Research on prostate cancer biology, detection, and outcomes. Covers genetic clues, DNA damage, diet and survival, and screening awareness.
A randomised clinical trial found that post-operative radiotherapy significantly improved biological and clinical progression-free survival in men with high-risk prostate cancer. The study showed a clear benefit in terms of biological progression-free survival for men who received radiotherapy treatment in addition to surgery.
A multi-center, double-blind study found that patients taking toremifene 20 mg had a lower cumulative incidence of cancer after 12 months, with a 48% reduction compared to placebo. High-grade prostatic intraepithelial neoplasia (PIN) is a precursor to prostate cancer.
A recent study published by the American Association for Cancer Research found that men with high-grade prostate intraepithelial neoplasia (PIN) are at a higher risk of developing invasive prostate cancer. Within one year, men in the placebo group had a 31.4% risk of being diagnosed with prostate cancer.
African-American men reported significantly higher sexual and urinary function five years after prostatectomy compared to non-Latino white men. However, they also experienced slightly more bother from changes in their function.
Researchers found that docetaxel administered every three weeks significantly improved survival, pain relief, and quality of life for patients with advanced hormone-refractory prostate cancer. The treatment increased life expectancy by an average of three months.
Researchers found that younger men and those with increased disease recurrence risk experience more frequent PSA bounces, but without additional treatment, their survival rates are comparable to those without a bounce. The large-scale study provides evidence that a PSA bounce may not automatically dictate hormone therapy.
Researchers examined the effect of treatment delay on patients treated with external-beam radiation for prostate cancer. The study found that a delay within certain limits does not alter ultimate clinical outcome, but using hormone therapy during this time should be avoided in men with favorable risk factors.
A recent study published by Fox Chase Cancer Center found that patients who used nonsteroidal anti-inflammatory drugs (NSAIDs) regularly before their diagnosis and treatment had improved overall survival rates. The research involved 1,206 men with localized prostate cancer and compared the outcomes of those who used NSAIDs regularly to...
Researchers at Mount Sinai present groundbreaking studies on prostate and breast cancer treatments, identifying genetic predictors for adverse side effects and developing tailored radiotherapy regimens. The studies aim to improve clinical trials and patient outcomes for these devastating diseases.
A study found that even healthy subjects experience declines in sexual function over five years, but patients treated for prostate cancer show much greater decline with significant impact on urinary function. Men undergoing radical prostatectomy are particularly affected.
A study found that black men aged 65+ were half as likely to be tested for prostate cancer as white men, highlighting racial disparities in healthcare access. Low screening rates among African American men may contribute to higher prostate cancer mortality rates.
A study of over 67,000 men found blacks are 35% less likely than whites to undergo PSA testing, with disparities in healthcare access and education levels potentially contributing factors
Men who consumed four or more glasses of red wine per week reduced their risk of prostate cancer by 50 percent, while white wine showed no significant effect. The study suggests resveratrol, an antioxidant in red grapes, may be responsible for this benefit.
A new study found that prostate cancer treatment can significantly impact men's quality of life, with both radical prostatectomy and radiotherapy causing declines in sexual function, urinary incontinence, and bowel issues. The study, which followed over 1,100 men with clinically localized prostate cancer, suggests that the treatments d...
Researchers found that Hedgehog signaling is greatly activated in prostate cancers, distinguishing them from benign ones. The study's findings suggest that targeting the Hedgehog pathway may lead to new treatments for human disease.
Researchers found that Hedgehog activity in localized prostate tumors is significantly lower than in metastatic cancers. Blocking the Hedgehog signal with cyclopamine slowed tumor growth and even reversed aggressive cancer progression in mice experiments.
A study by Thomas Stamey and colleagues found that the correlation between PSA levels and prostate cancer severity has decreased over time, making the test less useful for early detection. Instead, they recommend a yearly digital rectal exam for men over 50.
A recent study found that popular magazines rarely provide in-depth information on prostate and colon cancer screening. Key points such as risk factors, early screening benefits, and potential harms are often missing from magazine articles. This lack of information may contribute to the public's misperception about cancer risks.
Researchers found that mice engineered to lose a single copy of the Rb gene in their prostate develop a precancerous condition analogous to human prostate cancer. This suggests that loss of Rb could be the initial spark for prostate cancer development.
A molecule called hepsin has been found to promote the deadly progression of prostate cancer by disrupting tissue organization. This discovery may lead to the development of new therapeutics designed to decrease the spread of prostate cancer.
