A new study predicts prostate cancer up to six years earlier than current methods by analyzing the ratio of free to total prostate-specific antigen (PSA) in a man's blood. The research, published in 1996, showed that men with high total PSA levels may have prostate cancer or benign prostatic hypertrophy.
Scientists have identified a major gene, HPC-1, that predisposes men to prostate cancer, located on chromosome 1. The gene is believed to contribute to at least a third of familial prostate cancer cases.
Researchers at the University of Chicago Medical Center have found that testosterone can shrink experimental human prostate tumors that no longer depend on the hormone. This suggests a potential new approach for treating advanced prostate cancer.
A multi-institutional study found that surgery is effective for localized prostate cancer, with tumor grade being the best predictor of long-term survival. Ten years after surgery, men with grade 1 tumors had a 6% mortality rate, while those with grade 2 and 3 tumors had 20% and 23% mortality rates, respectively.
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Stanford researchers are working on a new PSA test that can distinguish between cancerous and non-cancerous prostate enlargement. By analyzing the PSA protein extracted from enlarged prostates, they aim to eliminate unnecessary biopsies. The team's approach has shown promising results, reducing false positives by up to 86%.