Articles tagged with Prostate Cancer
A new test has been developed to detect prostate cancer spread in lymph nodes at an earlier stage, which may lead to better treatments and improved patient outcomes. The test was found to be more sensitive than existing methods and associated with increased recurrence and decreased survival rates.
A new 'roulette wheel' tool can help patients visualize the risks and benefits of prostate cancer screening, allowing them to make more informed decisions. The tool presents probabilities in a clear and accessible way, helping patients weigh the potential benefits against the risks.
A study comparing Japanese American and white male patients who received hormone treatment for prostate cancer found that the former had a significantly higher five-year overall survival rate of 66% compared to 42%. The result was not affected by cancer stage or PSA levels, suggesting genetic and lifestyle factors may play a role.
Researchers have discovered gene SLIRP with the potential to shut down oestrogen in breast cancer cells and testosterone in prostate cancer cells, depending on the cancers' survival. This breakthrough could lead to the development of 'smart' drugs that target specific genes, potentially reducing side effects and improving survival rates.
Researchers have developed a new treatment protocol combining radionuclide therapy and chemotherapy that induces regression of prostate cancer in patients with metastatic disease. The combination regimen has been shown to alleviate bone pain and produce clinical benefit, including prolonged survival and reduced PSA levels.
Researchers found a new predictor of disease for overweight men using PSA density calculation, helping to accurately diagnose prostate cancer in this high-risk group. The study analyzed 647 men with elevated PSA levels and identified a lower PSAD calculation needed for accurate diagnosis, beating prior predictors.
Researchers found that when treatment was restarted after a chemotherapy holiday, roughly three-quarters of study subjects responded again or experienced stabilized PSA levels. The median duration of the first chemotherapy holiday was 16 weeks, providing a clinically meaningful break for most patients.
A study found that early exposure to estrogen or BPA increases the risk of precancerous lesions in the prostate. Researchers discovered that this leads to epigenetic reprogramming, altering gene expression patterns that promote prostate disease with aging.
Research using transgenic mice found that lower levels of selenoproteins accelerate prostate cancer development, highlighting the importance of selenium-containing proteins in preventing cancer. Further research is needed to understand how selenium supplements can maximize benefits.
Researchers found that men with the same hemoglobin levels before treatment experienced significantly different overall and progression-free survival depending on whether they were black or white. Anemic blacks fare worse than anemic whites, while blacks with high baseline hemoglobin fare better.
A new study found that postmenopausal women who use statins have the same risk of invasive breast cancer as those who do not. Hydrophobic statins were associated with an 18% decreased risk of breast cancer, but individual statin associations warrant further research.
A recent study found that young men with localized prostate cancer can benefit from external beam radiation therapy, similar to older patients. The study showed no statistically significant differences in survival rates, disease progression, or signs of recurrence between three age groups: under 55, 60-69, and 70 and over.
Researchers have identified a novel protein called JHDM2A that plays a key role in gene activation mediated by the androgen receptor, a protein responding to testosterone and dihydrotestosterone. This discovery has implications for prostate cancer treatment, as lowering androgen levels can shrink or slow cancer growth.
Researchers found that BRCA1 and BRCA2 mutation carriers experience a similar reduction in breast cancer risk with increasing number of pregnancies carried to full-term, parallel to that in the general population. Additionally, they discovered that first childbirth at age 20 years or older is associated with increased risk of breast ca...
Researchers developed a risk calculator that uses various statistical tests to analyze biopsy results, family history of prostate cancer, race, age, rectal examination results, and previous biopsy history. The model can help patients and physicians decide whether a prostate biopsy should be performed.
A study analyzing 551 men with prostate cancer found that a 30% decline in serum PSA levels within three months of treatment can reduce the risk of death by at least 50%. The researchers suggest that PSAs could be used as reliable endpoint measures for prostate cancer treatment efficacy.
Researchers found a statistically significant direct relationship between high cholesterol and prostate cancer. Men with prostate cancer were around 50% more likely to have had high cholesterol levels than non-prostate cancer controls, especially those diagnosed before age 50 or over 65.
Phenethyl-ITC, a phytochemical found in cruciferous vegetables, has been shown to suppress the growth of human prostate cancer cells. Mice grafted with human prostate tumors and administered PEITC daily exhibited significantly reduced tumor volume compared to controls.
Regular use of antihistamines has been linked to a higher risk of developing low-grade and anaplastic astrocytomas, two types of brain tumors. Conversely, anti-inflammatory medications may help protect against glioblastoma, a more deadly type of tumor.