Using combination therapies that include 6 months of androgen suppression therapy (AST) alongside radiation therapy (RT) improves survival rates for patients with locally advanced prostate cancer. The study found significantly higher survival rates, lower prostate cancer-specific mortality, and a reduced need for salvage AST in the com...
Researchers have identified strong evidence for a prostate cancer gene on chromosome 17, which is also known to harbor the breast cancer gene BRCA1. A separate study found that a variant of the MIC-1 gene, involved in inflammation, is associated with a decreased risk for prostate cancer.
A large family-based study identified specific genes associated with increased prostate cancer susceptibility, highlighting the potential for early detection and targeted surveillance. The study's findings also revealed that prostate cancers in genetically predisposed individuals tend to be more aggressive and fatal.
A new study has identified five chromosomal regions that are likely to harbor prostate cancer susceptibility genes. The study found evidence of a gene on the long arm of chromosome 17 and four other regions that might hold susceptibility genes. Additionally, researchers have discovered that men who carry a specific mutation in the MIC-...
Researchers found that prostate cancer cells shed immunostimulatory molecules, allowing them to evade the immune system's natural killer cell defense. Soluble MIC levels in serum correlated with high-grade and invasive tumor status, suggesting a potential biomarker for disease progression.
Researchers have discovered a new gene, EphB2, that plays a critical role in regulating tissue organization and maintaining normal cell behavior. The study found that this gene is inactivated in prostate cancer cells, leading to disorganization and tumor growth.
Researchers found DNA and proteins from BK virus in prostate tissue with abnormal cell changes, a precursor stage of prostate cancer. The virus may induce uncontrolled cell growth, leading to cancer.
Thomas Jefferson University is developing a clinical trial using a bone-targeted agent to treat microscopic bony metastasis in high-risk prostate cancer patients. The trial aims to improve death rates from prostate cancer by combining hormones and radiation with the targeted agent, Quadramet.
A new study by Mount Sinai School of Medicine researchers found that combining three therapeutic modalities increases the percentage of high-risk patients who are free from recurrence after five years. A three-pronged approach that included brachytherapy, external beam radiation therapy and hormonal therapy produced an 86 percent rate ...
A recent study found a significant correlation between active Stat5 protein and high-grade prostate cancer. The research suggests that blocking the signals that turn on Stat5 may lead to effective treatment strategies for advanced prostate cancer.
Researchers identified 671 genes with altered expression in prostate cancer tissue, revealing a high degree of similarity between benign adjacent tissue and cancerous tissue. The study found that genetic alterations occur throughout the gland, even in seemingly benign areas, providing new insights into prostate cancer progression.
Two projects aim to study angiogenesis and anti-angiogenic therapy, as well as the interaction between hormones and growth factors in prostate tumor growth. The ultimate goal is to develop new treatment strategies that suppress metastases by prolonging dormant states.
A study published in NEJM found that rapid rise in PSA levels prior to diagnosis is a stronger indicator of prostate cancer death than the actual PSA level. Early and annual testing are recommended for men with high PSA velocity to detect potential aggressiveness of cancers.
Researchers found that bicalutamide treatment resulted in increased bone mineral density, reduced body fat, and fewer side effects compared to leuprolide. This study suggests a single-drug treatment plan using bicalutamide may be an attractive alternative for men with non-metastatic prostate cancer.
A new study suggests that early hormone therapy can increase survival time by up to 14 years for men with aggressive prostate cancer, compared to those who delay treatment. Prostate cancer affects over 220,000 men annually in the US, with approximately 30,000 dying from the disease each year.
Researchers found that Cox-2 inhibitors slowed disease progression in men with recurrent prostate cancer by inhibiting tumor growth and increasing programmed cell death. The study showed significant results in 22 of 24 patients, with a 92% reduction in PSA levels after three months.
A study of 223 patients with early-stage, initially untreated prostate cancer found that disease progression increased significantly after 15 years of follow-up. After 10-15 years, most cancers had an indolent course, but progression rates decreased over time.
Two landmark studies show that Taxotere-based regimens improve patients' PSA responses by 43% and pain responses by 59%, leading to a 27% increase in disease-progression-free survival. The treatment also provides hope to thousands of men worldwide, offering an important new option for living longer.
A new study shows that estrogen skin patches can counteract high cholesterol associated with hormone therapy for prostate cancer. The patches decreased overall cholesterol levels by 10 percent and increased good cholesterol (HDL), while also improving lipid profiles.
