Research on prostate cancer biology, detection, and outcomes. Covers genetic clues, DNA damage, diet and survival, and screening awareness.
A multi-center study analyzing 2,056 prostate cancer patients found that metastatic disease carries a significant mortality rate and incurs substantial healthcare expenses. Patients with metastatic disease had ten times the death rate of those with localized disease, with $13,650 more in annual healthcare costs.
Researchers discovered that specific p53 mutations facilitate androgen-independent growth in human prostate cells, while another gene, Id-1, promotes tumor aggressiveness. These findings could lead to new therapeutic strategies for hormone-independent prostate cancer.
A new technique developed by Malins' laboratory uses Fourier transform-infrared spectroscopy to analyze DNA from prostate tumor biopsies, allowing doctors to identify patients at high risk for metastasis. This breakthrough enables more informed treatment decisions and potentially saves lives.
Researchers identified lifestyle factors that predict prostate cancer recurrence in treated patients. Patients with low body mass index, regular exercise, and annual screenings had lower risk of progression.
Researchers found that 11C-acetate PET scans were more sensitive than 18F-FDG PET scans in detecting recurrent prostate cancer. The study used 46 patients with detectable serum PSA, and the imaging procedures were conducted on the same day.
Researchers discovered a link between genetic markers and prostate cancer spread in African-American men. The study found that the ratio of MMP to E-cadherin accurately predicted cancer metastasis.
A $10 million grant will fund a new prostate cancer research consortium led by Emory University, comprising 13 universities from eight states. The consortium aims to identify new therapeutic targets for advanced prostate cancer treatment.
A study found that 75% of men aged 50 and older reported undergoing PSA testing, compared to 63% for colorectal cancer screening. The mismatch between screening rates highlights the need for better patient education on effective cancer tests.
A new study by Dartmouth researchers finds that more American men are screened for prostate cancer than for colorectal cancer, contradicting scientific evidence. The study, which analyzed data from over 50,000 men, reveals a significant disparity in screening rates between the two cancers.
A new study led by Queen's University aims to increase the sensitivity of prostate cancers to anti-cancer drugs using nitroglycerine. Researchers hope to develop a better understanding of how prostate cancer cells become resistant to chemotherapy, with potential applications for other cancers such as breast cancer.
The Prostate Cancer Series assesses the epidemiology of prostate cancer, highlighting the impact of genetic and environmental risk factors. Despite progress in understanding diet-related risks, familial clustering, and ethnic variation remain poorly understood, presenting opportunities for further research.
A Mayo Clinic phase II study of 42 patients with advanced androgen-independent prostate cancer found that green tea did not provide therapeutic benefit. The study showed no sustained decline in PSA levels, and high doses of green tea were associated with significant side effects.
A study by Dr. Michael Gaziano and colleagues found a significant link between greater height and increased risk of prostate cancer in men aged 50 and above, with risks increasing by 32% for those over 72 inches tall. However, no association was found between weight or body mass index and prostate cancer risk.
Researchers found the prevalence of overweight among Los Angeles County school children to be 20.6 percent, with higher rates among boys and Latinos. An email-based program for nutrition intervention was also shown to be effective in changing dietary behavior, with over 50% of participants reporting success.
Researchers found that selenium supplements reduced DNA damage in elderly male dogs' prostates, potentially benefiting aging prostate health. A separate study suggests a new retinoid treatment may prevent lung cancer in former smokers by restoring RAR-ß expression and reducing squamous metaplasia.
A recent study found that over 75% of participants took supplements regularly, with women using more supplements overall and men with medical conditions taking more supplements. The study suggests that healthcare providers need to educate patients on safe supplement use to prevent potential harm.
Researchers have found a promising combination therapy that may significantly improve treatment outcomes for patients with advanced prostate cancer. In a phase II clinical trial, the combination of calcitriol and docetaxel showed a higher PSA response rate compared to docetaxel alone.
Researchers found that a flaxseed-rich diet inhibited tumor growth and reduced aggression in genetically engineered mice. The study suggests that lignans in flaxseed could play a role in inhibiting prostate cancer progression by influencing estrogen and testosterone metabolism.
Researchers found that PC-SPES reduced the effectiveness of paclitaxel treatment in both androgen-sensitive and androgen-independent models of prostate carcinoma. Consumption of garlic, chives, and other allium vegetables may be associated with a reduced risk of prostate cancer.
The UCLA SPORE will focus on identifying new molecular targets for therapies and investigating nutritional strategies to prevent prostate cancer. Researchers will work together to develop targeted therapies that focus on what is broken in the cancer cell.