A new study identifies a gene rearrangement involved in prostate cancer, suggesting that fusions involving ETV4 and two other genes may account for the majority of prostate cancers. The finding confirms the importance of the ETS gene pathway in causing prostate cancer.
Scientists detect novel gammaretrovirus more frequently in men with RNASEL gene mutations, sparking questions about a potential viral cause for prostate cancer. The discovery raises several questions for future experimentation, including the relationship between the virus and the disease.
Research on grape seed extract's potential to lower blood pressure, discovery of new elements, and studies on prostate cancer were among the topics presented at the ACS meeting. The conference also featured discussions on improving America's scientific competitiveness and food safety.
A new human retrovirus, XMRV, has been found in patients with a rare type of prostate cancer, suggesting a possible link between the virus and cancer development. The discovery was made using a microarray-based screening method and found that prostate cancers with specific genetic mutations were more likely to harbor XMRV infection.
Research reveals that men's concerns about controlling their cancer drive treatment choices, despite limited reliance on scientific evidence. The study highlights the need for improved patient education and informed decision-making support.
A study by Mayo Clinic researchers identified 8 genes with significant under-expression and 3 with over-expression, strongly implicating them in prostate cancer development and progression. The findings suggest that these genes may serve as biomarkers for diagnosing and predicting prostate cancer, potentially improving treatment outcomes.
Researchers at Cedars-Sinai Medical Center have identified the potential benefits of Raloxifene in treating advanced prostate cancer. The study showed that Raloxifene can slow or stop the growth of prostate cancer, offering new hope for patients with androgen-independent disease.
Researchers found that capsaicin induced apoptosis in human prostate cancer cells, reducing tumor size and proliferation. The study suggests capsaicin may slow prostate tumor development and production of PSA protein.
A study suggests that delayed surgical intervention can be a safe alternative to immediate treatment for men diagnosed with early-stage, low-grade prostate cancer. The research found equivalent risks of noncurable prostate cancer in both groups, depending on factors like age and PSA levels.
A new study by Johns Hopkins Medicine found that men with low-grade prostate cancer who receive active surveillance may not be at increased risk of noncurable prostate cancer. The study compared outcomes in men who delayed surgery for two years to those who underwent immediate treatment, finding no significant difference in risk.
Researchers found that a common osteoporosis treatment helped men with prostate cancer recover significant bone mass after two years of androgen deprivation therapy. The study suggests that bone density tests should be encouraged for men at risk, and bone-preserving therapy could prevent debilitating fractures.
A large population-based study found that older men with early prostate cancer who received radiation therapy or surgery lived significantly longer than those who were observed. The study, which examined over 48,000 men between 65 and 80 years old, demonstrated a survival advantage for treatment over observation.
Researchers found that administration of a bisphosphonate called zoledronic acid every three months significantly increased bone density in men with advanced prostate cancer. The study supports guidelines for monitoring bone density and initiating treatment to prevent fractures.
A new study found that androgen deprivation therapy is ineffective in preventing the spread of localized prostate cancer, despite its increasing use among men with non-spreading disease. Researchers suggest that men may endure significant side effects for uncertain benefits.
Research suggests that antioxidant supplementation with vitamin E, vitamin C, and beta-carotene is not associated with a decreased risk of prostate cancer. However, specific subgroups, such as current or recent smokers, may benefit from high-dose vitamin E supplementation to reduce advanced prostate cancer risk.
A study of 61,228 men aged 65 and older with local or regional stage prostate cancer found that lower socioeconomic status was significantly associated with decreased survival. Socioeconomic factors, including education level and community poverty, were the primary drivers of disparities in survival.
A new study from UCSD found that macrophage signaling can activate processes in both cancer cells and immune cells, altering the activity of androgen antagonists and allowing tumor growth. The research identifies a novel binding site on steroid receptors that makes them responsive to inflammatory signals.
Macrophage interaction reverses activity of hormone receptors in prostate cancer cells, leading to shifts in gene expression and drug resistance.
Researchers discovered that vitamin D significantly limits the ability of prostate cancer cells to invade healthy cells by reducing two key enzymes. Vitamin D also increases counterpart enzymes that inhibit these proteases, leading to reduced cancer progression.
A study found that only 25% of high-risk black men aged 60-69 are screened for prostate cancer, compared to 81% of white men. This disparity highlights a need for increased awareness and targeted screening efforts among black males with positive family histories.
Researchers found that specific single-nucleotide polymorphisms (SNPs) in the IGF1 gene were linked to an increased risk of prostate cancer, accounting for 10% of cases. The study's findings suggest a biologic effect across different ethnic groups.
