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Science News for December 16, 2003


Treaty violations in wartime predictable

Researcher Ashley Leeds found that alliance commitments are fulfilled about 75 percent of the time, but this rate drops to 6 percent for countries with significant changes in international power. Non-democratic states and major powers are more likely to violate treaties due to lower costs and increased influence.

SourceRice University·JournalInternational Organization·DateDec 16, 2003

Study supports tailoring adjuvant therapy for early-stage breast cancer

A new study suggests that premenopausal women with ER-negative breast cancer may benefit from adjuvant chemotherapy alone or followed by goserelin, while those with ER-positive tumors show no significant difference in outcomes. The findings support the idea of ovarian suppression as a treatment alternative for some premenopausal women.

SourceJournal of the National Cancer Institute·JournalJNCI Journal of the National Cancer Institute·DateDec 16, 2003

Oral drug showing promise for breast cancer prevention in a mouse model

Researchers found that oral drug ZD1839 suppressed the growth of ER-negative breast cancer cells and delayed the formation of tumors in transgenic mice. The treatment also reduced proliferation of normal breast cells by 20.3% and tumor cells by 42%. However, long-term safety data are needed for further research.

SourceJournal of the National Cancer Institute·JournalJNCI Journal of the National Cancer Institute·DateDec 16, 2003

Other highlights in the December 17 issue of JNCI

Researchers identified frequent BRAF mutations in intermittent sun-exposed skin melanomas, but rare mutations in chronically sun-damaged or unseen skin. Additionally, bladder cancer cell lines showed defective checkpoint function, suggesting barriers to carcinogenesis. These findings may inform therapeutic strategies for these diseases.

SourceJournal of the National Cancer Institute·JournalJNCI Journal of the National Cancer Institute·DateDec 16, 2003