Researchers have developed a test that analyzes protein patterns in blood serum samples to predict prostate cancer diagnosis. The technique proved effective in identifying 95% of cases and 78% of benign diseases, showing promise as a new tool for reducing unnecessary biopsies.
A new blood test has been developed to detect prostate cancer with high accuracy, helping identify men who need a biopsy and those who don't. The test correctly identified 36 of 38 prostate cancer cases, as well as 70 asymptomatic men with benign conditions.
Researchers found that EZH2 expression was significantly higher in metastatic prostate cancer tissue compared to localized prostate cancer. A future test for high levels of EZH2 protein could serve as a red flag for physicians to identify men with the most aggressive form of the disease.
The initiative involves over 50 investigators in Seattle and Vancouver, B.C., aiming to develop improved therapies for men with recurrent or advanced disease. Prostate cancer affects one in six men, with an estimated 189,000 diagnoses this year and 30,200 deaths.
A new clinical trial is investigating the combination of high-dose calcitriol and docetaxel in treating advanced prostate cancer, with the goal of reducing PSA levels by 50% or more. The study builds on promising preliminary results from a previous Oregon Health & Science University trial.
Researchers have identified a genetic link between macrophage scavenger receptor-1 (MSR1) and increased risk of prostate cancer. MSR1 mutations were found in approximately 12.5% of African American men with prostate cancer, compared to 1.8% without the disease.
A research team led by Wake Forest and Johns Hopkins universities found that mutations in the MSR1 gene are associated with an increased risk of aggressive prostate cancer, particularly in African-American men. The study identified seven potentially important mutations of the MSR1 gene, including one that leads to rapid metastasis.
A recent analysis of eight PC-SPES lots revealed widespread contamination with indomethacin and diethylstilbestrol, two potent synthetic compounds that undermine the supplement's anticancer potency. The study suggests that the contaminated batches had significantly reduced anticancer activity.
A recent study of over 1,350 men found no correlation between a low-fat, high-fiber diet and reduced PSA levels over a four-year period. The study suggests that a healthy dietary pattern may still have an inhibitory effect on prostate cancer incidence despite the lack of impact on PSA levels.
A new study published in the Journal of Clinical Oncology found that a healthy diet does not significantly affect Prostate-Specific Antigen (PSA) levels over a relatively short period. The researchers believe that longer-term dietary effects on prostate cancer are still unknown.
Researchers at Cedars-Sinai Medical Center have found that a potent experimental drug called 2C4 slows tumor growth in both breast and prostate cancer tumors in mice, even when small amounts of HER-2/neu are expressed. The study's findings may lead to a new way to treat breast and prostate cancers.
A new study found that men with early-stage prostate cancer who follow a low-fat diet have half the risk of late-stage disease compared to those who consume more fat. Low-fat diets also reduced blood levels of testosterone, which fuels prostate growth and may contribute to cancer development.
Researchers at Michigan Medicine have discovered a new predictive marker, HIP1, associated with an increased risk of developing prostate and colon cancer. HIP1 levels were found to rise significantly in tumor cells, making it a potential target for therapy.
Researchers engineered a virus to target prostate-specific antigen, appearing as 'hot spots' in primary tumors and distant metastases. This method could deliver toxic treatments directly to prostate cancer cells, killing them while sparing surrounding healthy tissue.
The Prostate Interactive Educational System (PIES) is an interactive, computer-based program designed to provide comprehensive information tailored to the patient's preferences. The program will present disease and treatment information, a virtual support group, and allow patients to jot down notes in a virtual notebook.
Researchers will examine genes responsible for prostate cancer growth and identify potential diagnostic markers and therapeutic targets. The study aims to understand why prostate cancer spreads into bones, leading to a better understanding of this disease and potential treatments.
Researchers found that measuring Mcm5 levels in urine could detect bladder cancer with higher sensitivity than current tests. Additionally, a study linked effective DNA repair capacity to poorer survival rates in NSCLC patients treated with chemotherapy.
Researchers found that adding hormone-suppression therapy to radiotherapy for advanced prostate cancer significantly improved five-year disease-free survival rates. The study involved 415 patients, with those receiving combined therapy showing a substantial increase in overall survival rates.
A study finds that PSA testing led to a 29% and 44% overdiagnosis rate among white and black men, respectively. The increased incidence was partly due to unnecessary biopsies and side effects from treatment.
A new study conducted in New Zealand found no increased risk of prostate cancer among men who had undergone vasectomy. The study, which interviewed over 2,200 men, suggests that vasectomy does not pose a biological risk for prostate cancer.