Researchers found that the combination of curcumin and PEITC significantly retards prostate cancer tumor growth in laboratory mice. The discovery suggests potential for using plant-based compounds as alternative therapies to treat advanced prostate cancers.
A study of over 1,000 male veterans found that prostate cancer screening with PSA testing did not prolong survival. Researchers compared men who died from prostate cancer to those living with the disease and found no difference in screening rates.
A study published in the Journal of the American Medical Association (JAMA) found that screening for prostate cancer does not necessarily prolong survival. The research, which included over 72,000 veterans, showed that even men who received screenings were not at lower risk of death from prostate cancer.
Researchers at the Burnham Institute, along with partners from six institutions, are working on a NCI-funded project to develop an accurate early-stage diagnosis method for prostate cancer. The goal is to identify specific gene products indicative of the disease's clinical behavior.
Researchers will use a tumor biopsy or blood examination to identify a 'gene signature' that indicates aggressive prostate cancer, allowing patients to make informed treatment decisions. The study aims to improve outcomes for up to 30% of men with prostate cancer who do not require radical treatments.
Researchers found significant associations between PSA velocity and demographic characteristics like age, race, and diet. Men who gained or lost weight had distinct changes in PSA velocity, while African Americans had higher velocities on average.
Researchers have developed a new cell line to study prostate cancer and its effects on the body. Anti-nerve growth factor therapy shows promise in reducing skeletal pain associated with prostate cancer, outperforming morphine.
A study found that Ack1 is a key driver of tumor growth in prostate cancer, and its inhibition can slow tumor formation. The researchers also discovered an experimental drug called geldanamycin that can inhibit Ack1 activity by interfering with its molecular interactions.
A study of 24 patients found that MRI with an endorectal coil at 1.5T outperforms conventional body coils in staging prostate cancer. The results suggest a need for advances in coil technology to improve imaging at higher field strengths.
The study found that patients with rapid increases in PSA levels (PSAV) or quick doubling of PSA levels (PSADT) were more likely to experience cancer spread, recurrence, and death. These findings provide valuable pretreatment prognostic factors for prostate cancer.
A recent Columbia University study published in Nutrition and Cancer showed that Zyflamend reduces prostate cancer cell proliferation by up to 78% and induces cancer cell death. The research confirms Zyflamend's COX-1 and COX-2 anti-inflammatory effects, with independent anti-cancer benefits against prostate cancer cells.
A Dutch study found that higher doses of radiotherapy significantly improved patient outcome over a five-year period. An anti-androgen therapy trial suggested early treatment can benefit locally advanced disease, while immunotherapy trials are showing promising results for androgen-independent prostate cancer.
A new study found that a vitamin D pill combination extended the lives of men with advanced prostate cancer by about eight months compared to those receiving chemotherapy and placebo. The pill, DN-101, also protected against major side effects of chemotherapy.
Researchers discovered that calcitriol and QW-1624-F2-2 slowed prostate cancer progression in intact mice after 14 weeks of treatment, reducing tumor burden. However, chronic treatment showed side effects, highlighting the need for further studies to understand how these agents prevent prostate cancer.
A protein called TAP has been found to suppress prostate cancer growth and enhance the effects of vitamin E. High levels of TAP in normal prostate cells suggest it facilitates the transport of vitamin E into tissue and helps retain high concentrations.
Researchers developed nanoparticles that can target and deliver drugs to prostate cancer cells using aptamers, achieving highly specific and efficient tumour targeting. The bioconjugates successfully adhered to PSMA-positive prostate cancer cells and were rapidly internalised into the targeted cells.
A novel computational model predicts androgen receptor binding sites in the prostate cancer genome. Experimental verification confirms the accuracy of the model, providing new insights into prostate cancer biology.
Researchers found a unique molecular signature of fused genes in most prostate cancer tissue samples but not in benign tissue. The discovery could lead to a diagnostic test that detects the fused genes or their protein products, making it more accurate than current screening tests.
Researchers analyzed human genome variation in various populations to understand disease susceptibility, reproductive success and genetic disorders. Gene conversion played a critical role in shaping the genetic diversity of the Luteinizing Hormone/Chorionic Gonadotropin Beta cluster, which is associated with pregnancy success.
A study by Case Western Reserve University researchers found that apigenin, a plant flavonoid, slowed tumor growth in mice with prostate cancer. Apigenin also reduced IGF-1 levels associated with increased cancer risk and triggered cell self-destruction.