer are more likely to receive surgery if they see a urologist, while those who see a radiation oncologist and urologist tend to receive radiation therapy. The study suggests that men should seek a balanced perspective on treatment options from specialists.
A new study developed a simple marker that allows urologists to identify men at risk for high-grade prostate cancer, even after a negative initial biopsy. This finding could reduce overtreatment and unnecessary biopsies while improving patient outcomes.
The OHSU Cancer Institute study found that sipuleucel-T vaccine slowed the rate of rise of serum PSA in exploratory analyses, but did not significantly delay cancer progression. The treatment also showed a favorable safety profile with common side effects like fatigue and chills.
Researchers found that radium-223 significantly reduced levels of bone alkaline phosphatase, a marker for HRPC progression, by 66% and prolonged median survival time by 41 weeks. However, treatment had no significant effect on skeletal-related events.
Researchers have identified C-reactive protein (CRP) as a strong indicator of survival for men with advanced prostate cancer. The study found that higher levels of CRP are associated with shorter survival and lower response to chemotherapy.
A study found that men with a high rate of increase in prostate-specific antigen (PSA) levels before treatment have a higher risk of death from prostate cancer. Elevated PSA velocity was a stronger predictor of poor prognosis than other single indicators, such as biopsy Gleason scores or advanced disease categories.
Researchers found a strong correlation between initial PSA levels and future diagnosis of advanced disease. Men with high PSA levels had a higher risk of developing advanced disease, emphasizing the importance of early testing.
A recent study has discovered a strong hereditary component to aggressive prostate cancer, with patients carrying the 8q24 genetic marker having a higher risk of developing the disease. The marker is twice as common in African-American men, who also experience the disease at a younger age and have a higher incidence rate.
Researchers found a direct correlation between statin use and decreased prostate-specific antigen levels, as well as lower mortality rates from prostate cancer. The study suggests that increased statin use may be contributing to declining prostate cancer mortality rates in the US between 1993 and 2003.
Researchers have found that veterans exposed to Agent Orange have a 48% higher risk of prostate cancer recurrence following surgery compared to their unexposed peers. Black veterans with a history of exposure were also more likely to experience aggressive disease and rapid PSA level increases.
Researchers found that TRPM8 is expressed in mature, differentiated human prostate primary epithelial luminal cells, but also in prostate cancer cells. The study suggests that inhibiting ER-TRPM8 or PM-TRPM8 may be a potential therapeutic approach for treating prostate cancer. Additionally, the authors propose that blocking aggrecanase...
Researchers found no association between lycopene and prostate cancer prevention, contrary to previous studies. A diet rich in beta-carotene, another antioxidant, was linked to an increased risk of aggressive prostate cancer.
Research suggests that TRPM8 is overexpressed in prostate cancer cells, indicating its potential as a therapeutic target. The study also found that endoplasmic reticulum TRPM8 retains functional activity regardless of cell differentiation status, which may contribute to cancer cell growth.
A study found no association between regular multivitamin use and localized prostate cancer, but an increased risk of advanced prostate cancer among men who took high doses or had a family history. Men taking selenium, beta-carotene, or zinc supplements were also at higher risk.
A web-based program is being tested to help prostate cancer patients make informed treatment decisions by providing information on different approaches. The program aims to reduce inner conflict and increase patient satisfaction.
Researchers at the University of North Carolina Health Care identified protein Ack1 as a trigger for advanced prostate cancer recurrence in men undergoing hormone treatment. This finding may lead to the development of targeted therapies against this protein.
A recent study found that MRI and MRS correctly staged 12 out of 16 patients with prostate cancer, enabling surgeons to plan wide resection of the neurovascular bundle. This improved accuracy helps ensure negative surgical margins and effective operations.
A recent study found that MR imaging can predict prostate cancer recurrence in patients with extracapsular extension. The study, which analyzed 74 men with biopsy-proven prostate cancer, identified features on imaging that indicated a higher risk of metastasis.
Researchers found that high dose radiotherapy (74 Gy) improved cancer control and reduced the need for additional hormone treatment compared to standard radiotherapy (64 Gy). The new conformal radiotherapy method minimized bowel side effects.
The study demonstrates that real-time intra-operative planning consistently achieves optimal coverage of the prostate with minimal doses to healthy structures. This results in improved survival rates and reduced side effects, saving $450 million a year nationwide.
A UCLA study found that three common prostate cancer treatments affect men's lives in different ways, with varying degrees of erectile dysfunction and urinary symptoms. The study tracked 580 men for five years and used a web-based data collection system to gather accurate information.
Researchers found that the androgen receptor plays a key role in bladder cancer development, which explains why it affects men more than women. The discovery opens doors to new treatment options and may help doctors predict tumor recurrence.
Men with lower educational levels experience a significant drop in quality of life after prostate cancer treatment compared to those with more education. The study controlled for various factors, including income and healthcare access, to show that low education alone is associated with lower quality of life.
The American Association for Cancer Research (AACR) has awarded its inaugural Team Science Award to a multidisciplinary team of researchers from the University of Michigan and Harvard Medical School/Brigham and Women's Hospital. The award recognizes their groundbreaking discovery of gene fusions in prostate cancer, which has significan...
Scientists from Wake Forest University School of Medicine found that stress hormone epinephrine can cause changes in prostate and breast cancer cells, making them resistant to cell death. This link between stress and cancer has been suggested but previously unexplored, with potential implications for patients and researchers.
A study of 372 men with prostate cancer found that 49% had osteoporosis, with those receiving hormone therapy and having undergone radical prostatectomy being at highest risk. The authors suggest that daily calcium intake could be used as a prognostic factor for osteoporosis in these patients.
Researchers are investigating a genetically modified variant of Avian Newcastle disease virus to treat human prostate cancer. The virus is designed to replicate only in the presence of prostate-specific antigen, found exclusively in cancerous cells.
A detectable PSA level is first indicator of recurrent prostate cancer after radical prostatectomy, with a doubling time of less than three months indicating imminent death from prostate cancer. Patients with longer doubling times are at significant risk for disease recurrence and cancer-specific death.
New study finds that PSA measurement is associated with prostate cancer prognosis but poorly predicts lethal cancer. Researchers emphasize the need for improved surveillance strategies to identify life-threatening tumors.
A study led by USC and Harvard researchers identified multiple genetic risk factors that predict a man's probability of developing prostate cancer. The findings highlight the importance of this region in prostate cancer, providing potential tools for early screening and prevention efforts.
Researchers, Lucille Sanzero Eller and Elise Lev, are developing a targeted intervention to address physical and psychological symptoms in men with prostate cancer. The study aims to improve quality of life by reducing symptoms such as urinary and bowel incontinence and depression.
A study by Duke University Medical Center researchers found that obese and overweight men are more likely to have aggressive prostate cancer than biopsy results indicate. This discrepancy may lead to inadequate or inappropriate treatment, emphasizing the need for more accurate biopsies.
Alan Garen and Zhiwei Hu have developed a way to target and destroy tumor blood vessels using nanoparticles. The technology uses a synthetic gene that activates an immune response, allowing for selective destruction of tumors while leaving normal tissue unharmed.
A study found that patients who received preventive health exams were more likely to undergo cancer screenings, including colorectal, breast, and prostate cancer testing. The examination may serve as a forum for promoting evidence-based cancer screening.
Cancer researchers have identified a promising compound, ASC-J9, that slows the progression of Kennedy's disease in mice carrying the mutant human gene. The compound breaks up a molecular clog in neurons affected by the disease, improving mobility and muscle function.