A new test measures the ratio of cathepsin B to inhibitor stefin A in prostate tissue, revealing differences in tumors not visible under the microscope. The test can identify biologically aggressive and less aggressive forms of cancer, guiding treatment decisions for patients.
Researchers at Temple University discovered that the Rb2 gene's lack of expression could be an early indicator of prostate cancer. A study found lower expression levels of Rb2 in prostate tissue as it progresses from normal to cancerous, suggesting its potential use as a diagnostic marker.
This study estimates the direct and indirect costs of prostate cancer in California for 1998, finding that hospitalization costs account for almost three-fifths of total costs. Prostate cancer adds significant costs to patients with comorbid conditions, such as heart disease or respiratory illness.
A new study by Columbia University Irving Medical Center reveals significant differences in PSA (Prostate-Specific Antigen) and PSAD (Prostate-Specific Antigen Density) test measurements between Caucasian and Hispanic men. The study found that while PSAD can accurately predict cancer risk in Caucasians, it is less effective in Hispanic...
Researchers discovered a set of 511 genes that distinguish four groups of patients with benign prostatic hyperplasia (BPH), including those with symptoms and cancer. The findings suggest a potential link between BPH and prostate cancer, as well as a genetic 'field effect' in individuals with prostate cancer.
A recent study has challenged the long-held notion that African-Americans with prostate cancer have a poorer prognosis than their white counterparts. Researchers found that, when treated within clinical trial settings, African-American patients survived for an average of 15 months, comparable to 14-month survival rates for whites.
The study found patients who received the high-dose regimen had significantly longer overall and disease-free survival rates than those who received a lower dose. The company plans to initiate a Phase III trial of GVAX prostate cancer vaccine in the first half of 2003.
Researchers found that freezing cancer cells in test tubes increases their vulnerability to bleomycin, a potent anti-cancer drug. This combination therapy may lead to a powerful new form of cancer treatment targeting malignant cells while leaving healthy tissue unharmed.
Researchers at UIC are testing a new vaccine for advanced prostate cancer, targeting patients with a specific immune type. The vaccine uses a fragment of the protein PSA to stimulate the immune system and destroy tumor cells.
Hopkins researchers identified a nine-fold increase in expression of the AMACR gene in prostate cancers, making it a promising early marker and potential drug target. Overexpression patterns were also found in precancerous lesions, highlighting the gene's potential for non-invasive detection and prevention.
Researchers are developing a new method to improve the diagnosis of prostate cancer by using contrast-enhanced ultrasound. The study aims to identify areas in the prostate with more blood vessels, allowing for targeted biopsies and potentially reducing the number of unnecessary procedures.
Researchers found that a combination of targeted therapies can effectively inhibit tumor growth in prostate cancer. Using different drugs after resistance occurred inhibited tumor growth, suggesting multiple treatments may be needed to manage the disease. This approach is similar to how advanced breast cancer is treated today.
Prostate cancer tumors produce factors that inhibit dendritic cell growth and induce apoptosis, explaining immunological non-responsiveness in advanced patients. Stimulating dendritic cell growth is a promising area for future prostate cancer therapies.
The grant will allow Rush to increase awareness among African-American men aged 50+, who are disproportionately affected by prostate cancer. The organization plans to conduct free screenings and refer patients to local doctors or Rush after diagnosis.
Researchers have identified new markers for prostate and colon cancers, as well as a potential tumor suppressor gene. TIG1 was found to be expressed in normal prostate tissue but not malignant tumors, suggesting it may play a role in cancer progression.
Researchers at the University of Michigan have identified a gene, AMACR, which triggers production of a specific enzyme involved in fat metabolism. The protein is detected in over 95% of localized prostate cancer cells and shows high sensitivity and selectivity ratings for diagnostic purposes.
Men treated with ADT experienced increased complications, including impotence (80%), breast swelling, and hot flashes. Despite this, many reported feeling free of cancer after treatment.
A recent study published in the Mayo Clinic Proceedings found that daily NSAID use reduced prostate cancer risk by up to 60% in men aged 60 and older. The study, which followed 1,362 Caucasian men for an average of five and a half years, suggests that the beneficial effect may increase with age.
Late-stage prostate cancer unresponsive to hormone therapy due to hypermethylation of estrogen receptor genes. A new study suggests that demethylating agents could restore effectiveness of hormone therapy by reversing methylation.
Two new studies published in the Journal of the National Cancer Institute suggest that frequent tomato product consumption may reduce prostate cancer risk. Additionally, researchers found a possible role for the Ras gene in neuroblastoma regression and increased levels of GRP growth factor in head and neck cancers.