A global study led by Johns Hopkins Medicine found that docetaxel therapy significantly improves survival time for hormone-resistant prostate cancer patients. Patients treated with tri-weekly docetaxel survived 2.4 months longer than those receiving the standard chemotherapy drug, mitoxantrone.
A new study finds that estrogen therapy significantly improves verbal memory performance in men with advanced prostate cancer, while hormone deprivation impairs it. Estrogen also reduces depression and confusion in these patients.
A new study found that hormone deprivation therapy is less effective for younger men with higher grade tumors, suggesting it needs further investigation as an alternative treatment for localized prostate cancer. The study also revealed a higher risk of bone fractures in men on hormone therapy due to osteoporosis.
A new study suggests that men who take statins, common cholesterol-lowering drugs, have a significantly reduced risk of prostate cancer. Statin use was associated with a 58% lower risk of prostate cancer and a 55% lower risk of elevated PSA levels.
Researchers found four distinct risk groups and seven independent risk factors for prostate cancer detection, including abnormal exam findings, age, family history, and PSA density. Men with high-risk features remain at risk despite multiple negative biopsies, emphasizing the need for vigilant follow-up.
A new medication called atrasentan has shown promise in slowing the progression of prostate cancer to the bone, reducing pain and maintaining quality of life. The drug's effect on stabilizing disease progression was observed across phase II and III clinical trials.
Researchers explore alternative biomarkers for prostate cancer using immune responses to AMACR, while a new RNA interference strategy shows potential in silencing PLK1 genes. The latest AJCC breast cancer staging system revision also influences false-negative rates.
Researchers developed two treatments to minimize nerve damage and facilitate nerve recovery, preserving ability to have an erection after radical prostatectomy. Muscle-derived cells and glial cell-derived neurotrophic factors improved erectile function in animal models with cavernous nerve injury.
Researchers found that quality of life for men treated for prostate cancer continues to evolve long-term, with some experiencing improvements and others worsening. Sexual function remains a significant concern for survivors, with reported lower quality of life compared to non-cancerous individuals.
A study by Mount Sinai School of Medicine found that brachytherapy effectively treats prostate cancer while preserving quality of life. The research team followed 255 patients with prostate cancer treated with I-125 and reported minimal urinary symptoms, preserved potency, and reduced bleeding.
A UMHS study found that African-American men with a history of gonorrhea are more likely to develop prostate cancer. The research suggests an inflammatory effect from the bacterial infection may trigger pre-existing cancerous cells to multiply, increasing risk.
Researchers have identified a new biomarker, EPCA, which may enable early detection and treatment of prostate cancer. The study found that EPCA was expressed in tissue samples from patients with prostate cancer who initially had negative biopsies.
Researchers found a significant association between high blood testosterone levels and an increased risk of prostate cancer in older men. The study, which followed over 3,000 men for 40 years, also showed that the protein sex hormone-binding globulin (SHBG) was associated with a slightly decreased risk for prostate cancer.
Moderately and severely obese patients experienced higher Gleason scores and rising PSA levels after surgery, indicating aggressive prostate cancer. Men with a BMI of greater than 35 kg/m2 had a 60% risk of cancer recurrence within three years.
A study found that over half of men taking part in a prostate cancer risk assessment program reported using dietary supplements to prevent the disease. The most commonly used supplements were vitamins and minerals, with saw-palmetto being one popular option.
A University of Michigan study found that most prostate cancer treatment guides overlook key details and favor active treatment over watchful waiting. The researchers recommend complete information on risks and benefits, clear writing styles, and visual elements to engage readers.
A study confirmed that BRCA2 mutations are linked to prostate cancer, with a risk 4.8 times higher than in healthy individuals. The results suggest that prostate cancer screening may begin at age 50 for men carrying these mutations.
A study found that black men with prostate cancer are more likely to die from the disease due to delayed or inadequate care, particularly those without other diagnosed illnesses. The researchers suggest that cultural and social factors contribute to this disparity.
A study found that men who consumed green and black tea for five days had slower-growing prostate cancer cells compared to those who drank diet or regular soda. The researchers discovered a significant negative correlation between total polyamine levels and tea polyphenol content in the tissue.
A new online tool provides personalized 10-year survival predictions for prostate cancer patients, taking into account age, race, co-morbidities, and treatment type. The model also highlights the significant impact of co-morbidities on long-term survival rates.
Prostate cancer cell lines exhibit high levels of free radical damage and defective repair mechanisms, leading to a cascade of events culminating in further DNA damage and cellular dysfunction. The new research provides solid evidence for the critical role of free radicals and repair in prostate cancer development.